ID   Q930F6_RHIME            Unreviewed;      1058 AA.
AC   Q930F6;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:AAK64900.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:AAK64900.1};
GN   Name=cyaI2 {ECO:0000313|EMBL:AAK64900.1};
GN   ORFNames=SMa0464 {ECO:0000313|EMBL:AAK64900.1};
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OG   Plasmid pSymA {ECO:0000313|EMBL:AAK64900.1,
OG   ECO:0000313|Proteomes:UP000001976}.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834 {ECO:0000313|EMBL:AAK64900.1, ECO:0000313|Proteomes:UP000001976};
RN   [1] {ECO:0000313|EMBL:AAK64900.1, ECO:0000313|Proteomes:UP000001976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021 {ECO:0000313|EMBL:AAK64900.1,
RC   ECO:0000313|Proteomes:UP000001976};
RC   PLASMID=Plasmid pSymA {ECO:0000313|Proteomes:UP000001976};
RX   PubMed=11481432; DOI=10.1073/pnas.161294798;
RA   Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F.,
RA   Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L.,
RA   Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H., Palm C.,
RA   Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A.,
RA   Long S.R.;
RT   "Nucleotide sequence and predicted functions of the entire Sinorhizobium
RT   meliloti pSymA megaplasmid.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001).
RN   [2] {ECO:0000313|Proteomes:UP000001976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021 {ECO:0000313|Proteomes:UP000001976};
RC   PLASMID=Plasmid pSymA {ECO:0000313|Proteomes:UP000001976};
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
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DR   EMBL; AE006469; AAK64900.1; -; Genomic_DNA.
DR   PIR; B95292; B95292.
DR   RefSeq; NP_435488.1; NC_003037.1.
DR   RefSeq; WP_010967237.1; NC_003037.1.
DR   AlphaFoldDB; Q930F6; -.
DR   EnsemblBacteria; AAK64900; AAK64900; SMa0464.
DR   GeneID; 61599080; -.
DR   KEGG; sme:SMa0464; -.
DR   PATRIC; fig|266834.11.peg.256; -.
DR   HOGENOM; CLU_004435_0_1_5; -.
DR   OrthoDB; 9785312at2; -.
DR   Proteomes; UP000001976; Plasmid pSymA.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:AAK64900.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Plasmid {ECO:0000313|EMBL:AAK64900.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001976}.
FT   DOMAIN          34..163
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1058 AA;  115468 MW;  7F742F8BB1FE1BC5 CRC64;
     MAVIRRPSRS LTPTEEIALA RPEPPAEDVR KTITILIADI VDSSRLSLTL DPEALRELFA
     RYFDEMTSTI QRHGGVVDRY VGDEILAVFG VPTLHEDDAL RAVSAAVDMR DTLARLNHEF
     ETGWGVQLAH RIGLNTGEVF TGIDRWGHRF LTGEAVRVAK RLQEAAAANE ILMGEATHKL
     VRHAVVVESS SPRAVKHGET FPAIIVLTVI ARTTGFQRRF DTPFVGRKRQ LAMISTLLGD
     FVSNRTCHLL TVLGEAGVGK SRLVSEVAGN LAREMTVAHG RCLPYGDGIT YWLLADIVRE
     IFRAGGGDSG KLSVAAIAEV LAGVDKAKLI AERIAGLLGF GAGDPGTREE TFWAVRRLFE
     VFARERPVVI VVEDLHWADP TLLDFIEHLV DFSHGFPIMI VATARPELLD TRPGWGGGTP
     NATTIALEPL SEAESRDMVL NLLHRLPLSP AVELMITRAV GGNPLFAEEL VAMLVDEELL
     RRNEDCWVAR EDLSELPVPS TIIALLAARL EGLTSQERAI LTAAAVEGAV FHRSAVDELA
     RPAPKALGDG LLSLVRRDLI RPEAPSFVGE ETYRFRHDMI REAAYRSLPK NARADLHERF
     ASWLEITAKE RLREFEEVVG YHLEQAFQYR IALGPRGARA ASLAARACER LEAAGRRALV
     RSDLSAAISL LERVSRLLLA DDPRRIALLA ELSGALIESG RLDDAGRVLE EAGGLAGAAM
     DRRLAAHVRV QRQFLRLLHG EEGGLEKAAQ AAAEVIPVFE GFGDDLGLCR ARRLEAWLFF
     NGARGEAAAA AWERAAAHAR RAGNLHEYYE ILTWIASSLW FGPTPAAEGI RRCEAMRAEV
     GESLESEAAI LRQLACLNAV VGRFAIAREL IAASNATYAD LGLTLYVASS EHEAVVELLA
     GNPAAAERSA RAAYRALEEM GERAFRSTMA ASLAVVILEQ GRDEEAEDFA KLSAQLAASG
     DLVTQVRWRR VRARVLARRA EISAAEALAR EALEIAEKTD FINDRADALV DLSHVLEASR
     RRDEAVAAAT GAVHLYELKG NVVAAAATRL RLGKLVAM
//