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Protein

Mediator of RNA polymerase II transcription subunit 12

Gene

MED12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.3 Publications

GO - Molecular functioni

  • chromatin binding Source: Ensembl
  • ligand-dependent nuclear receptor transcription coactivator activity Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB
  • receptor activity Source: UniProtKB
  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  • RNA polymerase II transcription coactivator activity Source: GO_Central
  • RNA polymerase II transcription cofactor activity Source: UniProtKB
  • thyroid hormone receptor binding Source: UniProtKB
  • transcription coactivator activity Source: MGI
  • transcription cofactor activity Source: UniProtKB
  • ubiquitin protein ligase activity Source: Ensembl
  • vitamin D receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:G66-32344-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-212436. Generic Transcription Pathway.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
SignaLinkiQ93074.
SIGNORiQ93074.

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 12
Alternative name(s):
Activator-recruited cofactor 240 kDa component
Short name:
ARC240
CAG repeat protein 45
Mediator complex subunit 12
OPA-containing protein
Thyroid hormone receptor-associated protein complex 230 kDa component
Short name:
Trap230
Trinucleotide repeat-containing gene 11 protein
Gene namesi
Name:MED12
Synonyms:ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:11957. MED12.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: HPA
  • mediator complex Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • ubiquitin ligase complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Opitz-Kaveggia syndrome (OKS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionX-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.
See also OMIM:305450
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033112961R → W in OKS. 1 PublicationCorresponds to variant rs80338758dbSNPEnsembl.1
Lujan-Fryns syndrome (LUJFRYS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionClinically, Lujan-Fryns syndrome can be distinguished from Opitz-Kaveggia syndrome by tall stature, hypernasal voice, hyperextensible digits and high nasal root.
See also OMIM:309520
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0375341007N → S in LUJFRYS. 1 PublicationCorresponds to variant rs80338759dbSNPEnsembl.1
Ohdo syndrome, X-linked (OHDOX)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by mental retardation, feeding problems, and distinctive facial appearance with coarse facial features, severe blepharophimosis, ptosis, a bulbous nose, micrognathia and a small mouth. Dental hypoplasia and deafness can be considered as common manifestations of the syndrome. Male patients show cryptorchidism and scrotal hypoplasia.
See also OMIM:300895
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0697701148R → H in OHDOX. 1 PublicationCorresponds to variant rs387907360dbSNPEnsembl.1
Natural variantiVAR_0697711165S → P in OHDOX. 1 PublicationCorresponds to variant rs387907361dbSNPEnsembl.1
Natural variantiVAR_0697721729H → N in OHDOX. 1 PublicationCorresponds to variant rs387907362dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi9968.
MalaCardsiMED12.
MIMi300895. phenotype.
305450. phenotype.
309520. phenotype.
OpenTargetsiENSG00000184634.
Orphaneti293707. Blepharophimosis-intellectual disability syndrome, MKB type.
93932. FG syndrome type 1.
776. X-linked intellectual disability with marfanoid habitus.
777. X-linked non-syndromic intellectual disability.
PharmGKBiPA36645.

Polymorphism and mutation databases

BioMutaiMED12.
DMDMi209572775.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000963591 – 2177Mediator of RNA polymerase II transcription subunit 12Add BLAST2177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80N6-acetyllysineBy similarity1
Modified residuei166PhosphotyrosineCombined sources1
Modified residuei635PhosphoserineCombined sources1
Modified residuei665PhosphoserineCombined sources1
Modified residuei698PhosphoserineCombined sources1
Modified residuei700PhosphoserineCombined sources1
Modified residuei1258PhosphoserineCombined sources1
Modified residuei1269PhosphoserineCombined sources1
Modified residuei1798N6-acetyllysineBy similarity1
Modified residuei1899Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei1899Omega-N-methylarginine; alternateBy similarity1
Modified residuei1910Omega-N-methylarginineBy similarity1
Modified residuei1994Asymmetric dimethylarginineCombined sources1
Modified residuei2015Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ93074.
MaxQBiQ93074.
PaxDbiQ93074.
PeptideAtlasiQ93074.
PRIDEiQ93074.

PTM databases

iPTMnetiQ93074.
PhosphoSitePlusiQ93074.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000184634.
CleanExiHS_MED12.
ExpressionAtlasiQ93074. baseline and differential.
GenevisibleiQ93074. HS.

Organism-specific databases

HPAiHPA003184.
HPA003185.

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Also interacts with CTNNB1 and GLI3.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
APLP1P516932EBI-394357,EBI-74648
APLP2Q064812EBI-394357,EBI-79306
APPP050672EBI-394357,EBI-77613
MED4Q9NPJ66EBI-394357,EBI-394607
TGFBR2P371733EBI-394357,EBI-296151

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB
  • thyroid hormone receptor binding Source: UniProtKB
  • vitamin D receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115293. 88 interactors.
DIPiDIP-31459N.
IntActiQ93074. 67 interactors.
STRINGi9606.ENSP00000363193.

