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Protein

Ribonuclease K6

Gene

RNASE6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a role in host defense.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38Proton acceptorBy similarity1
Binding sitei86SubstrateBy similarity1
Binding sitei105SubstrateBy similarity1
Active sitei145Proton donorBy similarity1

GO - Molecular functioni

  • endonuclease activity Source: GO_Central
  • nucleic acid binding Source: InterPro
  • ribonuclease activity Source: UniProtKB

GO - Biological processi

  • antibacterial humoral response Source: UniProtKB
  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • antimicrobial humoral response Source: Reactome
  • defense response Source: ProtInc
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • defense response to virus Source: UniProtKB
  • innate immune response Source: UniProtKB
  • RNA catabolic process Source: ProtInc
  • RNA phosphodiester bond hydrolysis Source: UniProtKB

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease K6 (EC:3.1.27.-)
Short name:
RNase K6
Gene namesi
Name:RNASE6
Synonyms:RNS6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000169413.2
HGNCiHGNC:10048 RNASE6
MIMi601981 gene
neXtProtiNX_Q93091

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6039
OpenTargetsiENSG00000169413
PharmGKBiPA34416

Polymorphism and mutation databases

BioMutaiRNASE6
DMDMi3123285

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000003089224 – 150Ribonuclease K6Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 104By similarity
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi60 ↔ 114By similarity
Disulfide bondi78 ↔ 129By similarity
Disulfide bondi85 ↔ 92By similarity
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ93091
PaxDbiQ93091
PeptideAtlasiQ93091
PRIDEiQ93091

Expressioni

Tissue specificityi

Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and skeletal muscle. Also expressed in monocytes and neutrophils.

Gene expression databases

BgeeiENSG00000169413
CleanExiHS_RNASE6
ExpressionAtlasiQ93091 baseline and differential
GenevisibleiQ93091 HS

Organism-specific databases

HPAiHPA000698

Interactioni

Protein-protein interaction databases

BioGridi111968, 1 interactor
IntActiQ93091, 1 interactor
STRINGi9606.ENSP00000302046

Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 38Combined sources9
Helixi46 – 57Combined sources12
Beta strandi62 – 67Combined sources6
Helixi71 – 75Combined sources5
Helixi76 – 79Combined sources4
Beta strandi92 – 94Combined sources3
Beta strandi99 – 108Combined sources10
Beta strandi115 – 130Combined sources16
Beta strandi142 – 150Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4X09X-ray1.72A24-150[»]
ProteinModelPortaliQ93091
SMRiQ93091
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 65Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYEW Eukaryota
ENOG4111D8Q LUCA
GeneTreeiENSGT00900000140993
HOGENOMiHOG000276882
HOVERGENiHBG008396
InParanoidiQ93091
KOiK01172
OMAiLQCNRAM
OrthoDBiEOG091G0U42
PhylomeDBiQ93091
TreeFamiTF333393

Family and domain databases

Gene3Di3.10.130.10, 1 hit
InterProiView protein in InterPro
IPR001427 RNaseA
IPR036816 RNaseA-like_dom_sf
IPR023411 RNaseA_AS
IPR023412 RNaseA_domain
PANTHERiPTHR11437 PTHR11437, 1 hit
PfamiView protein in Pfam
PF00074 RnaseA, 1 hit
PRINTSiPR00794 RIBONUCLEASE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000535 RNaseA, 1 hit
SMARTiView protein in SMART
SM00092 RNAse_Pc, 1 hit
SUPFAMiSSF54076 SSF54076, 1 hit
PROSITEiView protein in PROSITE
PS00127 RNASE_PANCREATIC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLCFPLLLL LLVLWGPVCP LHAWPKRLTK AHWFEIQHIQ PSPLQCNRAM
60 70 80 90 100
SGINNYTQHC KHQNTFLHDS FQNVAAVCDL LSIVCKNRRH NCHQSSKPVN
110 120 130 140 150
MTDCRLTSGK YPQCRYSAAA QYKFFIVACD PPQKSDPPYK LVPVHLDSIL
Length:150
Mass (Da):17,196
Last modified:July 15, 1998 - v2
Checksum:i4C1F722066BCC13A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01204889R → Q. Corresponds to variant dbSNP:rs1045922Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64998 Genomic DNA Translation: AAC51848.1
BC020848 mRNA Translation: AAH20848.1
CCDSiCCDS9558.1
PIRiS72361
RefSeqiNP_005606.1, NM_005615.4
XP_016877055.1, XM_017021566.1
XP_016877056.1, XM_017021567.1
UniGeneiHs.23262

Genome annotation databases

EnsembliENST00000304677; ENSP00000302046; ENSG00000169413
GeneIDi6039
KEGGihsa:6039
UCSCiuc001vye.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRNAS6_HUMAN
AccessioniPrimary (citable) accession number: Q93091
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health