Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

Names and origin

Protein names

Recommended name:
    Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
      Short name=SERCA3
    EC=3.6.3.8
Alternative name(s):
    Calcium pump 3
    SR Ca(2+)-ATPase 3

Gene names

Name:

ATP2A3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1043 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Catalytic activity	ATP + H₂O + Ca²⁺(Cis) = ADP + phosphate + Ca²⁺(Trans).
Subcellular location	Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue specificity	Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IIA subfamily.

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Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Endoplasmic reticulum Membrane Nucleus Sarcoplasmic reticulum
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane
Ligand	ATP-binding Calcium Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro calcium ion transport Ref.1 Traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-KW sarcoplasmic reticulum Ref.1 Inferred from direct assay. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Ref.1 Traceable author statement. Source: ProtInc magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
NCK1	P16333	1	EBI-1046185,EBI-389883
WDR8	Q9P2S5	1	EBI-1046185,EBI-1054904

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Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select] Note: The same names have been attributed to different isoforms.

Isoform SERCA3B (identifier: Q93084-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform SERCA3A (identifier: Q93084-2) Also known as: HuS3-II; The sequence of this isoform differs from the canonical sequence as follows: 994-1043: ACLYPGLLRTVSQAWSRQPLTTSWTPDHTGRNEPEVSAGNRVESPVCTSD → EEMSQK

Isoform SERCA3C (identifier: Q93084-3) Also known as: HuS3-IV; The sequence of this isoform differs from the canonical sequence as follows: 1024-1043: RNEPEVSAGNRVESPVCTSD → LASLKK

Isoform SERCA3D (identifier: Q93084-4) Also known as: HuS3-I; The sequence of this isoform differs from the canonical sequence as follows: 994-1043: ACLYPGLLRTVSQAWSRQPLTTSWTPDHTGRNEPEVSAGNRVESPVCTSD → EMSQK

Isoform SERCA3E (identifier: Q93084-5) The sequence of this isoform differs from the canonical sequence as follows: 1024-1043: RNEPEVSAGNRVESPVCTSD → LASLGQGHSIVSLSELLREGGSREE

Isoform SERCA3F (identifier: Q93084-6) The sequence of this isoform differs from the canonical sequence as follows: 1024-1043: RNEPEVSAGNRVESPVCTSD → ARDTASSRCQSCSEREEAGK

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1043

1043

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

PRO_0000046202

Regions

Topological domain

1 – 48

48

Cytoplasmic By similarity

Transmembrane

49 – 69

21

1 By similarity

Topological domain

70 – 89

20

Lumenal By similarity

Transmembrane

90 – 110

21

2 By similarity

Topological domain

111 – 253

143

Cytoplasmic By similarity

Transmembrane

254 – 273

20

3 By similarity

Topological domain

274 – 295

22

Lumenal By similarity

Transmembrane

296 – 313

18

4 By similarity

Topological domain

314 – 757

444

Cytoplasmic By similarity

Transmembrane

758 – 777

20

5 By similarity

Topological domain

778 – 787

10

Lumenal By similarity

Transmembrane

788 – 808

21

6 By similarity

Topological domain

809 – 828

20

Cytoplasmic By similarity

Transmembrane

829 – 851

23

7 By similarity

Topological domain

852 – 897

46

Lumenal By similarity

Transmembrane

898 – 917

20

8 By similarity

Topological domain

918 – 930

13

Cytoplasmic By similarity

Transmembrane

931 – 949

19

9 By similarity

Topological domain

950 – 964

15

Lumenal By similarity

Transmembrane

965 – 985

21

10 By similarity

Topological domain

986 – 1043

58

Cytoplasmic By similarity

Sites

Active site

351

1

4-aspartylphosphate intermediate By similarity

Metal binding

304

1

Calcium 2; via carbonyl oxygen By similarity

Metal binding

305

1

Calcium 2; via carbonyl oxygen By similarity

Metal binding

307

1

Calcium 2; via carbonyl oxygen By similarity

Metal binding

309

1

Calcium 2 By similarity

Metal binding

703

1

Magnesium By similarity

Metal binding

707

1

Magnesium By similarity

Metal binding

768

1

Calcium 1 By similarity

Metal binding

771

1

Calcium 1 By similarity

Metal binding

796

1

Calcium 2 By similarity

Metal binding

799

1

Calcium 1 By similarity

Metal binding

800

1

Calcium 1 By similarity

Metal binding

800

1

Calcium 2 By similarity

Metal binding

908

1

Calcium 1 By similarity

Binding site

515

1

ATP By similarity

Amino acid modifications

Modified residue

1

N-acetylmethionine Ref.6 Ref.7

Natural variations

Alternative sequence

994 – 1043

50

ACLYP…VCTSD → EEMSQK in isoform SERCA3A.

VSP_000364

Alternative sequence

994 – 1043

50

ACLYP…VCTSD → EMSQK in isoform SERCA3D.

VSP_000365

Alternative sequence

1024 – 1043

20

RNEPE…VCTSD → LASLKK in isoform SERCA3C.

VSP_000366

Alternative sequence

1024 – 1043

20

RNEPE…VCTSD → LASLGQGHSIVSLSELLREG GSREE in isoform SERCA3E.

VSP_000367

Alternative sequence

1024 – 1043

20

RNEPE…VCTSD → ARDTASSRCQSCSEREEAGK in isoform SERCA3F.

VSP_000368

Natural variant

674

1

R → H in a breast cancer sample; somatic mutation. Ref.10

VAR_036498

Natural variant

869

1

Q → H: dbSNP rs11654827.

VAR_048372

Experimental info

Sequence conflict

673

1

A → T in AAC24525. Ref.4

Sequence conflict

802

1

L → H in CAA75739. Ref.3

Sequence conflict

817

1

M → I in CAA93737. Ref.1

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Sequences

Sequence		Length	Mass (Da)
Isoform SERCA3B [UniParc]. Last modified October 18, 2001. Version 2. Checksum: CB6514B36E00E091 Show »	FASTA	1,043	113,977
10 20 30 40 50 60 MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL 70 80 90 100 110 120 LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 130 140 150 160 170 180 EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 190 200 210 220 230 240 TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA 250 260 270 280 290 300 AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 310 320 330 340 350 360 ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 370 380 390 400 410 420 MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC 430 440 450 460 470 480 NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR 490 500 510 520 530 540 KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT 550 560 570 580 590 600 SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML 610 620 630 640 650 660 DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD 670 680 690 700 710 720 LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 730 740 750 760 770 780 GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI 790 800 810 820 830 840 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI 850 860 870 880 890 900 GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDCEV FESRFPTTMA 910 920 930 940 950 960 LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT 970 980 990 1000 1010 1020 PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHACLYPGL LRTVSQAWSR QPLTTSWTPD 1030 1040 HTGRNEPEVS AGNRVESPVC TSD « Hide
Isoform SERCA3A (HuS3-II). Checksum: 44E9F1FBF41FE36A Show »	FASTA	999	109,256
10 20 30 40 50 60 MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL 70 80 90 100 110 120 LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 130 140 150 160 170 180 EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 190 200 210 220 230 240 TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA 250 260 270 280 290 300 AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 310 320 330 340 350 360 ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 370 380 390 400 410 420 MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC 430 440 450 460 470 480 NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR 490 500 510 520 530 540 KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT 550 560 570 580 590 600 SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML 610 620 630 640 650 660 DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD 670 680 690 700 710 720 LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 730 740 750 760 770 780 GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI 790 800 810 820 830 840 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI 850 860 870 880 890 900 GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDCEV FESRFPTTMA 910 920 930 940 950 960 LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT 970 980 990 PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHEEMSQK « Hide
Isoform SERCA3C (HuS3-IV). Checksum: F92E6B85AC5BBB81 Show »	FASTA	1,029	112,490
10 20 30 40 50 60 MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL 70 80 90 100 110 120 LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 130 140 150 160 170 180 EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 190 200 210 220 230 240 TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA 250 260 270 280 290 300 AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 310 320 330 340 350 360 ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 370 380 390 400 410 420 MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC 430 440 450 460 470 480 NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR 490 500 510 520 530 540 KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT 550 560 570 580 590 600 SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML 610 620 630 640 650 660 DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD 670 680 690 700 710 720 LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 730 740 750 760 770 780 GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI 790 800 810 820 830 840 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI 850 860 870 880 890 900 GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDCEV FESRFPTTMA 910 920 930 940 950 960 LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT 970 980 990 1000 1010 1020 PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHACLYPGL LRTVSQAWSR QPLTTSWTPD HTGLASLKK « Hide
