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Q93097

- WNT2B_HUMAN

UniProt

Q93097 - WNT2B_HUMAN

Protein

Protein Wnt-2b

Gene

WNT2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (20 Jun 2001)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis.

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome

    GO - Biological processi

    1. canonical Wnt signaling pathway Source: Ensembl
    2. cell fate commitment Source: RefGenome
    3. chondrocyte differentiation Source: UniProtKB
    4. cornea development in camera-type eye Source: BHF-UCL
    5. forebrain regionalization Source: UniProtKB
    6. hematopoietic stem cell proliferation Source: BHF-UCL
    7. iris morphogenesis Source: BHF-UCL
    8. lens development in camera-type eye Source: BHF-UCL
    9. lung induction Source: Ensembl
    10. male gonad development Source: UniProtKB
    11. mesenchymal-epithelial cell signaling Source: Ensembl
    12. neuron differentiation Source: UniProtKB
    13. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
    14. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
    15. Wnt signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-2b
    Alternative name(s):
    Protein Wnt-13
    Gene namesi
    Name:WNT2B
    Synonyms:WNT13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:12781. WNT2B.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37382.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 391Protein Wnt-2bPRO_0000041413
    Signal peptidei1 – ?Sequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi107 ↔ 118By similarity
    Glycosylationi117 – 1171N-linked (GlcNAc...)1 Publication
    Disulfide bondi158 ↔ 166By similarity
    Disulfide bondi168 ↔ 188By similarity
    Disulfide bondi237 ↔ 251By similarity
    Disulfide bondi239 ↔ 246By similarity
    Lipidationi243 – 2431O-palmitoyl serine; by PORCNBy similarity
    Glycosylationi283 – 2831N-linked (GlcNAc...)1 Publication
    Disulfide bondi325 ↔ 340By similarity
    Disulfide bondi355 ↔ 370By similarity
    Disulfide bondi357 ↔ 367By similarity
    Disulfide bondi362 ↔ 363By similarity

    Post-translational modificationi

    Palmitoylation at Ser-243 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ93097.
    PRIDEiQ93097.

    PTM databases

    PhosphoSiteiQ93097.

    Expressioni

    Tissue specificityi

    Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines.

    Gene expression databases

    ArrayExpressiQ93097.
    BgeeiQ93097.
    CleanExiHS_WNT2B.
    GenevestigatoriQ93097.

    Organism-specific databases

    HPAiHPA060696.

    Interactioni

    Protein-protein interaction databases

    BioGridi113319. 2 interactions.
    STRINGi9606.ENSP00000358698.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93097.
    SMRiQ93097. Positions 95-379.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiQ93097.
    KOiK00182.
    OMAiDYCVMDK.
    PhylomeDBiQ93097.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: Q93097-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLRPGGAEEA AQLPLRRASA PVPVPSPAAP DGSRASARLG LACLLLLLLL    50
    TLPARVDTSW WYIGALGARV ICDNIPGLVS RQRQLCQRYP DIMRSVGEGA 100
    REWIRECQHQ FRHHRWNCTT LDRDHTVFGR VMLRSSREAA FVYAISSAGV 150
    VHAITRACSQ GELSVCSCDP YTRGRHHDQR GDFDWGGCSD NIHYGVRFAK 200
    AFVDAKEKRL KDARALMNLH NNRCGRTAVR RFLKLECKCH GVSGSCTLRT 250
    CWRALSDFRR TGDYLRRRYD GAVQVMATQD GANFTAARQG YRRATRTDLV 300
    YFDNSPDYCV LDKAAGSLGT AGRVCSKTSK GTDGCEIMCC GRGYDTTRVT 350
    RVTQCECKFH WCCAVRCKEC RNTVDVHTCK APKKAEWLDQ T 391
    Length:391
    Mass (Da):43,770
    Last modified:June 20, 2001 - v2
    Checksum:iBD7BB7F795FB33B1
    GO
    Isoform 1 (identifier: Q93097-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-61: MLRPGGAEEA...LPARVDTSWW → MLDGLGVVAI...QSAFNKCLQR

    Show »
    Length:372
    Mass (Da):41,830
    Checksum:i9D8820B9E42ECA29
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti151 – 1511V → I in CAA96283. (PubMed:8761309)Curated
    Sequence conflicti182 – 1821D → T in CAA96283. (PubMed:8761309)Curated
    Sequence conflicti233 – 2331L → V in CAA96283. (PubMed:8761309)Curated
    Sequence conflicti287 – 2871A → T(PubMed:9441749)Curated
    Sequence conflicti297 – 2971T → S in CAA96283. (PubMed:8761309)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6161MLRPG…DTSWW → MLDGLGVVAISIFGIQLKTE GSLRTAVPGIPTQSAFNKCL QR in isoform 1. 2 PublicationsVSP_006794Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71621 mRNA. Translation: CAA96283.1.
    AB045116 mRNA. Translation: BAB11984.1.
    AB045117 mRNA. Translation: BAB11985.1.
    AK312696 mRNA. Translation: BAG35575.1.
    AL354760, AL109932 Genomic DNA. Translation: CAI22309.1.
    AL109932, AL354760 Genomic DNA. Translation: CAI22706.1.
    CH471122 Genomic DNA. Translation: EAW56519.1.
    BC141825 mRNA. Translation: AAI41826.1.
    AF028701 mRNA. Translation: AAC39552.1.
    CCDSiCCDS846.1. [Q93097-2]
    CCDS847.1. [Q93097-1]
    PIRiT09612.
    RefSeqiNP_004176.2. NM_004185.4. [Q93097-2]
    NP_078613.1. NM_024494.2. [Q93097-1]
    UniGeneiHs.258575.

    Genome annotation databases

    EnsembliENST00000369684; ENSP00000358698; ENSG00000134245. [Q93097-1]
    ENST00000369686; ENSP00000358700; ENSG00000134245. [Q93097-2]
    GeneIDi7482.
    KEGGihsa:7482.
    UCSCiuc001eca.3. human. [Q93097-2]
    uc001ecb.3. human. [Q93097-1]

    Polymorphism databases

    DMDMi14424481.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71621 mRNA. Translation: CAA96283.1 .
    AB045116 mRNA. Translation: BAB11984.1 .
    AB045117 mRNA. Translation: BAB11985.1 .
    AK312696 mRNA. Translation: BAG35575.1 .
    AL354760 , AL109932 Genomic DNA. Translation: CAI22309.1 .
    AL109932 , AL354760 Genomic DNA. Translation: CAI22706.1 .
    CH471122 Genomic DNA. Translation: EAW56519.1 .
    BC141825 mRNA. Translation: AAI41826.1 .
    AF028701 mRNA. Translation: AAC39552.1 .
    CCDSi CCDS846.1. [Q93097-2 ]
    CCDS847.1. [Q93097-1 ]
    PIRi T09612.
    RefSeqi NP_004176.2. NM_004185.4. [Q93097-2 ]
    NP_078613.1. NM_024494.2. [Q93097-1 ]
    UniGenei Hs.258575.

    3D structure databases

    ProteinModelPortali Q93097.
    SMRi Q93097. Positions 95-379.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113319. 2 interactions.
    STRINGi 9606.ENSP00000358698.

    PTM databases

    PhosphoSitei Q93097.

    Polymorphism databases

    DMDMi 14424481.

    Proteomic databases

    PaxDbi Q93097.
    PRIDEi Q93097.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369684 ; ENSP00000358698 ; ENSG00000134245 . [Q93097-1 ]
    ENST00000369686 ; ENSP00000358700 ; ENSG00000134245 . [Q93097-2 ]
    GeneIDi 7482.
    KEGGi hsa:7482.
    UCSCi uc001eca.3. human. [Q93097-2 ]
    uc001ecb.3. human. [Q93097-1 ]

    Organism-specific databases

    CTDi 7482.
    GeneCardsi GC01P113009.
    HGNCi HGNC:12781. WNT2B.
    HPAi HPA060696.
    MIMi 601968. gene.
    neXtProti NX_Q93097.
    PharmGKBi PA37382.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284879.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi Q93097.
    KOi K00182.
    OMAi DYCVMDK.
    PhylomeDBi Q93097.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).

    Miscellaneous databases

    GeneWikii WNT2B.
    GenomeRNAii 7482.
    NextBioi 29308.
    PROi Q93097.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q93097.
    Bgeei Q93097.
    CleanExi HS_WNT2B.
    Genevestigatori Q93097.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family."
      Katoh M., Hirai M., Sugimura T., Terada M.
      Oncogene 13:873-876(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21."
      Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C.
      Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 243-359.
    8. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
      Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
      Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-117 AND ASN-283.
      Tissue: Milk.

    Entry informationi

    Entry nameiWNT2B_HUMAN
    AccessioniPrimary (citable) accession number: Q93097
    Secondary accession number(s): O14903
    , Q5TEH9, Q5TEI2, Q9HDC1, Q9HDC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3