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Q93092 (TALDO_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Transaldolase
EC=2.2.1.2
Gene names
Name:Taldo1
Synonyms:Tal, Taldo
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway By similarity.

Catalytic activity

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the transaldolase family. Type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Transaldolase
PRO_0000173565

Sites

Active site1421 By similarity

Amino acid modifications

Modified residue41Phosphoserine By similarity
Modified residue2191N6-acetyllysine By similarity
Modified residue2371Phosphoserine By similarity
Modified residue2691N6-acetyllysine By similarity
Modified residue2861N6-acetyllysine By similarity
Modified residue3211N6-acetyllysine By similarity

Secondary structure

1 ...................................................... 337
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q93092 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: B0AD351FD778367F

FASTA33737,387
        10         20         30         40         50         60 
MSGSPVKRQR MESALDQLKQ FTTVVADTGD FNAIDEYKPQ DATTNPSLIL AAAQMPAYQE 

        70         80         90        100        110        120 
LVEEAIAYGK KLGGPQEEQI KNAIDKLFVL FGAEILKKIP GRVSTEVDAR LSFDKDAMVA 

       130        140        150        160        170        180 
RARRLIELYK EAGVGKDRIL IKLSSTWEGI QAGKELEEQH GIHCNMTLLF SFAQAVACAE 

       190        200        210        220        230        240 
AGVTLISPFV GRILDWHVAN TDKKSYEPQE DPGVKSVTKI YNYYKKFGYK TIVMGASFRN 

       250        260        270        280        290        300 
TGEIKALAGC DFLTISPKLL GELLKDNSKL APALSVKAAQ TSDSEKIHLD EKAFRWLHNE 

       310        320        330 
DQMAVEKLSD GIRKFAADAI KLERMLTERM FSAENGK

« Hide

References

« Hide 'large scale' references
[1]"Cloning and chromosomal localization of a paralog and a mouse homolog of the human transaldolase gene."
Kusuda J., Hirai M., Toyoda A., Tanuma R., Nomura-Kitabayashi A., Hashimoto K.
Gene 209:13-21(1998) [PubMed: 9524206] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N and FVB/N-3.
Tissue: Mammary gland.
[3]Lubec G., Klug S., Yang J.W., Zigmond M., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 87-97 AND 259-265, MASS SPECTROMETRY.
Strain: OF1.
Tissue: Brain and Hippocampus.
[4]"Crystal structure of mouse transaldolase."
RIKEN structural genomics initiative (RSGI)
Submitted (DEC-2005) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 13-337.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U67611 mRNA. Translation: AAB83955.1.
U63158 mRNA. Translation: AAB08722.1. Sequence problems.
U63159 mRNA. Translation: AAB08723.1. Sequence problems.
BC004754 mRNA. Translation: AAH04754.1.
BC094277 mRNA. Translation: AAH94277.1.
IPIIPI00124692.
RefSeqNP_035658.1. NM_011528.4.
UniGeneMm.29182.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CWNX-ray2.10A/B13-337[»]
2E1DX-ray2.00A/B11-334[»]
ProteinModelPortalQ93092.
SMRQ93092. Positions 11-331.
ModBaseSearch...

Protein-protein interaction databases

IntActQ93092. 1 interaction.
STRINGQ93092.

PTM databases

PhosphoSiteQ93092.

2D gel databases

REPRODUCTION-2DPAGEIPI00124692.
Q93092.

Proteomic databases

PRIDEQ93092.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026576; ENSMUSP00000026576; ENSMUSG00000025503.
GeneID21351.
KEGGmmu:21351.
UCSCuc009kkv.2. mouse.

Organism-specific databases

CTD6888.
MGIMGI:1274789. Taldo1.

Phylogenomic databases

eggNOGroNOG07008.
GeneTreeENSGT00390000017361.
HOGENOMHBG286747.
HOVERGENHBG054014.
InParanoidQ93092.
OMADTGDFHA.
OrthoDBEOG4GQQ5B.
PhylomeDBQ93092.

Gene expression databases

ArrayExpressQ93092.
BgeeQ93092.
CleanExMM_TALDO1.
GenevestigatorQ93092.
GermOnlineENSMUSG00000025503. Mus musculus.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR001585. Transaldolase.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00616.
PANTHERPTHR10683. Transaldolase. 1 hit.
PfamPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00874. TalAB. 1 hit.
PROSITEPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio300544.
SOURCESearch...

Entry information

Entry nameTALDO_MOUSE
AccessionPrimary (citable) accession number: Q93092
Secondary accession number(s): P70358, P70703, Q52KM4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: November 16, 2011
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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