Structurei

3D structure databases

ProteinModelPortaliQ93074.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1616 – 2051Interaction with CTNNB1 and GLI31 PublicationAdd BLAST436

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1732 – 1777Pro-richAdd BLAST46
Compositional biasi1900 – 2168Gln-richAdd BLAST269

Sequence similaritiesi

Belongs to the Mediator complex subunit 12 family.Curated

Phylogenomic databases

eggNOGiENOG410ISJR. Eukaryota.
ENOG41119EY. LUCA.
GeneTreeiENSGT00440000037505.
HOGENOMiHOG000231423.
HOVERGENiHBG052447.
InParanoidiQ93074.
KOiK15162.
OMAiEMAIRQW.
OrthoDBiEOG091G00I6.
PhylomeDBiQ93074.
TreeFamiTF324178.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR019035. Mediator_Med12.
IPR021989. Mediator_Med12_catenin-bd.
IPR021990. Mediator_Med12_LCEWAV.
[Graphical view]
PfamiPF09497. Med12. 1 hit.
PF12145. Med12-LCEWAV. 1 hit.
PF12144. Med12-PQL. 1 hit.
[Graphical view]
SMARTiSM01281. Med12. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q93074-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAFGILSYE HRPLKRPRLG PPDVYPQDPK QKEDELTALN VKQGFNNQPA
60 70 80 90 100
VSGDEHGSAK NVSFNPAKIS SNFSSIIAEK LRCNTLPDTG RRKPQVNQKD
110 120 130 140 150
NFWLVTARSQ SAINTWFTDL AGTKPLTQLA KKVPIFSKKE EVFGYLAKYT
160 170 180 190 200
VPVMRAAWLI KMTCAYYAAI SETKVKKRHV DPFMEWTQII TKYLWEQLQK
210 220 230 240 250
MAEYYRPGPA GSGGCGSTIG PLPHDVEVAI RQWDYTEKLA MFMFQDGMLD
260 270 280 290 300
RHEFLTWVLE CFEKIRPGED ELLKLLLPLL LRYSGEFVQS AYLSRRLAYF
310 320 330 340 350
CTRRLALQLD GVSSHSSHVI SAQSTSTLPT TPAPQPPTSS TPSTPFSDLL
360 370 380 390 400
MCPQHRPLVF GLSCILQTIL LCCPSALVWH YSLTDSRIKT GSPLDHLPIA
410 420 430 440 450
PSNLPMPEGN SAFTQQVRAK LREIEQQIKE RGQAVEVRWS FDKCQEATAG
460 470 480 490 500
FTIGRVLHTL EVLDSHSFER SDFSNSLDSL CNRIFGLGPS KDGHEISSDD
510 520 530 540 550
DAVVSLLCEW AVSCKRSGRH RAMVVAKLLE KRQAEIEAER CGESEAADEK
560 570 580 590 600
GSIASGSLSA PSAPIFQDVL LQFLDTQAPM LTDPRSESER VEFFNLVLLF
610 620 630 640 650
CELIRHDVFS HNMYTCTLIS RGDLAFGAPG PRPPSPFDDP ADDPEHKEAE
660 670 680 690 700
GSSSSKLEDP GLSESMDIDP SSSVLFEDME KPDFSLFSPT MPCEGKGSPS
710 720 730 740 750
PEKPDVEKEV KPPPKEKIEG TLGVLYDQPR HVQYATHFPI PQEESCSHEC
760 770 780 790 800
NQRLVVLFGV GKQRDDARHA IKKITKDILK VLNRKGTAET DQLAPIVPLN
810 820 830 840 850
PGDLTFLGGE DGQKRRRNRP EAFPTAEDIF AKFQHLSHYD QHQVTAQVSR
