Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q93097

- WNT2B_HUMAN

UniProt

Q93097 - WNT2B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein Wnt-2b

Gene

WNT2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis.

GO - Molecular functioni

  1. frizzled binding Source: RefGenome

GO - Biological processi

  1. canonical Wnt signaling pathway Source: Ensembl
  2. cell fate commitment Source: RefGenome
  3. cellular response to starvation Source: Ensembl
  4. chondrocyte differentiation Source: UniProtKB
  5. cornea development in camera-type eye Source: BHF-UCL
  6. forebrain regionalization Source: UniProtKB
  7. hematopoietic stem cell proliferation Source: BHF-UCL
  8. iris morphogenesis Source: BHF-UCL
  9. lens development in camera-type eye Source: BHF-UCL
  10. lung induction Source: Ensembl
  11. male gonad development Source: UniProtKB
  12. mesenchymal-epithelial cell signaling Source: Ensembl
  13. neuron differentiation Source: UniProtKB
  14. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
  15. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  16. Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-2b
Alternative name(s):
Protein Wnt-13
Gene namesi
Name:WNT2B
Synonyms:WNT13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:12781. WNT2B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB
  3. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 391Protein Wnt-2bPRO_0000041413
Signal peptidei1 – ?Sequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi107 ↔ 118By similarity
Glycosylationi117 – 1171N-linked (GlcNAc...)1 Publication
Disulfide bondi158 ↔ 166By similarity
Disulfide bondi168 ↔ 188By similarity
Disulfide bondi237 ↔ 251By similarity
Disulfide bondi239 ↔ 246By similarity
Lipidationi243 – 2431O-palmitoyl serine; by PORCNBy similarity
Glycosylationi283 – 2831N-linked (GlcNAc...)1 Publication
Disulfide bondi325 ↔ 340By similarity
Disulfide bondi355 ↔ 370By similarity
Disulfide bondi357 ↔ 367By similarity
Disulfide bondi362 ↔ 363By similarity

Post-translational modificationi

Palmitoylation at Ser-243 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ93097.
PRIDEiQ93097.

PTM databases

PhosphoSiteiQ93097.

Expressioni

Tissue specificityi

Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines.

Gene expression databases

BgeeiQ93097.
CleanExiHS_WNT2B.
ExpressionAtlasiQ93097. baseline and differential.
GenevestigatoriQ93097.

Organism-specific databases

HPAiHPA060696.

Interactioni

Protein-protein interaction databases

BioGridi113319. 2 interactions.
STRINGi9606.ENSP00000358698.

Structurei

3D structure databases

ProteinModelPortaliQ93097.
SMRiQ93097. Positions 95-379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284879.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiQ93097.
KOiK00182.
OMAiDYCVMDK.
PhylomeDBiQ93097.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 2 (identifier: Q93097-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRPGGAEEA AQLPLRRASA PVPVPSPAAP DGSRASARLG LACLLLLLLL
60 70 80 90 100
TLPARVDTSW WYIGALGARV ICDNIPGLVS RQRQLCQRYP DIMRSVGEGA
110 120 130 140 150
REWIRECQHQ FRHHRWNCTT LDRDHTVFGR VMLRSSREAA FVYAISSAGV
160 170 180 190 200
VHAITRACSQ GELSVCSCDP YTRGRHHDQR GDFDWGGCSD NIHYGVRFAK
210 220 230 240 250
AFVDAKEKRL KDARALMNLH NNRCGRTAVR RFLKLECKCH GVSGSCTLRT
260 270 280 290 300
CWRALSDFRR TGDYLRRRYD GAVQVMATQD GANFTAARQG YRRATRTDLV
310 320 330 340 350
YFDNSPDYCV LDKAAGSLGT AGRVCSKTSK GTDGCEIMCC GRGYDTTRVT
360 370 380 390
RVTQCECKFH WCCAVRCKEC RNTVDVHTCK APKKAEWLDQ T
Length:391
Mass (Da):43,770
Last modified:June 20, 2001 - v2
Checksum:iBD7BB7F795FB33B1
GO
Isoform 1 (identifier: Q93097-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MLRPGGAEEA...LPARVDTSWW → MLDGLGVVAI...QSAFNKCLQR

