SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q93050

- VPP1_HUMAN

UniProt

Q93050 - VPP1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
V-type proton ATPase 116 kDa subunit a isoform 1
Gene
ATP6V0A1, ATP6N1, ATP6N1A, VPP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle By similarity.

GO - Molecular functioni

  1. ATPase binding Source: UniProtKB
  2. hydrogen ion transmembrane transporter activity Source: InterPro
  3. protein binding Source: HGNC

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. cellular iron ion homeostasis Source: Reactome
  3. insulin receptor signaling pathway Source: Reactome
  4. interaction with host Source: Reactome
  5. phagosome maturation Source: Reactome
  6. transferrin transport Source: Reactome
  7. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000033627-MONOMER.
ReactomeiREACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Protein family/group databases

TCDBi3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase 116 kDa subunit a isoform 1
Short name:
V-ATPase 116 kDa isoform a1
Alternative name(s):
Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit
Vacuolar adenosine triphosphatase subunit Ac116
Vacuolar proton pump subunit 1
Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
Gene namesi
Synonyms:ATP6N1, ATP6N1A, VPP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:865. ATP6V0A1.

Subcellular locationi

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome
Note: Coated vesicle. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 388388Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei389 – 40719Helical; Reviewed prediction
Add
BLAST
Topological domaini408 – 4092Vacuolar Reviewed prediction
Transmembranei410 – 42617Helical; Reviewed prediction
Add
BLAST
Topological domaini427 – 44115Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei442 – 47130Helical; Reviewed prediction
Add
BLAST
Topological domaini472 – 53463Vacuolar Reviewed prediction
Add
BLAST
Transmembranei535 – 55420Helical; Reviewed prediction
Add
BLAST
Topological domaini555 – 57218Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei573 – 59321Helical; Reviewed prediction
Add
BLAST
Topological domaini594 – 63845Vacuolar Reviewed prediction
Add
BLAST
Transmembranei639 – 65820Helical; Reviewed prediction
Add
BLAST
Topological domaini659 – 72466Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei725 – 74925Helical; Reviewed prediction
Add
BLAST
Topological domaini750 – 77021Vacuolar Reviewed prediction
Add
BLAST
Transmembranei771 – 80939Helical; Reviewed prediction
Add
BLAST
Topological domaini810 – 83728Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: HPA
  2. cytoplasm Source: HPA
  3. endosome membrane Source: Reactome
  4. extracellular vesicular exosome Source: UniProt
  5. integral component of membrane Source: UniProtKB-KW
  6. intracellular membrane-bounded organelle Source: HPA
  7. melanosome Source: UniProtKB-SubCell
  8. nucleus Source: HPA
  9. phagocytic vesicle membrane Source: Reactome
  10. plasma membrane Source: UniProtKB
  11. vacuolar proton-transporting V-type ATPase, V0 domain Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25146.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 837837V-type proton ATPase 116 kDa subunit a isoform 1
PRO_0000119211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei364 – 3641Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ93050.
PaxDbiQ93050.
PRIDEiQ93050.

PTM databases

PhosphoSiteiQ93050.

Expressioni

Gene expression databases

ArrayExpressiQ93050.
BgeeiQ93050.
CleanExiHS_ATP6V0A1.
GenevestigatoriQ93050.

Organism-specific databases

HPAiHPA022144.

Interactioni

Subunit structurei

The V-ATPase is a heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits a, d, c, c', and c''.

Protein-protein interaction databases

BioGridi107018. 22 interactions.
IntActiQ93050. 7 interactions.
MINTiMINT-3049850.
STRINGi9606.ENSP00000264649.

Structurei

3D structure databases

ProteinModelPortaliQ93050.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1269.
HOGENOMiHOG000037059.
HOVERGENiHBG014606.
KOiK02154.
OMAiVIPRERM.
OrthoDBiEOG74FF04.
PhylomeDBiQ93050.
TreeFamiTF300346.

Family and domain databases

InterProiIPR002490. V-ATPase_116kDa_su.
IPR026028. V-type_ATPase_116kDa_su_euka.
[Graphical view]
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiPF01496. V_ATPase_I. 1 hit.
[Graphical view]
PIRSFiPIRSF001293. ATP6V0A1. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q93050-2) [UniParc]FASTAAdd to Basket

Also known as: I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK    50
FVNEVRRCEE MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEAN 100
FEKIENELKE INTNQEALKR NFLELTELKF ILRKTQQFFD EMADPDLLEE 150
SSSLLEPSEM GRGTPLRLGF VAGVINRERI PTFERMLWRV CRGNVFLRQA 200
EIENPLEDPV TGDYVHKSVF IIFFQGDQLK NRVKKICEGF RASLYPCPET 250
PQERKEMASG VNTRIDDLQM VLNQTEDHRQ RVLQAAAKNI RVWFIKVRKM 300
KAIYHTLNLC NIDVTQKCLI AEVWCPVTDL DSIQFALRRG TEHSGSTVPS 350
ILNRMQTNQT PPTYNKTNKF TYGFQNIVDA YGIGTYREIN PAPYTIITFP 400
FLFAVMFGDF GHGILMTLFA VWMVLRESRI LSQKNENEMF STVFSGRYII 450
LLMGVFSMYT GLIYNDCFSK SLNIFGSSWS VRPMFTYNWT EETLRGNPVL 500
QLNPALPGVF GGPYPFGIDP IWNIATNKLT FLNSFKMKMS VILGIIHMLF 550
GVSLSLFNHI YFKKPLNIYF GFIPEIIFMT SLFGYLVILI FYKWTAYDAH 600
TSENAPSLLI HFINMFLFSY PESGYSMLYS GQKGIQCFLV VVALLCVPWM 650
LLFKPLVLRR QYLRRKHLGT LNFGGIRVGN GPTEEDAEII QHDQLSTHSE 700
DADEPSEDEV FDFGDTMVHQ AIHTIEYCLG CISNTASYLR LWALSLAHAQ 750
LSEVLWTMVI HIGLSVKSLA GGLVLFFFFT AFATLTVAIL LIMEGLSAFL 800
HALRLHWVEF QNKFYSGTGF KFLPFSFEHI REGKFEE 837
Length:837
Mass (Da):96,413
Last modified:February 15, 2005 - v3
Checksum:i80E4842CF6ADEE44
GO
Isoform 2 (identifier: Q93050-1) [UniParc]FASTAAdd to Basket

Also known as: II

The sequence of this isoform differs from the canonical sequence as follows:
     705-710: Missing.

Show »
Length:831
Mass (Da):95,756
Checksum:iB16170B568A3D586
GO
Isoform 3 (identifier: Q93050-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-141: E → EAELHHQQ
     705-710: Missing.

Note: No experimental confirmation available.

Show »
Length:838
Mass (Da):96,600
Checksum:iBE9A648B592B7C67
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei141 – 1411E → EAELHHQQ in isoform 3.
VSP_043532
Alternative sequencei705 – 7106Missing in isoform 2 and isoform 3.
VSP_012814

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti750 – 7512QL → HV in CAA96077. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71460 mRNA. Translation: CAA96077.1.
AK295682 mRNA. Translation: BAH12153.1.
AK316305 mRNA. Translation: BAH14676.1.
AC067852 Genomic DNA. No translation available.
AC107993 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60830.1.
BC032398 mRNA. Translation: AAH32398.1.
AL137683 mRNA. Translation: CAB70874.1.
CCDSiCCDS11426.1. [Q93050-1]
CCDS45683.1. [Q93050-3]
CCDS45684.1. [Q93050-2]
PIRiT46449.
RefSeqiNP_001123492.1. NM_001130020.1. [Q93050-3]
NP_001123493.1. NM_001130021.1. [Q93050-2]
NP_005168.2. NM_005177.3. [Q93050-1]
UniGeneiHs.463074.

Genome annotation databases

EnsembliENST00000264649; ENSP00000264649; ENSG00000033627. [Q93050-3]
ENST00000343619; ENSP00000342951; ENSG00000033627. [Q93050-2]
ENST00000393829; ENSP00000377415; ENSG00000033627. [Q93050-1]
GeneIDi535.
KEGGihsa:535.
UCSCiuc002hzq.3. human. [Q93050-1]
uc002hzr.3. human. [Q93050-2]
uc002hzs.3. human. [Q93050-3]

Polymorphism databases

DMDMi59803038.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71460 mRNA. Translation: CAA96077.1 .
AK295682 mRNA. Translation: BAH12153.1 .
AK316305 mRNA. Translation: BAH14676.1 .
AC067852 Genomic DNA. No translation available.
AC107993 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60830.1 .
BC032398 mRNA. Translation: AAH32398.1 .
AL137683 mRNA. Translation: CAB70874.1 .
CCDSi CCDS11426.1. [Q93050-1 ]
CCDS45683.1. [Q93050-3 ]
CCDS45684.1. [Q93050-2 ]
PIRi T46449.
RefSeqi NP_001123492.1. NM_001130020.1. [Q93050-3 ]
NP_001123493.1. NM_001130021.1. [Q93050-2 ]
NP_005168.2. NM_005177.3. [Q93050-1 ]
UniGenei Hs.463074.

3D structure databases

ProteinModelPortali Q93050.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107018. 22 interactions.
IntActi Q93050. 7 interactions.
MINTi MINT-3049850.
STRINGi 9606.ENSP00000264649.

Protein family/group databases

TCDBi 3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSitei Q93050.

Polymorphism databases

DMDMi 59803038.

Proteomic databases

MaxQBi Q93050.
PaxDbi Q93050.
PRIDEi Q93050.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264649 ; ENSP00000264649 ; ENSG00000033627 . [Q93050-3 ]
ENST00000343619 ; ENSP00000342951 ; ENSG00000033627 . [Q93050-2 ]
ENST00000393829 ; ENSP00000377415 ; ENSG00000033627 . [Q93050-1 ]
GeneIDi 535.
KEGGi hsa:535.
UCSCi uc002hzq.3. human. [Q93050-1 ]
uc002hzr.3. human. [Q93050-2 ]
uc002hzs.3. human. [Q93050-3 ]

Organism-specific databases

CTDi 535.
GeneCardsi GC17P040610.
H-InvDB HIX0013842.
HGNCi HGNC:865. ATP6V0A1.
HPAi HPA022144.
MIMi 192130. gene.
neXtProti NX_Q93050.
PharmGKBi PA25146.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1269.
HOGENOMi HOG000037059.
HOVERGENi HBG014606.
KOi K02154.
OMAi VIPRERM.
OrthoDBi EOG74FF04.
PhylomeDBi Q93050.
TreeFami TF300346.

Enzyme and pathway databases

BioCyci MetaCyc:ENSG00000033627-MONOMER.
Reactomei REACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Miscellaneous databases

ChiTaRSi ATP6V0A1. human.
GeneWikii ATPase,_H%2B_transporting,_lysosomal_V0_subunit_a1.
GenomeRNAii 535.
NextBioi 2223.
PROi Q93050.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q93050.
Bgeei Q93050.
CleanExi HS_ATP6V0A1.
Genevestigatori Q93050.

Family and domain databases

InterProi IPR002490. V-ATPase_116kDa_su.
IPR026028. V-type_ATPase_116kDa_su_euka.
[Graphical view ]
PANTHERi PTHR11629. PTHR11629. 1 hit.
Pfami PF01496. V_ATPase_I. 1 hit.
[Graphical view ]
PIRSFi PIRSF001293. ATP6V0A1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and alternative splicing in human 115 kDa subunit of vacuolar-type H(+)-ATPase."
    Fehr C.N., Gillies R.J., Wang H.-Y., Ullrich A.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Pancreas.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Hippocampus and Placenta.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 675-837 (ISOFORM 2).
    Tissue: Testis.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.
  8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.

Entry informationi

Entry nameiVPP1_HUMAN
AccessioniPrimary (citable) accession number: Q93050
Secondary accession number(s): B7Z3B7, Q8N5G7, Q9NSX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 15, 2005
Last modified: September 3, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi