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Protein

Protein tyrosine phosphatase type IVA 1

Gene

PTP4A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.3 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.1 Publication

Enzyme regulationi

Inhibited by sodium orthovanadate and pentamidine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton donorCurated1
Active sitei104Phosphocysteine intermediate1
Binding sitei110Substrate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciZFISH:HS03541-MONOMER.
BRENDAi3.1.3.16. 2681.
SIGNORiQ93096.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tyrosine phosphatase type IVA 1 (EC:3.1.3.48)
Alternative name(s):
PTP(CAAXI)
Protein-tyrosine phosphatase 4a1
Protein-tyrosine phosphatase of regenerating liver 1
Short name:
PRL-1
Gene namesi
Name:PTP4A1
Synonyms:PRL1, PTPCAAX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:9634. PTP4A1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoplasmic side of plasma membrane Source: UniProtKB
  • early endosome Source: UniProtKB-SubCell
  • endoplasmic reticulum Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • nucleus Source: GO_Central
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi13T → F: Reduces trimerization. 1 Publication1
Mutagenesisi71D → A: No effect on catalytic activity. 1 Publication1
Mutagenesisi72D → A: 80% loss of catalytic activity; delay in progression through G2/M. 1 Publication1
Mutagenesisi104C → S: Abolishes enzymatic activity. 1 Publication1
Mutagenesisi131Q → A: Reduces trimerization. 1 Publication1
Mutagenesisi170C → S: Redistributes to the nucleus in resting cells, but still locates to the mitotic spindle in dividing cells. Induces defects in cytokinesis. 1 Publication1
Mutagenesisi171C → S: No effect on subcellular location. 1 Publication1

Organism-specific databases

DisGeNETi7803.
OpenTargetsiENSG00000112245.
PharmGKBiPA33977.

Chemistry databases

ChEMBLiCHEMBL1075169.

Polymorphism and mutation databases

DMDMi68566217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947801 – 170Protein tyrosine phosphatase type IVA 1Add BLAST170
PropeptideiPRO_0000396726171 – 173Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 1041 Publication
Modified residuei170Cysteine methyl esterCurated1
Lipidationi170S-farnesyl cysteine1 Publication1

Post-translational modificationi

Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.

Keywords - PTMi

Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ93096.
MaxQBiQ93096.
PaxDbiQ93096.
PeptideAtlasiQ93096.
PRIDEiQ93096.

PTM databases

DEPODiQ93096.
iPTMnetiQ93096.
PhosphoSitePlusiQ93096.

Expressioni

Tissue specificityi

Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.2 Publications

Developmental stagei

Expressed in fetal liver.1 Publication

Inductioni

Strongly down-regulated upon tetrodotoxin treatment.1 Publication

Gene expression databases

BgeeiENSG00000112245.
CleanExiHS_PTP4A1.
ExpressionAtlasiQ93096. baseline and differential.
GenevisibleiQ93096. HS.

Organism-specific databases

HPAiHPA003281.

Interactioni

Subunit structurei

Homotrimer. Interacts with ATF5 (By similarity). Interacts with tubulin.By similarity2 Publications

Protein-protein interaction databases

BioGridi113578. 18 interactors.
IntActiQ93096. 7 interactors.
MINTiMINT-194351.
STRINGi9606.ENSP00000359685.

Chemistry databases

BindingDBiQ93096.

Structurei

Secondary structure

1173
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 14Combined sources5
Beta strandi17 – 21Combined sources5
Helixi27 – 29Combined sources3
Helixi30 – 39Combined sources10
Beta strandi42 – 47Combined sources6
Helixi56 – 60Combined sources5
Beta strandi64 – 67Combined sources4
Beta strandi72 – 74Combined sources3
Helixi78 – 94Combined sources17
Beta strandi99 – 103Combined sources5
Beta strandi105 – 108Combined sources4
Turni109 – 111Combined sources3
Helixi112 – 121Combined sources10
Helixi126 – 134Combined sources9
Helixi143 – 151Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RXDX-ray1.90A/B/C2-160[»]
1XM2X-ray2.70A/B/C/D/E/F1-173[»]
DisProtiDP00255.
ProteinModelPortaliQ93096.
SMRiQ93096.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ93096.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 148Tyrosine-protein phosphataseAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 132Interaction with ATF5By similarityAdd BLAST36
Regioni105 – 110Phosphate binding6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2836. Eukaryota.
ENOG4111I7J. LUCA.
GeneTreeiENSGT00390000009788.
HOGENOMiHOG000231265.
HOVERGENiHBG071295.
InParanoidiQ93096.
KOiK18041.
OMAiETIAVHC.
OrthoDBiEOG091G0MYM.
PhylomeDBiQ93096.
TreeFamiTF313384.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93096-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE
60 70 80 90 100
ATYDTTLVEK EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI
110 120 130 140 150
AVHCVAGLGR APVLVALALI EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE
160 170
KYRPKMRLRF KDSNGHRNNC CIQ
Length:173
Mass (Da):19,815
Last modified:July 5, 2005 - v2
Checksum:i702008013D3F3835
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48296 mRNA. Translation: AAB40597.1.
AF051160 Genomic DNA. Translation: AAC39836.1.
AK312526 mRNA. Translation: BAG35425.1.
CR749458 mRNA. Translation: CAH18292.1.
AL135905 Genomic DNA. Translation: CAC12761.1.
CH471143 Genomic DNA. Translation: EAW88494.1.
BC023975 mRNA. Translation: AAH23975.1.
BC045571 mRNA. Translation: AAH45571.1.
U69701 mRNA. Translation: AAB09080.1.
CCDSiCCDS4965.1.
RefSeqiNP_003454.1. NM_003463.4.
XP_011534413.1. XM_011536111.1.
XP_011534414.1. XM_011536112.1.
XP_016866759.1. XM_017011270.1.
XP_016866760.1. XM_017011271.1.
UniGeneiHs.227777.
Hs.706850.

