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Q93091

- RNAS6_HUMAN

UniProt

Q93091 - RNAS6_HUMAN

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Protein
Ribonuclease K6
Gene
RNASE6, RNS6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May have a role in host defense.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptor By similarity
Binding sitei86 – 861Substrate By similarity
Binding sitei105 – 1051Substrate By similarity
Active sitei145 – 1451Proton donor By similarity

GO - Molecular functioni

  1. endoribonuclease activity, producing 3'-phosphomonoesters Source: InterPro
  2. nucleic acid binding Source: InterPro
  3. ribonuclease activity Source: ProtInc

GO - Biological processi

  1. RNA catabolic process Source: ProtInc
  2. RNA phosphodiester bond hydrolysis Source: GOC
  3. defense response Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease K6 (EC:3.1.27.-)
Short name:
RNase K6
Gene namesi
Name:RNASE6
Synonyms:RNS6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:10048. RNASE6.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: ProtInc
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34416.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarity
Add
BLAST
Chaini24 – 150127Ribonuclease K6
PRO_0000030892Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 104 By similarity
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi60 ↔ 114 By similarity
Disulfide bondi78 ↔ 129 By similarity
Disulfide bondi85 ↔ 92 By similarity
Glycosylationi100 – 1001N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ93091.
PeptideAtlasiQ93091.
PRIDEiQ93091.

Expressioni

Tissue specificityi

Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and skeletal muscle. Also expressed in monocytes and neutrophils.

Gene expression databases

ArrayExpressiQ93091.
BgeeiQ93091.
CleanExiHS_RNASE6.
GenevestigatoriQ93091.

Organism-specific databases

HPAiHPA000698.

Interactioni

Protein-protein interaction databases

BioGridi111968. 1 interaction.
IntActiQ93091. 1 interaction.
MINTiMINT-1409629.
STRINGi9606.ENSP00000302046.

Structurei

3D structure databases

ProteinModelPortaliQ93091.
SMRiQ93091. Positions 25-150.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 655Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45773.
HOGENOMiHOG000276882.
HOVERGENiHBG008396.
InParanoidiQ93091.
KOiK01172.
OMAiLQCNRAM.
OrthoDBiEOG7J1826.
PhylomeDBiQ93091.
TreeFamiTF333393.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93091-1 [UniParc]FASTAAdd to Basket

« Hide

MVLCFPLLLL LLVLWGPVCP LHAWPKRLTK AHWFEIQHIQ PSPLQCNRAM    50
SGINNYTQHC KHQNTFLHDS FQNVAAVCDL LSIVCKNRRH NCHQSSKPVN 100
MTDCRLTSGK YPQCRYSAAA QYKFFIVACD PPQKSDPPYK LVPVHLDSIL 150
Length:150
Mass (Da):17,196
Last modified:July 15, 1998 - v2
Checksum:i4C1F722066BCC13A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891R → Q.
Corresponds to variant rs1045922 [ dbSNP | Ensembl ].
VAR_012048

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U64998 Genomic DNA. Translation: AAC51848.1.
BC020848 mRNA. Translation: AAH20848.1.
CCDSiCCDS9558.1.
PIRiS72361.
RefSeqiNP_005606.1. NM_005615.4.
UniGeneiHs.23262.

Genome annotation databases

EnsembliENST00000304677; ENSP00000302046; ENSG00000169413.
GeneIDi6039.
KEGGihsa:6039.
UCSCiuc001vye.4. human.

Polymorphism databases

DMDMi3123285.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U64998 Genomic DNA. Translation: AAC51848.1 .
BC020848 mRNA. Translation: AAH20848.1 .
CCDSi CCDS9558.1.
PIRi S72361.
RefSeqi NP_005606.1. NM_005615.4.
UniGenei Hs.23262.

3D structure databases

ProteinModelPortali Q93091.
SMRi Q93091. Positions 25-150.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111968. 1 interaction.
IntActi Q93091. 1 interaction.
MINTi MINT-1409629.
STRINGi 9606.ENSP00000302046.

Polymorphism databases

DMDMi 3123285.

Proteomic databases

PaxDbi Q93091.
PeptideAtlasi Q93091.
PRIDEi Q93091.

Protocols and materials databases

DNASUi 6039.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304677 ; ENSP00000302046 ; ENSG00000169413 .
GeneIDi 6039.
KEGGi hsa:6039.
UCSCi uc001vye.4. human.

Organism-specific databases

CTDi 6039.
GeneCardsi GC14P021249.
HGNCi HGNC:10048. RNASE6.
HPAi HPA000698.
MIMi 601981. gene.
neXtProti NX_Q93091.
PharmGKBi PA34416.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45773.
HOGENOMi HOG000276882.
HOVERGENi HBG008396.
InParanoidi Q93091.
KOi K01172.
OMAi LQCNRAM.
OrthoDBi EOG7J1826.
PhylomeDBi Q93091.
TreeFami TF333393.

Miscellaneous databases

GenomeRNAii 6039.
NextBioi 23539.
PROi Q93091.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q93091.
Bgeei Q93091.
CleanExi HS_RNASE6.
Genevestigatori Q93091.

Family and domain databases

Gene3Di 3.10.130.10. 1 hit.
InterProi IPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view ]
PANTHERi PTHR11437. PTHR11437. 1 hit.
Pfami PF00074. RnaseA. 1 hit.
[Graphical view ]
PRINTSi PR00794. RIBONUCLEASE.
ProDomi PD000535. RNaseA. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00092. RNAse_Pc. 1 hit.
[Graphical view ]
SUPFAMi SSF54076. SSF54076. 1 hit.
PROSITEi PS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family."
    Rosenberg H.F., Dyer K.D.
    Nucleic Acids Res. 24:3507-3513(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Rosenberg H.F.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 76.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiRNAS6_HUMAN
AccessioniPrimary (citable) accession number: Q93091
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: September 3, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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