Q93091 (RNAS6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease K6
Short name=RNase K6
EC=3.1.27.-

Gene names

Name:	RNASE6
Synonyms:	RNS6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	150 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have a role in host defense.
Subcellular location	Secreted.
Tissue specificity	Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and skeletal muscle. Also expressed in monocytes and neutrophils.
Sequence similarities	Belongs to the pancreatic ribonuclease family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Endonuclease Hydrolase Nuclease
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA catabolic process Traceable author statement Ref.1. Source: ProtInc defense response Traceable author statement Ref.1. Source: ProtInc
Cellular_component	extracellular region Traceable author statement Ref.1. Source: ProtInc
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro pancreatic ribonuclease activity Inferred from electronic annotation. Source: InterPro ribonuclease activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	By similarity
	Chain	24 – 150	127	Ribonuclease K6		PRO_0000030892
Regions
	Region	61 – 65	5	Substrate binding By similarity
Sites
	Active site	38	1	Proton acceptor By similarity
	Active site	145	1	Proton donor By similarity
	Binding site	86	1	Substrate By similarity
	Binding site	105	1	Substrate By similarity
Amino acid modifications
	Glycosylation	55	1	N-linked (GlcNAc...) Potential
	Glycosylation	100	1	N-linked (GlcNAc...) Potential
	Disulfide bond	46 ↔ 104		By similarity
	Disulfide bond	60 ↔ 114		By similarity
	Disulfide bond	78 ↔ 129		By similarity
	Disulfide bond	85 ↔ 92		By similarity
Natural variations
	Natural variant	89	1	R → Q. Corresponds to variant rs1045922 [ dbSNP | Ensembl ].		VAR_012048

Sequences

	Sequence		Length	Mass (Da)
	Q93091 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: 4C1F722066BCC13A	FASTA	150	17,196
	10 20 30 40 50 60 MVLCFPLLLL LLVLWGPVCP LHAWPKRLTK AHWFEIQHIQ PSPLQCNRAM SGINNYTQHC 70 80 90 100 110 120 KHQNTFLHDS FQNVAAVCDL LSIVCKNRRH NCHQSSKPVN MTDCRLTSGK YPQCRYSAAA 130 140 150 QYKFFIVACD PPQKSDPPYK LVPVHLDSIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family." Rosenberg H.F., Dyer K.D. Nucleic Acids Res. 24:3507-3513(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Rosenberg H.F. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 76.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U64998 Genomic DNA. Translation: AAC51848.1. BC020848 mRNA. Translation: AAH20848.1.
IPI	IPI00004114.
PIR	S72361.
RefSeq	NP_005606.1. NM_005615.4.
UniGene	Hs.23262.
3D structure databases
ProteinModelPortal	Q93091.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q93091. 1 interaction.
MINT	MINT-1409629.
STRING	9606.ENSP00000302046.
Polymorphism databases
DMDM	3123285.
Proteomic databases
PaxDb	Q93091.
PeptideAtlas	Q93091.
PRIDE	Q93091.
Protocols and materials databases
DNASU	6039.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304677; ENSP00000302046; ENSG00000169413.
GeneID	6039.
KEGG	hsa:6039.
UCSC	uc001vye.4. human.
Organism-specific databases
CTD	6039.
GeneCards	GC14P021249.
HGNC	HGNC:10048. RNASE6.
HPA	HPA000698.
MIM	601981. gene.
neXtProt	NX_Q93091.
PharmGKB	PA34416.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45773.
HOGENOM	HOG000276882.
HOVERGEN	HBG008396.
InParanoid	Q93091.
KO	K01172.
OMA	LQCNRAM.
OrthoDB	EOG4J9N18.
PhylomeDB	Q93091.
Gene expression databases
ArrayExpress	Q93091.
Bgee	Q93091.
CleanEx	HS_RNASE6.
Genevestigator	Q93091.
GermOnline	ENSG00000169413. Homo sapiens.
Family and domain databases
Gene3D	3.10.130.10. 1 hit.
InterPro	IPR001427. RNaseA. IPR023411. RNaseA_AS. IPR023412. RNaseA_domain. [Graphical view]
PANTHER	PTHR11437. PTHR11437. 1 hit.
Pfam	PF00074. RnaseA. 1 hit. [Graphical view]
PRINTS	PR00794. RIBONUCLEASE.
ProDom	PD000535. RNaseA. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00092. RNAse_Pc. 1 hit. [Graphical view]
SUPFAM	SSF54076. RNaseA. 1 hit.
PROSITE	PS00127. RNASE_PANCREATIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6039.
NextBio	23539.
SOURCE	Search...

Entry information

Entry name

RNAS6_HUMAN

Accession

Primary (citable) accession number: Q93091

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 15, 1998
Last modified:	May 1, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.