860 870 880 890 900
NVLEQITSFA LGMSYHLPLV QHVQFIFDLM EYSLSISGLI DFAIQLLNEL
910 920 930 940 950
SVVEAELLLK SSDLVGSYTT SLCLCIVAVL RHYHACLILN QDQMAQVFEG
960 970 980 990 1000
LCGVVKHGMN RSDGSSAERC ILAYLYDLYT SCSHLKNKFG ELFSDFCSKV
1010 1020 1030 1040 1050
KNTIYCNVEP SESNMRWAPE FMIDTLENPA AHTFTYTGLG KSLSENPANR
1060 1070 1080 1090 1100
YSFVCNALMH VCVGHHDPDR VNDIAILCAE LTGYCKSLSA EWLGVLKALC
1110 1120 1130 1140 1150
CSSNNGTCGF NDLLCNVDVS DLSFHDSLAT FVAILIARQC LLLEDLIRCA
1160 1170 1180 1190 1200
AIPSLLNAAC SEQDSEPGAR LTCRILLHLF KTPQLNPCQS DGNKPTVGIR
1210 1220 1230 1240 1250
SSCDRHLLAA SQNRIVDGAV FAVLKAVFVL GDAELKGSGF TVTGGTEELP
1260 1270 1280 1290 1300
EEEGGGGSGG RRQGGRNISV ETASLDVYAK YVLRSICQQE WVGERCLKSL
1310 1320 1330 1340 1350
CEDSNDLQDP VLSSAQAQRL MQLICYPHRL LDNEDGENPQ RQRIKRILQN
1360 1370 1380 1390 1400
LDQWTMRQSS LELQLMIKQT PNNEMNSLLE NIAKATIEVF QQSAETGSSS
1410 1420 1430 1440 1450
GSTASNMPSS SKTKPVLSSL ERSGVWLVAP LIAKLPTSVQ GHVLKAAGEE
1460 1470 1480 1490 1500
LEKGQHLGSS SRKERDRQKQ KSMSLLSQQP FLSLVLTCLK GQDEQREGLL
1510 1520 1530 1540 1550
TSLYSQVHQI VNNWRDDQYL DDCKPKQLMH EALKLRLNLV GGMFDTVQRS
1560 1570 1580 1590 1600
TQQTTEWAML LLEIIISGTV DMQSNNELFT TVLDMLSVLI NGTLAADMSS
1610 1620 1630 1640 1650
ISQGSMEENK RAYMNLAKKL QKELGERQSD SLEKVRQLLP LPKQTRDVIT
1660 1670 1680 1690 1700
CEPQGSLIDT KGNKIAGFDS IFKKEGLQVS TKQKISPWDL FEGLKPSAPL
1710 1720 1730 1740 1750
SWGWFGTVRV DRRVARGEEQ QRLLLYHTHL RPRPRAYYLE PLPLPPEDEE
1760 1770 1780 1790 1800
PPAPTLLEPE KKAPEPPKTD KPGAAPPSTE ERKKKSTKGK KRSQPATKTE
1810 1820 1830 1840 1850
DYGMGPGRSG PYGVTVPPDL LHHPNPGSIT HLNYRQGSIG LYTQNQPLPA
1860 1870 1880 1890 1900
GGPRVDPYRP VRLPMQKLPT RPTYPGVLPT TMTGVMGLEP SSYKTSVYRQ
1910 1920 1930 1940 1950
QQPAVPQGQR LRQQLQQSQG MLGQSSVHQM TPSSSYGLQT SQGYTPYVSH
1960 1970 1980 1990 2000
VGLQQHTGPA GTMVPPSYSS QPYQSTHPST NPTLVDPTRH LQQRPSGYVH
2010 2020 2030 2040 2050
QQAPTYGHGL TSTQRFSHQT LQQTPMISTM TPMSAQGVQA GVRSTAILPE
2060 2070 2080 2090 2100
QQQQQQQQQQ QQQQQQQQQQ QQQQQQYHIR QQQQQQILRQ QQQQQQQQQQ
2110 2120 2130 2140 2150
QQQQQQQQQQ QQQQQHQQQQ QQQAAPPQPQ PQSQPQFQRQ GLQQTQQQQQ
2160 2170
TAALVRQLQQ QLSNTQPQPS TNIFGRY
Length:2,177
Mass (Da):243,081
Last modified:October 14, 2008 - v4
Checksum:i7492B07BA0F6EA9D
GO
Isoform 2 (identifier: Q93074-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1916-1916: Q → QAKI

