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Reviewed, UniProtKB/Swiss-Prot Q93083 (MT1L_HUMAN)

Last modified November 24, 2009. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Metallothionein-1L
      Short name=MT-1L
Alternative name(s):
    Metallothionein-IL
      Short name=MT-IL
Gene names
Name: MT1L
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length61 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids By similarity.

Subunit structure

Monomer By similarity.

Tissue specificity

Expressed in reticulocytes.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6161Metallothionein-1L
PRO_0000197242

Regions

Region1 – 2929Beta
Region30 – 6132Alpha

Sites

Metal binding51Cluster B
Metal binding71Cluster B
Metal binding131Cluster B
Metal binding151Cluster B
Metal binding191Cluster B
Metal binding211Cluster B
Metal binding241Cluster B
Metal binding261Cluster B
Metal binding291Cluster B
Metal binding331Cluster A
Metal binding341Cluster A
Metal binding361Cluster A
Metal binding371Cluster A
Metal binding411Cluster A
Metal binding441Cluster A
Metal binding481Cluster A
Metal binding501Cluster A
Metal binding571Cluster A
Metal binding591Cluster A
Metal binding601Cluster A

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q93083-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 650A7904E672F5D1

FASTA616,062
        10         20         30         40         50         60 
MDPNCSCATG GSCSCASSCK CKECKCTSCK KSCCSCCPMG CAKCAQGCVC KGASEKCSCC 


A 

« Hide

References

[1]"Cloning and sequencing a novel metallothionein I isoform expressed in human reticulocytes."
Lambert E., Kille P., Swaminathan R.
FEBS Lett. 389:210-212(1996) [PubMed: 8766831] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Reticulocyte.
+Additional computationally mapped references.

Cross-references

Sequence databases

X97261 mRNA. Translation: CAA65916.1.
IPIIPI00386275.
PIRS69277.
UniGeneHs.647358

3D structure databases

SMRQ93083. Positions 1-61.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ93083.

Proteomic databases

PRIDEQ93083.

Genome annotation databases

EnsemblENST00000306061; ENSP00000307706; ENSG00000169715; Homo sapiens. [Genome view]

Organism-specific databases

GeneCardsGC16P055208.
H-InvDBHIX0013057.
HIX0041621.
HGNCHGNC:7404. MT1L.
MIM156358. gene.
PharmGKBPA31209.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ93083.

Gene expression databases

ArrayExpressQ93083.
BgeeQ93083.
GenevestigatorQ93083.
GermOnlineENSG00000169715. Homo sapiens.

Family and domain databases

InterProIPR017854. Metallothionein_sfam.
IPR003019. Metallothionein_sfam_euk.
IPR000006. Metallothionein_vert.
IPR018064. Metallothionein_vert_metal_BS.
[Graphical view]
Gene3DG3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHERPTHR23299. Metallothionein_vert. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Entry information

Entry nameMT1L_HUMAN
AccessionPrimary (citable) accession number: Q93083
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 24, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

Metallothioneins

Classification of metallothioneins and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents