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Q93086 (P2RX5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
P2X purinoceptor 5

Short name=P2X5
Alternative name(s):
ATP receptor
Purinergic receptor
Gene names
Name:P2RX5
Synonyms:P2X5
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for ATP that acts as a ligand-gated ion channel.

Subunit structure

Homo- or heteropolymers By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed at high levels in brain and immune system.

Sequence similarities

Belongs to the P2X receptor family.

Sequence caution

The sequence AAF43106.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AK307959 differs from that shown. Reason: Frameshift at position 112.

The sequence BAD92860.1 differs from that shown. Reason: Frameshift at position 112.

The sequence BC028084 differs from that shown. Reason: Frameshift at position 112.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q93086-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q93086-1)

Also known as: A;

The sequence of this isoform differs from the canonical sequence as follows:
     205-206: KS → N
Isoform 3 (identifier: Q93086-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     97-120: Missing.
     205-206: KS → N
Isoform 4 (identifier: Q93086-4)

The sequence of this isoform differs from the canonical sequence as follows:
     421-422: ST → LRTPSASPLHQE
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422P2X purinoceptor 5
PRO_0000161555

Regions

Topological domain1 – 3030Cytoplasmic Potential
Transmembrane31 – 5121Helical; Name=1; Potential
Topological domain52 – 319268Extracellular Potential
Transmembrane320 – 34021Helical; Name=2; Potential
Topological domain341 – 42282Cytoplasmic Potential

Amino acid modifications

Modified residue551Phosphotyrosine Ref.8
Glycosylation771N-linked (GlcNAc...) Potential
Glycosylation2021N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence97 – 12024Missing in isoform 3.
VSP_004503
Alternative sequence205 – 2062KS → N in isoform 2 and isoform 3.
VSP_035587
Alternative sequence421 – 4222ST → LRTPSASPLHQE in isoform 4.
VSP_035588

Experimental info

Sequence conflict961Q → E in AAB08577. Ref.1
Sequence conflict97 – 982GE → EK in AAB08576. Ref.1
Sequence conflict1561E → G in AAC51931. Ref.2
Sequence conflict237 – 2382VI → IV in AAC51931. Ref.2
Sequence conflict2511E → R in AAC51931. Ref.2
Sequence conflict3301F → S in AAB08576. Ref.1
Sequence conflict3301F → S in AAB08577. Ref.1
Sequence conflict3521E → Q in AAB08576. Ref.1
Sequence conflict3521E → Q in AAB08577. Ref.1
Sequence conflict399 – 4002KR → NV in AAB08576. Ref.1
Sequence conflict399 – 4002KR → NV in AAB08577. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 14, 2008. Version 4.
Checksum: B122027A23B2A240

FASTA42247,205
        10         20         30         40         50         60 
MGQAGCKGLC LSLFDYKTEK YVIAKNKKVG LLYRLLQASI LAYLVVWVFL IKKGYQDVDT 

        70         80         90        100        110        120 
SLQSAVITKV KGVAFTNTSD LGQRIWDVAD YVIPAQGENV FFVVTNLIVT PNQRQNVCAE 

       130        140        150        160        170        180 
NEGIPDGACS KDSDCHAGEA VTAGNGVKTG RCLRRENLAR GTCEIFAWCP LETSSRPEEP 

       190        200        210        220        230        240 
FLKEAEDFTI FIKNHIRFPK FNFSKSNVMD VKDRSFLKSC HFGPKNHYCP IFRLGSVIRW 

       250        260        270        280        290        300 
AGSDFQDIAL EGGVIGINIE WNCDLDKAAS ECHPHYSFSR LDNKLSKSVS SGYNFRFARY 

       310        320        330        340        350        360 
YRDAAGVEFR TLMKAYGIRF DVMVNGKGAF FCDLVLIYLI KKREFYRDKK YEEVRGLEDS 

       370        380        390        400        410        420 
SQEAEDEASG LGLSEQLTSG PGLLGMPEQQ ELQEPPEAKR GSSSQKGNGS VCPQLLEPHR 


ST 

« Hide

Isoform 2 (A) [UniParc].