Genome annotation databases

EnsembliENST00000370651; ENSP00000359685; ENSG00000112245.
ENST00000626021; ENSP00000485687; ENSG00000112245.
GeneIDi7803.
KEGGihsa:7803.
UCSCiuc003pel.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48296 mRNA. Translation: AAB40597.1.
AF051160 Genomic DNA. Translation: AAC39836.1.
AK312526 mRNA. Translation: BAG35425.1.
CR749458 mRNA. Translation: CAH18292.1.
AL135905 Genomic DNA. Translation: CAC12761.1.
CH471143 Genomic DNA. Translation: EAW88494.1.
BC023975 mRNA. Translation: AAH23975.1.
BC045571 mRNA. Translation: AAH45571.1.
U69701 mRNA. Translation: AAB09080.1.
CCDSiCCDS4965.1.
RefSeqiNP_003454.1. NM_003463.4.
XP_011534413.1. XM_011536111.1.
XP_011534414.1. XM_011536112.1.
XP_016866759.1. XM_017011270.1.
XP_016866760.1. XM_017011271.1.
UniGeneiHs.227777.
Hs.706850.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RXDX-ray1.90A/B/C2-160[»]
1XM2X-ray2.70A/B/C/D/E/F1-173[»]
DisProtiDP00255.
ProteinModelPortaliQ93096.
SMRiQ93096.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113578. 18 interactors.
IntActiQ93096. 7 interactors.
MINTiMINT-194351.
STRINGi9606.ENSP00000359685.

Chemistry databases

BindingDBiQ93096.
ChEMBLiCHEMBL1075169.

PTM databases

DEPODiQ93096.
iPTMnetiQ93096.
PhosphoSitePlusiQ93096.

Polymorphism and mutation databases

DMDMi68566217.

Proteomic databases

EPDiQ93096.
MaxQBiQ93096.
PaxDbiQ93096.
PeptideAtlasiQ93096.
PRIDEiQ93096.

Protocols and materials databases

DNASUi7803.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370651; ENSP00000359685; ENSG00000112245.
ENST00000626021; ENSP00000485687; ENSG00000112245.
GeneIDi7803.
KEGGihsa:7803.
UCSCiuc003pel.5. human.

Organism-specific databases

CTDi7803.
DisGeNETi7803.
GeneCardsiPTP4A1.
HGNCiHGNC:9634. PTP4A1.
HPAiHPA003281.
MIMi601585. gene.
neXtProtiNX_Q93096.
OpenTargetsiENSG00000112245.
PharmGKBiPA33977.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2836. Eukaryota.
ENOG4111I7J. LUCA.
GeneTreeiENSGT00390000009788.
HOGENOMiHOG000231265.
HOVERGENiHBG071295.
InParanoidiQ93096.
KOiK18041.
OMAiETIAVHC.
OrthoDBiEOG091G0MYM.
PhylomeDBiQ93096.
TreeFamiTF313384.

Enzyme and pathway databases

BioCyciZFISH:HS03541-MONOMER.
BRENDAi3.1.3.16. 2681.
SIGNORiQ93096.

Miscellaneous databases

ChiTaRSiPTP4A1. human.
EvolutionaryTraceiQ93096.
GeneWikiiPTP4A1.
GenomeRNAii7803.
PROiQ93096.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112245.
CleanExiHS_PTP4A1.
ExpressionAtlasiQ93096. baseline and differential.
GenevisibleiQ93096. HS.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTP4A1_HUMAN
AccessioniPrimary (citable) accession number: Q93096
Secondary accession number(s): B2R6C8, O00648, Q49A54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.