Reviewed, UniProtKB/Swiss-Prot Q93098 (WNT8B_HUMAN)

Names and originHide

Protein names

Recommended name:
Protein Wnt-8b

Gene names

Name:

WNT8B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributesHide

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)Hide

Function	Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. Ref.1
Subcellular location	Secreted › extracellular space › extracellular matrix.
Tissue specificity	Expression is restricted to the brain, and more specifically to the forebrain. Ref.1
Sequence similarities	Belongs to the Wnt family.

OntologiesHide

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway, calcium modulating pathway Inferred from electronic annotation. Source: InterPro cell-cell signaling Traceable author statement. Source: ProtInc nervous system development Traceable author statement. Source: ProtInc signal transduction Traceable author statement. Source: ProtInc
Cellular component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	signal transducer activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)Hide

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 351	329	Protein Wnt-8b		PRO_0000041450
Amino acid modifications
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
	Glycosylation	259	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	11	1	C → S. [dbSNP:rs3793771]		VAR_020310
	Natural variant	53	1	E → Q in a colorectal cancer sample; somatic mutation. Ref.5		VAR_036288
Experimental info
	Sequence conflict	230	1	G → A Ref.1
	Sequence conflict	230	1	G → A Ref.4
	Sequence conflict	284	1	R → L Ref.1
	Sequence conflict	284	1	R → L Ref.4

SequencesHide

	Sequence		Length	Mass (Da)
	Q93098-1 [UniParc]. Last modified May 24, 2005. Version 3. Checksum: DD242070948813F8	FASTA	351	38,721
	10 20 30 40 50 60 MFLSKPSVYI CLFTCVLQLS HSWSVNNFLM TGPKAYLIYS SSVAAGAQSG IEECKYQFAW 70 80 90 100 110 120 DRWNCPERAL QLSSHGGLRS ANRETAFVHA ISSAGVMYTL TRNCSLGDFD NCGCDDSRNG 130 140 150 160 170 180 QLGGQGWLWG GCSDNVGFGE AISKQFVDAL ETGQDARAAM NLHNNEAGRK AVKGTMKRTC 190 200 210 220 230 240 KCHGVSGSCT TQTCWLQLPE FREVGAHLKE KYHAALKVDL LQGAGNSAAG RGAIADTFRS 250 260 270 280 290 300 ISTRELVHLE DSPDYCLENK TLGLLGTEGR ECLRRGRALG RWERRSCRRL CGDCGLAVEE 310 320 330 340 350 RRAETVSSCN CKFHWCCAVR CEQCRRRVTK YFCSRAERPR GGAAHKPGRK P

ReferencesHide

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel mammalian Wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain." Lako M., Lindsay S., Bullen P., Wilson D.I., Robson S.C., Strachan T. Hum. Mol. Genet. 7:813-822(1998) [PubMed: 9536085] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]	"Up-regulation of WNT8B mRNA in human gastric cancer." Saitoh T., Mine T., Katoh M. Int. J. Oncol. 20:343-348(2002) [PubMed: 11788899] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain.
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24." Lako M., Strachan T., Curtis A.R.J., Lindsay S. Genomics 35:386-388(1996) [PubMed: 8661156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-317.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-53.
+	Additional computationally mapped references.

Cross-referencesHide

Sequence databases
EMBL GenBank DDBJ	Y11094 mRNA. Translation: CAA71968.1. Y11108 Genomic DNA. Translation: CAA71994.1. AB073637 mRNA. Translation: BAB83924.1. AL359759, AL133352 Genomic DNA. Translation: CAH71991.1. AL133352, AL359759 Genomic DNA. Translation: CAH73565.1. X91940 mRNA. Translation: CAA63017.1.
IPI	IPI00004125.
RefSeq	NP_003384.2.
UniGene	Hs.421281
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q93098.
Proteomic databases
PRIDE	Q93098.
Genome annotation databases
Ensembl	ENST00000343737; ENSP00000340677; ENSG00000075290; Homo sapiens. [Genome view]
GeneID	7479.
KEGG	hsa:7479.
UCSC	uc001krb.1. human.
Organism-specific databases
CTD	7479.
GeneCards	GC10P102212.
H-InvDB	HIX0035306.
HGNC	HGNC:12789. WNT8B.
MIM	601396. gene.
PharmGKB	PA37390.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14592.
HOGENOM	HBG446188.
HOVERGEN	HBG001595.
InParanoid	Q93098.
OMA	KWEKRSC.
OrthoDB	EOG9XH2JW.
PhylomeDB	Q93098.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	Q93098.
Bgee	Q93098.
CleanEx	HS_WNT8B.
Genevestigator	Q93098.
GermOnline	ENSG00000075290. Homo sapiens.
Family and domain databases
InterPro	IPR013301. Wnt8. IPR005816. Wnt_grthfactor. IPR018161. Wnt_grthfactor_CS. IPR005817. Wnt_SF. [Graphical view]
PANTHER	PTHR12027. Wnt. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01892. WNT8PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	29296.
SOURCE	Search...

Entry informationHide

Entry name

WNT8B_HUMAN

Accession

Primary (citable) accession number: Q93098
Secondary accession number(s): O00771, Q5VX55, Q8WYK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 24, 2005
Last modified:	July 13, 2010
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.