Checksum: 6B47307AA14C2A6C
Show »

FASTA42147,104
Isoform 3 (B) [UniParc].

Checksum: C3DB8AB55858CEB0
Show »

FASTA39744,430
Isoform 4 [UniParc].

Checksum: 53AD66E4F75A69E3
Show »

FASTA43248,334

References

« Hide 'large scale' references
[1]"Cloning of human P2X purinoceptor new subtype (P2X5)."
Tokuyama Y., Mereu L., Chen X., Rouard M., Bell G.I.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
[2]"Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system."
Le K.-T., Paquet M., Nouel D., Babinski K., Seguela P.
FEBS Lett. 418:195-199(1997) [PubMed: 9414125] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion."
Touchman J.W., Anikster Y., Dietrich N.L., Maduro V.V.B., McDowell G., Shotelersuk V., Bouffard G.G., Beckstrom-Sternberg S.M., Gahl W.A., Green E.D.
Genome Res. 10:165-173(2000) [PubMed: 10673275] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]Yu W., Gibbs R.A.
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Erythroleukemia and Mesangial cell.
[6]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Spleen.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Leukocyte and Lung.
[8]"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-55, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.

Web resources

Wikipedia

P2X receptor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U49395 mRNA. Translation: AAB08576.1.
U49396 mRNA. Translation: AAB08577.1.
AF016709 mRNA. Translation: AAC51931.1.
AF168787 Genomic DNA. Translation: AAF43105.1.
AF168787 Genomic DNA. Translation: AAF43106.1. Sequence problems.
AF070573 mRNA. Translation: AAC28645.1.
AK290889 mRNA. Translation: BAF83578.1.
AK307959 mRNA. No translation available.
AB209623 mRNA. Translation: BAD92860.1. Frameshift.
BC028084 mRNA. No translation available.
BC039015 mRNA. Translation: AAH39015.1.
IPIIPI00217666.
IPI00789729.
IPI00873205.
IPI00914060.
RefSeqNP_001191448.1. NM_001204519.1.
NP_001191449.1. NM_001204520.1.
NP_002552.2. NM_002561.3.
NP_778255.1. NM_175080.2.
UniGeneHs.408615.

3D structure databases

ProteinModelPortalQ93086.
SMRQ93086. Positions 34-331.
ModBaseSearch...

Protein-protein interaction databases

IntActQ93086. 1 interaction.
STRINGQ93086.

Polymorphism databases

DMDM209572778.

Proteomic databases

PRIDEQ93086.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000225328; ENSP00000225328; ENSG00000083454.
GeneID5026.
KEGGhsa:5026.
UCSCuc002fwh.1. human.
uc002fwj.1. human.

Organism-specific databases

CTD5026.
GeneCardsGC17M003575.
HGNCHGNC:8536. P2RX5.
HPAHPA021948.
MIM602836. gene.
neXtProtNX_Q93086.
PharmGKBPA32865.
GenAtlasSearch...

Phylogenomic databases

GeneTreeENSGT00390000016028.
HOVERGENHBG053086.
OrthoDBEOG46Q6SQ.
PhylomeDBQ93086.

Gene expression databases

ArrayExpressQ93086.
BgeeQ93086.
CleanExHS_P2RX5.
GenevestigatorQ93086.
GermOnlineENSG00000083454. Homo sapiens.

Family and domain databases

InterProIPR003048. P2X5_purnocptor.
IPR001429. P2X_purnocptor.
[Graphical view]
KOK05219.
PANTHERPTHR10125. ATP_P2X_rcpt. 1 hit.
PTHR10125:SF12. P2X5_purnocptor. 1 hit.
PfamPF00864. P2X_receptor. 2 hits.
[Graphical view]
PRINTSPR01312. P2X5RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsTIGR00863. P2X. 1 hit.
PROSITEPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio19350.
SOURCESearch...

Entry information

Entry nameP2RX5_HUMAN
AccessionPrimary (citable) accession number: Q93086
Secondary accession number(s): O43450 expand/collapse secondary AC list , O75540, Q59F38, Q8IXW4, Q93087, Q9NZV0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: January 25, 2012
This is version 101 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families