Q93084 (AT2A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Short name=SERCA3
Short name=SR Ca(2+)-ATPase 3
EC=3.6.3.8

Alternative name(s):
Calcium pump 3

Gene names

Name:

ATP2A3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1043 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Ref.11 Ref.12
Catalytic activity	ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).
Subcellular location	Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein Ref.12.
Tissue specificity	Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelial, or embryonic origin and also expressed in several cancer cell lines. Ref.11 Ref.12
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Endoplasmic reticulum Membrane Nucleus Sarcoplasmic reticulum
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Calcium Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum membrane Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell platelet dense tubular network membrane Traceable author statement. Source: Reactome sarcoplasmic reticulum Inferred from direct assay Ref.1. Source: UniProtKB sarcoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Traceable author statement Ref.1. Source: ProtInc metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Note: The same names have been attributed to different isoforms.

Isoform SERCA3B (identifier: Q93084-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform SERCA3A (identifier: Q93084-2)

Also known as: HuS3-II;

The sequence of this isoform differs from the canonical sequence as follows:
     994-1043: ACLYPGLLRTVSQAWSRQPLTTSWTPDHTGRNEPEVSAGNRVESPVCTSD → EEMSQK

Isoform SERCA3C (identifier: Q93084-3)

Also known as: HuS3-IV;

The sequence of this isoform differs from the canonical sequence as follows:
     1024-1043: RNEPEVSAGNRVESPVCTSD → LASLKK

Isoform SERCA3G (identifier: Q93084-4)

Also known as: HuS3-I;

The sequence of this isoform differs from the canonical sequence as follows:
     994-1043: ACLYPGLLRTVSQAWSRQPLTTSWTPDHTGRNEPEVSAGNRVESPVCTSD → EMSQK

Isoform SERCA3E (identifier: Q93084-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1024-1043: RNEPEVSAGNRVESPVCTSD → LASLGQGHSIVSLSELLREGGSREEMSQK

Isoform SERCA3D (identifier: Q93084-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1024-1043: RNEPEVSAGNRVESPVCTSD → ARDTASSRCQSCSEREEAGKK

Isoform SERCA3F (identifier: Q93084-7)

The sequence of this isoform differs from the canonical sequence as follows:
     994-1022: ACLYPGLLRTVSQAWSRQPLTTSWTPDHT → GPGTQHRLAVRAAQRGRKQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1043	1043	Sarcoplasmic/endoplasmic reticulum calcium ATPase 3		PRO_0000046202
Regions
	Topological domain	1 – 48	48	Cytoplasmic By similarity
	Transmembrane	49 – 69	21	Helical; Name=1; By similarity
	Topological domain	70 – 89	20	Lumenal By similarity
	Transmembrane	90 – 110	21	Helical; Name=2; By similarity
	Topological domain	111 – 253	143	Cytoplasmic By similarity
	Transmembrane	254 – 273	20	Helical; Name=3; By similarity
	Topological domain	274 – 295	22	Lumenal By similarity
	Transmembrane	296 – 313	18	Helical; Name=4; By similarity
	Topological domain	314 – 757	444	Cytoplasmic By similarity
	Transmembrane	758 – 777	20	Helical; Name=5; By similarity
	Topological domain	778 – 787	10	Lumenal By similarity
	Transmembrane	788 – 808	21	Helical; Name=6; By similarity
	Topological domain	809 – 828	20	Cytoplasmic By similarity
	Transmembrane	829 – 851	23	Helical; Name=7; By similarity
	Topological domain	852 – 897	46	Lumenal By similarity
	Transmembrane	898 – 917	20	Helical; Name=8; By similarity
	Topological domain	918 – 930	13	Cytoplasmic By similarity
	Transmembrane	931 – 949	19	Helical; Name=9; By similarity
	Topological domain	950 – 964	15	Lumenal By similarity
	Transmembrane	965 – 985	21	Helical; Name=10; By similarity
	Topological domain	986 – 1043	58	Cytoplasmic By similarity
Sites
	Active site	351	1	4-aspartylphosphate intermediate By similarity
	Metal binding	304	1	Calcium 2; via carbonyl oxygen By similarity
	Metal binding	305	1	Calcium 2; via carbonyl oxygen By similarity
	Metal binding	307	1	Calcium 2; via carbonyl oxygen By similarity
	Metal binding	309	1	Calcium 2 By similarity
	Metal binding	703	1	Magnesium By similarity
	Metal binding	707	1	Magnesium By similarity
	Metal binding	768	1	Calcium 1 By similarity
	Metal binding	771	1	Calcium 1 By similarity
	Metal binding	796	1	Calcium 2 By similarity
	Metal binding	799	1	Calcium 1 By similarity
	Metal binding	800	1	Calcium 1 By similarity
	Metal binding	800	1	Calcium 2 By similarity
	Metal binding	908	1	Calcium 1 By similarity
	Binding site	515	1	ATP By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.8 Ref.9
	Modified residue	662	1	Phosphoserine Ref.13
Natural variations
	Alternative sequence	994 – 1043	50	ACLYP…VCTSD → EEMSQK in isoform SERCA3A.		VSP_000364
	Alternative sequence	994 – 1043	50	ACLYP…VCTSD → EMSQK in isoform SERCA3G.		VSP_000365
	Alternative sequence	994 – 1022	29	ACLYP…TPDHT → GPGTQHRLAVRAAQRGRKQ in isoform SERCA3F.		VSP_042296
	Alternative sequence	1024 – 1043	20	RNEPE…VCTSD → LASLKK in isoform SERCA3C.		VSP_000366
	Alternative sequence	1024 – 1043	20	RNEPE…VCTSD → ARDTASSRCQSCSEREEAGK K in isoform SERCA3D.		VSP_000368
	Alternative sequence	1024 – 1043	20	RNEPE…VCTSD → LASLGQGHSIVSLSELLREG GSREEMSQK in isoform SERCA3E.		VSP_000367
	Natural variant	674	1	R → H in a breast cancer sample; somatic mutation. Ref.15		VAR_036498
	Natural variant	869	1	Q → H. Corresponds to variant rs11654827 [ dbSNP | Ensembl ].		VAR_048372
Experimental info
	Sequence conflict	673	1	A → T in AAC24525. Ref.4
	Sequence conflict	802	1	L → H in CAA75739. Ref.3
	Sequence conflict	817	1	M → I in CAA93737. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform SERCA3B [UniParc]. Last modified October 18, 2001. Version 2. Checksum: CB6514B36E00E091	FASTA	1,043	113,977
	10 20 30 40 50 60 MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL 70 80 90 100 110 120 LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 130 140 150 160 170 180 EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 190 200 210 220 230 240 TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA 250 260 270 280 290 300 AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 310 320 330 340 350 360 ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 370 380 390 400 410 420 MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC 430 440 450 460 470 480 NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR 490 500 510 520 530 540 KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT 550 560 570 580 590 600 SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML 610 620 630 640 650 660 DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD 670 680 690 700 710 720 LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 730 740 750 760 770 780 GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI 790 800 810 820 830 840 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI 850 860 870 880 890 900 GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDCEV FESRFPTTMA 910 920 930 940 950 960 LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT 970 980 990 1000 1010 1020 PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHACLYPGL LRTVSQAWSR QPLTTSWTPD 1030 1040 HTGRNEPEVS AGNRVESPVC TSD
	Isoform SERCA3A (HuS3-II) [UniParc]. Checksum: 44E9F1FBF41FE36A	FASTA	999	109,256
	10 20 30 40 50 60 MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL 70 80 90 100 110 120 LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 130 140 150 160 170 180 EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 190 200 210 220 230 240 TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA 250 260 270 280 290 300 AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 310 320 330 340 350 360 ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 370 380 390 400 410 420 MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC 430 440 450 460 470 480 NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR 490 500 510 520 530 540 KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT 550 560 570 580 590 600 SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML 610 620 630 640 650 660 DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD 670 680 690 700 710 720 LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 730 740 750 760 770 780 GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI 790 800 810 820 830 840 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI 850 860 870 880 890 900 GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDCEV FESRFPTTMA 910 920 930 940 950 960 LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT 970 980 990 PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHEEMSQK
	Isoform SERCA3C (HuS3-IV) [UniParc]. Checksum: F92E6B85AC5BBB81	FASTA	1,029	112,490
