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Protein

Stathmin-2

Gene

STMN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).By similarity

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • tubulin binding Source: GO_Central

GO - Biological processi

  • cellular response to nerve growth factor stimulus Source: UniProtKB
  • microtubule depolymerization Source: GO_Central
  • negative regulation of microtubule depolymerization Source: UniProtKB
  • negative regulation of microtubule polymerization Source: UniProtKB
  • negative regulation of neuron projection development Source: UniProtKB
  • neuron projection development Source: GO_Central
  • positive regulation of microtubule depolymerization Source: UniProtKB
  • positive regulation of neuron projection development Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ93045.

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-2
Alternative name(s):
Superior cervical ganglion-10 protein
Short name:
Protein SCG10
Gene namesi
Name:STMN2
Synonyms:SCG10, SCGN10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:10577. STMN2.

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB
  • endosome Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB-SubCell
  • growth cone Source: UniProtKB
  • lamellipodium Source: UniProtKB
  • membrane Source: UniProtKB-SubCell
  • neuronal cell body Source: UniProtKB
  • neuron projection Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35540.

Polymorphism and mutation databases

BioMutaiSTMN2.
DMDMi51704330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Stathmin-2PRO_0000182396Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161PhosphoserineSequence analysis
Lipidationi22 – 221S-palmitoyl cysteine1 Publication
Lipidationi24 – 241S-palmitoyl cysteine1 Publication
Modified residuei50 – 501PhosphoserineSequence analysisBy similarity
Modified residuei62 – 621PhosphoserineCombined sources
Modified residuei73 – 731PhosphoserineBy similarity
Modified residuei97 – 971PhosphoserineSequence analysis

Post-translational modificationi

Sumoylated.1 Publication
Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex.By similarity
N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ93045.
MaxQBiQ93045.
PaxDbiQ93045.
PRIDEiQ93045.

PTM databases

iPTMnetiQ93045.
PhosphoSiteiQ93045.

Expressioni

Tissue specificityi

Neuron specific.

Gene expression databases

BgeeiQ93045.
CleanExiHS_STMN2.
ExpressionAtlasiQ93045. baseline and differential.
GenevisibleiQ93045. HS.

Interactioni

Subunit structurei

Interacts with MAPK8 (By similarity). Interacts with ITM2C. Interacts with KIF1BP. Interacts (via the N-terminal region) with CIB1 (via C-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the neurite outgrowth inhibition of STMN2.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TEX11Q8IYF35EBI-714194,EBI-742397
TFCP2Q128003EBI-714194,EBI-717422
TXLNAP402223EBI-714194,EBI-359793

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • tubulin binding Source: GO_Central

Protein-protein interaction databases

BioGridi116258. 23 interactions.
IntActiQ93045. 11 interactions.
MINTiMINT-242849.
STRINGi9606.ENSP00000429243.

Structurei

3D structure databases

ProteinModelPortaliQ93045.
SMRiQ93045. Positions 40-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 179142SLDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2626Membrane attachmentSequence analysisAdd
BLAST
Regioni39 – 9658Regulatory/phosphorylation domainSequence analysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili75 – 179105Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the stathmin family.Curated
Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJ9S. Eukaryota.
ENOG410YFK3. LUCA.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiQ93045.
OMAiVCEFEDM.
OrthoDBiEOG744TBN.
PhylomeDBiQ93045.
TreeFamiTF326935.

Family and domain databases

InterProiIPR026729. Stathmin-2.
IPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF18. PTHR10104:SF18. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q93045-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKTAMAYKE KMKELSMLSL ICSCFYPEPR NINIYTYDDM EVKQINKRAS
60 70 80 90 100
GQAFELILKP PSPISEAPRT LASPKKKDLS LEEIQKKLEA AEERRKSQEA
110 120 130 140 150
QVLKQLAEKR EHEREVLQKA LEENNNFSKM AEEKLILKME QIKENREANL
160 170
AAIIERLQEK ERHAAEVRRN KELQVELSG
Length:179
Mass (Da):20,828
Last modified:August 31, 2004 - v3
Checksum:iF9A258A1B57E620D
GO
Isoform 2 (identifier: Q93045-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-179: ERHAAEVRRNKELQVELSG → LVKFISSELKESIESQFLELQREGEKQ

Note: No experimental confirmation available.
Show »
Length:187
Mass (Da):21,802
Checksum:i79F9F10FF182FD01
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921E → G in AAB36428 (PubMed:8622778).Curated
Sequence conflicti122 – 1221E → G in BAA23326 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei161 – 17919ERHAA…VELSG → LVKFISSELKESIESQFLEL QREGEKQ in isoform 2. 1 PublicationVSP_045047Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82024 mRNA. Translation: AAB36428.1.
D50375 mRNA. Translation: BAA23326.1.
BT020034 mRNA. Translation: AAV38837.1.
CR456833 mRNA. Translation: CAG33114.1.
AK292737 mRNA. Translation: BAF85426.1.
AC016240 Genomic DNA. No translation available.
AC025599 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87064.1.
CH471068 Genomic DNA. Translation: EAW87065.1.
BC006302 mRNA. Translation: AAH06302.1.
BQ069488 mRNA. No translation available.
CCDSiCCDS43748.1. [Q93045-1]
CCDS56542.1. [Q93045-2]
RefSeqiNP_001186143.1. NM_001199214.1. [Q93045-2]
NP_008960.2. NM_007029.3. [Q93045-1]
UniGeneiHs.521651.

Genome annotation databases

EnsembliENST00000220876; ENSP00000220876; ENSG00000104435. [Q93045-1]
ENST00000518111; ENSP00000429243; ENSG00000104435. [Q93045-2]
GeneIDi11075.
KEGGihsa:11075.
UCSCiuc003ybj.3. human. [Q93045-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82024 mRNA. Translation: AAB36428.1.
D50375 mRNA. Translation: BAA23326.1.
BT020034 mRNA. Translation: AAV38837.1.
CR456833 mRNA. Translation: CAG33114.1.
AK292737 mRNA. Translation: BAF85426.1.
AC016240 Genomic DNA. No translation available.
AC025599 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87064.1.
CH471068 Genomic DNA. Translation: EAW87065.1.
BC006302 mRNA. Translation: AAH06302.1.
BQ069488 mRNA. No translation available.
CCDSiCCDS43748.1. [Q93045-1]
CCDS56542.1. [Q93045-2]
RefSeqiNP_001186143.1. NM_001199214.1. [Q93045-2]
NP_008960.2. NM_007029.3. [Q93045-1]
UniGeneiHs.521651.

3D structure databases

ProteinModelPortaliQ93045.
SMRiQ93045. Positions 40-174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116258. 23 interactions.
IntActiQ93045. 11 interactions.
MINTiMINT-242849.
STRINGi9606.ENSP00000429243.

PTM databases

iPTMnetiQ93045.
PhosphoSiteiQ93045.

Polymorphism and mutation databases

BioMutaiSTMN2.
DMDMi51704330.

Proteomic databases

EPDiQ93045.
MaxQBiQ93045.
PaxDbiQ93045.
PRIDEiQ93045.

Protocols and materials databases

DNASUi11075.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220876; ENSP00000220876; ENSG00000104435. [Q93045-1]
ENST00000518111; ENSP00000429243; ENSG00000104435. [Q93045-2]
GeneIDi11075.
KEGGihsa:11075.
UCSCiuc003ybj.3. human. [Q93045-1]

Organism-specific databases

CTDi11075.
GeneCardsiSTMN2.
HGNCiHGNC:10577. STMN2.
MIMi600621. gene.
neXtProtiNX_Q93045.
PharmGKBiPA35540.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ9S. Eukaryota.
ENOG410YFK3. LUCA.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiQ93045.
OMAiVCEFEDM.
OrthoDBiEOG744TBN.
PhylomeDBiQ93045.
TreeFamiTF326935.

Enzyme and pathway databases

SignaLinkiQ93045.

Miscellaneous databases

ChiTaRSiSTMN2. human.
GeneWikiiSTMN2.
GenomeRNAii11075.
NextBioi42102.
PROiQ93045.
SOURCEiSearch...

Gene expression databases

BgeeiQ93045.
CleanExiHS_STMN2.
ExpressionAtlasiQ93045. baseline and differential.
GenevisibleiQ93045. HS.

Family and domain databases

InterProiIPR026729. Stathmin-2.
IPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF18. PTHR10104:SF18. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SCG10, a neuron-specific growth-associated protein in Alzheimer's disease."
    Okazaki T., Wang H., Masliah E., Cao M., Johnson S.A., Sundsmo M., Saitoh T., Mori N.
    Neurobiol. Aging 16:883-894(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Molecular cloning of a human homologue of chicken silencer element (SCG10) gene."
    Fujiwara T., Kawai A., Shimizu F., Shinomiya K., Hirano H., Okuno S., Ozaki K., Katagiri T., Takeda S., Kuga Y., Shimada Y., Nagata M., Takaichi A., Watanabe T., Horie M., Nakamura Y., Takahashi E., Hirai Y.
    Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  6. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Neuroblastoma.
  9. Lubec G., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 12-43; 48-69; 78-86; 147-156 AND 172-179, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetal brain cortex.
  10. "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."
    Gocke C.B., Yu H., Kang J.
    J. Biol. Chem. 280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION.
  11. "BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells."
    Gong Y., Wu J., Qiang H., Liu B., Chi Z., Chen T., Yin B., Peng X., Yuan J.
    BMB Rep. 41:287-293(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ITM2C.
  12. "KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation."
    Alves M.M., Burzynski G., Delalande J.M., Osinga J., van der Goot A., Dolga A.M., de Graaff E., Brooks A.S., Metzger M., Eisel U.L., Shepherd I., Eggen B.J., Hofstra R.M.
    Hum. Mol. Genet. 19:3642-3651(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KIF1BP.
  13. "Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth."
    Sobczak A., Debowska K., Blazejczyk M., Kreutz M.R., Kuznicki J., Wojda U.
    Biochim. Biophys. Acta 1813:1025-1037(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CIB1, SUBCELLULAR LOCATION.
  14. "Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases."
    Levy A.D., Devignot V., Fukata Y., Fukata M., Sobel A., Chauvin S.
    Mol. Biol. Cell 22:1930-1942(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-22 AND CYS-24 BY ZDHHC3; ZDHHC7 AND ZDHHC15, SUBCELLULAR LOCATION.
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSTMN2_HUMAN
AccessioniPrimary (citable) accession number: Q93045
Secondary accession number(s): A8K9M2
, G3V110, O14952, Q6PK68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 31, 2004
Last modified: March 16, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.