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Protein

Selenocysteine insertion sequence-binding protein 2-like

Gene

SECISBP2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Selenocysteine insertion sequence-binding protein 2-like
Short name:
SECIS-binding protein 2-like
Gene namesi
Name:SECISBP2L
Synonyms:KIAA0256
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:28997. SECISBP2L.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi721 – 7211G → R: Loss of binding to SELV and TXNRD1 SECIS elements. 1 Publication

Organism-specific databases

PharmGKBiPA164725649.

Polymorphism and mutation databases

BioMutaiSECISBP2L.
DMDMi59803102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11011101Selenocysteine insertion sequence-binding protein 2-likePRO_0000050739Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei276 – 2761PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ93073.
MaxQBiQ93073.
PaxDbiQ93073.
PeptideAtlasiQ93073.
PRIDEiQ93073.

PTM databases

iPTMnetiQ93073.
PhosphoSiteiQ93073.

Expressioni

Gene expression databases

BgeeiQ93073.
ExpressionAtlasiQ93073. baseline and differential.
GenevisibleiQ93073. HS.

Organism-specific databases

HPAiHPA039875.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DYNLL2Q96FJ23EBI-2805647,EBI-742371

Protein-protein interaction databases

BioGridi115077. 6 interactions.
IntActiQ93073. 4 interactions.
STRINGi9606.ENSP00000453854.

Structurei

3D structure databases

ProteinModelPortaliQ93073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IEN2. Eukaryota.
ENOG410Z16U. LUCA.
GeneTreeiENSGT00490000043356.
HOGENOMiHOG000231783.
InParanoidiQ93073.
OMAiKNPDTFM.
OrthoDBiEOG7RRF7R.
PhylomeDBiQ93073.
TreeFamiTF328821.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q93073-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRAPTEQNV KLSAEVEPFI PQKKSPDTFM IPMALPNDNG SVSGVEPTPI
60 70 80 90 100
PSYLITCYPF VQENQSNRQF PLYNNDIRWQ QPNPNPTGPY FAYPIISAQP
110 120 130 140 150
PVSTEYTYYQ LMPAPCAQVM GFYHPFPTPY SNTFQAANTV NAITTECTER
160 170 180 190 200
PSQLGQVFPL SSHRSRNSNR GSVVPKQQLL QQHIKSKRPL VKNVATQKET
210 220 230 240 250
NAAGPDSRSK IVLLVDASQQ TDFPSDIANK SLSETTATML WKSKGRRRRA
260 270 280 290 300
SHPTAESSSE QGASEADIDS DSGYCSPKHS NNQPAAGALR NPDSGTMNHV
310 320 330 340 350
ESSMCAGGVN WSNVTCQATQ KKPWMEKNQT FSRGGRQTEQ RNNSQVGFRC
360 370 380 390 400
RGHSTSSERR QNLQKRPDNK HLSSSQSHRS DPNSESLYFE DEDGFQELNE
410 420 430 440 450
NGNAKDENIQ QKLSSKVLDD LPENSPINIV QTPIPITTSV PKRAKSQKKK
460 470 480 490 500
ALAAALATAQ EYSEISMEQK KLQEALSKAA GKKNKTPVQL DLGDMLAALE
510 520 530 540 550
KQQQAMKARQ ITNTRPLSYT VVTAASFHTK DSTNRKPLTK SQPCLTSFNS
560 570 580 590 600
VDIASSKAKK GKEKEIAKLK RPTALKKVIL KEREEKKGRL TVDHNLLGSE
610 620 630 640 650
EPTEMHLDFI DDLPQEIVSQ EDTGLSMPSD TSLSPASQNS PYCMTPVSQG
660 670 680 690 700
SPASSGIGSP MASSTITKIH SKRFREYCNQ VLCKEIDECV TLLLQELVSF
710 720 730 740 750
QERIYQKDPV RAKARRRLVM GLREVTKHMK LNKIKCVIIS PNCEKIQSKG
760 770 780 790 800
GLDEALYNVI AMAREQEIPF VFALGRKALG RCVNKLVPVS VVGIFNYFGA
810 820 830 840 850
ESLFNKLVEL TEEARKAYKD MVAAMEQEQA EEALKNVKKV PHHMGHSRNP
860 870 880 890 900
SAASAISFCS VISEPISEVN EKEYETNWRN MVETSDGLEA SENEKEVSCK
910 920 930 940 950
HSTSEKPSKL PFDTPPIGKQ PSLVATGSTT SATSAGKSTA SDKEEVKPDD
960 970 980 990 1000
LEWASQQSTE TGSLDGSCRD LLNSSITSTT STLVPGMLEE EEDEDEEEEE
1010 1020 1030 1040 1050
DYTHEPISVE VQLNSRIESW VSETQRTMET LQLGKTLNGS EEDNVEQSGE
1060 1070 1080 1090 1100
EEAEAPEVLE PGMDSEAWTA DQQASPGQQK SSNCSSLNKE HSDSNYTTQT

T
Length:1,101
Mass (Da):121,776
Last modified:February 15, 2005 - v3
Checksum:iC946BC473619FF6D
GO
Isoform 2 (identifier: Q93073-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-390: Missing.

Note: No experimental confirmation available.
Show »
Length:1,056
Mass (Da):116,547
Checksum:iC22DAB889A120FE7
GO

Sequence cautioni

The sequence BAA13386.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti756 – 7561L → F in AAH33001 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei346 – 39045Missing in isoform 2. 1 PublicationVSP_016342Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87445 mRNA. Translation: BAA13386.3. Different initiation.
BC033001 mRNA. Translation: AAH33001.1.
CCDSiCCDS32234.1. [Q93073-2]
CCDS53942.1. [Q93073-1]
RefSeqiNP_001180418.1. NM_001193489.1. [Q93073-1]
NP_055516.2. NM_014701.3. [Q93073-2]
UniGeneiHs.9997.

Genome annotation databases

EnsembliENST00000261847; ENSP00000261847; ENSG00000138593. [Q93073-2]
ENST00000559471; ENSP00000453854; ENSG00000138593. [Q93073-1]
GeneIDi9728.
KEGGihsa:9728.
UCSCiuc001zxd.4. human. [Q93073-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87445 mRNA. Translation: BAA13386.3. Different initiation.
BC033001 mRNA. Translation: AAH33001.1.
CCDSiCCDS32234.1. [Q93073-2]
CCDS53942.1. [Q93073-1]
RefSeqiNP_001180418.1. NM_001193489.1. [Q93073-1]
NP_055516.2. NM_014701.3. [Q93073-2]
UniGeneiHs.9997.

3D structure databases

ProteinModelPortaliQ93073.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115077. 6 interactions.
IntActiQ93073. 4 interactions.
STRINGi9606.ENSP00000453854.

PTM databases

iPTMnetiQ93073.
PhosphoSiteiQ93073.

Polymorphism and mutation databases

BioMutaiSECISBP2L.
DMDMi59803102.

Proteomic databases

EPDiQ93073.
MaxQBiQ93073.
PaxDbiQ93073.
PeptideAtlasiQ93073.
PRIDEiQ93073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261847; ENSP00000261847; ENSG00000138593. [Q93073-2]
ENST00000559471; ENSP00000453854; ENSG00000138593. [Q93073-1]
GeneIDi9728.
KEGGihsa:9728.
UCSCiuc001zxd.4. human. [Q93073-1]

Organism-specific databases

CTDi9728.
GeneCardsiSECISBP2L.
H-InvDBHIX0012223.
HIX0172803.
HGNCiHGNC:28997. SECISBP2L.
HPAiHPA039875.
MIMi615756. gene.
neXtProtiNX_Q93073.
PharmGKBiPA164725649.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEN2. Eukaryota.
ENOG410Z16U. LUCA.
GeneTreeiENSGT00490000043356.
HOGENOMiHOG000231783.
InParanoidiQ93073.
OMAiKNPDTFM.
OrthoDBiEOG7RRF7R.
PhylomeDBiQ93073.
TreeFamiTF328821.

Miscellaneous databases

ChiTaRSiSECISBP2L. human.
GenomeRNAii9728.
PROiQ93073.
SOURCEiSearch...

Gene expression databases

BgeeiQ93073.
ExpressionAtlasiQ93073. baseline and differential.
GenevisibleiQ93073. HS.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Aortic endothelium.
  2. Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression."
    Donovan J., Copeland P.R.
    PLoS ONE 7:E35581-E35581(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: BINDING TO SECIS ELEMENTS, LACK OF FUNCTION IN SEC INCORPORATION, MUTAGENESIS OF GLY-721.

Entry informationi

Entry nameiSBP2L_HUMAN
AccessioniPrimary (citable) accession number: Q93073
Secondary accession number(s): Q8N767
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 15, 2005
Last modified: July 6, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.