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Protein

Protein Wnt-8b

Gene

WNT8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.1 Publication

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • receptor ligand activity Source: WormBase

GO - Biological processi

  • beta-catenin destruction complex disassembly Source: Reactome
  • canonical Wnt signaling pathway Source: WormBase
  • cell fate commitment Source: GO_Central
  • cellular response to retinoic acid Source: UniProtKB
  • determination of dorsal identity Source: BHF-UCL
  • gastrulation Source: BHF-UCL
  • nervous system development Source: ProtInc
  • neuron differentiation Source: UniProtKB
  • response to estradiol Source: BHF-UCL
  • response to retinoic acid Source: BHF-UCL
  • signal transduction Source: ProtInc
  • Wnt signaling pathway Source: GO_Central

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-201681. TCF dependent signaling in response to WNT.
R-HSA-3238698. WNT ligand biogenesis and trafficking.
R-HSA-373080. Class B/2 (Secretin family receptors).
R-HSA-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.
SIGNORiQ93098.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-8b
Gene namesi
Name:WNT8B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000075290.7.
HGNCiHGNC:12789. WNT8B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7479.
OpenTargetsiENSG00000075290.
PharmGKBiPA37390.

Polymorphism and mutation databases

BioMutaiWNT8B.
DMDMi66774217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000004145023 – 351Protein Wnt-8bAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 65By similarity
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104 ↔ 112By similarity
Disulfide bondi114 ↔ 132By similarity
Disulfide bondi180 ↔ 194By similarity
Disulfide bondi182 ↔ 189By similarity
Lipidationi186O-palmitoleoyl serineBy similarity1
Disulfide bondi256 ↔ 294By similarity
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi272 ↔ 287By similarity
Disulfide bondi291 ↔ 333By similarity
Disulfide bondi309 ↔ 324By similarity
Disulfide bondi311 ↔ 321By similarity
Disulfide bondi316 ↔ 317By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).By similarity
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8B.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiQ93098.
PRIDEiQ93098.

Expressioni

Tissue specificityi

Expression is restricted to the brain, and more specifically to the forebrain.1 Publication

Gene expression databases

BgeeiENSG00000075290.
CleanExiHS_WNT8B.
GenevisibleiQ93098. HS.

Organism-specific databases

HPAiHPA036570.

Interactioni

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • receptor ligand activity Source: WormBase

Protein-protein interaction databases

STRINGi9606.ENSP00000340677.

Structurei

3D structure databases

ProteinModelPortaliQ93098.
SMRiQ93098.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiQ93098.
KOiK00714.
OMAiKWEKRSC.
OrthoDBiEOG091G0B1B.
PhylomeDBiQ93098.
TreeFamiTF105310.

Family and domain databases

InterProiView protein in InterPro
IPR034311. Protein_Wnt-8B.
IPR005817. Wnt.
IPR013301. Wnt8.
IPR018161. Wnt_CS.
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF94. PTHR12027:SF94. 1 hit.
PfamiView protein in Pfam
PF00110. wnt. 1 hit.
PRINTSiPR01892. WNT8PROTEIN.
PR01349. WNTPROTEIN.
SMARTiView protein in SMART
SM00097. WNT1. 1 hit.
PROSITEiView protein in PROSITE
PS00246. WNT1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLSKPSVYI CLFTCVLQLS HSWSVNNFLM TGPKAYLIYS SSVAAGAQSG
60 70 80 90 100
IEECKYQFAW DRWNCPERAL QLSSHGGLRS ANRETAFVHA ISSAGVMYTL
110 120 130 140 150
TRNCSLGDFD NCGCDDSRNG QLGGQGWLWG GCSDNVGFGE AISKQFVDAL
160 170 180 190 200
ETGQDARAAM NLHNNEAGRK AVKGTMKRTC KCHGVSGSCT TQTCWLQLPE
210 220 230 240 250
FREVGAHLKE KYHAALKVDL LQGAGNSAAG RGAIADTFRS ISTRELVHLE
260 270 280 290 300
DSPDYCLENK TLGLLGTEGR ECLRRGRALG RWERRSCRRL CGDCGLAVEE
310 320 330 340 350
RRAETVSSCN CKFHWCCAVR CEQCRRRVTK YFCSRAERPR GGAAHKPGRK

P
Length:351
Mass (Da):38,721
Last modified:May 24, 2005 - v3
Checksum:iDD242070948813F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti230G → A (PubMed:9536085).Curated1
Sequence conflicti230G → A (PubMed:8661156).Curated1
Sequence conflicti284R → L (PubMed:9536085).Curated1
Sequence conflicti284R → L (PubMed:8661156).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02031011C → S. Corresponds to variant dbSNP:rs3793771Ensembl.1
Natural variantiVAR_03628853E → Q in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11094 mRNA. Translation: CAA71968.1.
Y11108 Genomic DNA. Translation: CAA71994.1.
AB073637 mRNA. Translation: BAB83924.1.
AL359759 Genomic DNA. No translation available.
AL133352 Genomic DNA. No translation available.
X91940 mRNA. Translation: CAA63017.1.
CCDSiCCDS7494.1.
RefSeqiNP_003384.2. NM_003393.3.
UniGeneiHs.421281.

Genome annotation databases

EnsembliENST00000343737; ENSP00000340677; ENSG00000075290.
GeneIDi7479.
KEGGihsa:7479.
UCSCiuc001krb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWNT8B_HUMAN
AccessioniPrimary (citable) accession number: Q93098
Secondary accession number(s): O00771, Q5VX55, Q8WYK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 24, 2005
Last modified: November 22, 2017
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families