HIST1H2BH

Functionⁱ

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functionⁱ

DNA binding Source: GO_Central
protein heterodimerization activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

nucleosome assembly Source: GO_Central
protein ubiquitination Source: Reactome

Complete GO annotation...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1221632. Meiotic synapsis. R-HSA-171306. Packaging Of Telomere Ends. R-HSA-201722. Formation of the beta-catenin:TCF transactivating complex. R-HSA-212300. PRC2 methylates histones and DNA. R-HSA-2299718. Condensation of Prophase Chromosomes. R-HSA-2559580. Oxidative Stress Induced Senescence. R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP). R-HSA-2559586. DNA Damage/Telomere Stress Induced Senescence. R-HSA-3214815. HDACs deacetylate histones. R-HSA-3214847. HATs acetylate histones. R-HSA-427359. SIRT1 negatively regulates rRNA Expression. R-HSA-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression. R-HSA-427413. NoRC negatively regulates rRNA expression. R-HSA-5250924. B-WICH complex positively regulates rRNA expression. R-HSA-5334118. DNA methylation. R-HSA-5578749. Transcriptional regulation by small RNAs. R-HSA-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis. R-HSA-5625886. Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. R-HSA-5689880. Ub-specific processing proteases. R-HSA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks. R-HSA-5693571. Nonhomologous End-Joining (NHEJ). R-HSA-5693607. Processing of DNA double-strand break ends. R-HSA-606279. Deposition of new CENPA-containing nucleosomes at the centromere. R-HSA-69473. G2/M DNA damage checkpoint. R-HSA-73728. RNA Polymerase I Promoter Opening. R-HSA-73777. RNA Polymerase I Chain Elongation. R-HSA-8866654. E3 ubiquitin ligases ubiquitinate target proteins. R-HSA-912446. Meiotic recombination. R-HSA-977225. Amyloid fiber formation.

Reactomeⁱ

R-HSA-1221632. Meiotic synapsis.
R-HSA-171306. Packaging Of Telomere Ends.
R-HSA-201722. Formation of the beta-catenin:TCF transactivating complex.
R-HSA-212300. PRC2 methylates histones and DNA.
R-HSA-2299718. Condensation of Prophase Chromosomes.
R-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-HSA-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-HSA-3214815. HDACs deacetylate histones.
R-HSA-3214847. HATs acetylate histones.
R-HSA-427359. SIRT1 negatively regulates rRNA Expression.
R-HSA-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.
R-HSA-427413. NoRC negatively regulates rRNA expression.
R-HSA-5250924. B-WICH complex positively regulates rRNA expression.
R-HSA-5334118. DNA methylation.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
R-HSA-5625886. Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
R-HSA-5689880. Ub-specific processing proteases.
R-HSA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-HSA-5693571. Nonhomologous End-Joining (NHEJ).
R-HSA-5693607. Processing of DNA double-strand break ends.
R-HSA-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-HSA-69473. G2/M DNA damage checkpoint.
R-HSA-73728. RNA Polymerase I Promoter Opening.
R-HSA-73777. RNA Polymerase I Chain Elongation.
R-HSA-8866654. E3 ubiquitin ligases ubiquitinate target proteins.
R-HSA-912446. Meiotic recombination.
R-HSA-977225. Amyloid fiber formation.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histone H2B type 1-H Alternative name(s): Histone H2B.j Short name: H2B/j
Gene namesⁱ	Name:HIST1H2BH Synonyms:H2BFJ
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4755. HIST1H2BH.

HGNCⁱ

HGNC:4755. HIST1H2BH.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytosol Source: HPA
extracellular exosome
Source: UniProtKB
Inferred from direct assayⁱ
- 20458337
nucleoplasm Source: HPA
nucleosome
Source: UniProtKB
Non-traceable author statementⁱ
- 9119399
nucleus
Source: UniProtKB
Inferred from direct assayⁱ
- 16319397
- 21630459

Complete GO annotation...

Keywords - Cellular componentⁱ

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000275713.
PharmGKBⁱ	PA29130.

Polymorphism and mutation databases

BioMutaⁱ	HIST1H2BH.
DMDMⁱ	7387739.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000071833	2 – 126	Histone H2B type 1-HAdd BLAST		125

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylprolineBy similarity	1
Modified residueⁱ	6	N6-acetyllysine; alternate2 Publications	1
Modified residueⁱ	6	N6-crotonyllysine; alternate1 Publication	1
Cross-linkⁱ	6	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	12	N6-acetyllysine; alternate1 Publication	1
Modified residueⁱ	12	N6-crotonyllysine; alternate1 Publication	1
Modified residueⁱ	13	N6-acetyllysine; alternate2 Publications	1
Modified residueⁱ	13	N6-crotonyllysine; alternate1 Publication	1
Modified residueⁱ	15	Phosphoserine; by STK4/MST11 Publication	1
Modified residueⁱ	16	N6-acetyllysine; alternate2 Publications	1
Modified residueⁱ	16	N6-crotonyllysine; alternate1 Publication	1
Modified residueⁱ	17	N6-acetyllysine; alternate1 Publication	1
Modified residueⁱ	17	N6-crotonyllysine; alternate1 Publication	1
Modified residueⁱ	21	N6-acetyllysine; alternate2 Publications	1
Modified residueⁱ	21	N6-crotonyllysine; alternate1 Publication	1
Cross-linkⁱ	21	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	24	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	24	N6-crotonyllysine; alternate1 Publication	1
Modified residueⁱ	35	N6-crotonyllysine; alternate1 Publication	1
Cross-linkⁱ	35	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residueⁱ	37	Phosphoserine; by AMPKBy similarity	1
Modified residueⁱ	47	N6-methyllysine1 Publication	1
Modified residueⁱ	58	N6,N6-dimethyllysine1 Publication	1
Modified residueⁱ	80	Dimethylated arginineBy similarity	1
Modified residueⁱ	86	N6,N6,N6-trimethyllysine; alternateBy similarity	1
Modified residueⁱ	86	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	87	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	93	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	109	N6-methyllysine1 Publication	1
Glycosylationⁱ	113	O-linked (GlcNAc) serineBy similarity	1
Modified residueⁱ	116	PhosphothreonineBy similarity	1
Modified residueⁱ	117	N6-methylated lysineBy similarity	1
Cross-linkⁱ	121	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)3 Publications

Post-translational modificationⁱ

Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.1 Publication

Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.By similarity1 Publication

GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).By similarity

Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.1 Publication

Keywords - PTMⁱ

Acetylation, Glycoprotein, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q93079.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q93079.
PaxDbⁱ	Q93079.
PeptideAtlas More...PeptideAtlasⁱ	Q93079.
PRIDEⁱ	Q93079.
TopDownProteomicsⁱ	Q93079.

PTM databases

iPTMnetⁱ	Q93079.
PhosphoSitePlusⁱ	Q93079.
SwissPalmⁱ	Q93079.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000275713.
CleanExⁱ	HS_HIST1H2BH.
Genevisibleⁱ	Q93079. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042205. HPA043013. HPA048671.

HPAⁱ

HPA042205.
HPA043013.
HPA048671.

Interactionⁱ

Subunit structureⁱ

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functionⁱ

protein heterodimerization activity Source: InterPro

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	113941. 10 interactors.
IntActⁱ	Q93079. 9 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4829860.
STRINGⁱ	9606.ENSP00000348706.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q93079.
SMRⁱ	Q93079.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1744. Eukaryota. ENOG4111NV5. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118976.
HOGENOMⁱ	HOG000231213.
HOVERGENⁱ	HBG007774.
InParanoidⁱ	Q93079.
KEGG Orthology (KO) More...KOⁱ	K11252.
OMAⁱ	YTSANRR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XGD.
PhylomeDBⁱ	Q93079.
TreeFamⁱ	TF300212.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009072. Histone-fold. IPR007125. Histone_H2A/H2B/H3. IPR000558. Histone_H2B.
PANTHERⁱ	PTHR23428. PTHR23428. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00125. Histone. 1 hit.
PRINTSⁱ	PR00621. HISTONEH2B.
SMARTⁱ	View protein in SMART SM00427. H2B. 1 hit.
SUPFAMⁱ	SSF47113. SSF47113. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00357. HISTONE_H2B. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q93079-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPDPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH 
        60         70         80         90        100
PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR 
       110        120 
LLLPGELAKH AVSEGTKAVT KYTSSK

Length:126

Mass (Da):13,892

Last modified:January 23, 2007 - v3

Checksum:ⁱFAE0F79FF4BF703D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z80781 Genomic DNA. Translation: CAB02543.1. AF531291 Genomic DNA. Translation: AAN06691.1. AK312052 mRNA. Translation: BAG34988.1. AL031777 Genomic DNA. No translation available. CH471087 Genomic DNA. Translation: EAW55552.1. BC096116 mRNA. Translation: AAH96116.1. BC096117 mRNA. Translation: AAH96117.1. BC096118 mRNA. Translation: AAH96118.1. BC096119 mRNA. Translation: AAH96119.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4601.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_003515.1. NM_003524.2.
UniGeneⁱ	Hs.247815.

Genome annotation databases

Ensemblⁱ	ENST00000619466; ENSP00000479169; ENSG00000275713.
GeneIDⁱ	8345.
KEGGⁱ	hsa:8345.
UCSC genome browser More...UCSCⁱ	uc003nhh.4. human.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q93079	F7H706 G1U155 H2PI63 H2R7K3 F2Z581 A0A1U7UDT5 G3STA3 UPI0004F01038	Homo sapiens (Human) Callithrix jacchus (White-tufted-ear marmoset) Oryctolagus cuniculus (Rabbit) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Sus scrofa (Pig) Tarsius syrichta (Philippine tarsier) Loxodonta africana (African elephant)	126	UniRef100_Q93079	Cluster: Histone H2B type 1-H	9

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q93079	F7H706 G1U155 H2PI63 H2R7K3 F2Z581 A0A1U7UDT5 G3STA3 UPI0004F01038 UPI000333CB1E L8ITV4 +3	Homo sapiens (Human) Callithrix jacchus (White-tufted-ear marmoset) Oryctolagus cuniculus (Rabbit) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Sus scrofa (Pig) Tarsius syrichta (Philippine tarsier) Loxodonta africana (African elephant) Octodon degus (Degu) (Sciurus degus) Bos mutus (wild yak)	126	UniRef90_Q93079	Cluster: Histone H2B type 1-H	14

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q93079	O60814 A0A024RCL8 I0FVV7 H2RAX0 F7FWZ8 M3WVP6 L5JVZ3 J9P6S8 F2Z4F9 H0XT51 +128	Homo sapiens (Human) Macaca mulatta (Rhesus macaque) Pan troglodytes (Chimpanzee) Callithrix jacchus (White-tufted-ear marmoset) Felis catus (Cat) (Felis silvestris catus) Pteropus alecto (Black flying fox) Canis lupus familiaris (Dog) (Canis familiaris) Bos taurus (Bovine) Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) And more	126	UniRef50_O60814	Cluster: Histone H2B type 1-K	139

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z80781 Genomic DNA. Translation: CAB02543.1. AF531291 Genomic DNA. Translation: AAN06691.1. AK312052 mRNA. Translation: BAG34988.1. AL031777 Genomic DNA. No translation available. CH471087 Genomic DNA. Translation: EAW55552.1. BC096116 mRNA. Translation: AAH96116.1. BC096117 mRNA. Translation: AAH96117.1. BC096118 mRNA. Translation: AAH96118.1. BC096119 mRNA. Translation: AAH96119.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4601.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_003515.1. NM_003524.2.
UniGeneⁱ	Hs.247815.

3D structure databases

ProteinModelPortalⁱ	Q93079.
SMRⁱ	Q93079.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113941. 10 interactors.
IntActⁱ	Q93079. 9 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4829860.
STRINGⁱ	9606.ENSP00000348706.

PTM databases

iPTMnetⁱ	Q93079.
PhosphoSitePlusⁱ	Q93079.
SwissPalmⁱ	Q93079.

Polymorphism and mutation databases

BioMutaⁱ	HIST1H2BH.
DMDMⁱ	7387739.

Proteomic databases

EPDⁱ	Q93079.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q93079.
PaxDbⁱ	Q93079.
PeptideAtlas More...PeptideAtlasⁱ	Q93079.
PRIDEⁱ	Q93079.
TopDownProteomicsⁱ	Q93079.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000619466; ENSP00000479169; ENSG00000275713.
GeneIDⁱ	8345.
KEGGⁱ	hsa:8345.
UCSC genome browser More...UCSCⁱ	uc003nhh.4. human.

Organism-specific databases

CTDⁱ	8345.
GeneCardsⁱ	HIST1H2BH.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4755. HIST1H2BH.
Human Protein Atlas More...HPAⁱ	HPA042205. HPA043013. HPA048671.
MIMⁱ	602806. gene.
neXtProtⁱ	NX_Q93079.
Open Targets More...OpenTargetsⁱ	ENSG00000275713.
PharmGKBⁱ	PA29130.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1744. Eukaryota. ENOG4111NV5. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118976.
HOGENOMⁱ	HOG000231213.
HOVERGENⁱ	HBG007774.
InParanoidⁱ	Q93079.
KEGG Orthology (KO) More...KOⁱ	K11252.
OMAⁱ	YTSANRR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XGD.
PhylomeDBⁱ	Q93079.
TreeFamⁱ	TF300212.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1221632. Meiotic synapsis. R-HSA-171306. Packaging Of Telomere Ends. R-HSA-201722. Formation of the beta-catenin:TCF transactivating complex. R-HSA-212300. PRC2 methylates histones and DNA. R-HSA-2299718. Condensation of Prophase Chromosomes. R-HSA-2559580. Oxidative Stress Induced Senescence. R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP). R-HSA-2559586. DNA Damage/Telomere Stress Induced Senescence. R-HSA-3214815. HDACs deacetylate histones. R-HSA-3214847. HATs acetylate histones. R-HSA-427359. SIRT1 negatively regulates rRNA Expression. R-HSA-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression. R-HSA-427413. NoRC negatively regulates rRNA expression. R-HSA-5250924. B-WICH complex positively regulates rRNA expression. R-HSA-5334118. DNA methylation. R-HSA-5578749. Transcriptional regulation by small RNAs. R-HSA-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis. R-HSA-5625886. Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. R-HSA-5689880. Ub-specific processing proteases. R-HSA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks. R-HSA-5693571. Nonhomologous End-Joining (NHEJ). R-HSA-5693607. Processing of DNA double-strand break ends. R-HSA-606279. Deposition of new CENPA-containing nucleosomes at the centromere. R-HSA-69473. G2/M DNA damage checkpoint. R-HSA-73728. RNA Polymerase I Promoter Opening. R-HSA-73777. RNA Polymerase I Chain Elongation. R-HSA-8866654. E3 ubiquitin ligases ubiquitinate target proteins. R-HSA-912446. Meiotic recombination. R-HSA-977225. Amyloid fiber formation.

Reactomeⁱ

R-HSA-1221632. Meiotic synapsis.
R-HSA-171306. Packaging Of Telomere Ends.
R-HSA-201722. Formation of the beta-catenin:TCF transactivating complex.
R-HSA-212300. PRC2 methylates histones and DNA.
R-HSA-2299718. Condensation of Prophase Chromosomes.
R-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-HSA-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-HSA-3214815. HDACs deacetylate histones.
R-HSA-3214847. HATs acetylate histones.
R-HSA-427359. SIRT1 negatively regulates rRNA Expression.
R-HSA-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.
R-HSA-427413. NoRC negatively regulates rRNA expression.
R-HSA-5250924. B-WICH complex positively regulates rRNA expression.
R-HSA-5334118. DNA methylation.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
R-HSA-5625886. Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
R-HSA-5689880. Ub-specific processing proteases.
R-HSA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-HSA-5693571. Nonhomologous End-Joining (NHEJ).
R-HSA-5693607. Processing of DNA double-strand break ends.
R-HSA-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-HSA-69473. G2/M DNA damage checkpoint.
R-HSA-73728. RNA Polymerase I Promoter Opening.
R-HSA-73777. RNA Polymerase I Chain Elongation.
R-HSA-8866654. E3 ubiquitin ligases ubiquitinate target proteins.
R-HSA-912446. Meiotic recombination.
R-HSA-977225. Amyloid fiber formation.

Miscellaneous databases

ChiTaRSⁱ	HIST1H2BH. human.
GeneWikiⁱ	HIST1H2BH.
GenomeRNAiⁱ	8345.
Protein Ontology More...PROⁱ	PR:Q93079.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000275713.
CleanExⁱ	HS_HIST1H2BH.
Genevisibleⁱ	Q93079. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009072. Histone-fold. IPR007125. Histone_H2A/H2B/H3. IPR000558. Histone_H2B.
PANTHERⁱ	PTHR23428. PTHR23428. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00125. Histone. 1 hit.
PRINTSⁱ	PR00621. HISTONEH2B.
SMARTⁱ	View protein in SMART SM00427. H2B. 1 hit.
SUPFAMⁱ	SSF47113. SSF47113. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00357. HISTONE_H2B. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H2B1H_HUMAN
Accessionⁱ	Q93079Primary (citable) accession number: Q93079 Secondary accession number(s): B2R541, Q4VB74
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	January 23, 2007
	Last modified:	August 30, 2017
	This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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Supporting data

UniProtKB - Q93079 (H2B1H_HUMAN)

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Histone H2B type 1-H

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