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Protein

Putative deoxyribonuclease TATDN2

Gene

TATDN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative deoxyribonuclease.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi499Divalent metal cation 1By similarity1
Metal bindingi501Divalent metal cation 1By similarity1
Metal bindingi593Divalent metal cation 1By similarity1
Metal bindingi593Divalent metal cation 2By similarity1
Metal bindingi630Divalent metal cation 2By similarity1
Metal bindingi655Divalent metal cation 2By similarity1
Metal bindingi707Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157014-MONOMER.
ReactomeiR-HSA-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative deoxyribonuclease TATDN2 (EC:3.1.21.-)
Gene namesi
Name:TATDN2
Synonyms:KIAA0218
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28988. TATDN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157014.
PharmGKBiPA134959721.

Polymorphism and mutation databases

BioMutaiTATDN2.
DMDMi209572689.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002019931 – 761Putative deoxyribonuclease TATDN2Add BLAST761

Proteomic databases

EPDiQ93075.
MaxQBiQ93075.
PaxDbiQ93075.
PeptideAtlasiQ93075.
PRIDEiQ93075.

PTM databases

iPTMnetiQ93075.
PhosphoSitePlusiQ93075.

Expressioni

Gene expression databases

BgeeiENSG00000157014.
CleanExiHS_TATDN2.
ExpressionAtlasiQ93075. baseline and differential.
GenevisibleiQ93075. HS.

Organism-specific databases

HPAiHPA036822.
HPA058001.

Interactioni

Protein-protein interaction databases

BioGridi115140. 8 interactors.
IntActiQ93075. 1 interactor.
STRINGi9606.ENSP00000287652.

Structurei

3D structure databases

ProteinModelPortaliQ93075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TatD-type hydrolase family.Curated

Phylogenomic databases

eggNOGiKOG3020. Eukaryota.
COG0084. LUCA.
GeneTreeiENSGT00720000108776.
HOGENOMiHOG000082522.
HOVERGENiHBG055051.
InParanoidiQ93075.
KOiK03424.
OMAiKRSCLRE.
OrthoDBiEOG091G036L.
PhylomeDBiQ93075.
TreeFamiTF324192.

Family and domain databases

InterProiIPR018228. DNase_TatD-rel_CS.
IPR032466. Metal_Hydrolase.
IPR001130. TatD_family.
[Graphical view]
PANTHERiPTHR10060. PTHR10060. 2 hits.
PfamiPF01026. TatD_DNase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS01137. TATD_1. 1 hit.
PS01090. TATD_2. 1 hit.
PS01091. TATD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASERGKVKH NWSSTSEGCP RKRSCLREPC DVAPSSRPAQ RSASRSGGPS
60 70 80 90 100
SPKRLKAQKE DDVACSRRLS WGSSRRRNNS SSSFSPHFLG PGVGGAASKG
110 120 130 140 150
CLIRNTRGFL SSGGSPLRPA NASLEEMASL EEEACSLKVD SKDSSHNSTN
160 170 180 190 200
SEFAAEAEGQ NDTIEEPNKV QKRKRDRLRD QGSTMIYLKA IQGILGKSMP
210 220 230 240 250
KRKGEAATRA KPSAAEHPSH GEGPARSEGP AKTAEGAARS VTVTAAQKEK
260 270 280 290 300
DATPEVSMEE DKTVPERSSF YDRRVVIDPQ EKPSEEPLGD RRTVIDKCSP
310 320 330 340 350
PLEFLDDSDS HLEIQKHKDR EVVMEHPSSG SDWSDVEEIS TVRFSQEEPV
360 370 380 390 400
SLKPSAVPEP SSFTTDYVMY PPHLYSSPWC DYASYWTSSP KPSSYPSTGS
410 420 430 440 450
SSNDAAQVGK SSRSRMSDYS PNSTGSVQNT SRDMEASEEG WSQNSRSFRF
460 470 480 490 500
SRSSEEREVK EKRTFQEEMP PRPCGGHASS SLPKSHLEPS LEEGFIDTHC
510 520 530 540 550
HLDMLYSKLS FQGTFTKFRK IYSSSFPKEF QGCISDFCDP RTLTDCLWEE
560 570 580 590 600
LLKEDLVWGA FGCHPHFARY YSESQERNLL QALRHPKAVA FGEMGLDYSY
610 620 630 640 650
KCTTPVPEQH KVFERQLQLA VSLKKPLVIH CREADEDLLE IMKKFVPPDY
660 670 680 690 700
KIHRHCFTGS YPVIEPLLKY FPNMSVGFTA VLTYSSAWEA REALRQIPLE
710 720 730 740 750
RIIVETDAPY FLPRQVPKSL CQYAHPGLAL HTVREIARVK DQPLSLTLAA
760
LRENTSRLYS L
Length:761
Mass (Da):85,023
Last modified:October 14, 2008 - v2
Checksum:i11BF3683608EE617
GO

Sequence cautioni

The sequence BAA13208 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047028217H → R.Corresponds to variant rs2241314dbSNPEnsembl.1
Natural variantiVAR_047029256V → I.1 PublicationCorresponds to variant rs394558dbSNPEnsembl.1
Natural variantiVAR_047030358P → L.1 PublicationCorresponds to variant rs2075352dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86972 mRNA. Translation: BAA13208.2. Different initiation.
CH471055 Genomic DNA. Translation: EAW64070.1.
BC090935 mRNA. Translation: AAH90935.1.
BC101770 mRNA. Translation: AAI01771.1.
BC101776 mRNA. Translation: AAI01777.1.
CCDSiCCDS33698.1.
RefSeqiNP_055575.3. NM_014760.3.
UniGeneiHs.475401.

Genome annotation databases

EnsembliENST00000287652; ENSP00000287652; ENSG00000157014.
ENST00000448281; ENSP00000408736; ENSG00000157014.
GeneIDi9797.
KEGGihsa:9797.
UCSCiuc003bvf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86972 mRNA. Translation: BAA13208.2. Different initiation.
CH471055 Genomic DNA. Translation: EAW64070.1.
BC090935 mRNA. Translation: AAH90935.1.
BC101770 mRNA. Translation: AAI01771.1.
BC101776 mRNA. Translation: AAI01777.1.
CCDSiCCDS33698.1.
RefSeqiNP_055575.3. NM_014760.3.
UniGeneiHs.475401.

3D structure databases

ProteinModelPortaliQ93075.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115140. 8 interactors.
IntActiQ93075. 1 interactor.
STRINGi9606.ENSP00000287652.

PTM databases

iPTMnetiQ93075.
PhosphoSitePlusiQ93075.

Polymorphism and mutation databases

BioMutaiTATDN2.
DMDMi209572689.

Proteomic databases

EPDiQ93075.
MaxQBiQ93075.
PaxDbiQ93075.
PeptideAtlasiQ93075.
PRIDEiQ93075.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287652; ENSP00000287652; ENSG00000157014.
ENST00000448281; ENSP00000408736; ENSG00000157014.
GeneIDi9797.
KEGGihsa:9797.
UCSCiuc003bvf.4. human.

Organism-specific databases

CTDi9797.
GeneCardsiTATDN2.
HGNCiHGNC:28988. TATDN2.
HPAiHPA036822.
HPA058001.
neXtProtiNX_Q93075.
OpenTargetsiENSG00000157014.
PharmGKBiPA134959721.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3020. Eukaryota.
COG0084. LUCA.
GeneTreeiENSGT00720000108776.
HOGENOMiHOG000082522.
HOVERGENiHBG055051.
InParanoidiQ93075.
KOiK03424.
OMAiKRSCLRE.
OrthoDBiEOG091G036L.
PhylomeDBiQ93075.
TreeFamiTF324192.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157014-MONOMER.
ReactomeiR-HSA-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSiTATDN2. human.
GenomeRNAii9797.
PROiQ93075.

Gene expression databases

BgeeiENSG00000157014.
CleanExiHS_TATDN2.
ExpressionAtlasiQ93075. baseline and differential.
GenevisibleiQ93075. HS.

Family and domain databases

InterProiIPR018228. DNase_TatD-rel_CS.
IPR032466. Metal_Hydrolase.
IPR001130. TatD_family.
[Graphical view]
PANTHERiPTHR10060. PTHR10060. 2 hits.
PfamiPF01026. TatD_DNase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS01137. TATD_1. 1 hit.
PS01090. TATD_2. 1 hit.
PS01091. TATD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTATD2_HUMAN
AccessioniPrimary (citable) accession number: Q93075
Secondary accession number(s): Q3MIL9, Q5BKU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.