Show »
Length:372
Mass (Da):41,830
Checksum:i9D8820B9E42ECA29
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511V → I in CAA96283. (PubMed:8761309)Curated
Sequence conflicti182 – 1821D → T in CAA96283. (PubMed:8761309)Curated
Sequence conflicti233 – 2331L → V in CAA96283. (PubMed:8761309)Curated
Sequence conflicti287 – 2871A → T(PubMed:9441749)Curated
Sequence conflicti297 – 2971T → S in CAA96283. (PubMed:8761309)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6161MLRPG…DTSWW → MLDGLGVVAISIFGIQLKTE GSLRTAVPGIPTQSAFNKCL QR in isoform 1. 2 PublicationsVSP_006794Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71621 mRNA. Translation: CAA96283.1.
AB045116 mRNA. Translation: BAB11984.1.
AB045117 mRNA. Translation: BAB11985.1.
AK312696 mRNA. Translation: BAG35575.1.
AL354760, AL109932 Genomic DNA. Translation: CAI22309.1.
AL109932, AL354760 Genomic DNA. Translation: CAI22706.1.
CH471122 Genomic DNA. Translation: EAW56519.1.
BC141825 mRNA. Translation: AAI41826.1.
AF028701 mRNA. Translation: AAC39552.1.
CCDSiCCDS846.1. [Q93097-2]
CCDS847.1. [Q93097-1]
PIRiT09612.
RefSeqiNP_001278809.1. NM_001291880.1.
NP_004176.2. NM_004185.4. [Q93097-2]
NP_078613.1. NM_024494.2. [Q93097-1]
UniGeneiHs.258575.

Genome annotation databases

EnsembliENST00000369684; ENSP00000358698; ENSG00000134245. [Q93097-1]
ENST00000369686; ENSP00000358700; ENSG00000134245. [Q93097-2]
GeneIDi7482.
KEGGihsa:7482.
UCSCiuc001eca.3. human. [Q93097-2]
uc001ecb.3. human. [Q93097-1]

Polymorphism databases

DMDMi14424481.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71621 mRNA. Translation: CAA96283.1 .
AB045116 mRNA. Translation: BAB11984.1 .
AB045117 mRNA. Translation: BAB11985.1 .
AK312696 mRNA. Translation: BAG35575.1 .
AL354760 , AL109932 Genomic DNA. Translation: CAI22309.1 .
AL109932 , AL354760 Genomic DNA. Translation: CAI22706.1 .
CH471122 Genomic DNA. Translation: EAW56519.1 .
BC141825 mRNA. Translation: AAI41826.1 .
AF028701 mRNA. Translation: AAC39552.1 .
CCDSi CCDS846.1. [Q93097-2 ]
CCDS847.1. [Q93097-1 ]
PIRi T09612.
RefSeqi NP_001278809.1. NM_001291880.1.
NP_004176.2. NM_004185.4. [Q93097-2 ]
NP_078613.1. NM_024494.2. [Q93097-1 ]
UniGenei Hs.258575.

3D structure databases

ProteinModelPortali Q93097.
SMRi Q93097. Positions 95-379.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113319. 2 interactions.
STRINGi 9606.ENSP00000358698.

PTM databases

PhosphoSitei Q93097.

Polymorphism databases

DMDMi 14424481.

Proteomic databases

PaxDbi Q93097.
PRIDEi Q93097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369684 ; ENSP00000358698 ; ENSG00000134245 . [Q93097-1 ]
ENST00000369686 ; ENSP00000358700 ; ENSG00000134245 . [Q93097-2 ]
GeneIDi 7482.
KEGGi hsa:7482.
UCSCi uc001eca.3. human. [Q93097-2 ]
uc001ecb.3. human. [Q93097-1 ]

Organism-specific databases

CTDi 7482.
GeneCardsi GC01P113009.
HGNCi HGNC:12781. WNT2B.
HPAi HPA060696.
MIMi 601968. gene.
neXtProti NX_Q93097.
PharmGKBi PA37382.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284879.
GeneTreei ENSGT00760000118943.
HOGENOMi HOG000039529.
HOVERGENi HBG001595.
InParanoidi Q93097.
KOi K00182.
OMAi DYCVMDK.
PhylomeDBi Q93097.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).

Miscellaneous databases

GeneWikii WNT2B.
GenomeRNAii 7482.
NextBioi 29308.
PROi Q93097.
SOURCEi Search...

Gene expression databases

Bgeei Q93097.
CleanExi HS_WNT2B.
ExpressionAtlasi Q93097. baseline and differential.
Genevestigatori Q93097.

Family and domain databases

InterProi IPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family."
    Katoh M., Hirai M., Sugimura T., Terada M.
    Oncogene 13:873-876(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21."
    Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C.
    Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 243-359.
  8. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
    Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
    Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-117 AND ASN-283.
    Tissue: Milk.

Entry informationi

Entry nameiWNT2B_HUMAN
AccessioniPrimary (citable) accession number: Q93097
Secondary accession number(s): O14903
, Q5TEH9, Q5TEI2, Q9HDC1, Q9HDC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 20, 2001
Last modified: October 29, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3