RNA-binding protein with multiple splicing

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Reviewed, UniProtKB/Swiss-Prot Q93062 (RBPMS_HUMAN)

Last modified July 7, 2009. Version 86. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
RNA-binding protein with multiple splicing
Short name=RBP-MS

Gene names

Name:

RBPMS

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	May bind RNA.
Tissue specificity	Ubiquitously expressed, at various levels depending on the isoform and the tissue.
Sequence similarities	Contains 1 RRM (RNA recognition motif) domain.

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Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	RNA processing Ref.1 Traceable author statement. Source: ProtInc
Molecular function	RNA binding Ref.1 Traceable author statement. Source: ProtInc nucleotide binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
ATXN1	P54253	1	EBI-740322,EBI-930964
QKI	Q96PU8	1	EBI-740322,EBI-945792
SMUG1	Q53HV7	1	EBI-740322,EBI-749970

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Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select] Note: Additional isoforms seem to exist.

Isoform A (identifier: Q93062-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform B (identifier: Q93062-2) The sequence of this isoform differs from the canonical sequence as follows: 177-196: MRWLPPSEATSQGWKSRQFC → LCEGQTVRRSHPLSAPSPDSASLAWFPV

Isoform C (identifier: Q93062-3) The sequence of this isoform differs from the canonical sequence as follows: 177-196: MRWLPPSEATSQGWKSRQFC → CFSPEAKPNTPVFCPLLQQIRFVSGNVFVTYQPTADQQRELPC

Isoform D (identifier: Q93062-4) The sequence of this isoform differs from the canonical sequence as follows: 133-196: YELTVPALYPSSPEVWAPYPLYPAELAPALPPPAFTYPASLHAQMRWLPPSEATSQGWKSRQFC → LGGANEHGERQ

Isoform E (identifier: Q93062-5) The sequence of this isoform differs from the canonical sequence as follows: 133-176: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 196

196

RNA-binding protein with multiple splicing

PRO_0000081793

Regions

Domain

24 – 101

RRM

Amino acid modifications

Modified residue

113

Phosphothreonine Ref.4

Modified residue

118

Phosphothreonine Ref.4

Natural variations

Alternative sequence

133 – 196

YELTV…SRQFC → LGGANEHGERQ in isoform D.

VSP_005815

Alternative sequence

133 – 176

Missing in isoform E.

VSP_005816

Alternative sequence

177 – 196

MRWLP…SRQFC → LCEGQTVRRSHPLSAPSPDS ASLAWFPV in isoform B.

VSP_005813

Alternative sequence

177 – 196

MRWLP…SRQFC → CFSPEAKPNTPVFCPLLQQI RFVSGNVFVTYQPTADQQRE LPC in isoform C.

VSP_005814

Secondary structure

196

Helix Strand Turn

Details...