	10 20 30 40 50 60 MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL 70 80 90 100 110 120 LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 130 140 150 160 170 180 EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 190 200 210 220 230 240 TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA 250 260 270 280 290 300 AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 310 320 330 340 350 360 ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 370 380 390 400 410 420 MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC 430 440 450 460 470 480 NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR 490 500 510 520 530 540 KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT 550 560 570 580 590 600 SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML 610 620 630 640 650 660 DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD 670 680 690 700 710 720 LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 730 740 750 760 770 780 GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI 790 800 810 820 830 840 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI 850 860 870 880 890 900 GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDCEV FESRFPTTMA 910 920 930 940 950 960 LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT 970 980 990 1000 1010 1020 PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHACLYPGL LRTVSQAWSR QPLTTSWTPD HTGLASLKK
	Isoform SERCA3G (HuS3-I) [UniParc]. Checksum: 5C1288D99FE36A3D	FASTA	998	109,127
	10 20 30 40 50 60 MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL 70 80 90 100 110 120 LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 130 140 150 160 170 180 EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 190 200 210 220 230 240 TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA 250 260 270 280 290 300 AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 310 320 330 340 350 360 ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 370 380 390 400 410 420 MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC 430 440 450 460 470 480 NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR 490 500 510 520 530 540 KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT 550 560 570 580 590 600 SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML 610 620 630 640 650 660 DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD 670 680 690 700 710 720 LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 730 740 750 760 770 780 GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI 790 800 810 820 830 840 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI 850 860 870 880 890 900 GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDCEV FESRFPTTMA 910 920 930 940 950 960 LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT 970 980 990 PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHEMSQK
	Isoform SERCA3E [UniParc]. Checksum: 95DCA1787DEDE2B9	FASTA	1,052	114,931
	10 20 30 40 50 60 MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL 70 80 90 100 110 120 LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 130 140 150 160 170 180 EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 190 200 210 220 230 240 TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA 250 260 270 280 290 300 AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 310 320 330 340 350 360 ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 370 380 390 400 410 420 MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC 430 440 450 460 470 480 NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR 490 500 510 520 530 540 KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT 550 560 570 580 590 600 SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML 610 620 630 640 650 660 DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD 670 680 690 700 710 720 LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 730 740 750 760 770 780 GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI 790 800 810 820 830 840 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI 850 860 870 880 890 900 GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDCEV FESRFPTTMA 910 920 930 940 950 960 LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT 970 980 990 1000 1010 1020 PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHACLYPGL LRTVSQAWSR QPLTTSWTPD 1030 1040 1050 HTGLASLGQG HSIVSLSELL REGGSREEMS QK
	Isoform SERCA3D [UniParc]. Checksum: 2D26449A0E4EDC9A	FASTA	1,044	114,131
	10 20 30 40 50 60 MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL 70 80 90 100 110 120 LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 130 140 150 160 170 180 EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 190 200 210 220 230 240 TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA 250 260 270 280 290 300 AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 310 320 330 340 350 360 ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 370 380 390 400 410 420 MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC 430 440 450 460 470 480 NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR 490 500 510 520 530 540 KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT 550 560 570 580 590 600 SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML 610 620 630 640 650 660 DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD 670 680 690 700 710 720 LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 730 740 750 760 770 780 GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI 790 800 810 820 830 840 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI 850 860 870 880 890 900 GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDCEV FESRFPTTMA 910 920 930 940 950 960 LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT 970 980 990 1000 1010 1020 PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHACLYPGL LRTVSQAWSR QPLTTSWTPD 1030 1040 HTGARDTASS RCQSCSEREE AGKK
	Isoform SERCA3F [UniParc]. Checksum: 02356BCFB8CDA61F	FASTA	1,033	112,778
	10 20 30 40 50 60 MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL 70 80 90 100 110 120 LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 130 140 150 160 170 180 EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 190 200 210 220 230 240 TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA 250 260 270 280 290 300 AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 310 320 330 340 350 360 ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 370 380 390 400 410 420 MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC 430 440 450 460 470 480 NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR 490 500 510 520 530 540 KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT 550 560 570 580 590 600 SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML 610 620 630 640 650 660 DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD 670 680 690 700 710 720 LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 730 740 750 760 770 780 GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI 790 800 810 820 830 840 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI 850 860 870 880 890 900 GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDCEV FESRFPTTMA 910 920 930 940 950 960 LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT 970 980 990 1000 1010 1020 PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHGPGTQHR LAVRAAQRGR KQGRNEPEVS 1030 AGNRVESPVC TSD

