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Q93070

- NAR4_HUMAN

UniProt

Q93070 - NAR4_HUMAN

Protein

Ecto-ADP-ribosyltransferase 4

Gene

ART4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (13 Aug 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei126 – 1261NADBy similarity
    Binding sitei206 – 2061NADBy similarity
    Binding sitei240 – 2401NADBy similarity
    Active sitei251 – 2511By similarity

    GO - Molecular functioni

    1. NAD(P)+-protein-arginine ADP-ribosyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. arginine metabolic process Source: UniProtKB
    2. protein ADP-ribosylation Source: UniProtKB

    Keywords - Molecular functioni

    Blood group antigen, Glycosyltransferase, Transferase

    Keywords - Ligandi

    NAD, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ecto-ADP-ribosyltransferase 4 (EC:2.4.2.31)
    Alternative name(s):
    ADP-ribosyltransferase C2 and C3 toxin-like 4
    Short name:
    ARTC4
    Dombrock blood group carrier molecule
    Mono(ADP-ribosyl)transferase 4
    NAD(P)(+)--arginine ADP-ribosyltransferase 4
    CD_antigen: CD297
    Gene namesi
    Name:ART4
    Synonyms:DO, DOK1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:726. ART4.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi110600. gene+phenotype.
    PharmGKBiPA142672580.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4646Sequence AnalysisAdd
    BLAST
    Chaini47 – 285239Ecto-ADP-ribosyltransferase 4PRO_0000019329Add
    BLAST
    Propeptidei286 – 31429Removed in mature formSequence AnalysisPRO_0000019330Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi69 ↔ 280By similarity
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi182 ↔ 231By similarity
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Lipidationi285 – 2851GPI-anchor amidated alanineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ93070.
    PRIDEiQ93070.

    PTM databases

    PhosphoSiteiQ93070.

    Expressioni

    Tissue specificityi

    Expressed in spleen and T-cells.

    Gene expression databases

    ArrayExpressiQ93070.
    BgeeiQ93070.
    CleanExiHS_ART4.
    HS_DOK1.
    GenevestigatoriQ93070.

    Organism-specific databases

    HPAiHPA040879.

    Interactioni

    Protein-protein interaction databases

    BioGridi106913. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93070.
    SMRiQ93070. Positions 55-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44842.
    HOGENOMiHOG000273888.
    HOVERGENiHBG004464.
    InParanoidiQ93070.
    KOiK06717.
    OrthoDBiEOG7D85WV.
    PhylomeDBiQ93070.
    TreeFamiTF335356.

    Family and domain databases

    InterProiIPR000768. ART.
    [Graphical view]
    PANTHERiPTHR10339. PTHR10339. 1 hit.
    PfamiPF01129. ART. 1 hit.
    [Graphical view]
    PRINTSiPR00970. RIBTRNSFRASE.
    PROSITEiPS01291. ART. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q93070-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPLINRCKK ILLPTTVPPA TMRIWLLGGL LPFLLLLSGL QRPTEGSEVA    50
    IKIDFDFAPG SFDDQYQGCS KQVMEKLTQG DYFTKDIEAQ KNYFRMWQKA 100
    HLAWLNQGKV LPQNMTTTHA VAILFYTLNS NVHSDFTRAM ASVARTPQQY 150
    ERSFHFKYLH YYLTSAIQLL RKDSIMENGT LCYEVHYRTK DVHFNAYTGA 200
    TIRFGQFLST SLLKEEAQEF GNQTLFTIFT CLGAPVQYFS LKKEVLIPPY 250
    ELFKVINMSY HPRGNWLQLR STGNLSTYNC QLLKASSKKC IPDPIAIASL 300
    SFLTSVIIFS KSRV 314
    Length:314
    Mass (Da):35,878
    Last modified:August 13, 2002 - v2
    Checksum:i174913890C9D158F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti48 – 481E → Q in CAA65095. (PubMed:9119374)Curated
    Sequence conflicti116 – 1161T → S in CAA65095. (PubMed:9119374)Curated

    Polymorphismi

    DO is responsible for the Dombrock blood group system. The molecular basis of the Do(a)/Do(b) blood group antigen is a single variation in position 265; Asn-265 corresponds to Do(a) and Asp-265 to Do(b). It is also responsible for the antigens Gregory [Gy(a)], Holley [Hy] and Joseph [Jo(a)].

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti108 – 1081G → V in Hy1 and Hy2. 1 Publication
    Corresponds to variant rs28362797 [ dbSNP | Ensembl ].
    VAR_013707
    Natural varianti117 – 1171T → I in Jo(a). 1 Publication
    Corresponds to variant rs28362798 [ dbSNP | Ensembl ].
    VAR_013708
    Natural varianti135 – 1351D → E.1 Publication
    Corresponds to variant rs28362799 [ dbSNP | Ensembl ].
    VAR_022266
    Natural varianti189 – 1891T → M.1 Publication
    Corresponds to variant rs28362800 [ dbSNP | Ensembl ].
    VAR_022267
    Natural varianti265 – 2651N → D in Do(b), Hy1 and Hy2. 1 Publication
    Corresponds to variant rs11276 [ dbSNP | Ensembl ].
    VAR_013709
    Natural varianti300 – 3001L → V in Hy1. 1 Publication
    Corresponds to variant rs3088190 [ dbSNP | Ensembl ].
    VAR_013710

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF290204 mRNA. Translation: AAG17845.1.
    AF382213, AF382211, AF382212 Genomic DNA. Translation: AAM21462.1.
    AF382216, AF382214, AF382215 Genomic DNA. Translation: AAM21464.1.
    AF382219, AF382217, AF382218 Genomic DNA. Translation: AAM21465.1.
    AF382222, AF382220, AF382221 Genomic DNA. Translation: AAM21466.1.
    AF382225, AF382223, AF382224 Genomic DNA. Translation: AAM21467.1.
    AY899803 Genomic DNA. Translation: AAW65375.1.
    BC074727 mRNA. Translation: AAH74727.1.
    X95826 Genomic DNA. Translation: CAA65095.1.
    AF340233 Genomic DNA. Translation: AAK11274.1.
    AF340234 Genomic DNA. Translation: AAK11275.1.
    CCDSiCCDS8668.1.
    RefSeqiNP_066549.2. NM_021071.2.
    UniGeneiHs.591158.
    Hs.655792.
    Hs.668803.

    Genome annotation databases

    EnsembliENST00000228936; ENSP00000228936; ENSG00000111339.
    GeneIDi420.
    KEGGihsa:420.
    UCSCiuc001rcl.1. human.

    Polymorphism databases

    DMDMi22261809.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    dbRBC/BGMUT

    Blood group antigen gene mutation database

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF290204 mRNA. Translation: AAG17845.1 .
    AF382213 , AF382211 , AF382212 Genomic DNA. Translation: AAM21462.1 .
    AF382216 , AF382214 , AF382215 Genomic DNA. Translation: AAM21464.1 .
    AF382219 , AF382217 , AF382218 Genomic DNA. Translation: AAM21465.1 .
    AF382222 , AF382220 , AF382221 Genomic DNA. Translation: AAM21466.1 .
    AF382225 , AF382223 , AF382224 Genomic DNA. Translation: AAM21467.1 .
    AY899803 Genomic DNA. Translation: AAW65375.1 .
    BC074727 mRNA. Translation: AAH74727.1 .
    X95826 Genomic DNA. Translation: CAA65095.1 .
    AF340233 Genomic DNA. Translation: AAK11274.1 .
    AF340234 Genomic DNA. Translation: AAK11275.1 .
    CCDSi CCDS8668.1.
    RefSeqi NP_066549.2. NM_021071.2.
    UniGenei Hs.591158.
    Hs.655792.
    Hs.668803.

    3D structure databases

    ProteinModelPortali Q93070.
    SMRi Q93070. Positions 55-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106913. 2 interactions.

    PTM databases

    PhosphoSitei Q93070.

    Polymorphism databases

    DMDMi 22261809.

    Proteomic databases

    PaxDbi Q93070.
    PRIDEi Q93070.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000228936 ; ENSP00000228936 ; ENSG00000111339 .
    GeneIDi 420.
    KEGGi hsa:420.
    UCSCi uc001rcl.1. human.

    Organism-specific databases

    CTDi 420.
    GeneCardsi GC12M014982.
    H-InvDB HIX0036719.
    HGNCi HGNC:726. ART4.
    HPAi HPA040879.
    MIMi 110600. gene+phenotype.
    neXtProti NX_Q93070.
    PharmGKBi PA142672580.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44842.
    HOGENOMi HOG000273888.
    HOVERGENi HBG004464.
    InParanoidi Q93070.
    KOi K06717.
    OrthoDBi EOG7D85WV.
    PhylomeDBi Q93070.
    TreeFami TF335356.

    Miscellaneous databases

    GeneWikii ART4.
    GenomeRNAii 420.
    NextBioi 1775.
    PROi Q93070.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q93070.
    Bgeei Q93070.
    CleanExi HS_ART4.
    HS_DOK1.
    Genevestigatori Q93070.

    Family and domain databases

    InterProi IPR000768. ART.
    [Graphical view ]
    PANTHERi PTHR10339. PTHR10339. 1 hit.
    Pfami PF01129. ART. 1 hit.
    [Graphical view ]
    PRINTSi PR00970. RIBTRNSFRASE.
    PROSITEi PS01291. ART. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the Dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family."
      Gubin A.N., Njoroge J.M., Wojda U., Pack S.D., Rios M., Reid M.E., Miller J.L.
      Blood 96:2621-2627(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT DO(B).
    2. "Insights into the Holley- and Joseph- phenotypes."
      Rios M., Hue-Roye K., Oyen R., Miller J., Reid M.E.
      Transfusion 42:52-58(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS DO(B); JO(A); HY1 AND HY2.
    3. SeattleSNPs variation discovery resource
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-108; ILE-117; GLU-135; MET-189; ASP-265 AND VAL-300.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins."
      Koch-Nolte F., Haag F., Braren R., Kuehl M., Hoovers J., Balasubramanian S., Bazan J.F., Thiele H.-G.
      Genomics 39:370-376(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 48-314.
    6. "Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors."
      Wu G.-G., Jin S.-Z., Deng Z.-H., Zhao T.-M.
      Vox Sang. 81:49-51(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 49-284, VARIANT DO(B).
    7. "Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
      Hottiger M.O., Hassa P.O., Luscher B., Schuler H., Koch-Nolte F.
      Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiNAR4_HUMAN
    AccessioniPrimary (citable) accession number: Q93070
    Secondary accession number(s): Q9BZ50, Q9BZ51, Q9HB06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: August 13, 2002
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Blood group antigen proteins
      Nomenclature of blood group antigens and list of entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3