Show »
Length:2,180
Mass (Da):243,394
Checksum:i22DB2ABC4A1CCA6B
GO
Isoform 3 (identifier: Q93074-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1916-1916: Missing.

Note: No experimental confirmation available.
Show »
Length:2,176
Mass (Da):242,953
Checksum:i440A5E60BA3E7273
GO

Sequence cautioni

The sequence AAD22033 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16R → RPR in AAD22033 (PubMed:10198638).Curated1
Sequence conflicti397Missing AA sequence (PubMed:10235266).Curated1
Sequence conflicti1166E → V in AAD44162 (PubMed:10480376).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033112961R → W in OKS. 1 PublicationCorresponds to variant rs80338758dbSNPEnsembl.1
Natural variantiVAR_0375341007N → S in LUJFRYS. 1 PublicationCorresponds to variant rs80338759dbSNPEnsembl.1
Natural variantiVAR_0697701148R → H in OHDOX. 1 PublicationCorresponds to variant rs387907360dbSNPEnsembl.1
Natural variantiVAR_0697711165S → P in OHDOX. 1 PublicationCorresponds to variant rs387907361dbSNPEnsembl.1
Natural variantiVAR_0466721392Q → R.2 PublicationsCorresponds to variant rs1139013dbSNPEnsembl.1
Natural variantiVAR_0697721729H → N in OHDOX. 1 PublicationCorresponds to variant rs387907362dbSNPEnsembl.1
Natural variantiVAR_0740181974Q → H Probable disease-associated mutation found in a family with X-linked intellectual disability. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0355201916Q → QAKI in isoform 2. 1 Publication1
Alternative sequenceiVSP_0355211916Missing in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117755 mRNA. Translation: AAD22033.1. Different initiation.
AL590764 Genomic DNA. No translation available.
D83783 mRNA. Translation: BAA12112.1.
AF071309 mRNA. Translation: AAC83163.1.
AF132033 Genomic DNA. Translation: AAD44162.1.
U80742 mRNA. Translation: AAB91440.1.
CCDSiCCDS43970.1. [Q93074-1]
RefSeqiNP_005111.2. NM_005120.2. [Q93074-1]
UniGeneiHs.409226.

Genome annotation databases

EnsembliENST00000374080; ENSP00000363193; ENSG00000184634. [Q93074-1]
ENST00000374102; ENSP00000363215; ENSG00000184634. [Q93074-3]
GeneIDi9968.
KEGGihsa:9968.
UCSCiuc004dyy.4. human. [Q93074-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117755 mRNA. Translation: AAD22033.1. Different initiation.
AL590764 Genomic DNA. No translation available.
D83783 mRNA. Translation: BAA12112.1.
AF071309 mRNA. Translation: AAC83163.1.
AF132033 Genomic DNA. Translation: AAD44162.1.
U80742 mRNA. Translation: AAB91440.1.
CCDSiCCDS43970.1. [Q93074-1]
RefSeqiNP_005111.2. NM_005120.2. [Q93074-1]
UniGeneiHs.409226.

3D structure databases

ProteinModelPortaliQ93074.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115293. 88 interactors.
DIPiDIP-31459N.
IntActiQ93074. 67 interactors.
STRINGi9606.ENSP00000363193.

PTM databases

iPTMnetiQ93074.
PhosphoSitePlusiQ93074.

Polymorphism and mutation databases

BioMutaiMED12.
DMDMi209572775.

Proteomic databases

EPDiQ93074.
MaxQBiQ93074.
PaxDbiQ93074.
PeptideAtlasiQ93074.
PRIDEiQ93074.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374080; ENSP00000363193; ENSG00000184634. [Q93074-1]
ENST00000374102; ENSP00000363215; ENSG00000184634. [Q93074-3]
GeneIDi9968.
KEGGihsa:9968.
UCSCiuc004dyy.4. human. [Q93074-1]

Organism-specific databases

CTDi9968.
DisGeNETi9968.
GeneCardsiMED12.
GeneReviewsiMED12.
HGNCiHGNC:11957. MED12.
HPAiHPA003184.
HPA003185.
MalaCardsiMED12.
MIMi300188. gene.
300895. phenotype.
305450. phenotype.
309520. phenotype.
neXtProtiNX_Q93074.
OpenTargetsiENSG00000184634.
Orphaneti293707. Blepharophimosis-intellectual disability syndrome, MKB type.
93932. FG syndrome type 1.
776. X-linked intellectual disability with marfanoid habitus.
777. X-linked non-syndromic intellectual disability.
PharmGKBiPA36645.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISJR. Eukaryota.
ENOG41119EY. LUCA.
GeneTreeiENSGT00440000037505.
HOGENOMiHOG000231423.
HOVERGENiHBG052447.
InParanoidiQ93074.
KOiK15162.
OMAiEMAIRQW.
OrthoDBiEOG091G00I6.
PhylomeDBiQ93074.
TreeFamiTF324178.

Enzyme and pathway databases

BioCyciZFISH:G66-32344-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-212436. Generic Transcription Pathway.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
SignaLinkiQ93074.
SIGNORiQ93074.

Miscellaneous databases

ChiTaRSiMED12. human.
GeneWikiiMED12.
GenomeRNAii9968.
PROiQ93074.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184634.
CleanExiHS_MED12.
ExpressionAtlasiQ93074. baseline and differential.
GenevisibleiQ93074. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR019035. Mediator_Med12.
IPR021989. Mediator_Med12_catenin-bd.
IPR021990. Mediator_Med12_LCEWAV.
[Graphical view]
PfamiPF09497. Med12. 1 hit.
PF12145. Med12-LCEWAV. 1 hit.
PF12144. Med12-PQL. 1 hit.
[Graphical view]
SMARTiSM01281. Med12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMED12_HUMAN
AccessioniPrimary (citable) accession number: Q93074
Secondary accession number(s): O15410
, O75557, Q9UHV6, Q9UND7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: November 30, 2016
This is version 168 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.