Isoform SERCA3D (HuS3-I). Checksum: 5C1288D99FE36A3D Show »	FASTA	998	109,127
10 20 30 40 50 60 MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL 70 80 90 100 110 120 LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 130 140 150 160 170 180 EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 190 200 210 220 230 240 TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA 250 260 270 280 290 300 AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 310 320 330 340 350 360 ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 370 380 390 400 410 420 MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC 430 440 450 460 470 480 NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR 490 500 510 520 530 540 KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT 550 560 570 580 590 600 SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML 610 620 630 640 650 660 DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD 670 680 690 700 710 720 LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 730 740 750 760 770 780 GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI 790 800 810 820 830 840 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI 850 860 870 880 890 900 GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDCEV FESRFPTTMA 910 920 930 940 950 960 LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT 970 980 990 PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHEMSQK « Hide
Isoform SERCA3E. Checksum: 4DEDE2B9B2F20784 Show »	FASTA	1,048	114,456
10 20 30 40 50 60 MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL 70 80 90 100 110 120 LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 130 140 150 160 170 180 EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 190 200 210 220 230 240 TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA 250 260 270 280 290 300 AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 310 320 330 340 350 360 ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 370 380 390 400 410 420 MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC 430 440 450 460 470 480 NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR 490 500 510 520 530 540 KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT 550 560 570 580 590 600 SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML 610 620 630 640 650 660 DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD 670 680 690 700 710 720 LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 730 740 750 760 770 780 GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI 790 800 810 820 830 840 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI 850 860 870 880 890 900 GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDCEV FESRFPTTMA 910 920 930 940 950 960 LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT 970 980 990 1000 1010 1020 PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHACLYPGL LRTVSQAWSR QPLTTSWTPD 1030 1040 HTGLASLGQG HSIVSLSELL REGGSREE « Hide
Isoform SERCA3F. Checksum: 26449A0E4EDC9A7B Show »	FASTA	1,043	114,002
10 20 30 40 50 60 MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL 70 80 90 100 110 120 LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK 130 140 150 160 170 180 EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL 190 200 210 220 230 240 TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA 250 260 270 280 290 300 AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV 310 320 330 340 350 360 ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 370 380 390 400 410 420 MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC 430 440 450 460 470 480 NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR 490 500 510 520 530 540 KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT 550 560 570 580 590 600 SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML 610 620 630 640 650 660 DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD 670 680 690 700 710 720 LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 730 740 750 760 770 780 GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI 790 800 810 820 830 840 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI 850 860 870 880 890 900 GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDCEV FESRFPTTMA 910 920 930 940 950 960 LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT 970 980 990 1000 1010 1020 PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHACLYPGL LRTVSQAWSR QPLTTSWTPD 1030 1040 HTGARDTASS RCQSCSEREE AGK « Hide

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References

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[1]	"cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca(2+)-ATPase 3 gene." Dode L., Wuytack F., Kools P.F.J., Baba-Aissa F., Raeymaekers L., Brik F., van de Ven W.J.M., Casteels R. Biochem. J. 318:689-699(1996) [PubMed: 8809064] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM SERCA3A). Tissue: Leukemic T-cell.
[2]	Erratum Dode L., Wuytack F., Kools P.F.J., Baba-Aissa F., Raeymaekers L., Brik F., van de Ven W.J.M., Casteels R. Biochem. J. 319:1008-1008(1996)
[3]	"Structure of the human sarco/endoplasmic reticulum Ca2+-ATPase 3 gene. Promoter analysis and alternative splicing of the SERCA3 pre-mRNA." Dode L., De Greef C., Mountian I., Attard M., Town M.M., Casteels R., Wuytack F. J. Biol. Chem. 273:13982-13994(1998) [PubMed: 9593748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS SERCA3B AND SERCA3C).
[4]	"Functional characterization of alternatively spliced human SERCA3 transcripts." Poch E., Leach S., Snape S., Cacic T., McLennan D.H., Lytton J. Am. J. Physiol. 275:C1449-C1458(1998) [PubMed: 9843705] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SERCA3A; SERCA3C AND SERCA3D). Tissue: Kidney and Leukemic T-cell.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SERCA3A). Tissue: Ovary.
[6]	"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed: 12665801] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-14, ACETYLATION AT MET-1. Tissue: Platelet.
[7]	Bienvenut W.V., Claeys D. Submitted (NOV-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 1-33; 111-120; 219-234; 482-489; 516-524; 549-560 AND 657-667, ACETYLATION AT MET-1, MASS SPECTROMETRY. Tissue: Platelet.
[8]	"A sarco/endoplasmic reticulum Ca(2+)-ATPase 3-type Ca2+ pump is expressed in platelets, in lymphoid cells, and in mast cells." Wuytack F., Papp B., Verboomen H., Raeymaekers L., Dode L., Bobe R., Enouf J., Bokkala S., Authi K.S., Casteels R. J. Biol. Chem. 269:1410-1416(1994) [PubMed: 8288608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 454-509.
[9]	"Splicing of sarco/endoplasmic reticulum Ca2+ ATPase 3 genes generates multiple and species-specific variants of Ca2+ transporting pumps." Martin V., Bredoux R., Corvazier E., van Gorp R., Kovacs T., Gelebart P., Papp B., Enouf J. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 892-1043 (ISOFORMS SERCA3E AND SERCA3F).
[10]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-674.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	Z69881 mRNA. Translation: CAA93737.1. Z69880 Genomic DNA. Translation: CAA93736.1. Y15724 Y15730 Genomic DNA. Translation: CAA75739.1. Y15738 Genomic DNA. Translation: CAA75748.1. Y15737 Genomic DNA. Translation: CAA75747.1. AF068220 mRNA. Translation: AAC24525.1. AF068221 mRNA. Translation: AAC24526.1. BC035729 mRNA. Translation: AAH35729.1. S68239 mRNA. Translation: AAB29700.1. AF458228 mRNA. Translation: AAL78967.1. AF458229 mRNA. Translation: AAL78968.1.
IPI	IPI00004092. IPI00218440. IPI00218442. IPI00303760. IPI00478023. IPI00748794.
PIR	I55399. S72267.
RefSeq	NP_005164.2. NP_777613.1. NP_777614.1. NP_777615.1. NP_777616.1. NP_777617.1. NP_777618.1.
UniGene	Hs.513870
3D structure databases
HSSP	HSSP built from PDB template 1EUL based on UniProtKB P04191.
SMR	Q93084. Positions 1-994.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q93084. 6 interactions.
STRING	Q93084.
PTM databases
PhosphoSite	Q93084.
Proteomic databases
PRIDE	Q93084.
Genome annotation databases
Ensembl	ENST00000309890; ENSP00000312577; ENSG00000074370; Homo sapiens. [Genome view] ENST00000352011; ENSP00000301387; ENSG00000074370; Homo sapiens. [Genome view] ENST00000359983; ENSP00000353072; ENSG00000074370; Homo sapiens. [Genome view] ENST00000397035; ENSP00000380229; ENSG00000074370; Homo sapiens. [Genome view] ENST00000397039; ENSP00000380232; ENSG00000074370; Homo sapiens. [Genome view] ENST00000397041; ENSP00000380234; ENSG00000074370; Homo sapiens. [Genome view] ENST00000397043; ENSP00000380236; ENSG00000074370; Homo sapiens. [Genome view] ENST00000397045; ENSP00000380238; ENSG00000074370; Homo sapiens. [Genome view]
GeneID	489.
KEGG	hsa:489.
UCSC	uc002fwx.1. human. uc002fwy.1. human. uc002fwz.1. human. uc002fxb.1. human. uc002fxc.1. human. uc002fxd.1. human.
Organism-specific databases
CTD	489.
GeneCards	GC17M003761.
H-InvDB	HIX0027123.
HGNC	HGNC:813. ATP2A3.
HPA	CAB010882. HPA007180.
MIM	601929. gene.
PharmGKB	PA25106.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q93084.
Enzyme and pathway databases
BRENDA	3.6.3.8. 247.
Gene expression databases
ArrayExpress	Q93084.
Bgee	Q93084.
CleanEx	HS_ATP2A3.
Genevestigator	Q93084.
GermOnline	ENSG00000074370. Homo sapiens.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR005782. ATPase_P-typ_Ca-transp. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR000695. ATPase_P-typ_H-transp. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
TIGRFAMs	TIGR01116. ATPase-IIA1_Ca. 1 hit. TIGR01494. ATPase_P-type. 4 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	2037.
SOURCE	Search...

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Entry information

Entry name

AT2A3_HUMAN

Accession

Primary (citable) accession number: Q93084
Secondary accession number(s): O60900

Q8TEX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	October 18, 2001
Last modified:	October 13, 2009
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents