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Q93098 (WNT8B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-8b
Gene names
Name:WNT8B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. Ref.1

Subcellular location

Secretedextracellular spaceextracellular matrix.

Tissue specificity

Expression is restricted to the brain, and more specifically to the forebrain. Ref.1

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

cellular response to retinoic acid

Inferred from sequence or structural similarity. Source: UniProtKB

determination of dorsal identity

Inferred from sequence or structural similarity PubMed 7635061. Source: BHF-UCL

gastrulation

Inferred from sequence or structural similarity PubMed 7635061. Source: BHF-UCL

negative regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

nervous system development

Traceable author statement Ref.1. Source: ProtInc

neuron differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Non-traceable author statement PubMed 11956596. Source: BHF-UCL

response to retinoic acid

Non-traceable author statement PubMed 11956596. Source: BHF-UCL

signal transduction

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfrizzled binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 351329Protein Wnt-8b
PRO_0000041450

Amino acid modifications

Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation2591N-linked (GlcNAc...) Potential

Natural variations

Natural variant111C → S.
Corresponds to variant rs3793771 [ dbSNP | Ensembl ].
VAR_020310
Natural variant531E → Q in a colorectal cancer sample; somatic mutation. Ref.5
VAR_036288

Experimental info

Sequence conflict2301G → A Ref.1
Sequence conflict2301G → A Ref.4
Sequence conflict2841R → L Ref.1
Sequence conflict2841R → L Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q93098 [UniParc].

Last modified May 24, 2005. Version 3.
Checksum: DD242070948813F8

FASTA35138,721
        10         20         30         40         50         60 
MFLSKPSVYI CLFTCVLQLS HSWSVNNFLM TGPKAYLIYS SSVAAGAQSG IEECKYQFAW 

        70         80         90        100        110        120 
DRWNCPERAL QLSSHGGLRS ANRETAFVHA ISSAGVMYTL TRNCSLGDFD NCGCDDSRNG 

       130        140        150        160        170        180 
QLGGQGWLWG GCSDNVGFGE AISKQFVDAL ETGQDARAAM NLHNNEAGRK AVKGTMKRTC 

       190        200        210        220        230        240 
KCHGVSGSCT TQTCWLQLPE FREVGAHLKE KYHAALKVDL LQGAGNSAAG RGAIADTFRS 

       250        260        270        280        290        300 
ISTRELVHLE DSPDYCLENK TLGLLGTEGR ECLRRGRALG RWERRSCRRL CGDCGLAVEE 

       310        320        330        340        350 
RRAETVSSCN CKFHWCCAVR CEQCRRRVTK YFCSRAERPR GGAAHKPGRK P 

« Hide

References

« Hide 'large scale' references
[1]"A novel mammalian Wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain."
Lako M., Lindsay S., Bullen P., Wilson D.I., Robson S.C., Strachan T.
Hum. Mol. Genet. 7:813-822(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]"Up-regulation of WNT8B mRNA in human gastric cancer."
Saitoh T., Mine T., Katoh M.
Int. J. Oncol. 20:343-348(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal brain.
[3]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24."
Lako M., Strachan T., Curtis A.R.J., Lindsay S.
Genomics 35:386-388(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-317.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-53.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y11094 mRNA. Translation: CAA71968.1.
Y11108 Genomic DNA. Translation: CAA71994.1.
AB073637 mRNA. Translation: BAB83924.1.
AL359759, AL133352 Genomic DNA. Translation: CAH71991.1.
AL133352, AL359759 Genomic DNA. Translation: CAH73565.1.
X91940 mRNA. Translation: CAA63017.1.
RefSeqNP_003384.2. NM_003393.3.
UniGeneHs.421281.

3D structure databases

ProteinModelPortalQ93098.
SMRQ93098. Positions 31-334.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000340677.

PTM databases

PhosphoSiteQ93098.

Polymorphism databases

DMDM66774217.

Proteomic databases

PaxDbQ93098.
PRIDEQ93098.

Protocols and materials databases

DNASU7479.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000343737; ENSP00000340677; ENSG00000075290.
GeneID7479.
KEGGhsa:7479.
UCSCuc001krb.3. human.

Organism-specific databases

CTD7479.
GeneCardsGC10P102212.
HGNCHGNC:12789. WNT8B.
HPAHPA036570.
MIM601396. gene.
neXtProtNX_Q93098.
PharmGKBPA37390.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG277037.
HOGENOMHOG000039529.
HOVERGENHBG001595.
InParanoidQ93098.
KOK00714.
OMAKYFCVRK.
OrthoDBEOG7C8GJ8.
PhylomeDBQ93098.
TreeFamTF105310.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ93098.
CleanExHS_WNT8B.
GenevestigatorQ93098.

Family and domain databases

InterProIPR005817. Wnt.
IPR013301. Wnt8.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF6. PTHR12027:SF6. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01892. WNT8PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiWNT8B.
GenomeRNAi7479.
NextBio29296.
PROQ93098.
SOURCESearch...

Entry information

Entry nameWNT8B_HUMAN
AccessionPrimary (citable) accession number: Q93098
Secondary accession number(s): O00771, Q5VX55, Q8WYK9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM