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Protein

P2X purinoceptor 5

Gene

P2RX5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.

GO - Molecular functioni

  • ATP binding Source: BHF-UCL
  • extracellular ATP-gated cation channel activity Source: BHF-UCL
  • ion channel activity Source: ProtInc
  • purinergic nucleotide receptor activity Source: BHF-UCL
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • activation of mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
  • nervous system development Source: ProtInc
  • positive regulation of calcium ion transport into cytosol Source: BHF-UCL
  • positive regulation of calcium-mediated signaling Source: BHF-UCL
  • purinergic nucleotide receptor signaling pathway Source: GOC
  • response to ATP Source: InterPro
  • signal transduction Source: ProtInc
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 5
Short name:
P2X5
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2RX5
Synonyms:P2X5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8536. P2RX5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini52 – 319268ExtracellularSequence AnalysisAdd
BLAST
Transmembranei320 – 34021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini341 – 42282CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of nuclear inner membrane Source: GO_Central
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32865.

Polymorphism and mutation databases

BioMutaiP2RX5.
DMDMi209572778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422P2X purinoceptor 5PRO_0000161555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi118 ↔ 169By similarity
Disulfide bondi129 ↔ 152By similarity
Disulfide bondi135 ↔ 163By similarity
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi220 ↔ 229By similarity
Disulfide bondi263 ↔ 272By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ93086.
PaxDbiQ93086.
PRIDEiQ93086.

PTM databases

PhosphoSiteiQ93086.

Expressioni

Tissue specificityi

Expressed at high levels in brain and immune system.

Gene expression databases

BgeeiQ93086.
CleanExiHS_P2RX5.
ExpressionAtlasiQ93086. baseline and differential.
GenevestigatoriQ93086.

Organism-specific databases

HPAiHPA021948.

Interactioni

Subunit structurei

Functional P2XRs are organized as homomeric and heteromeric trimers.By similarity

Protein-protein interaction databases

BioGridi111065. 27 interactions.
IntActiQ93086. 1 interaction.
STRINGi9606.ENSP00000225328.

Structurei

3D structure databases

ProteinModelPortaliQ93086.
SMRiQ93086. Positions 32-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47843.
GeneTreeiENSGT00390000016028.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiQ93086.
KOiK05219.
OMAiAGAFFCD.
PhylomeDBiQ93086.
TreeFamiTF328633.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003048. P2X5_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF12. PTHR10125:SF12. 1 hit.
PfamiPF00864. P2X_receptor. 2 hits.
[Graphical view]
PRINTSiPR01312. P2X5RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q93086-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQAGCKGLC LSLFDYKTEK YVIAKNKKVG LLYRLLQASI LAYLVVWVFL
60 70 80 90 100
IKKGYQDVDT SLQSAVITKV KGVAFTNTSD LGQRIWDVAD YVIPAQGENV
110 120 130 140 150
FFVVTNLIVT PNQRQNVCAE NEGIPDGACS KDSDCHAGEA VTAGNGVKTG
160 170 180 190 200
RCLRRENLAR GTCEIFAWCP LETSSRPEEP FLKEAEDFTI FIKNHIRFPK
210 220 230 240 250
FNFSKSNVMD VKDRSFLKSC HFGPKNHYCP IFRLGSVIRW AGSDFQDIAL
260 270 280 290 300
EGGVIGINIE WNCDLDKAAS ECHPHYSFSR LDNKLSKSVS SGYNFRFARY
310 320 330 340 350
YRDAAGVEFR TLMKAYGIRF DVMVNGKGAF FCDLVLIYLI KKREFYRDKK
360 370 380 390 400
YEEVRGLEDS SQEAEDEASG LGLSEQLTSG PGLLGMPEQQ ELQEPPEAKR
410 420
GSSSQKGNGS VCPQLLEPHR ST
Length:422
Mass (Da):47,205
Last modified:October 14, 2008 - v4
Checksum:iB122027A23B2A240
GO
Isoform 2 (identifier: Q93086-1) [UniParc]FASTAAdd to basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     205-206: KS → N

Show »
Length:421
Mass (Da):47,104
Checksum:i6B47307AA14C2A6C
GO
Isoform 3 (identifier: Q93086-2) [UniParc]FASTAAdd to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     97-120: Missing.
     205-206: KS → N

Show »
Length:397
Mass (Da):44,430
Checksum:iC3DB8AB55858CEB0
GO
Isoform 4 (identifier: Q93086-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     421-422: ST → LRTPSASPLHQE

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:432
Mass (Da):48,334
Checksum:i53AD66E4F75A69E3
GO
Isoform 5 (identifier: Q93086-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-120: Missing.

Show »
Length:398
Mass (Da):44,531
Checksum:i15CA9EC0EC4BB6A4
GO

Sequence cautioni

The sequence AAF43106.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AK307959 differs from that shown. Reason: Frameshift at position 112. Curated
The sequence BAD92860.1 differs from that shown. Reason: Frameshift at position 112. Curated
The sequence BC028084 differs from that shown. Reason: Frameshift at position 112. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961Q → E in AAB08577 (Ref. 1) Curated
Sequence conflicti97 – 982GE → EK in AAB08576 (Ref. 1) Curated
Sequence conflicti156 – 1561E → G in AAC51931 (PubMed:9414125).Curated
Sequence conflicti237 – 2382VI → IV in AAC51931 (PubMed:9414125).Curated
Sequence conflicti251 – 2511E → R in AAC51931 (PubMed:9414125).Curated
Sequence conflicti330 – 3301F → S in AAB08576 (Ref. 1) Curated
Sequence conflicti330 – 3301F → S in AAB08577 (Ref. 1) Curated
Sequence conflicti350 – 3501K → R in ABB29978 (Ref. 5) Curated
Sequence conflicti352 – 3521E → Q in AAB08576 (Ref. 1) Curated
Sequence conflicti352 – 3521E → Q in AAB08577 (Ref. 1) Curated
Sequence conflicti399 – 4002KR → NV in AAB08576 (Ref. 1) Curated
Sequence conflicti399 – 4002KR → NV in AAB08577 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei97 – 12024Missing in isoform 3 and isoform 5. 3 PublicationsVSP_004503Add
BLAST
Alternative sequencei205 – 2062KS → N in isoform 2 and isoform 3. 4 PublicationsVSP_035587
Alternative sequencei421 – 4222ST → LRTPSASPLHQE in isoform 4. 1 PublicationVSP_035588

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49395 mRNA. Translation: AAB08576.1.
U49396 mRNA. Translation: AAB08577.1.
AF016709 mRNA. Translation: AAC51931.1.
AF168787 Genomic DNA. Translation: AAF43105.1.
AF168787 Genomic DNA. Translation: AAF43106.1. Sequence problems.
AF070573 mRNA. Translation: AAC28645.1.
DQ234349 mRNA. Translation: ABB29978.1.
AK290889 mRNA. Translation: BAF83578.1.
AK307959 mRNA. No translation available.
AB209623 mRNA. Translation: BAD92860.1. Frameshift.
AC132942 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90483.1.
BC028084 mRNA. No translation available.
BC039015 mRNA. Translation: AAH39015.1.
CCDSiCCDS11034.1. [Q93086-3]
CCDS11035.1. [Q93086-2]
CCDS56014.1. [Q93086-5]
CCDS56015.1. [Q93086-1]
RefSeqiNP_001191448.1. NM_001204519.1. [Q93086-1]
NP_001191449.1. NM_001204520.1. [Q93086-5]
NP_002552.2. NM_002561.3. [Q93086-3]
NP_778255.1. NM_175080.2. [Q93086-2]
UniGeneiHs.731607.

Genome annotation databases

EnsembliENST00000225328; ENSP00000225328; ENSG00000083454. [Q93086-3]
ENST00000345901; ENSP00000342161; ENSG00000083454. [Q93086-5]
ENST00000547178; ENSP00000448355; ENSG00000083454. [Q93086-1]
ENST00000551178; ENSP00000447545; ENSG00000083454. [Q93086-2]
GeneIDi5026.
KEGGihsa:5026.
UCSCiuc002fwi.3. human. [Q93086-3]
uc002fwj.3. human. [Q93086-2]
uc002fwk.3. human. [Q93086-1]
uc002fwl.3. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Wikipedia

P2X receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49395 mRNA. Translation: AAB08576.1.
U49396 mRNA. Translation: AAB08577.1.
AF016709 mRNA. Translation: AAC51931.1.
AF168787 Genomic DNA. Translation: AAF43105.1.
AF168787 Genomic DNA. Translation: AAF43106.1. Sequence problems.
AF070573 mRNA. Translation: AAC28645.1.
DQ234349 mRNA. Translation: ABB29978.1.
AK290889 mRNA. Translation: BAF83578.1.
AK307959 mRNA. No translation available.
AB209623 mRNA. Translation: BAD92860.1. Frameshift.
AC132942 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90483.1.
BC028084 mRNA. No translation available.
BC039015 mRNA. Translation: AAH39015.1.
CCDSiCCDS11034.1. [Q93086-3]
CCDS11035.1. [Q93086-2]
CCDS56014.1. [Q93086-5]
CCDS56015.1. [Q93086-1]
RefSeqiNP_001191448.1. NM_001204519.1. [Q93086-1]
NP_001191449.1. NM_001204520.1. [Q93086-5]
NP_002552.2. NM_002561.3. [Q93086-3]
NP_778255.1. NM_175080.2. [Q93086-2]
UniGeneiHs.731607.

3D structure databases

ProteinModelPortaliQ93086.
SMRiQ93086. Positions 32-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111065. 27 interactions.
IntActiQ93086. 1 interaction.
STRINGi9606.ENSP00000225328.

Chemistry

BindingDBiQ93086.
ChEMBLiCHEMBL4942.
GuidetoPHARMACOLOGYi482.

PTM databases

PhosphoSiteiQ93086.

Polymorphism and mutation databases

BioMutaiP2RX5.
DMDMi209572778.

Proteomic databases

MaxQBiQ93086.
PaxDbiQ93086.
PRIDEiQ93086.

Protocols and materials databases

DNASUi5026.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225328; ENSP00000225328; ENSG00000083454. [Q93086-3]
ENST00000345901; ENSP00000342161; ENSG00000083454. [Q93086-5]
ENST00000547178; ENSP00000448355; ENSG00000083454. [Q93086-1]
ENST00000551178; ENSP00000447545; ENSG00000083454. [Q93086-2]
GeneIDi5026.
KEGGihsa:5026.
UCSCiuc002fwi.3. human. [Q93086-3]
uc002fwj.3. human. [Q93086-2]
uc002fwk.3. human. [Q93086-1]
uc002fwl.3. human.

Organism-specific databases

CTDi5026.
GeneCardsiGC17M003575.
HGNCiHGNC:8536. P2RX5.
HPAiHPA021948.
MIMi602836. gene.
neXtProtiNX_Q93086.
PharmGKBiPA32865.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47843.
GeneTreeiENSGT00390000016028.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiQ93086.
KOiK05219.
OMAiAGAFFCD.
PhylomeDBiQ93086.
TreeFamiTF328633.

Miscellaneous databases

ChiTaRSiP2RX5. human.
GeneWikiiP2RX5.
GenomeRNAii5026.
NextBioi19350.
PROiQ93086.
SOURCEiSearch...

Gene expression databases

BgeeiQ93086.
CleanExiHS_P2RX5.
ExpressionAtlasiQ93086. baseline and differential.
GenevestigatoriQ93086.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003048. P2X5_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF12. PTHR10125:SF12. 1 hit.
PfamiPF00864. P2X_receptor. 2 hits.
[Graphical view]
PRINTSiPR01312. P2X5RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human P2X purinoceptor new subtype (P2X5)."
    Tokuyama Y., Mereu L., Chen X., Rouard M., Bell G.I.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
  2. "Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system."
    Le K.-T., Paquet M., Nouel D., Babinski K., Seguela P.
    FEBS Lett. 418:195-199(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion."
    Touchman J.W., Anikster Y., Dietrich N.L., Maduro V.V.B., McDowell G., Shotelersuk V., Bouffard G.G., Beckstrom-Sternberg S.M., Gahl W.A., Green E.D.
    Genome Res. 10:165-173(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Yu W., Gibbs R.A.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  5. Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Tang Z., Huang B., Lin L., Yang S.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Erythroleukemia and Mesangial cell.
  7. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Spleen.
  8. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Leukocyte and Lung.

Entry informationi

Entry nameiP2RX5_HUMAN
AccessioniPrimary (citable) accession number: Q93086
Secondary accession number(s): G5E981
, O43450, O75540, Q308M5, Q59F38, Q8IXW4, Q93087, Q9NZV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: May 27, 2015
This is version 135 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.