Reviewed, UniProtKB/Swiss-Prot Q930J0 (HIS83_RHIME)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 3
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 3

Gene names

Name:	hisC3
Ordered Locus Names:	RA0206
ORF Names:	SMa0387

Encoded on

Plasmid pSymA (megaplasmid 1)

Organism

Rhizobium meliloti (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

382 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Histidinol-phosphate aminotransferase 3 HAMAP MF_01023		PRO_0000153437
Amino acid modifications
	Modified residue	229	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q930J0-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 81A868235F0EE332	FASTA	370	40,712
	10 20 30 40 50 60 MAIPSRPIRE EIRSIAPYNA GLTLEEVRAK YHVDEVAKLS SNENPLGPSP ALRRLFPDIG 70 80 90 100 110 120 ELARLYPDPQ GRALCARLAA SFDVENNQVI LGNGSEDLIA VICRSVVRAG DTVVTLYPSF 130 140 150 160 170 180 PLHEDYTTLM GGKVDRVTVT PDLSVDMDAL LAAIARKPRM LMFSNPMNPV GSWLTPLQLA 190 200 210 220 230 240 KVVAALDPET LIVVDEAYAE YAAGDDYPSA AEVLKVTGLN WVVLRTFSKA YGLAGLRIGY 250 260 270 280 290 300 GIVSDGSLCD FFNRARTPFN TNAIAQVSAL AAFDDTYHLN RSVELALVER ERMKKELATM 310 320 330 340 350 360 GYRIAPSKCN FLFFDARTEA TPVAEALLRR GVIVKPWKQP RFETYIRVSI GSPVENDHFI 370 HALKEVEAVG

References

[1]

"Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmid." Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F., Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L., Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H. , Palm C., Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A., Long S.R. Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001) [PubMed: 11481432] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006469 Genomic DNA. Translation: AAK64864.1.
PIR	F95287.
RefSeq	NP_435452.1.
3D structure databases
SMR	Q930J0. Positions 6-366.
ModBase	Search...
Genome annotation databases
GeneID	1235431.
GenomeReviews	Gene locus RA0206 in contig AE006469_GR.
KEGG	sme:SMa0387.
NMPDR	fig|266834.1.peg.206.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646350.
OMA	SFPLHED.
Enzyme and pathway databases
BioCyc	SMEL266834:SMA0387-MONOMER.
BRENDA	2.6.1.9. 142.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS83_RHIME

Accession

Primary (citable) accession number: Q930J0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	December 1, 2001
Last modified:	February 9, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)