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Q93091

- RNAS6_HUMAN

UniProt

Q93091 - RNAS6_HUMAN

Protein

Ribonuclease K6

Gene

RNASE6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May have a role in host defense.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei38 – 381Proton acceptorBy similarity
    Binding sitei86 – 861SubstrateBy similarity
    Binding sitei105 – 1051SubstrateBy similarity
    Active sitei145 – 1451Proton donorBy similarity

    GO - Molecular functioni

    1. endoribonuclease activity, producing 3'-phosphomonoesters Source: InterPro
    2. nucleic acid binding Source: InterPro
    3. ribonuclease activity Source: ProtInc

    GO - Biological processi

    1. defense response Source: ProtInc
    2. RNA catabolic process Source: ProtInc
    3. RNA phosphodiester bond hydrolysis Source: GOC

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease K6 (EC:3.1.27.-)
    Short name:
    RNase K6
    Gene namesi
    Name:RNASE6
    Synonyms:RNS6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:10048. RNASE6.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: ProtInc
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34416.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 150127Ribonuclease K6PRO_0000030892Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi46 ↔ 104By similarity
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi60 ↔ 114By similarity
    Disulfide bondi78 ↔ 129By similarity
    Disulfide bondi85 ↔ 92By similarity
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ93091.
    PeptideAtlasiQ93091.
    PRIDEiQ93091.

    Expressioni

    Tissue specificityi

    Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and skeletal muscle. Also expressed in monocytes and neutrophils.

    Gene expression databases

    ArrayExpressiQ93091.
    BgeeiQ93091.
    CleanExiHS_RNASE6.
    GenevestigatoriQ93091.

    Organism-specific databases

    HPAiHPA000698.

    Interactioni

    Protein-protein interaction databases

    BioGridi111968. 1 interaction.
    IntActiQ93091. 1 interaction.
    MINTiMINT-1409629.
    STRINGi9606.ENSP00000302046.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93091.
    SMRiQ93091. Positions 25-150.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni61 – 655Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the pancreatic ribonuclease family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45773.
    HOGENOMiHOG000276882.
    HOVERGENiHBG008396.
    InParanoidiQ93091.
    KOiK01172.
    OMAiLQCNRAM.
    OrthoDBiEOG7J1826.
    PhylomeDBiQ93091.
    TreeFamiTF333393.

    Family and domain databases

    Gene3Di3.10.130.10. 1 hit.
    InterProiIPR001427. RNaseA.
    IPR023411. RNaseA_AS.
    IPR023412. RNaseA_domain.
    [Graphical view]
    PANTHERiPTHR11437. PTHR11437. 1 hit.
    PfamiPF00074. RnaseA. 1 hit.
    [Graphical view]
    PRINTSiPR00794. RIBONUCLEASE.
    ProDomiPD000535. RNaseA. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00092. RNAse_Pc. 1 hit.
    [Graphical view]
    SUPFAMiSSF54076. SSF54076. 1 hit.
    PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q93091-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLCFPLLLL LLVLWGPVCP LHAWPKRLTK AHWFEIQHIQ PSPLQCNRAM    50
    SGINNYTQHC KHQNTFLHDS FQNVAAVCDL LSIVCKNRRH NCHQSSKPVN 100
    MTDCRLTSGK YPQCRYSAAA QYKFFIVACD PPQKSDPPYK LVPVHLDSIL 150
    Length:150
    Mass (Da):17,196
    Last modified:July 15, 1998 - v2
    Checksum:i4C1F722066BCC13A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti89 – 891R → Q.
    Corresponds to variant rs1045922 [ dbSNP | Ensembl ].
    VAR_012048

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64998 Genomic DNA. Translation: AAC51848.1.
    BC020848 mRNA. Translation: AAH20848.1.
    CCDSiCCDS9558.1.
    PIRiS72361.
    RefSeqiNP_005606.1. NM_005615.4.
    UniGeneiHs.23262.

    Genome annotation databases

    EnsembliENST00000304677; ENSP00000302046; ENSG00000169413.
    GeneIDi6039.
    KEGGihsa:6039.
    UCSCiuc001vye.4. human.

    Polymorphism databases

    DMDMi3123285.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64998 Genomic DNA. Translation: AAC51848.1 .
    BC020848 mRNA. Translation: AAH20848.1 .
    CCDSi CCDS9558.1.
    PIRi S72361.
    RefSeqi NP_005606.1. NM_005615.4.
    UniGenei Hs.23262.

    3D structure databases

    ProteinModelPortali Q93091.
    SMRi Q93091. Positions 25-150.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111968. 1 interaction.
    IntActi Q93091. 1 interaction.
    MINTi MINT-1409629.
    STRINGi 9606.ENSP00000302046.

    Polymorphism databases

    DMDMi 3123285.

    Proteomic databases

    PaxDbi Q93091.
    PeptideAtlasi Q93091.
    PRIDEi Q93091.

    Protocols and materials databases

    DNASUi 6039.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304677 ; ENSP00000302046 ; ENSG00000169413 .
    GeneIDi 6039.
    KEGGi hsa:6039.
    UCSCi uc001vye.4. human.

    Organism-specific databases

    CTDi 6039.
    GeneCardsi GC14P021249.
    HGNCi HGNC:10048. RNASE6.
    HPAi HPA000698.
    MIMi 601981. gene.
    neXtProti NX_Q93091.
    PharmGKBi PA34416.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45773.
    HOGENOMi HOG000276882.
    HOVERGENi HBG008396.
    InParanoidi Q93091.
    KOi K01172.
    OMAi LQCNRAM.
    OrthoDBi EOG7J1826.
    PhylomeDBi Q93091.
    TreeFami TF333393.

    Miscellaneous databases

    GenomeRNAii 6039.
    NextBioi 23539.
    PROi Q93091.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q93091.
    Bgeei Q93091.
    CleanExi HS_RNASE6.
    Genevestigatori Q93091.

    Family and domain databases

    Gene3Di 3.10.130.10. 1 hit.
    InterProi IPR001427. RNaseA.
    IPR023411. RNaseA_AS.
    IPR023412. RNaseA_domain.
    [Graphical view ]
    PANTHERi PTHR11437. PTHR11437. 1 hit.
    Pfami PF00074. RnaseA. 1 hit.
    [Graphical view ]
    PRINTSi PR00794. RIBONUCLEASE.
    ProDomi PD000535. RNaseA. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00092. RNAse_Pc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54076. SSF54076. 1 hit.
    PROSITEi PS00127. RNASE_PANCREATIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family."
      Rosenberg H.F., Dyer K.D.
      Nucleic Acids Res. 24:3507-3513(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Rosenberg H.F.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 76.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiRNAS6_HUMAN
    AccessioniPrimary (citable) accession number: Q93091
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3