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Sequences

Sequence		Length	Mass (Da)
Isoform A [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 05DD964E62F8F88C Show »	FASTA	196	21,802
10 20 30 40 50 60 MNNGGKAEKE NTPSEANLQE EEVRTLFVSG LPLDIKPREL YLLFRPFKGY EGSLIKLTSK 70 80 90 100 110 120 QPVGFVSFDS RSEAEAAKNA LNGIRFDPEI PQTLRLEFAK ANTKMAKNKL VGTPNPSTPL 130 140 150 160 170 180 PNTVPQFIAR EPYELTVPAL YPSSPEVWAP YPLYPAELAP ALPPPAFTYP ASLHAQMRWL 190 PPSEATSQGW KSRQFC « Hide
Isoform B. Checksum: 60382A7EC1D4672F Show »	FASTA	204	22,416
10 20 30 40 50 60 MNNGGKAEKE NTPSEANLQE EEVRTLFVSG LPLDIKPREL YLLFRPFKGY EGSLIKLTSK 70 80 90 100 110 120 QPVGFVSFDS RSEAEAAKNA LNGIRFDPEI PQTLRLEFAK ANTKMAKNKL VGTPNPSTPL 130 140 150 160 170 180 PNTVPQFIAR EPYELTVPAL YPSSPEVWAP YPLYPAELAP ALPPPAFTYP ASLHAQLCEG 190 200 QTVRRSHPLS APSPDSASLA WFPV « Hide
Isoform C. Checksum: 700E9B9FA7682FAD Show »	FASTA	219	24,277
10 20 30 40 50 60 MNNGGKAEKE NTPSEANLQE EEVRTLFVSG LPLDIKPREL YLLFRPFKGY EGSLIKLTSK 70 80 90 100 110 120 QPVGFVSFDS RSEAEAAKNA LNGIRFDPEI PQTLRLEFAK ANTKMAKNKL VGTPNPSTPL 130 140 150 160 170 180 PNTVPQFIAR EPYELTVPAL YPSSPEVWAP YPLYPAELAP ALPPPAFTYP ASLHAQCFSP 190 200 210 EAKPNTPVFC PLLQQIRFVS GNVFVTYQPT ADQQRELPC « Hide
Isoform D. Checksum: 86DDB14345784716 Show »	FASTA	143	15,794
10 20 30 40 50 60 MNNGGKAEKE NTPSEANLQE EEVRTLFVSG LPLDIKPREL YLLFRPFKGY EGSLIKLTSK 70 80 90 100 110 120 QPVGFVSFDS RSEAEAAKNA LNGIRFDPEI PQTLRLEFAK ANTKMAKNKL VGTPNPSTPL 130 140 PNTVPQFIAR EPLGGANEHG ERQ « Hide
Isoform E. Checksum: B62DC25BB6EFB888 Show »	FASTA	152	17,022
10 20 30 40 50 60 MNNGGKAEKE NTPSEANLQE EEVRTLFVSG LPLDIKPREL YLLFRPFKGY EGSLIKLTSK 70 80 90 100 110 120 QPVGFVSFDS RSEAEAAKNA LNGIRFDPEI PQTLRLEFAK ANTKMAKNKL VGTPNPSTPL 130 140 150 PNTVPQFIAR EPMRWLPPSE ATSQGWKSRQ FC « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs." Shimamoto A., Kitao S., Ichikawa K., Suzuki N., Yamabe Y., Imamura O., Tokutake Y., Satoh M., Matsumoto T., Kuromitsu J., Kataoka H., Sugawara K., Sugawara M., Sugimoto M., Goto M., Furuichi Y. Proc. Natl. Acad. Sci. U.S.A. 93:10913-10917(1996) [PubMed: 8855282] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D AND E). Tissue: Lip.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C). Tissue: Placenta.
[3]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004) [PubMed: 14759258] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-113 AND THR-118, MASS SPECTROMETRY.

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Cross-references

Sequence databases

D84110 mRNA. Translation: BAA12228.1.
D84107 mRNA. Translation: BAA12225.1.
D84108 mRNA. Translation: BAA12226.1.
D84109 mRNA. Translation: BAA12227.1.
D84111 mRNA. Translation: BAA12229.1.
BC003608 mRNA. Translation: AAH03608.1.

IPI

IPI00004045.
IPI00101800.
IPI00216935.
IPI00216936.
IPI00414709.

PIR

JC6127.

RefSeq

NP_001008710.1.
NP_001008711.1.
NP_001008712.1.
NP_006858.1.

UniGene

Hs.334587

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BNY	model	-	A	15-111	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q93062. 49 interactions.

PTM databases

PhosphoSite

Q93062.

Genome annotation databases

Ensembl

ENSG00000157110. Homo sapiens. [Contig view]

GeneID

11030.

KEGG

hsa:11030.

UCSC

uc003xib.1. human.
uc003xic.1. human.
uc003xid.1. human.

Organism-specific databases

GeneCards

GC08P030361.

H-InvDB

HIX0007433.

HGNC

HGNC:19097. RBPMS.

MIM

601558. gene.

PharmGKB

PA134985584.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q93062.

OMA

Q93062. WIPPSEA.

Gene expression databases

ArrayExpress

Q93062.

Bgee

Q93062.

CleanEx

HS_RBPMS.

GermOnline

ENSG00000157110. Homo sapiens.

Family and domain databases

InterPro

IPR012677. a_b_plait_nuc_bd.
IPR000504. RRM_RNP1.
[Graphical view]

Gene3D

G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit.

Pfam

PF00076. RRM_1. 1 hit.
[Graphical view]

SMART

SM00360. RRM. 1 hit.
[Graphical view]

PROSITE

PS50102. RRM. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

41912.

SOURCE

Search...

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Entry information

Entry name

RBPMS_HUMAN

Accession

Primary (citable) accession number: Q93062
Secondary accession number(s): Q92516

Q96J26

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	February 1, 1997
Last modified:	July 7, 2009
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents