Q93045 (STMN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Stathmin-2

Alternative name(s):
Superior cervical ganglion-10 protein
Short name=Protein SCG10

Gene names

Name:	STMN2
Synonyms:	SCG10, SCGN10

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone By similarity.
Subunit structure	Interacts with MAPK8 By similarity. Interacts with ITM2C. Ref.10
Subcellular location	Cytoplasm By similarity. Cytoplasm › perinuclear region By similarity. Cell projection › growth cone. Membrane; Peripheral membrane protein; Cytoplasmic side Potential. Cell projection › axon. Golgi apparatus. Endosome By similarity. Note: Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms By similarity. Ref.13
Tissue specificity	Neuron specific.
Post-translational modification	Sumoylated. Ref.9 Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex By similarity. Ref.11 N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.
Sequence similarities	Belongs to the stathmin family.

Ontologies

Keywords
Cellular component	Cell projection Cytoplasm Endosome Golgi apparatus Membrane
Domain	Coiled coil
PTM	Lipoprotein Palmitate Phosphoprotein Ubl conjugation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro negative regulation of microtubule depolymerization Inferred from direct assay Ref.10. Source: UniProtKB negative regulation of microtubule polymerization Inferred from direct assay Ref.10. Source: UniProtKB negative regulation of neuron projection development Inferred from direct assay Ref.10. Source: UniProtKB neuron differentiation Non-traceable author statement. Source: UniProtKB positive regulation of microtubule depolymerization Inferred from direct assay Ref.10. Source: UniProtKB positive regulation of neuron projection development Inferred from direct assay Ref.10. Source: UniProtKB
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell axon Inferred from electronic annotation. Source: UniProtKB-SubCell endosome Inferred from electronic annotation. Source: UniProtKB-SubCell growth cone Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell membrane fraction Non-traceable author statement. Source: UniProtKB perinuclear region of cytoplasm Inferred from direct assay Ref.10. Source: UniProtKB soluble fraction Non-traceable author statement. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction Ref.10. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TEX11	Q8IYF3	2	EBI-714194,EBI-742397

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 179	179	Stathmin-2		PRO_0000182396
Regions
	Region	1 – 26	26	Membrane attachment Potential
	Region	39 – 96	58	Regulatory/phosphorylation domain Potential
	Coiled coil	75 – 179	105	Potential
Amino acid modifications
	Modified residue	16	1	Phosphoserine Potential
	Modified residue	50	1	Phosphoserine Potential
	Modified residue	62	1	Phosphoserine By similarity
	Modified residue	73	1	Phosphoserine By similarity
	Modified residue	80	1	Phosphoserine Ref.11
	Modified residue	97	1	Phosphoserine Potential
	Lipidation	22	1	S-palmitoyl cysteine Ref.13
	Lipidation	24	1	S-palmitoyl cysteine Ref.13
Experimental info
	Sequence conflict	92	1	E → G in AAB36428. Ref.1
	Sequence conflict	122	1	E → G in BAA23326. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q93045 [UniParc]. Last modified August 31, 2004. Version 3. Checksum: F9A258A1B57E620D	FASTA	179	20,828
	10 20 30 40 50 60 MAKTAMAYKE KMKELSMLSL ICSCFYPEPR NINIYTYDDM EVKQINKRAS GQAFELILKP 70 80 90 100 110 120 PSPISEAPRT LASPKKKDLS LEEIQKKLEA AEERRKSQEA QVLKQLAEKR EHEREVLQKA 130 140 150 160 170 LEENNNFSKM AEEKLILKME QIKENREANL AAIIERLQEK ERHAAEVRRN KELQVELSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SCG10, a neuron-specific growth-associated protein in Alzheimer's disease." Okazaki T., Wang H., Masliah E., Cao M., Johnson S.A., Sundsmo M., Saitoh T., Mori N. Neurobiol. Aging 16:883-894(1995) [PubMed: 8622778] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning of a human homologue of chicken silencer element (SCG10) gene." Fujiwara T., Kawai A., Shimizu F., Shinomiya K., Hirano H., Okuno S., Ozaki K., Katagiri T., Takeda S., Kuga Y., Shimada Y., Nagata M., Takaichi A., Watanabe T., Horie M., Nakamura Y., Takahashi E., Hirai Y. Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[8]	Lubec G., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 12-43; 48-69; 78-86; 147-156 AND 172-179, MASS SPECTROMETRY. Tissue: Fetal brain cortex.
[9]	"Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates." Gocke C.B., Yu H., Kang J. J. Biol. Chem. 280:5004-5012(2005) [PubMed: 15561718] [Abstract] Cited for: SUMOYLATION.
[10]	"BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells." Gong Y., Wu J., Qiang H., Liu B., Chi Z., Chen T., Yin B., Peng X., Yuan J. BMB Rep. 41:287-293(2008) [PubMed: 18452648] [Abstract] Cited for: INTERACTION WITH ITM2C.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases." Levy A.D., Devignot V., Fukata Y., Fukata M., Sobel A., Chauvin S. Mol. Biol. Cell 22:1930-1942(2011) [PubMed: 21471001] [Abstract] Cited for: PALMITOYLATION AT CYS-22 AND CYS-24 BY ZDHHC3; ZDHHC7 AND ZDHHC15, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S82024 mRNA. Translation: AAB36428.1. D50375 mRNA. Translation: BAA23326.1. BT020034 mRNA. Translation: AAV38837.1. CR456833 mRNA. Translation: CAG33114.1. AK292737 mRNA. Translation: BAF85426.1. CH471068 Genomic DNA. Translation: EAW87065.1. BC006302 mRNA. Translation: AAH06302.1.
IPI	IPI00218667.
RefSeq	NP_008960.2. NM_007029.3.
UniGene	Hs.521651.
3D structure databases
ProteinModelPortal	Q93045.
SMR	Q93045. Positions 39-174.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q93045. 3 interactions.
MINT	MINT-242849.
STRING	Q93045.
PTM databases
PhosphoSite	Q93045.
Polymorphism databases
DMDM	51704330.
Proteomic databases
PRIDE	Q93045.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000220876; ENSP00000220876; ENSG00000104435.
GeneID	11075.
KEGG	hsa:11075.
UCSC	uc003ybj.1. human.
Organism-specific databases
CTD	11075.
GeneCards	GC08P080573.
H-InvDB	HIX0007608.
HGNC	HGNC:10577. STMN2.
HPA	HPA026922.
MIM	600621. gene.
neXtProt	NX_Q93045.
PharmGKB	PA35540.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18764.
GeneTree	ENSGT00390000003691.
HOGENOM	HBG444413.
HOVERGEN	HBG054037.
InParanoid	Q93045.
OMA	NSNFSKM.
OrthoDB	EOG4DR9DK.
PhylomeDB	Q93045.
Gene expression databases
ArrayExpress	Q93045.
Bgee	Q93045.
CleanEx	HS_STMN2.
Genevestigator	Q93045.
GermOnline	ENSG00000104435. Homo sapiens.
Family and domain databases
InterPro	IPR000956. Stathmin. [Graphical view]
PANTHER	PTHR10104. Stathmin. 1 hit.
Pfam	PF00836. Stathmin. 1 hit. [Graphical view]
PIRSF	PIRSF002285. Stathmin. 1 hit.
PRINTS	PR00345. STATHMIN.
SUPFAM	SSF101494. Stathmin. 1 hit.
PROSITE	PS00563. STATHMIN_1. 1 hit. PS01041. STATHMIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	42102.
SOURCE	Search...

Entry information

Entry name

STMN2_HUMAN

Accession

Primary (citable) accession number: Q93045
Secondary accession number(s): A8K9M2, O14952, Q6PK68

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	August 31, 2004
Last modified:	January 25, 2012
This is version 102 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.