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Q93091 (RNAS6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease K6

Short name=RNase K6
EC=3.1.27.-
Gene names
Name:RNASE6
Synonyms:RNS6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length150 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have a role in host defense.

Subcellular location

Secreted.

Tissue specificity

Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and skeletal muscle. Also expressed in monocytes and neutrophils.

Sequence similarities

Belongs to the pancreatic ribonuclease family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 150127Ribonuclease K6
PRO_0000030892

Regions

Region61 – 655Substrate binding By similarity

Sites

Active site381Proton acceptor By similarity
Active site1451Proton donor By similarity
Binding site861Substrate By similarity
Binding site1051Substrate By similarity

Amino acid modifications

Glycosylation551N-linked (GlcNAc...) Potential
Glycosylation1001N-linked (GlcNAc...) Potential
Disulfide bond46 ↔ 104 By similarity
Disulfide bond60 ↔ 114 By similarity
Disulfide bond78 ↔ 129 By similarity
Disulfide bond85 ↔ 92 By similarity

Natural variations

Natural variant891R → Q.
Corresponds to variant rs1045922 [ dbSNP | Ensembl ].
VAR_012048

Sequences

Sequence LengthMass (Da)Tools
Q93091 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 4C1F722066BCC13A

FASTA15017,196
        10         20         30         40         50         60 
MVLCFPLLLL LLVLWGPVCP LHAWPKRLTK AHWFEIQHIQ PSPLQCNRAM SGINNYTQHC 

        70         80         90        100        110        120 
KHQNTFLHDS FQNVAAVCDL LSIVCKNRRH NCHQSSKPVN MTDCRLTSGK YPQCRYSAAA 

       130        140        150 
QYKFFIVACD PPQKSDPPYK LVPVHLDSIL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family."
Rosenberg H.F., Dyer K.D.
Nucleic Acids Res. 24:3507-3513(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Rosenberg H.F.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 76.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U64998 Genomic DNA. Translation: AAC51848.1.
BC020848 mRNA. Translation: AAH20848.1.
PIRS72361.
RefSeqNP_005606.1. NM_005615.4.
UniGeneHs.23262.

3D structure databases

ProteinModelPortalQ93091.
SMRQ93091. Positions 25-150.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111968. 1 interaction.
IntActQ93091. 1 interaction.
MINTMINT-1409629.
STRING9606.ENSP00000302046.

Polymorphism databases

DMDM3123285.

Proteomic databases

PaxDbQ93091.
PeptideAtlasQ93091.
PRIDEQ93091.

Protocols and materials databases

DNASU6039.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304677; ENSP00000302046; ENSG00000169413.
GeneID6039.
KEGGhsa:6039.
UCSCuc001vye.4. human.

Organism-specific databases

CTD6039.
GeneCardsGC14P021249.
HGNCHGNC:10048. RNASE6.
HPAHPA000698.
MIM601981. gene.
neXtProtNX_Q93091.
PharmGKBPA34416.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45773.
HOGENOMHOG000276882.
HOVERGENHBG008396.
InParanoidQ93091.
KOK01172.
OMALQCNRAM.
OrthoDBEOG7J1826.
PhylomeDBQ93091.
TreeFamTF333393.

Gene expression databases

ArrayExpressQ93091.
BgeeQ93091.
CleanExHS_RNASE6.
GenevestigatorQ93091.

Family and domain databases

Gene3D3.10.130.10. 1 hit.
InterProIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERPTHR11437. PTHR11437. 1 hit.
PfamPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSPR00794. RIBONUCLEASE.
ProDomPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMSSF54076. SSF54076. 1 hit.
PROSITEPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi6039.
NextBio23539.
PROQ93091.
SOURCESearch...

Entry information

Entry nameRNAS6_HUMAN
AccessionPrimary (citable) accession number: Q93091
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: April 16, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM