Q93086 (P2RX5_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 115.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: P2X purinoceptor 5 Short name=P2X5 Alternative name(s): ATP receptor Purinergic receptor | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 422 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Receptor for ATP that acts as a ligand-gated ion channel. |
| Subunit structure | Functional P2XRs are organized as homomeric and heteromeric trimers By similarity. |
| Subcellular location | |
| Tissue specificity | Expressed at high levels in brain and immune system. |
| Sequence similarities | Belongs to the P2X receptor family. |
| Sequence caution | The sequence AAF43106.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AK307959 differs from that shown. Reason: Frameshift at position 112. The sequence BAD92860.1 differs from that shown. Reason: Frameshift at position 112. The sequence BC028084 differs from that shown. Reason: Frameshift at position 112. |
Ontologies
Alternative products
| This entry describes 5 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q93086-3) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q93086-1) Also known as: A; The sequence of this isoform differs from the canonical sequence as follows: 205-206: KS → N | ||||||
| Isoform 3 (identifier: Q93086-2) Also known as: B; The sequence of this isoform differs from the canonical sequence as follows: 97-120: Missing. 205-206: KS → N | ||||||
| Isoform 4 (identifier: Q93086-4) The sequence of this isoform differs from the canonical sequence as follows: 421-422: ST → LRTPSASPLHQE | ||||||
| Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. | ||||||
| Isoform 5 (identifier: Q93086-5) The sequence of this isoform differs from the canonical sequence as follows: 97-120: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 422 | 422 | P2X purinoceptor 5 | PRO_0000161555 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 30 | 30 | Cytoplasmic Potential | ||||||||
| Transmembrane | 31 – 51 | 21 | Helical; Name=1; Potential | ||||||||
| Topological domain | 52 – 319 | 268 | Extracellular Potential | ||||||||
| Transmembrane | 320 – 340 | 21 | Helical; Name=2; Potential | ||||||||
| Topological domain | 341 – 422 | 82 | Cytoplasmic Potential | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 77 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 202 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 118 ↔ 169 | By similarity | |||||||||
| Disulfide bond | 129 ↔ 152 | By similarity | |||||||||
| Disulfide bond | 135 ↔ 163 | By similarity | |||||||||
| Disulfide bond | 220 ↔ 229 | By similarity | |||||||||
| Disulfide bond | 263 ↔ 272 | By similarity | |||||||||
Natural variations | |||||||||||
| Alternative sequence | 97 – 120 | 24 | Missing in isoform 3 and isoform 5. | VSP_004503 | |||||||
| Alternative sequence | 205 – 206 | 2 | KS → N in isoform 2 and isoform 3. | VSP_035587 | |||||||
| Alternative sequence | 421 – 422 | 2 | ST → LRTPSASPLHQE in isoform 4. | VSP_035588 | |||||||
Experimental info | |||||||||||
| Sequence conflict | 96 | 1 | Q → E in AAB08577. Ref.1 | ||||||||
| Sequence conflict | 97 – 98 | 2 | GE → EK in AAB08576. Ref.1 | ||||||||
| Sequence conflict | 156 | 1 | E → G in AAC51931. Ref.2 | ||||||||
| Sequence conflict | 237 – 238 | 2 | VI → IV in AAC51931. Ref.2 | ||||||||
| Sequence conflict | 251 | 1 | E → R in AAC51931. Ref.2 | ||||||||
| Sequence conflict | 330 | 1 | F → S in AAB08576. Ref.1 | ||||||||
| Sequence conflict | 330 | 1 | F → S in AAB08577. Ref.1 | ||||||||
| Sequence conflict | 350 | 1 | K → R in ABB29978. Ref.5 | ||||||||
| Sequence conflict | 352 | 1 | E → Q in AAB08576. Ref.1 | ||||||||
| Sequence conflict | 352 | 1 | E → Q in AAB08577. Ref.1 | ||||||||
| Sequence conflict | 399 – 400 | 2 | KR → NV in AAB08576. Ref.1 | ||||||||
| Sequence conflict | 399 – 400 | 2 | KR → NV in AAB08577. Ref.1 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning of human P2X purinoceptor new subtype (P2X5)." Tokuyama Y., Mereu L., Chen X., Rouard M., Bell G.I. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3). |
| [2] | "Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system." Le K.-T., Paquet M., Nouel D., Babinski K., Seguela P. FEBS Lett. 418:195-199(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Brain. |
| [3] | "The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion." Touchman J.W., Anikster Y., Dietrich N.L., Maduro V.V.B., McDowell G., Shotelersuk V., Bouffard G.G., Beckstrom-Sternberg S.M., Gahl W.A., Green E.D. Genome Res. 10:165-173(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | Yu W., Gibbs R.A. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain. |
| [5] | Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Tang Z., Huang B., Lin L., Yang S. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5). |
| [6] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Erythroleukemia and Mesangial cell. |
| [7] | Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Spleen. |
| [8] | "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. Nusbaum C.Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [9] | Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [10] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Leukocyte and Lung. |
Web resources
| Wikipedia P2X receptor entry |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U49395 mRNA. Translation: AAB08576.1. U49396 mRNA. Translation: AAB08577.1. AF016709 mRNA. Translation: AAC51931.1. AF168787 Genomic DNA. Translation: AAF43105.1. AF168787 Genomic DNA. Translation: AAF43106.1. Sequence problems. AF070573 mRNA. Translation: AAC28645.1. DQ234349 mRNA. Translation: ABB29978.1. AK290889 mRNA. Translation: BAF83578.1. AK307959 mRNA. No translation available. AB209623 mRNA. Translation: BAD92860.1. Frameshift. AC132942 Genomic DNA. No translation available. CH471108 Genomic DNA. Translation: EAW90483.1. BC028084 mRNA. No translation available. BC039015 mRNA. Translation: AAH39015.1. |
| IPI | IPI00217666. IPI00789729. IPI00873205. IPI00914060. IPI01008926. |
| RefSeq | NP_001191448.1. NM_001204519.1. NP_001191449.1. NM_001204520.1. NP_002552.2. NM_002561.3. NP_778255.1. NM_175080.2. |
| UniGene | Hs.731607. |
3D structure databases | |
| ProteinModelPortal | Q93086. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q93086. 1 interaction. |
| STRING | 9606.ENSP00000225328. |
PTM databases | |
| PhosphoSite | Q93086. |
Polymorphism databases | |
| DMDM | 209572778. |
Proteomic databases | |
| PaxDb | Q93086. |
| PRIDE | Q93086. |
Protocols and materials databases | |
| DNASU | 5026. |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000225328; ENSP00000225328; ENSG00000083454. ENST00000345901; ENSP00000342161; ENSG00000083454. ENST00000435558; ENSP00000415370; ENSG00000083454. ENST00000547178; ENSP00000448355; ENSG00000083454. ENST00000551178; ENSP00000447545; ENSG00000083454. |
| GeneID | 5026. |
| KEGG | hsa:5026. |
| UCSC | uc002fwi.3. human. uc002fwj.3. human. uc002fwk.3. human. |
Organism-specific databases | |
| CTD | 5026. |
| GeneCards | GC17M003575. |
| HGNC | HGNC:8536. P2RX5. |
| HPA | HPA021948. |
| MIM | 602836. gene. |
| neXtProt | NX_Q93086. |
| PharmGKB | PA32865. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG47843. |
| HOVERGEN | HBG053086. |
| KO | K05219. |
| OMA | VTPNQRQ. |
| OrthoDB | EOG46Q6SQ. |
| PhylomeDB | Q93086. |
Gene expression databases | |
| ArrayExpress | Q93086. |
| Bgee | Q93086. |
| CleanEx | HS_P2RX5. |
| Genevestigator | Q93086. |
| GermOnline | ENSG00000083454. Homo sapiens. |
Family and domain databases | |
| Gene3D | 2.60.490.10. 1 hit. |
| InterPro | IPR003048. P2X5_purnocptor. IPR027309. P2X_extracellular_dom. IPR001429. P2X_purnocptor. [Graphical view] |
| PANTHER | PTHR10125. PTHR10125. 1 hit. PTHR10125:SF12. PTHR10125:SF12. 1 hit. |
| Pfam | PF00864. P2X_receptor. 2 hits. [Graphical view] |
| PRINTS | PR01312. P2X5RECEPTOR. PR01307. P2XRECEPTOR. |
| TIGRFAMs | TIGR00863. P2X. 1 hit. |
| PROSITE | PS01212. P2X_RECEPTOR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| BindingDB | Q93086. |
| ChEMBL | CHEMBL4942. |
| GenomeRNAi | 5026. |
| NextBio | 19350. |
| SOURCE | Search... |
Entry information
| Entry name | P2RX5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q93086 Secondary accession number(s): G5E981 Q9NZV0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
