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Protein

Lipoma-preferred partner

Gene

LPP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processCell adhesion
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ93052

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoma-preferred partner
Alternative name(s):
LIM domain-containing preferred translocation partner in lipoma
Gene namesi
Name:LPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000145012.12
HGNCiHGNC:6679 LPP
MIMi600700 gene
neXtProtiNX_Q93052

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving LPP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with HMGA2 is shown in lipomas.
A chromosomal aberration involving LPP is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with HMGA2 is detected in pulmonary chondroid hamartomas.
A chromosomal aberration involving LPP is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with HMGA2 is also shown in one parosteal lipoma.
A chromosomal aberration involving LPP is associated with acute monoblastic leukemia. Translocation t(3;11)(q28;q23) with KMT2A/MLL1 is associated with acute monoblastic leukemia.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi610T → A: Abolishes binding to SCRIB. 1 Publication1
Mutagenesisi612L → A: Abolishes binding to SCRIB. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei371 – 372Breakpoint for translocation to form HMGA2-LPP2
Sitei470 – 471Breakpoint for translocation to form HMGA2-LPP and KMT2A/MLL1-LPP2

Organism-specific databases

DisGeNETi4026
MalaCardsiLPP
OpenTargetsiENSG00000145012
PharmGKBiPA30440

Polymorphism and mutation databases

BioMutaiLPP
DMDMi74751663

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758321 – 612Lipoma-preferred partnerAdd BLAST612

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108N6-acetyllysineBy similarity1
Modified residuei116PhosphoserineBy similarity1
Modified residuei151PhosphoserineBy similarity1
Modified residuei244PhosphotyrosineBy similarity1
Modified residuei301PhosphotyrosineBy similarity1
Cross-linki327Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei333PhosphothreonineCombined sources1
Modified residuei375PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ93052
MaxQBiQ93052
PaxDbiQ93052
PeptideAtlasiQ93052
PRIDEiQ93052
ProteomicsDBi75690

PTM databases

iPTMnetiQ93052
PhosphoSitePlusiQ93052

Expressioni

Tissue specificityi

Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes.2 Publications

Gene expression databases

BgeeiENSG00000145012
CleanExiHS_LPP
ExpressionAtlasiQ93052 baseline and differential
GenevisibleiQ93052 HS

Organism-specific databases

HPAiHPA011133
HPA017342

Interactioni

Subunit structurei

Interacts with VASP, with PDZ domains of SCRIB and with ACTN1/alpha-actinin.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LASP1Q148473EBI-718388,EBI-742828

Protein-protein interaction databases

BioGridi110208, 61 interactors
CORUMiQ93052
IntActiQ93052, 13 interactors
MINTiQ93052
STRINGi9606.ENSP00000318089

Structurei

3D structure databases

ProteinModelPortaliQ93052
SMRiQ93052
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini414 – 473LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini474 – 534LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini535 – 603LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 370Pro-richAdd BLAST330

Sequence similaritiesi

Belongs to the zyxin/ajuba family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1701 Eukaryota
ENOG410Y3GP LUCA
GeneTreeiENSGT00760000119039
HOGENOMiHOG000220910
HOVERGENiHBG093602
InParanoidiQ93052
KOiK16676
OMAiEQCSVCS
OrthoDBiEOG091G085F
PhylomeDBiQ93052
TreeFamiTF320310

Family and domain databases

InterProiView protein in InterPro
IPR028771 LPP
IPR001781 Znf_LIM
PANTHERiPTHR24207:SF0 PTHR24207:SF0, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 3 hits
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q93052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHPSWLPPK STGEPLGHVP ARMETTHSFG NPSISVSTQQ PPKKFAPVVA
60 70 80 90 100
PKPKYNPYKQ PGGEGDFLPP PPPPLDDSSA LPSISGNFPP PPPLDEEAFK
110 120 130 140 150
VQGNPGGKTL EERRSSLDAE IDSLTSILAD LECSSPYKPR PPQSSTGSTA
160 170 180 190 200
SPPVSTPVTG HKRMVIPNQP PLTATKKSTL KPQPAPQAGP IPVAPIGTLK
210 220 230 240 250
PQPQPVPASY TTASTSSRPT FNVQVKSAQP SPHYMAAPSS GQIYGSGPQG
260 270 280 290 300
YNTQPVPVSG QCPPPSTRGG MDYAYIPPPG LQPEPGYGYA PNQGRYYEGY
310 320 330 340 350
YAAGPGYGGR NDSDPTYGQQ GHPNTWKREP GYTPPGAGNQ NPPGMYPVTG
360 370 380 390 400
PKKTYITDPV SAPCAPPLQP KGGHSGQLGP SSVAPSFRPE DELEHLTKKM
410 420 430 440 450
LYDMENPPAD EYFGRCARCG ENVVGEGTGC TAMDQVFHVD CFTCIICNNK
460 470 480 490 500
LRGQPFYAVE KKAYCEPCYI NTLEQCNVCS KPIMERILRA TGKAYHPHCF
510 520 530 540 550
TCVMCHRSLD GIPFTVDAGG LIHCIEDFHK KFAPRCSVCK EPIMPAPGQE
560 570 580 590 600
ETVRIVALDR DFHVHCYRCE DCGGLLSEGD NQGCYPLDGH ILCKTCNSAR
610
IRVLTAKAST DL
Length:612
Mass (Da):65,746
Last modified:February 1, 1997 - v1
Checksum:i439CE0101FDE4DDD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050150146T → A. Corresponds to variant dbSNP:rs35417432Ensembl.1
Natural variantiVAR_050151259S → P. Corresponds to variant dbSNP:rs35940579Ensembl.1
Natural variantiVAR_034070346Y → H. Corresponds to variant dbSNP:rs7645635Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49957 mRNA Translation: AAC50738.1
U49968
, U49960, U49961, U49962, U49963, U49964, U49965, U49966, U49967 Genomic DNA Translation: AAC50739.1
CR457074 mRNA Translation: CAG33355.1
CH471052 Genomic DNA Translation: EAW78127.1
CH471052 Genomic DNA Translation: EAW78128.1
CH471052 Genomic DNA Translation: EAW78133.1
BC130584 mRNA Translation: AAI30585.1
AF393503 mRNA Translation: AAM73685.1 Different termination.
CCDSiCCDS3291.1
RefSeqiNP_001161143.1, NM_001167671.2
NP_005569.1, NM_005578.4
XP_005247503.1, XM_005247446.4
XP_005247507.1, XM_005247450.4
XP_005247508.1, XM_005247451.4
XP_005247510.1, XM_005247453.2
XP_011511122.1, XM_011512820.2
XP_011511129.1, XM_011512827.2
XP_011511130.1, XM_011512828.2
XP_011511133.1, XM_011512831.2
XP_011511135.1, XM_011512833.2
XP_011511136.1, XM_011512834.2
XP_016861866.1, XM_017006377.1
XP_016861867.1, XM_017006378.1
XP_016861868.1, XM_017006379.1
XP_016861869.1, XM_017006380.1
UniGeneiHs.720220

Genome annotation databases

EnsembliENST00000617246; ENSP00000478901; ENSG00000145012
ENST00000640853; ENSP00000491657; ENSG00000145012
GeneIDi4026
KEGGihsa:4026
UCSCiuc032sne.1 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLPP_HUMAN
AccessioniPrimary (citable) accession number: Q93052
Secondary accession number(s): A1L4L6, D3DNV6, Q8NFX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 1, 1997
Last modified: June 20, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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