Reviewed, UniProtKB/Swiss-Prot Q93045 (STMN2_HUMAN)

Names and origin

Protein names

Recommended name:
    Stathmin-2
Alternative name(s):
    Superior cervical ganglion-10 protein
      Short name=Protein SCG10

Gene names

Name:	STMN2
Synonyms:	SCG10, SCGN10

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in neuronal differentiation, and in modulating membrane interaction with the cytoskeleton during neurite outgrowth.
Subcellular location	Cytoplasm By similarity. Cytoplasm › perinuclear region By similarity. Cell projection › growth cone By similarity. Membrane; Peripheral membrane protein; Cytoplasmic side Potential. Cell projection › axon By similarity. Note: Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms By similarity.
Tissue specificity	Neuron specific.
Post-translational modification	Sumoylated. Ref.9
Sequence similarities	Belongs to the stathmin family.

Ontologies

Keywords
Cellular component	Cell projection Cytoplasm Membrane
Domain	Coiled coil
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro neuron differentiation Non-traceable author statement. Source: UniProtKB
Cellular component	axon Inferred from electronic annotation. Source: UniProtKB-SubCell extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell growth cone Inferred from electronic annotation. Source: UniProtKB-SubCell membrane fraction Non-traceable author statement. Source: UniProtKB perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell soluble fraction Non-traceable author statement. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TEX11	Q8IYF3	1	EBI-714194,EBI-742397

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 179	179	Stathmin-2		PRO_0000182396
Regions
	Region	1 – 26	26	Membrane attachment Potential
	Region	39 – 96	58	Regulatory/phosphorylation domain Potential
	Coiled coil	75 – 179	105	Potential
Amino acid modifications
	Modified residue	16	1	Phosphoserine Potential
	Modified residue	50	1	Phosphoserine Potential
	Modified residue	62	1	Phosphoserine Potential
	Modified residue	73	1	Phosphoserine Potential
	Modified residue	80	1	Phosphoserine Ref.10
	Modified residue	97	1	Phosphoserine Potential
Experimental info
	Sequence conflict	92	1	E → G in AAB36428. Ref.1
	Sequence conflict	122	1	E → G in BAA23326. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q93045-1 [UniParc]. Last modified August 31, 2004. Version 3. Checksum: F9A258A1B57E620D	FASTA	179	20,828
	10 20 30 40 50 60 MAKTAMAYKE KMKELSMLSL ICSCFYPEPR NINIYTYDDM EVKQINKRAS GQAFELILKP 70 80 90 100 110 120 PSPISEAPRT LASPKKKDLS LEEIQKKLEA AEERRKSQEA QVLKQLAEKR EHEREVLQKA 130 140 150 160 170 LEENNNFSKM AEEKLILKME QIKENREANL AAIIERLQEK ERHAAEVRRN KELQVELSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SCG10, a neuron-specific growth-associated protein in Alzheimer's disease." Okazaki T., Wang H., Masliah E., Cao M., Johnson S.A., Sundsmo M., Saitoh T., Mori N. Neurobiol. Aging 16:883-894(1995) [PubMed: 8622778] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning of a human homologue of chicken silencer element (SCG10) gene." Fujiwara T., Kawai A., Shimizu F., Shinomiya K., Hirano H., Okuno S., Ozaki K., Katagiri T., Takeda S., Kuga Y., Shimada Y., Nagata M., Takaichi A., Watanabe T., Horie M., Nakamura Y., Takahashi E., Hirai Y. Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[8]	Lubec G., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 12-43; 48-69; 78-86; 147-156 AND 172-179, MASS SPECTROMETRY. Tissue: Fetal brain cortex.
[9]	"Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates." Gocke C.B., Yu H., Kang J. J. Biol. Chem. 280:5004-5012(2005) [PubMed: 15561718] [Abstract] Cited for: SUMOYLATION.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, MASS SPECTROMETRY.
[11]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S82024 mRNA. Translation: AAB36428.1. D50375 mRNA. Translation: BAA23326.1. BT020034 mRNA. Translation: AAV38837.1. CR456833 mRNA. Translation: CAG33114.1. AK292737 mRNA. Translation: BAF85426.1. CH471068 Genomic DNA. Translation: EAW87065.1. BC006302 mRNA. Translation: AAH06302.1.
IPI	IPI00218667.
RefSeq	NP_008960.2.
UniGene	Hs.521651
3D structure databases
SMR	Q93045. Positions 40-174.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q93045. 3 interactions.
STRING	Q93045.
PTM databases
PhosphoSite	Q93045.
Proteomic databases
PRIDE	Q93045.
Genome annotation databases
Ensembl	ENST00000220876; ENSP00000220876; ENSG00000104435; Homo sapiens. [Genome view]
GeneID	11075.
KEGG	hsa:11075.
UCSC	uc003ybj.1. human.
Organism-specific databases
CTD	11075.
GeneCards	GC08P080685.
H-InvDB	HIX0007608.
HGNC	HGNC:10577. STMN2.
HPA	HPA026922.
MIM	600621. gene.
PharmGKB	PA35540.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18764.
HOGENOM	HBG444413.
HOVERGEN	Q93045.
InParanoid	Q93045.
OMA	NSNFSKM.
PhylomeDB	Q93045.
Gene expression databases
ArrayExpress	Q93045.
Bgee	Q93045.
CleanEx	HS_STMN2.
Genevestigator	Q93045.
GermOnline	ENSG00000104435. Homo sapiens.
Family and domain databases
InterPro	IPR000956. Stathmin. IPR015444. Stathmin_2. [Graphical view]
PANTHER	PTHR10104. Stathmin. 1 hit. PTHR10104:SF7. Stathmin_2. 1 hit.
Pfam	PF00836. Stathmin. 1 hit. [Graphical view]
PIRSF	PIRSF002285. Stathmin. 1 hit.
PRINTS	PR00345. STATHMIN.
PROSITE	PS00563. STATHMIN_1. 1 hit. PS01041. STATHMIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	42102.
SOURCE	Search...

Entry information

Entry name

STMN2_HUMAN

Accession

Primary (citable) accession number: Q93045
Secondary accession number(s): A8K9M2, O14952, Q6PK68

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	August 31, 2004
Last modified:	February 9, 2010
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.