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Protein

Ribonuclease K6

Gene

RNASE6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have a role in host defense.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptorBy similarity
Binding sitei86 – 861SubstrateBy similarity
Binding sitei105 – 1051SubstrateBy similarity
Active sitei145 – 1451Proton donorBy similarity

GO - Molecular functioni

  1. endonuclease activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro
  3. ribonuclease activity Source: ProtInc

GO - Biological processi

  1. defense response Source: ProtInc
  2. RNA catabolic process Source: ProtInc
  3. RNA phosphodiester bond hydrolysis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease K6 (EC:3.1.27.-)
Short name:
RNase K6
Gene namesi
Name:RNASE6
Synonyms:RNS6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:10048. RNASE6.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: ProtInc
  2. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34416.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 150127Ribonuclease K6PRO_0000030892Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 104By similarity
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi60 ↔ 114By similarity
Disulfide bondi78 ↔ 129By similarity
Disulfide bondi85 ↔ 92By similarity
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ93091.
PeptideAtlasiQ93091.
PRIDEiQ93091.

Expressioni

Tissue specificityi

Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and skeletal muscle. Also expressed in monocytes and neutrophils.

Gene expression databases

BgeeiQ93091.
CleanExiHS_RNASE6.
ExpressionAtlasiQ93091. baseline and differential.
GenevestigatoriQ93091.

Organism-specific databases

HPAiHPA000698.

Interactioni

Protein-protein interaction databases

BioGridi111968. 1 interaction.
IntActiQ93091. 1 interaction.
MINTiMINT-1409629.
STRINGi9606.ENSP00000302046.

Structurei

3D structure databases

ProteinModelPortaliQ93091.
SMRiQ93091. Positions 25-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 655Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45773.
GeneTreeiENSGT00390000007840.
HOGENOMiHOG000276882.
HOVERGENiHBG008396.
InParanoidiQ93091.
KOiK01172.
OMAiLQCNRAM.
OrthoDBiEOG7J1826.
PhylomeDBiQ93091.
TreeFamiTF333393.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLCFPLLLL LLVLWGPVCP LHAWPKRLTK AHWFEIQHIQ PSPLQCNRAM
60 70 80 90 100
SGINNYTQHC KHQNTFLHDS FQNVAAVCDL LSIVCKNRRH NCHQSSKPVN
110 120 130 140 150
MTDCRLTSGK YPQCRYSAAA QYKFFIVACD PPQKSDPPYK LVPVHLDSIL
Length:150
Mass (Da):17,196
Last modified:July 15, 1998 - v2
Checksum:i4C1F722066BCC13A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891R → Q.
Corresponds to variant rs1045922 [ dbSNP | Ensembl ].
VAR_012048

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64998 Genomic DNA. Translation: AAC51848.1.
BC020848 mRNA. Translation: AAH20848.1.
CCDSiCCDS9558.1.
PIRiS72361.
RefSeqiNP_005606.1. NM_005615.4.
UniGeneiHs.23262.

Genome annotation databases

EnsembliENST00000304677; ENSP00000302046; ENSG00000169413.
GeneIDi6039.
KEGGihsa:6039.
UCSCiuc001vye.4. human.

Polymorphism databases

DMDMi3123285.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64998 Genomic DNA. Translation: AAC51848.1.
BC020848 mRNA. Translation: AAH20848.1.
CCDSiCCDS9558.1.
PIRiS72361.
RefSeqiNP_005606.1. NM_005615.4.
UniGeneiHs.23262.

3D structure databases

ProteinModelPortaliQ93091.
SMRiQ93091. Positions 25-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111968. 1 interaction.
IntActiQ93091. 1 interaction.
MINTiMINT-1409629.
STRINGi9606.ENSP00000302046.

Polymorphism databases

DMDMi3123285.

Proteomic databases

PaxDbiQ93091.
PeptideAtlasiQ93091.
PRIDEiQ93091.

Protocols and materials databases

DNASUi6039.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304677; ENSP00000302046; ENSG00000169413.
GeneIDi6039.
KEGGihsa:6039.
UCSCiuc001vye.4. human.

Organism-specific databases

CTDi6039.
GeneCardsiGC14P021249.
HGNCiHGNC:10048. RNASE6.
HPAiHPA000698.
MIMi601981. gene.
neXtProtiNX_Q93091.
PharmGKBiPA34416.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45773.
GeneTreeiENSGT00390000007840.
HOGENOMiHOG000276882.
HOVERGENiHBG008396.
InParanoidiQ93091.
KOiK01172.
OMAiLQCNRAM.
OrthoDBiEOG7J1826.
PhylomeDBiQ93091.
TreeFamiTF333393.

Miscellaneous databases

GenomeRNAii6039.
NextBioi23539.
PROiQ93091.
SOURCEiSearch...

Gene expression databases

BgeeiQ93091.
CleanExiHS_RNASE6.
ExpressionAtlasiQ93091. baseline and differential.
GenevestigatoriQ93091.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family."
    Rosenberg H.F., Dyer K.D.
    Nucleic Acids Res. 24:3507-3513(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Rosenberg H.F.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 76.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiRNAS6_HUMAN
AccessioniPrimary (citable) accession number: Q93091
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: January 7, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.