References

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[1]	"cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca(2+)-ATPase 3 gene." Dode L., Wuytack F., Kools P.F.J., Baba-Aissa F., Raeymaekers L., Brik F., van de Ven W.J.M., Casteels R. Biochem. J. 318:689-699(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM SERCA3A). Tissue: Leukemic T-cell.
[2]	Erratum Dode L., Wuytack F., Kools P.F.J., Baba-Aissa F., Raeymaekers L., Brik F., van de Ven W.J.M., Casteels R. Biochem. J. 319:1008-1008(1996)
[3]	"Structure of the human sarco/endoplasmic reticulum Ca2+-ATPase 3 gene. Promoter analysis and alternative splicing of the SERCA3 pre-mRNA." Dode L., De Greef C., Mountian I., Attard M., Town M.M., Casteels R., Wuytack F. J. Biol. Chem. 273:13982-13994(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS SERCA3B AND SERCA3C).
[4]	"Functional characterization of alternatively spliced human SERCA3 transcripts." Poch E., Leach S., Snape S., Cacic T., McLennan D.H., Lytton J. Am. J. Physiol. 275:C1449-C1458(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SERCA3A; SERCA3C AND SERCA3G). Tissue: Kidney and Leukemic T-cell.
[5]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SERCA3A). Tissue: Ovary.
[8]	"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-14, ACETYLATION AT MET-1. Tissue: Platelet.
[9]	Bienvenut W.V., Claeys D. Submitted (NOV-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 1-33; 111-120; 219-234; 482-489; 516-524; 549-560 AND 657-667, ACETYLATION AT MET-1, MASS SPECTROMETRY. Tissue: Platelet.
[10]	"A sarco/endoplasmic reticulum Ca(2+)-ATPase 3-type Ca2+ pump is expressed in platelets, in lymphoid cells, and in mast cells." Wuytack F., Papp B., Verboomen H., Raeymaekers L., Dode L., Bobe R., Enouf J., Bokkala S., Authi K.S., Casteels R. J. Biol. Chem. 269:1410-1416(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 454-509.
[11]	"Three novel sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family." Martin V., Bredoux R., Corvazier E., Van Gorp R., Kovacs T., Gelebart P., Enouf J. J. Biol. Chem. 277:24442-24452(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 892-1043 (ISOFORMS SERCA3D AND SERCA3E), ALTERNATIVE SPLICING, FUNCTION, TISSUE SPECIFICITY.
[12]	"Identification, expression, function, and localization of a novel (sixth) isoform of the human sarco/endoplasmic reticulum Ca2+ATPase 3 gene." Bobe R., Bredoux R., Corvazier E., Andersen J.P., Clausen J.D., Dode L., Kovacs T., Enouf J. J. Biol. Chem. 279:24297-24306(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 892-1043 (ISOFORM SERCA3F), ALTERNATIVE SPLICING, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-662, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-674.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z69881 mRNA. Translation: CAA93737.1. Z69880 Genomic DNA. Translation: CAA93736.1. Y15724 , Y15725, Y15726, Y15727, Y15728, Y15729, Y15730 Genomic DNA. Translation: CAA75739.1. Y15738 Genomic DNA. Translation: CAA75748.1. Y15737 Genomic DNA. Translation: CAA75747.1. AF068220 mRNA. Translation: AAC24525.1. AF068221 mRNA. Translation: AAC24526.1. AC005940 Genomic DNA. No translation available. CH471108 Genomic DNA. Translation: EAW90468.1. CH471108 Genomic DNA. Translation: EAW90463.1. CH471108 Genomic DNA. Translation: EAW90469.1. BC035729 mRNA. Translation: AAH35729.1. S68239 mRNA. Translation: AAB29700.1. AF458228 mRNA. Translation: AAL78967.1. AF458229 mRNA. Translation: AAL78968.1. AY460339 mRNA. Translation: AAR15415.1.
IPI	IPI00004092. IPI00218440. IPI00303760. IPI00478023. IPI00748794. IPI00871568. IPI01010541.
PIR	I55399. S72267.
RefSeq	NP_005164.2. NM_005173.3. NP_777613.1. NM_174953.2. NP_777614.1. NM_174954.2. NP_777615.1. NM_174955.2. NP_777616.1. NM_174956.2. NP_777617.1. NM_174957.2. NP_777618.1. NM_174958.2.
UniGene	Hs.513870.
3D structure databases
ProteinModelPortal	Q93084.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q93084. 4 interactions.
STRING	9606.ENSP00000353072.
PTM databases
PhosphoSite	Q93084.
Polymorphism databases
DMDM	19864659.
Proteomic databases
PaxDb	Q93084.
PRIDE	Q93084.
Protocols and materials databases
DNASU	489.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309890; ENSP00000312577; ENSG00000074370. ENST00000352011; ENSP00000301387; ENSG00000074370. ENST00000359983; ENSP00000353072; ENSG00000074370. ENST00000397035; ENSP00000380229; ENSG00000074370. ENST00000397041; ENSP00000380234; ENSG00000074370. ENST00000397043; ENSP00000380236; ENSG00000074370. ENST00000570845; ENSP00000461480; ENSG00000074370. ENST00000572116; ENSP00000458865; ENSG00000074370.
GeneID	489.
KEGG	hsa:489.
UCSC	uc002fwx.2. human. uc002fwy.2. human. uc002fwz.2. human. uc002fxb.2. human. uc002fxc.2. human. uc002fxd.2. human.
Organism-specific databases
CTD	489.
GeneCards	GC17M003822.
HGNC	HGNC:813. ATP2A3.
HPA	CAB010882. HPA007180.
MIM	601929. gene.
neXtProt	NX_Q93084.
PharmGKB	PA25106.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0474.
HOGENOM	HOG000078632.
HOVERGEN	HBG105648.
KO	K05853.
OMA	GAGAMYH.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q93084.
Bgee	Q93084.
CleanEx	HS_ATP2A3.
Genevestigator	Q93084.
GermOnline	ENSG00000074370. Homo sapiens.
Family and domain databases
Gene3D	1.20.1110.10. 2 hits. 2.70.150.10. 2 hits. 3.40.1110.10. 1 hit.
InterPro	IPR005782. ATPase_P-typ_Ca-transp_IIA. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023299. ATPase_P-typ_cyto_domN. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR008250. ATPase_P-typ_transduc_dom_A. IPR001757. Cation_transp_P_typ_ATPase. IPR023214. HAD-like_dom. [Graphical view]
PANTHER	PTHR24093. PTHR24093. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01116. ATPase-IIA1_Ca. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL2401.
GenomeRNAi	489.
NextBio	2037.
SOURCE	Search...

Entry information

Entry name

AT2A3_HUMAN

Accession

Primary (citable) accession number: Q93084
Secondary accession number(s): A8MZG0 , D3DTJ8, O60900, O60901, O75501, O75502, Q16115, Q6JHX1, Q8TEX5, Q8TEX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	October 18, 2001
Last modified:	May 1, 2013
This is version 135 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.