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Q930I4

- HISX2_RHIME

UniProt

Q930I4 - HISX2_RHIME

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Protein

Histidinol dehydrogenase 2

Gene
hisD2, RA0212, SMa0398
Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi276 – 2761Zinc By similarity
Metal bindingi279 – 2791Zinc By similarity
Active sitei347 – 3471Proton acceptor By similarity
Active sitei348 – 3481Proton acceptor By similarity
Metal bindingi440 – 4401Zinc By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-5220-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 2 (EC:1.1.1.23)
Short name:
HDH 2
Gene namesi
Name:hisD2
Ordered Locus Names:RA0212
ORF Names:SMa0398
Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Plasmid pSymA

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Histidinol dehydrogenase 2UniRule annotationPRO_0000135833Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMa0398.

Structurei

3D structure databases

ProteinModelPortaliQ930I4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYEGFSSH.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q930I4-1 [UniParc]FASTAAdd to Basket

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MTLRPQLARY KDKTMTSVSF YEYSKLNAEE KAALLRRSET DISGFIEKVA    50
PILEAVRTEG DKALARFGRE LDKADVTEAN LKVTAAEFDA AFKLVDASVL 100
ESVQFGIDNI RKFHEEQKPE AMWLKEIRPG AFAGDRFTPI QSVALYVPRG 150
KGSFPSVTMM TSVPAVVAGV PNLAIVTPPA PDGSVDAATL VAARLAGVET 200
VYKAGGAQAV AAVAYGTETV KPALKIVGPG SPWVVAAKRS LSGVIDTGLP 250
AGPSEVMILA DDTVHGGLAA LDLLIEAEHG PDSSAYLVTH SGRVAEEALA 300
ALPEHWARMT EQRTAFSKTV LSGKTGGIVL TSSIEESYEF VNAYAPEHLE 350
LLSEQPFIHL GHITEASEIL MGTHTPVSIA NFSLGPNAVL PTSRWARTFG 400
PLSVTDFVKR SSIGYVTAPA YPEFARHSHN LAIYEGFSSH ALAVSPVRDA 450
YLKKGA 456
Length:456
Mass (Da):48,702
Last modified:December 1, 2001 - v1
Checksum:i958D34D91C28DEEA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006469 Genomic DNA. Translation: AAK64870.1.
PIRiD95288.
RefSeqiNP_435458.3. NC_003037.1.
WP_010967210.1. NC_003037.1.

Genome annotation databases

EnsemblBacteriaiAAK64870; AAK64870; SMa0398.
GeneIDi1235437.
KEGGisme:SMa0398.
PATRICi23626884. VBISinMel96828_0220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006469 Genomic DNA. Translation: AAK64870.1 .
PIRi D95288.
RefSeqi NP_435458.3. NC_003037.1.
WP_010967210.1. NC_003037.1.

3D structure databases

ProteinModelPortali Q930I4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMa0398.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK64870 ; AAK64870 ; SMa0398 .
GeneIDi 1235437.
KEGGi sme:SMa0398.
PATRICi 23626884. VBISinMel96828_0220.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YEGFSSH.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SMEL266834:GJF6-5220-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiHISX2_RHIME
AccessioniPrimary (citable) accession number: Q930I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

The conserved zinc-binding site Asp residue in position 381 is replaced by an Asn.

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3