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Protein

Transaldolase

Gene

Taldo1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.By similarity

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase (Taldo1)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei142 – 1421Schiff-base intermediate with substrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pentose shunt

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

ReactomeiR-MMU-163754. Insulin effects increased synthesis of Xylulose-5-Phosphate.
R-MMU-71336. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase (EC:2.2.1.2)
Gene namesi
Name:Taldo1
Synonyms:Tal, Taldo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1274789. Taldo1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337TransaldolasePRO_0000173565Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 1151N6-acetyllysineCombined sources
Modified residuei219 – 2191N6-acetyllysineBy similarity
Modified residuei237 – 2371PhosphoserineCombined sources
Modified residuei256 – 2561PhosphoserineBy similarity
Modified residuei269 – 2691N6-acetyllysineBy similarity
Modified residuei286 – 2861N6-acetyllysineBy similarity
Modified residuei321 – 3211N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ93092.
MaxQBiQ93092.
PaxDbiQ93092.
PeptideAtlasiQ93092.
PRIDEiQ93092.
TopDownProteomicsiQ93092.

2D gel databases

REPRODUCTION-2DPAGEIPI00124692.
Q93092.

PTM databases

iPTMnetiQ93092.
PhosphoSiteiQ93092.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025503.
CleanExiMM_TALDO1.
GenevisibleiQ93092. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi203964. 2 interactions.
IntActiQ93092. 2 interactions.
MINTiMINT-1855736.
STRINGi10090.ENSMUSP00000026576.

Structurei

Secondary structure

1
337
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi14 – 185Combined sources
Turni19 – 213Combined sources
Beta strandi22 – 276Combined sources
Helixi31 – 333Combined sources
Turni34 – 374Combined sources
Beta strandi40 – 434Combined sources
Helixi46 – 538Combined sources
Helixi56 – 583Combined sources
Helixi59 – 7214Combined sources
Helixi76 – 9823Combined sources
Beta strandi103 – 1064Combined sources
Helixi109 – 1113Combined sources
Helixi115 – 13117Combined sources
Helixi136 – 1383Combined sources
Beta strandi139 – 1446Combined sources
Helixi147 – 16014Combined sources
Beta strandi164 – 1696Combined sources
Helixi172 – 18110Combined sources
Beta strandi184 – 1907Combined sources
Helixi191 – 20010Combined sources
Helixi208 – 2103Combined sources
Helixi212 – 22615Combined sources
Beta strandi232 – 2365Combined sources
Helixi241 – 2455Combined sources
Turni246 – 2494Combined sources
Beta strandi250 – 2556Combined sources
Helixi257 – 2659Combined sources
Helixi276 – 2794Combined sources
Helixi291 – 2999Combined sources
Helixi302 – 33029Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CWNX-ray2.10A/B13-337[»]
2E1DX-ray2.00A/B11-334[»]
ProteinModelPortaliQ93092.
SMRiQ93092. Positions 11-331.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ93092.

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2772. Eukaryota.
COG0176. LUCA.
GeneTreeiENSGT00390000017361.
HOGENOMiHOG000281234.
HOVERGENiHBG054014.
InParanoidiQ93092.
KOiK00616.
OMAiFRNIDEI.
OrthoDBiEOG091G0FTU.
PhylomeDBiQ93092.
TreeFamiTF300757.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00492. Transaldolase_1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00874. talAB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSPVKRQR MESALDQLKQ FTTVVADTGD FNAIDEYKPQ DATTNPSLIL
60 70 80 90 100
AAAQMPAYQE LVEEAIAYGK KLGGPQEEQI KNAIDKLFVL FGAEILKKIP
110 120 130 140 150
GRVSTEVDAR LSFDKDAMVA RARRLIELYK EAGVGKDRIL IKLSSTWEGI
160 170 180 190 200
QAGKELEEQH GIHCNMTLLF SFAQAVACAE AGVTLISPFV GRILDWHVAN
210 220 230 240 250
TDKKSYEPQE DPGVKSVTKI YNYYKKFGYK TIVMGASFRN TGEIKALAGC
260 270 280 290 300
DFLTISPKLL GELLKDNSKL APALSVKAAQ TSDSEKIHLD EKAFRWLHNE
310 320 330
DQMAVEKLSD GIRKFAADAI KLERMLTERM FSAENGK
Length:337
Mass (Da):37,387
Last modified:July 15, 1998 - v2
Checksum:iB0AD351FD778367F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67611 mRNA. Translation: AAB83955.1.
U63158 mRNA. Translation: AAB08722.1. Sequence problems.
U63159 mRNA. Translation: AAB08723.1. Sequence problems.
BC004754 mRNA. Translation: AAH04754.1.
BC094277 mRNA. Translation: AAH94277.1.
CCDSiCCDS22011.1.
RefSeqiNP_035658.1. NM_011528.4.
UniGeneiMm.29182.

Genome annotation databases

EnsembliENSMUST00000026576; ENSMUSP00000026576; ENSMUSG00000025503.
GeneIDi21351.
KEGGimmu:21351.
UCSCiuc009kkv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67611 mRNA. Translation: AAB83955.1.
U63158 mRNA. Translation: AAB08722.1. Sequence problems.
U63159 mRNA. Translation: AAB08723.1. Sequence problems.
BC004754 mRNA. Translation: AAH04754.1.
BC094277 mRNA. Translation: AAH94277.1.
CCDSiCCDS22011.1.
RefSeqiNP_035658.1. NM_011528.4.
UniGeneiMm.29182.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CWNX-ray2.10A/B13-337[»]
2E1DX-ray2.00A/B11-334[»]
ProteinModelPortaliQ93092.
SMRiQ93092. Positions 11-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203964. 2 interactions.
IntActiQ93092. 2 interactions.
MINTiMINT-1855736.
STRINGi10090.ENSMUSP00000026576.

PTM databases

iPTMnetiQ93092.
PhosphoSiteiQ93092.

2D gel databases

REPRODUCTION-2DPAGEIPI00124692.
Q93092.

Proteomic databases

EPDiQ93092.
MaxQBiQ93092.
PaxDbiQ93092.
PeptideAtlasiQ93092.
PRIDEiQ93092.
TopDownProteomicsiQ93092.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026576; ENSMUSP00000026576; ENSMUSG00000025503.
GeneIDi21351.
KEGGimmu:21351.
UCSCiuc009kkv.2. mouse.

Organism-specific databases

CTDi6888.
MGIiMGI:1274789. Taldo1.

Phylogenomic databases

eggNOGiKOG2772. Eukaryota.
COG0176. LUCA.
GeneTreeiENSGT00390000017361.
HOGENOMiHOG000281234.
HOVERGENiHBG054014.
InParanoidiQ93092.
KOiK00616.
OMAiFRNIDEI.
OrthoDBiEOG091G0FTU.
PhylomeDBiQ93092.
TreeFamiTF300757.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.
ReactomeiR-MMU-163754. Insulin effects increased synthesis of Xylulose-5-Phosphate.
R-MMU-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

EvolutionaryTraceiQ93092.
PROiQ93092.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025503.
CleanExiMM_TALDO1.
GenevisibleiQ93092. MM.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00492. Transaldolase_1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00874. talAB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTALDO_MOUSE
AccessioniPrimary (citable) accession number: Q93092
Secondary accession number(s): P70358, P70703, Q52KM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: September 7, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.