Q93098 (WNT8B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Wnt-8b

Gene names

Name:

WNT8B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. Ref.1
Subcellular location	Secreted › extracellular space › extracellular matrix.
Tissue specificity	Expression is restricted to the brain, and more specifically to the forebrain. Ref.1
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway involved in forebrain neuron fate commitment Inferred from Biological aspect of Ancestor. Source: RefGenome axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome cellular response to retinoic acid Inferred from sequence or structural similarity. Source: UniProtKB determination of dorsal identity Inferred from sequence or structural similarity PubMed 7635061. Source: BHF-UCL endoderm development Inferred from Biological aspect of Ancestor. Source: RefGenome eye development Inferred from Biological aspect of Ancestor. Source: RefGenome gastrulation Inferred from sequence or structural similarity PubMed 7635061. Source: BHF-UCL hypothalamus development Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of gene expression Inferred from electronic annotation. Source: Compara otic placode formation Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of gene expression Inferred from Biological aspect of Ancestor. Source: RefGenome response to estradiol stimulus Non-traceable author statement PubMed 11956596. Source: BHF-UCL
Cellular_component	extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 351	329	Protein Wnt-8b		PRO_0000041450
Amino acid modifications
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
	Glycosylation	259	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	11	1	C → S. Corresponds to variant rs3793771 [ dbSNP | Ensembl ].		VAR_020310
	Natural variant	53	1	E → Q in a colorectal cancer sample; somatic mutation. Ref.5		VAR_036288
Experimental info
	Sequence conflict	230	1	G → A Ref.1
	Sequence conflict	230	1	G → A Ref.4
	Sequence conflict	284	1	R → L Ref.1
	Sequence conflict	284	1	R → L Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q93098 [UniParc]. Last modified May 24, 2005. Version 3. Checksum: DD242070948813F8	FASTA	351	38,721
	10 20 30 40 50 60 MFLSKPSVYI CLFTCVLQLS HSWSVNNFLM TGPKAYLIYS SSVAAGAQSG IEECKYQFAW 70 80 90 100 110 120 DRWNCPERAL QLSSHGGLRS ANRETAFVHA ISSAGVMYTL TRNCSLGDFD NCGCDDSRNG 130 140 150 160 170 180 QLGGQGWLWG GCSDNVGFGE AISKQFVDAL ETGQDARAAM NLHNNEAGRK AVKGTMKRTC 190 200 210 220 230 240 KCHGVSGSCT TQTCWLQLPE FREVGAHLKE KYHAALKVDL LQGAGNSAAG RGAIADTFRS 250 260 270 280 290 300 ISTRELVHLE DSPDYCLENK TLGLLGTEGR ECLRRGRALG RWERRSCRRL CGDCGLAVEE 310 320 330 340 350 RRAETVSSCN CKFHWCCAVR CEQCRRRVTK YFCSRAERPR GGAAHKPGRK P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel mammalian Wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain." Lako M., Lindsay S., Bullen P., Wilson D.I., Robson S.C., Strachan T. Hum. Mol. Genet. 7:813-822(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]	"Up-regulation of WNT8B mRNA in human gastric cancer." Saitoh T., Mine T., Katoh M. Int. J. Oncol. 20:343-348(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain.
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24." Lako M., Strachan T., Curtis A.R.J., Lindsay S. Genomics 35:386-388(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-317.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-53.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y11094 mRNA. Translation: CAA71968.1. Y11108 Genomic DNA. Translation: CAA71994.1. AB073637 mRNA. Translation: BAB83924.1. AL359759, AL133352 Genomic DNA. Translation: CAH71991.1. AL133352, AL359759 Genomic DNA. Translation: CAH73565.1. X91940 mRNA. Translation: CAA63017.1.
IPI	IPI00004125.
RefSeq	NP_003384.2. NM_003393.3.
UniGene	Hs.421281.
3D structure databases
ProteinModelPortal	Q93098.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000340677.
PTM databases
PhosphoSite	Q93098.
Polymorphism databases
DMDM	66774217.
Proteomic databases
PaxDb	Q93098.
PRIDE	Q93098.
Protocols and materials databases
DNASU	7479.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343737; ENSP00000340677; ENSG00000075290.
GeneID	7479.
KEGG	hsa:7479.
UCSC	uc001krb.3. human.
Organism-specific databases
CTD	7479.
GeneCards	GC10P102212.
HGNC	HGNC:12789. WNT8B.
HPA	HPA036570.
MIM	601396. gene.
neXtProt	NX_Q93098.
PharmGKB	PA37390.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG277037.
HOGENOM	HOG000039529.
HOVERGEN	HBG001595.
InParanoid	Q93098.
KO	K00714.
OMA	KYFCVRK.
OrthoDB	EOG4CNQRC.
PhylomeDB	Q93098.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q93098.
CleanEx	HS_WNT8B.
Genevestigator	Q93098.
GermOnline	ENSG00000075290. Homo sapiens.
Family and domain databases
InterPro	IPR005817. Wnt. IPR013301. Wnt8. IPR018161. Wnt_CS. [Graphical view]
PANTHER	PTHR12027. PTHR12027. 1 hit. PTHR12027:SF6. PTHR12027:SF6. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01892. WNT8PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7479.
NextBio	29296.
SOURCE	Search...

Entry information

Entry name

WNT8B_HUMAN

Accession

Primary (citable) accession number: Q93098
Secondary accession number(s): O00771, Q5VX55, Q8WYK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 113 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.