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Q93098

- WNT8B_HUMAN

UniProt

Q93098 - WNT8B_HUMAN

Protein

Protein Wnt-8b

Gene

WNT8B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (24 May 2005)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.1 Publication

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome

    GO - Biological processi

    1. cell fate commitment Source: RefGenome
    2. cellular response to retinoic acid Source: UniProtKB
    3. determination of dorsal identity Source: BHF-UCL
    4. gastrulation Source: BHF-UCL
    5. negative regulation of gene expression Source: Ensembl
    6. nervous system development Source: ProtInc
    7. neuron differentiation Source: UniProtKB
    8. positive regulation of gene expression Source: Ensembl
    9. response to estradiol Source: BHF-UCL
    10. response to retinoic acid Source: BHF-UCL
    11. signal transduction Source: ProtInc
    12. Wnt signaling pathway Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).
    REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_200777. TCF dependent signaling in response to WNT.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-8b
    Gene namesi
    Name:WNT8B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:12789. WNT8B.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: RefGenome
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37390.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 351329Protein Wnt-8bPRO_0000041450Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 65By similarity
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 112By similarity
    Disulfide bondi114 ↔ 132By similarity
    Disulfide bondi180 ↔ 194By similarity
    Disulfide bondi182 ↔ 189By similarity
    Disulfide bondi256 ↔ 294By similarity
    Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi272 ↔ 287By similarity
    Disulfide bondi291 ↔ 333By similarity
    Disulfide bondi309 ↔ 324By similarity
    Disulfide bondi311 ↔ 321By similarity
    Disulfide bondi316 ↔ 317By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ93098.
    PRIDEiQ93098.

    PTM databases

    PhosphoSiteiQ93098.

    Expressioni

    Tissue specificityi

    Expression is restricted to the brain, and more specifically to the forebrain.1 Publication

    Gene expression databases

    BgeeiQ93098.
    CleanExiHS_WNT8B.
    GenevestigatoriQ93098.

    Organism-specific databases

    HPAiHPA036570.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000340677.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93098.
    SMRiQ93098. Positions 31-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG277037.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiQ93098.
    KOiK00714.
    OMAiSTPQARW.
    OrthoDBiEOG7C8GJ8.
    PhylomeDBiQ93098.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR013301. Wnt8.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF94. PTHR12027:SF94. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01892. WNT8PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q93098-1 [UniParc]FASTAAdd to Basket

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    MFLSKPSVYI CLFTCVLQLS HSWSVNNFLM TGPKAYLIYS SSVAAGAQSG    50
    IEECKYQFAW DRWNCPERAL QLSSHGGLRS ANRETAFVHA ISSAGVMYTL 100
    TRNCSLGDFD NCGCDDSRNG QLGGQGWLWG GCSDNVGFGE AISKQFVDAL 150
    ETGQDARAAM NLHNNEAGRK AVKGTMKRTC KCHGVSGSCT TQTCWLQLPE 200
    FREVGAHLKE KYHAALKVDL LQGAGNSAAG RGAIADTFRS ISTRELVHLE 250
    DSPDYCLENK TLGLLGTEGR ECLRRGRALG RWERRSCRRL CGDCGLAVEE 300
    RRAETVSSCN CKFHWCCAVR CEQCRRRVTK YFCSRAERPR GGAAHKPGRK 350
    P 351
    Length:351
    Mass (Da):38,721
    Last modified:May 24, 2005 - v3
    Checksum:iDD242070948813F8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti230 – 2301G → A(PubMed:9536085)Curated
    Sequence conflicti230 – 2301G → A(PubMed:8661156)Curated
    Sequence conflicti284 – 2841R → L(PubMed:9536085)Curated
    Sequence conflicti284 – 2841R → L(PubMed:8661156)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111C → S.
    Corresponds to variant rs3793771 [ dbSNP | Ensembl ].
    VAR_020310
    Natural varianti53 – 531E → Q in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036288

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11094 mRNA. Translation: CAA71968.1.
    Y11108 Genomic DNA. Translation: CAA71994.1.
    AB073637 mRNA. Translation: BAB83924.1.
    AL359759, AL133352 Genomic DNA. Translation: CAH71991.1.
    AL133352, AL359759 Genomic DNA. Translation: CAH73565.1.
    X91940 mRNA. Translation: CAA63017.1.
    CCDSiCCDS7494.1.
    RefSeqiNP_003384.2. NM_003393.3.
    UniGeneiHs.421281.

    Genome annotation databases

    EnsembliENST00000343737; ENSP00000340677; ENSG00000075290.
    GeneIDi7479.
    KEGGihsa:7479.
    UCSCiuc001krb.3. human.

    Polymorphism databases

    DMDMi66774217.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11094 mRNA. Translation: CAA71968.1 .
    Y11108 Genomic DNA. Translation: CAA71994.1 .
    AB073637 mRNA. Translation: BAB83924.1 .
    AL359759 , AL133352 Genomic DNA. Translation: CAH71991.1 .
    AL133352 , AL359759 Genomic DNA. Translation: CAH73565.1 .
    X91940 mRNA. Translation: CAA63017.1 .
    CCDSi CCDS7494.1.
    RefSeqi NP_003384.2. NM_003393.3.
    UniGenei Hs.421281.

    3D structure databases

    ProteinModelPortali Q93098.
    SMRi Q93098. Positions 31-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000340677.

    PTM databases

    PhosphoSitei Q93098.

    Polymorphism databases

    DMDMi 66774217.

    Proteomic databases

    PaxDbi Q93098.
    PRIDEi Q93098.

    Protocols and materials databases

    DNASUi 7479.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343737 ; ENSP00000340677 ; ENSG00000075290 .
    GeneIDi 7479.
    KEGGi hsa:7479.
    UCSCi uc001krb.3. human.

    Organism-specific databases

    CTDi 7479.
    GeneCardsi GC10P102212.
    HGNCi HGNC:12789. WNT8B.
    HPAi HPA036570.
    MIMi 601396. gene.
    neXtProti NX_Q93098.
    PharmGKBi PA37390.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277037.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi Q93098.
    KOi K00714.
    OMAi STPQARW.
    OrthoDBi EOG7C8GJ8.
    PhylomeDBi Q93098.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).
    REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_200777. TCF dependent signaling in response to WNT.

    Miscellaneous databases

    GeneWikii WNT8B.
    GenomeRNAii 7479.
    NextBioi 29296.
    PROi Q93098.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q93098.
    CleanExi HS_WNT8B.
    Genevestigatori Q93098.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR013301. Wnt8.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF94. PTHR12027:SF94. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01892. WNT8PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel mammalian Wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain."
      Lako M., Lindsay S., Bullen P., Wilson D.I., Robson S.C., Strachan T.
      Hum. Mol. Genet. 7:813-822(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. "Up-regulation of WNT8B mRNA in human gastric cancer."
      Saitoh T., Mine T., Katoh M.
      Int. J. Oncol. 20:343-348(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24."
      Lako M., Strachan T., Curtis A.R.J., Lindsay S.
      Genomics 35:386-388(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-317.
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-53.

    Entry informationi

    Entry nameiWNT8B_HUMAN
    AccessioniPrimary (citable) accession number: Q93098
    Secondary accession number(s): O00771, Q5VX55, Q8WYK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3