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Q930I4

- HISX2_RHIME

UniProt

Q930I4 - HISX2_RHIME

Protein

Histidinol dehydrogenase 2

Gene

hisD2

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi276 – 2761ZincBy similarity
    Metal bindingi279 – 2791ZincBy similarity
    Active sitei347 – 3471Proton acceptorBy similarity
    Active sitei348 – 3481Proton acceptorBy similarity
    Metal bindingi440 – 4401ZincBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciSMEL266834:GJF6-5220-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase 2 (EC:1.1.1.23)
    Short name:
    HDH 2
    Gene namesi
    Name:hisD2
    Ordered Locus Names:RA0212
    ORF Names:SMa0398
    Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Plasmid pSymA

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456Histidinol dehydrogenase 2PRO_0000135833Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SMa0398.

    Structurei

    3D structure databases

    ProteinModelPortaliQ930I4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYEGFSSH.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q930I4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLRPQLARY KDKTMTSVSF YEYSKLNAEE KAALLRRSET DISGFIEKVA    50
    PILEAVRTEG DKALARFGRE LDKADVTEAN LKVTAAEFDA AFKLVDASVL 100
    ESVQFGIDNI RKFHEEQKPE AMWLKEIRPG AFAGDRFTPI QSVALYVPRG 150
    KGSFPSVTMM TSVPAVVAGV PNLAIVTPPA PDGSVDAATL VAARLAGVET 200
    VYKAGGAQAV AAVAYGTETV KPALKIVGPG SPWVVAAKRS LSGVIDTGLP 250
    AGPSEVMILA DDTVHGGLAA LDLLIEAEHG PDSSAYLVTH SGRVAEEALA 300
    ALPEHWARMT EQRTAFSKTV LSGKTGGIVL TSSIEESYEF VNAYAPEHLE 350
    LLSEQPFIHL GHITEASEIL MGTHTPVSIA NFSLGPNAVL PTSRWARTFG 400
    PLSVTDFVKR SSIGYVTAPA YPEFARHSHN LAIYEGFSSH ALAVSPVRDA 450
    YLKKGA 456
    Length:456
    Mass (Da):48,702
    Last modified:December 1, 2001 - v1
    Checksum:i958D34D91C28DEEA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006469 Genomic DNA. Translation: AAK64870.1.
    PIRiD95288.
    RefSeqiNP_435458.3. NC_003037.1.
    WP_010967210.1. NC_003037.1.

    Genome annotation databases

    EnsemblBacteriaiAAK64870; AAK64870; SMa0398.
    GeneIDi1235437.
    KEGGisme:SMa0398.
    PATRICi23626884. VBISinMel96828_0220.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006469 Genomic DNA. Translation: AAK64870.1 .
    PIRi D95288.
    RefSeqi NP_435458.3. NC_003037.1.
    WP_010967210.1. NC_003037.1.

    3D structure databases

    ProteinModelPortali Q930I4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMa0398.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK64870 ; AAK64870 ; SMa0398 .
    GeneIDi 1235437.
    KEGGi sme:SMa0398.
    PATRICi 23626884. VBISinMel96828_0220.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YEGFSSH.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci SMEL266834:GJF6-5220-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiHISX2_RHIME
    AccessioniPrimary (citable) accession number: Q930I4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    The conserved zinc-binding site Asp residue in position 381 is replaced by an Asn.Curated

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3