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Protein

Putative deoxyribonuclease TATDN2

Gene

TATDN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative deoxyribonuclease.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi499Divalent metal cation 1By similarity1
Metal bindingi501Divalent metal cation 1By similarity1
Metal bindingi593Divalent metal cation 1By similarity1
Metal bindingi593Divalent metal cation 2By similarity1
Metal bindingi630Divalent metal cation 2By similarity1
Metal bindingi655Divalent metal cation 2By similarity1
Metal bindingi707Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Nuclease
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
Putative deoxyribonuclease TATDN2 (EC:3.1.21.-)
Gene namesi
Name:TATDN2
Synonyms:KIAA0218
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000157014.10
HGNCiHGNC:28988 TATDN2
neXtProtiNX_Q93075

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157014
PharmGKBiPA134959721

Polymorphism and mutation databases

BioMutaiTATDN2
DMDMi209572689

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002019931 – 761Putative deoxyribonuclease TATDN2Add BLAST761

Proteomic databases

EPDiQ93075
MaxQBiQ93075
PaxDbiQ93075
PeptideAtlasiQ93075
PRIDEiQ93075
ProteomicsDBi75704

PTM databases

iPTMnetiQ93075
PhosphoSitePlusiQ93075

Expressioni

Gene expression databases

BgeeiENSG00000157014
CleanExiHS_TATDN2
ExpressionAtlasiQ93075 baseline and differential
GenevisibleiQ93075 HS

Organism-specific databases

HPAiHPA036822
HPA058001

Interactioni

Protein-protein interaction databases

BioGridi115140, 11 interactors
IntActiQ93075, 1 interactor
STRINGi9606.ENSP00000287652

Structurei

3D structure databases

ProteinModelPortaliQ93075
SMRiQ93075
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3020 Eukaryota
COG0084 LUCA
GeneTreeiENSGT00720000108776
HOGENOMiHOG000082522
HOVERGENiHBG055051
InParanoidiQ93075
KOiK03424
OMAiKRSCLRE
OrthoDBiEOG091G036L
PhylomeDBiQ93075
TreeFamiTF324192

Family and domain databases

CDDicd01310 TatD_DNAse, 1 hit
InterProiView protein in InterPro
IPR018228 DNase_TatD-rel_CS
IPR032466 Metal_Hydrolase
IPR001130 TatD_family
PANTHERiPTHR10060 PTHR10060, 1 hit
PfamiView protein in Pfam
PF01026 TatD_DNase, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
PROSITEiView protein in PROSITE
PS01137 TATD_1, 1 hit
PS01090 TATD_2, 1 hit
PS01091 TATD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q93075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASERGKVKH NWSSTSEGCP RKRSCLREPC DVAPSSRPAQ RSASRSGGPS
60 70 80 90 100
SPKRLKAQKE DDVACSRRLS WGSSRRRNNS SSSFSPHFLG PGVGGAASKG
110 120 130 140 150
CLIRNTRGFL SSGGSPLRPA NASLEEMASL EEEACSLKVD SKDSSHNSTN
160 170 180 190 200
SEFAAEAEGQ NDTIEEPNKV QKRKRDRLRD QGSTMIYLKA IQGILGKSMP
210 220 230 240 250
KRKGEAATRA KPSAAEHPSH GEGPARSEGP AKTAEGAARS VTVTAAQKEK
260 270 280 290 300
DATPEVSMEE DKTVPERSSF YDRRVVIDPQ EKPSEEPLGD RRTVIDKCSP
310 320 330 340 350
PLEFLDDSDS HLEIQKHKDR EVVMEHPSSG SDWSDVEEIS TVRFSQEEPV
360 370 380 390 400
SLKPSAVPEP SSFTTDYVMY PPHLYSSPWC DYASYWTSSP KPSSYPSTGS
410 420 430 440 450
SSNDAAQVGK SSRSRMSDYS PNSTGSVQNT SRDMEASEEG WSQNSRSFRF
460 470 480 490 500
SRSSEEREVK EKRTFQEEMP PRPCGGHASS SLPKSHLEPS LEEGFIDTHC
510 520 530 540 550
HLDMLYSKLS FQGTFTKFRK IYSSSFPKEF QGCISDFCDP RTLTDCLWEE
560 570 580 590 600
LLKEDLVWGA FGCHPHFARY YSESQERNLL QALRHPKAVA FGEMGLDYSY
610 620 630 640 650
KCTTPVPEQH KVFERQLQLA VSLKKPLVIH CREADEDLLE IMKKFVPPDY
660 670 680 690 700
KIHRHCFTGS YPVIEPLLKY FPNMSVGFTA VLTYSSAWEA REALRQIPLE
710 720 730 740 750
RIIVETDAPY FLPRQVPKSL CQYAHPGLAL HTVREIARVK DQPLSLTLAA
760
LRENTSRLYS L
Length:761
Mass (Da):85,023
Last modified:October 14, 2008 - v2
Checksum:i11BF3683608EE617
GO

Sequence cautioni

The sequence BAA13208 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047028217H → R. Corresponds to variant dbSNP:rs2241314Ensembl.1
Natural variantiVAR_047029256V → I1 PublicationCorresponds to variant dbSNP:rs394558Ensembl.1
Natural variantiVAR_047030358P → L1 PublicationCorresponds to variant dbSNP:rs2075352Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86972 mRNA Translation: BAA13208.2 Different initiation.
CH471055 Genomic DNA Translation: EAW64070.1
BC090935 mRNA Translation: AAH90935.1
BC101770 mRNA Translation: AAI01771.1
BC101776 mRNA Translation: AAI01777.1
CCDSiCCDS33698.1
RefSeqiNP_055575.3, NM_014760.3
UniGeneiHs.475401

Genome annotation databases

EnsembliENST00000287652; ENSP00000287652; ENSG00000157014
ENST00000448281; ENSP00000408736; ENSG00000157014
GeneIDi9797
KEGGihsa:9797
UCSCiuc003bvf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTATD2_HUMAN
AccessioniPrimary (citable) accession number: Q93075
Secondary accession number(s): Q3MIL9, Q5BKU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: June 20, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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