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Q930I4

- HISX2_RHIME

UniProt

Q930I4 - HISX2_RHIME

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Protein

Histidinol dehydrogenase 2

Gene

hisD2

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi276 – 2761ZincBy similarity
Metal bindingi279 – 2791ZincBy similarity
Active sitei347 – 3471Proton acceptorBy similarity
Active sitei348 – 3481Proton acceptorBy similarity
Metal bindingi440 – 4401ZincBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-5220-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 2 (EC:1.1.1.23)
Short name:
HDH 2
Gene namesi
Name:hisD2
Ordered Locus Names:RA0212
ORF Names:SMa0398
Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Plasmid pSymA

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Histidinol dehydrogenase 2PRO_0000135833Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMa0398.

Structurei

3D structure databases

ProteinModelPortaliQ930I4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYEGFSSH.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q930I4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLRPQLARY KDKTMTSVSF YEYSKLNAEE KAALLRRSET DISGFIEKVA
60 70 80 90 100
PILEAVRTEG DKALARFGRE LDKADVTEAN LKVTAAEFDA AFKLVDASVL
110 120 130 140 150
ESVQFGIDNI RKFHEEQKPE AMWLKEIRPG AFAGDRFTPI QSVALYVPRG
160 170 180 190 200
KGSFPSVTMM TSVPAVVAGV PNLAIVTPPA PDGSVDAATL VAARLAGVET
210 220 230 240 250
VYKAGGAQAV AAVAYGTETV KPALKIVGPG SPWVVAAKRS LSGVIDTGLP
260 270 280 290 300
AGPSEVMILA DDTVHGGLAA LDLLIEAEHG PDSSAYLVTH SGRVAEEALA
310 320 330 340 350
ALPEHWARMT EQRTAFSKTV LSGKTGGIVL TSSIEESYEF VNAYAPEHLE
360 370 380 390 400
LLSEQPFIHL GHITEASEIL MGTHTPVSIA NFSLGPNAVL PTSRWARTFG
410 420 430 440 450
PLSVTDFVKR SSIGYVTAPA YPEFARHSHN LAIYEGFSSH ALAVSPVRDA

YLKKGA
Length:456
Mass (Da):48,702
Last modified:December 1, 2001 - v1
Checksum:i958D34D91C28DEEA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006469 Genomic DNA. Translation: AAK64870.1.
PIRiD95288.
RefSeqiNP_435458.3. NC_003037.1.

Genome annotation databases

EnsemblBacteriaiAAK64870; AAK64870; SMa0398.
GeneIDi1235437.
KEGGisme:SMa0398.
PATRICi23626884. VBISinMel96828_0220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006469 Genomic DNA. Translation: AAK64870.1 .
PIRi D95288.
RefSeqi NP_435458.3. NC_003037.1.

3D structure databases

ProteinModelPortali Q930I4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMa0398.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK64870 ; AAK64870 ; SMa0398 .
GeneIDi 1235437.
KEGGi sme:SMa0398.
PATRICi 23626884. VBISinMel96828_0220.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YEGFSSH.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SMEL266834:GJF6-5220-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiHISX2_RHIME
AccessioniPrimary (citable) accession number: Q930I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

The conserved zinc-binding site Asp residue in position 381 is replaced by an Asn.Curated

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3