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Protein

Protein tyrosine phosphatase type IVA 1

Gene

PTP4A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.3 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.1 Publication

Enzyme regulationi

Inhibited by sodium orthovanadate and pentamidine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton donorCurated1
Active sitei104Phosphocysteine intermediate1
Binding sitei110Substrate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Protein phosphatase
Biological processCell cycle

Enzyme and pathway databases

BRENDAi3.1.3.16 2681
SIGNORiQ93096

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tyrosine phosphatase type IVA 1 (EC:3.1.3.48)
Alternative name(s):
PTP(CAAXI)
Protein-tyrosine phosphatase 4a1
Protein-tyrosine phosphatase of regenerating liver 1
Short name:
PRL-1
Gene namesi
Name:PTP4A1
Synonyms:PRL1, PTPCAAX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112245.9
HGNCiHGNC:9634 PTP4A1
MIMi601585 gene
neXtProtiNX_Q93096

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi13T → F: Reduces trimerization. 1 Publication1
Mutagenesisi71D → A: No effect on catalytic activity. 1 Publication1
Mutagenesisi72D → A: 80% loss of catalytic activity; delay in progression through G2/M. 1 Publication1
Mutagenesisi104C → S: Abolishes enzymatic activity. 1 Publication1
Mutagenesisi131Q → A: Reduces trimerization. 1 Publication1
Mutagenesisi170C → S: Redistributes to the nucleus in resting cells, but still locates to the mitotic spindle in dividing cells. Induces defects in cytokinesis. 1 Publication1
Mutagenesisi171C → S: No effect on subcellular location. 1 Publication1

Organism-specific databases

DisGeNETi7803
OpenTargetsiENSG00000112245
PharmGKBiPA33977

Chemistry databases

ChEMBLiCHEMBL1075169

Polymorphism and mutation databases

DMDMi68566217

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947801 – 170Protein tyrosine phosphatase type IVA 1Add BLAST170
PropeptideiPRO_0000396726171 – 173Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 1041 Publication
Modified residuei170Cysteine methyl esterCurated1
Lipidationi170S-farnesyl cysteine1 Publication1

Post-translational modificationi

Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.

Keywords - PTMi

Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ93096
MaxQBiQ93096
PaxDbiQ93096
PeptideAtlasiQ93096
PRIDEiQ93096

PTM databases

DEPODiQ93096
iPTMnetiQ93096
PhosphoSitePlusiQ93096

Expressioni

Tissue specificityi

Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.2 Publications

Developmental stagei

Expressed in fetal liver.1 Publication

Inductioni

Strongly down-regulated upon tetrodotoxin treatment.1 Publication

Gene expression databases

BgeeiENSG00000112245
CleanExiHS_PTP4A1
ExpressionAtlasiQ93096 baseline and differential
GenevisibleiQ93096 HS

Organism-specific databases

HPAiHPA003281

Interactioni

Subunit structurei

Homotrimer. Interacts with ATF5 (By similarity). Interacts with tubulin.By similarity2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi11357861 interactors.
IntActiQ93096 19 interactors.
MINTiQ93096
STRINGi9606.ENSP00000359685

Chemistry databases

BindingDBiQ93096

Structurei

Secondary structure

1173
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 14Combined sources5
Beta strandi17 – 21Combined sources5
Helixi27 – 29Combined sources3
Helixi30 – 39Combined sources10
Beta strandi42 – 47Combined sources6
Helixi56 – 60Combined sources5
Beta strandi64 – 67Combined sources4
Beta strandi72 – 74Combined sources3
Helixi78 – 94Combined sources17
Beta strandi99 – 103Combined sources5
Beta strandi105 – 108Combined sources4
Turni109 – 111Combined sources3
Helixi112 – 121Combined sources10
Helixi126 – 134Combined sources9
Helixi143 – 151Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RXDX-ray1.90A/B/C2-160[»]
1XM2X-ray2.70A/B/C/D/E/F1-173[»]
5BX1X-ray1.90A4-160[»]
ProteinModelPortaliQ93096
SMRiQ93096
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ93096

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 148Tyrosine-protein phosphataseAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 132Interaction with ATF5By similarityAdd BLAST36
Regioni105 – 110Phosphate binding6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2836 Eukaryota
ENOG4111I7J LUCA
GeneTreeiENSGT00390000009788
HOGENOMiHOG000231265
HOVERGENiHBG071295
InParanoidiQ93096
KOiK18041
OMAiNGQKNSC
OrthoDBiEOG091G0MYM
PhylomeDBiQ93096
TreeFamiTF313384

Family and domain databases

Gene3Di3.90.190.101 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
SMARTiView protein in SMART
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93096-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE
60 70 80 90 100
ATYDTTLVEK EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI
110 120 130 140 150
AVHCVAGLGR APVLVALALI EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE
160 170
KYRPKMRLRF KDSNGHRNNC CIQ
Length:173
Mass (Da):19,815
Last modified:July 5, 2005 - v2
Checksum:i702008013D3F3835
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48296 mRNA Translation: AAB40597.1
AF051160 Genomic DNA Translation: AAC39836.1
AK312526 mRNA Translation: BAG35425.1
CR749458 mRNA Translation: CAH18292.1
AL135905 Genomic DNA No translation available.
CH471143 Genomic DNA Translation: EAW88494.1
BC023975 mRNA Translation: AAH23975.1
BC045571 mRNA Translation: AAH45571.1
U69701 mRNA Translation: AAB09080.1
CCDSiCCDS4965.1
RefSeqiNP_003454.1, NM_003463.4
XP_011534413.1, XM_011536111.1
XP_011534414.1, XM_011536112.1
XP_016866759.1, XM_017011270.1
XP_016866760.1, XM_017011271.1
UniGeneiHs.227777
Hs.706850

Genome annotation databases

EnsembliENST00000370651; ENSP00000359685; ENSG00000112245
ENST00000626021; ENSP00000485687; ENSG00000112245
GeneIDi7803
KEGGihsa:7803
UCSCiuc003pel.5 human

Similar proteinsi

Entry informationi

Entry nameiTP4A1_HUMAN
AccessioniPrimary (citable) accession number: Q93096
Secondary accession number(s): B2R6C8, O00648, Q49A54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: March 28, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome