Q93038 (TNR25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor necrosis factor receptor superfamily member 25

Alternative name(s):
Apo-3
Apoptosis-inducing receptor AIR
Apoptosis-mediating receptor DR3
Apoptosis-mediating receptor TRAMP
Death receptor 3
Lymphocyte-associated receptor of death
Short name=LARD
Protein WSL
Protein WSL-1

Gene names

Name:	TNFRSF25
Synonyms:	APO3, DDR3, DR3, TNFRSF12, WSL, WSL1
ORF Names:	UNQ455/PRO779

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Subunit structure	Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4. Ref.14
Subcellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 9: Cell membrane; Single-pass type I membrane protein. Isoform 11: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Secreted. Isoform 6: Secreted. Isoform 7: Secreted. Isoform 8: Secreted. Isoform 10: Secreted. Isoform 12: Secreted.
Tissue specificity	Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
Post-translational modification	Glycosylated Probable.
Sequence similarities	Contains 1 death domain. Contains 4 TNFR-Cys repeats.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic signaling pathway Traceable author statement Ref.4. Source: ProtInc induction of apoptosis Traceable author statement Ref.2. Source: ProtInc
Cellular_component	cytosol Non-traceable author statement Ref.5. Source: UniProtKB extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Traceable author statement Ref.12. Source: ProtInc
Molecular_function	tumor necrosis factor-activated receptor activity Traceable author statement Ref.12. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 12 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q93038-1)

Also known as: WSL-1; LARD-1A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q93038-2)

Also known as: LARD-1B;

The sequence of this isoform differs from the canonical sequence as follows:
     236-236: A → AA

Isoform 3 (identifier: Q93038-3)

Also known as: WSL-S1; LARD-3;

The sequence of this isoform differs from the canonical sequence as follows:
     182-218: STLGSCPERCAAVCGWRQMFWVQVLLAGLVVPLLLGA → VLGPGAPGWPCGPPPAWGHPDLHIPPLLASQAPGYCR
     219-417: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 4 (identifier: Q93038-4)

Also known as: WSL-S2; LARD-2;

The sequence of this isoform differs from the canonical sequence as follows:
     200-253: MFWVQVLLAG...LTPPPATHLS → SRWCAGNARG...LWSPSCLGPP
     254-417: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 5 (identifier: Q93038-5)

Also known as: LARD-4; LARD-11;

The sequence of this isoform differs from the canonical sequence as follows:
     182-417: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 6 (identifier: Q93038-6)

Also known as: LARD-5;

The sequence of this isoform differs from the canonical sequence as follows:
     54-98: Missing.
     182-417: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 7 (identifier: Q93038-7)

Also known as: LARD-6;

The sequence of this isoform differs from the canonical sequence as follows:
     54-98: Missing.
     156-171: SRRDTDCGTCLPGFYE → HPSVTLGQRPHPSSTS
     172-417: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 8 (identifier: Q93038-8)

Also known as: LARD-7;

The sequence of this isoform differs from the canonical sequence as follows:
     54-236: Missing.

Isoform 9 (identifier: Q93038-9)

Also known as: LARD-8;

The sequence of this isoform differs from the canonical sequence as follows:
     54-98: Missing.

Isoform 10 (identifier: Q93038-10)

Also known as: LARD-9;

The sequence of this isoform differs from the canonical sequence as follows:
     200-237: MFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTAD → N

Isoform 11 (identifier: Q93038-11)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     182-200: STLGSCPERCAAVCGWRQM → PPPSLAGAPWGAVQSAVPLSVAGGRVGV

Isoform 12 (identifier: Q93038-12)

Also known as: Beta soluble;

The sequence of this isoform differs from the canonical sequence as follows:
     182-277: STLGSCPERC...SEKICTVQLV → PPPSLAGAPW...LASQAPGYCR
     278-417: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 417	393	Tumor necrosis factor receptor superfamily member 25		PRO_0000034606
Regions
	Topological domain	25 – 199	175	Extracellular Potential
	Transmembrane	200 – 220	21	Helical; Potential
	Topological domain	221 – 417	197	Cytoplasmic Potential
	Repeat	34 – 71	38	TNFR-Cys 1
	Repeat	72 – 115	44	TNFR-Cys 2
	Repeat	116 – 163	48	TNFR-Cys 3
	Repeat	164 – 192	29	TNFR-Cys 4
	Domain	332 – 413	82	Death
Amino acid modifications
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Glycosylation	106	1	N-linked (GlcNAc...) Potential
	Disulfide bond	35 ↔ 47		By similarity
	Disulfide bond	48 ↔ 61		By similarity
	Disulfide bond	51 ↔ 70		By similarity
	Disulfide bond	73 ↔ 89		By similarity
	Disulfide bond	92 ↔ 107		By similarity
	Disulfide bond	95 ↔ 115		By similarity
	Disulfide bond	117 ↔ 130		By similarity
	Disulfide bond	138 ↔ 155		By similarity
	Disulfide bond	141 ↔ 162		By similarity
	Disulfide bond	165 ↔ 176		By similarity
	Disulfide bond	179 ↔ 191		By similarity
	Disulfide bond	187 ↔ 195		By similarity
Natural variations
	Alternative sequence	54 – 236	183	Missing in isoform 8.		VSP_006492
	Alternative sequence	54 – 98	45	Missing in isoform 6, isoform 7 and isoform 9.		VSP_006491
	Alternative sequence	156 – 171	16	SRRDT…PGFYE → HPSVTLGQRPHPSSTS in isoform 7.		VSP_006493
	Alternative sequence	172 – 417	246	Missing in isoform 7.		VSP_006494
	Alternative sequence	182 – 417	236	Missing in isoform 5 and isoform 6.		VSP_006495
	Alternative sequence	182 – 277	96	STLGS…TVQLV → PPPSLAGAPWGAVQSAVPLS VAGGRVGGVLGMRVGELGWT EGRRVRRGATTQHPPAAFSV LGPGAPGWPCGPPPAWGHPD LHIPPLLASQAPGYCR in isoform 12.		VSP_006499
	Alternative sequence	182 – 218	37	STLGS…LLLGA → VLGPGAPGWPCGPPPAWGHP DLHIPPLLASQAPGYCR in isoform 3.		VSP_006497
	Alternative sequence	182 – 200	19	STLGS…GWRQM → PPPSLAGAPWGAVQSAVPLS VAGGRVGV in isoform 11.		VSP_006496
	Alternative sequence	200 – 253	54	MFWVQ…ATHLS → SRWCAGNARGRTGMDRGEAG EEGGNHPTPTSCFQCSGSRC SWLALWSPSCLGPP in isoform 4.		VSP_006501
	Alternative sequence	200 – 237	38	MFWVQ…LVTAD → N in isoform 10.		VSP_006503
	Alternative sequence	219 – 417	199	Missing in isoform 3.		VSP_006498
	Alternative sequence	236	1	A → AA in isoform 2.		VSP_006504
	Alternative sequence	254 – 417	164	Missing in isoform 4.		VSP_006502
	Alternative sequence	278 – 417	140	Missing in isoform 12.		VSP_006500
	Natural variant	23	1	R → Q. Ref.9 Corresponds to variant rs35771371 [ dbSNP | Ensembl ].		VAR_018826
	Natural variant	159	1	D → G. Ref.7 Ref.9 Corresponds to variant rs11800462 [ dbSNP | Ensembl ].		VAR_018827
	Natural variant	254	1	P → R. Ref.9 Corresponds to variant rs34529016 [ dbSNP | Ensembl ].		VAR_018828
	Natural variant	370	1	R → L. Corresponds to variant rs1064590 [ dbSNP | Ensembl ].		VAR_011814
	Natural variant	381	1	R → H. Corresponds to variant rs1059333 [ dbSNP | Ensembl ].		VAR_011815
Experimental info
	Mutagenesis	354	1	L → A: Suppresses homodimerization, TNFR1 interaction, and apoptosis induction.
	Mutagenesis	356	1	L → A: Suppresses homodimerization, and TNFR1 interaction.
	Mutagenesis	373	1	D → A: Suppresses homodimerization, and TNFR1 interaction.
	Sequence conflict	4 – 6	3	RPR → AAA in AAC51192. Ref.12
	Sequence conflict	4 – 6	3	RPR → AAA in AAC51193. Ref.12
	Sequence conflict	60	1	P → H in AAB41435. Ref.13
	Sequence conflict	167	1	P → L Ref.12
	Sequence conflict	167	1	P → L Ref.13
	Sequence conflict	312	1	A → R Ref.1
	Sequence conflict	312	1	A → R Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (WSL-1) (LARD-1A) [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 5226319DFDB46706	FASTA	417	45,385
	10 20 30 40 50 60 MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAGHYLKAP 70 80 90 100 110 120 CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS QVALENCSAV ADTRCGCKPG 130 140 150 160 170 180 WFVECQVSQC VSSSPFYCQP CLDCGALHRH TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP 190 200 210 220 230 240 TSTLGSCPER CAAVCGWRQM FWVQVLLAGL VVPLLLGATL TYTYRHCWPH KPLVTADEAG 250 260 270 280 290 300 MEALTPPPAT HLSPLDSAHT LLAPPDSSEK ICTVQLVGNS WTPGYPETQE ALCPQVTWSW 310 320 330 340 350 360 DQLPSRALGP AAAPTLSPES PAGSPAMMLQ PGPQLYDVMD AVPARRWKEF VRTLGLREAE 370 380 390 400 410 IEAVEVEIGR FRDQQYEMLK RWRQQQPAGL GAVYAALERM GLDGCVEDLR SRLQRGP
	Isoform 2 (LARD-1B) [UniParc]. Checksum: 54B48F8B35C620E2	FASTA	418	45,456
	10 20 30 40 50 60 MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAGHYLKAP 70 80 90 100 110 120 CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS QVALENCSAV ADTRCGCKPG 130 140 150 160 170 180 WFVECQVSQC VSSSPFYCQP CLDCGALHRH TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP 190 200 210 220 230 240 TSTLGSCPER CAAVCGWRQM FWVQVLLAGL VVPLLLGATL TYTYRHCWPH KPLVTAADEA 250 260 270 280 290 300 GMEALTPPPA THLSPLDSAH TLLAPPDSSE KICTVQLVGN SWTPGYPETQ EALCPQVTWS 310 320 330 340 350 360 WDQLPSRALG PAAAPTLSPE SPAGSPAMML QPGPQLYDVM DAVPARRWKE FVRTLGLREA 370 380 390 400 410 EIEAVEVEIG RFRDQQYEML KRWRQQQPAG LGAVYAALER MGLDGCVEDL RSRLQRGP
	Isoform 3 (WSL-S1) (LARD-3) [UniParc]. Checksum: 9B416919AFA442F6	FASTA	218	23,198
	10 20 30 40 50 60 MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAGHYLKAP 70 80 90 100 110 120 CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS QVALENCSAV ADTRCGCKPG 130 140 150 160 170 180 WFVECQVSQC VSSSPFYCQP CLDCGALHRH TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP 190 200 210 TVLGPGAPGW PCGPPPAWGH PDLHIPPLLA SQAPGYCR
	Isoform 4 (WSL-S2) (LARD-2) [UniParc]. Checksum: 50A06775B68FC3D7	FASTA	253	27,004
	10 20 30 40 50 60 MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAGHYLKAP 70 80 90 100 110 120 CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS QVALENCSAV ADTRCGCKPG 130 140 150 160 170 180 WFVECQVSQC VSSSPFYCQP CLDCGALHRH TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP 190 200 210 220 230 240 TSTLGSCPER CAAVCGWRQS RWCAGNARGR TGMDRGEAGE EGGNHPTPTS CFQCSGSRCS 250 WLALWSPSCL GPP
	Isoform 5 (LARD-4) (LARD-11) [UniParc]. Checksum: 59AAFEDBBB46E369	FASTA	181	19,432
	10 20 30 40 50 60 MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAGHYLKAP 70 80 90 100 110 120 CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS QVALENCSAV ADTRCGCKPG 130 140 150 160 170 180 WFVECQVSQC VSSSPFYCQP CLDCGALHRH TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP T
	Isoform 6 (LARD-5) [UniParc]. Checksum: 6846913006EEE40A	FASTA	136	14,439
	10 20 30 40 50 60 MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAASQVALE 70 80 90 100 110 120 NCSAVADTRC GCKPGWFVEC QVSQCVSSSP FYCQPCLDCG ALHRHTRLLC SRRDTDCGTC 130 LPGFYEHGDG CVSCPT
	Isoform 7 (LARD-6) [UniParc]. Checksum: EBAC98D7FB3EDB68	FASTA	126	13,349
	10 20 30 40 50 60 MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAASQVALE 70 80 90 100 110 120 NCSAVADTRC GCKPGWFVEC QVSQCVSSSP FYCQPCLDCG ALHRHTRLLC HPSVTLGQRP HPSSTS
	Isoform 8 (LARD-7) [UniParc]. Checksum: D082A4552EDF7531	FASTA	234	25,373
	10 20 30 40 50 60 MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPADEAGMEA 70 80 90 100 110 120 LTPPPATHLS PLDSAHTLLA PPDSSEKICT VQLVGNSWTP GYPETQEALC PQVTWSWDQL 130 140 150 160 170 180 PSRALGPAAA PTLSPESPAG SPAMMLQPGP QLYDVMDAVP ARRWKEFVRT LGLREAEIEA 190 200 210 220 230 VEVEIGRFRD QQYEMLKRWR QQQPAGLGAV YAALERMGLD GCVEDLRSRL QRGP
	Isoform 9 (LARD-8) [UniParc]. Checksum: D4F87353AB7F40F6	FASTA	372	40,391
	10 20 30 40 50 60 MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAASQVALE 70 80 90 100 110 120 NCSAVADTRC GCKPGWFVEC QVSQCVSSSP FYCQPCLDCG ALHRHTRLLC SRRDTDCGTC 130 140 150 160 170 180 LPGFYEHGDG CVSCPTSTLG SCPERCAAVC GWRQMFWVQV LLAGLVVPLL LGATLTYTYR 190 200 210 220 230 240 HCWPHKPLVT ADEAGMEALT PPPATHLSPL DSAHTLLAPP DSSEKICTVQ LVGNSWTPGY 250 260 270 280 290 300 PETQEALCPQ VTWSWDQLPS RALGPAAAPT LSPESPAGSP AMMLQPGPQL YDVMDAVPAR 310 320 330 340 350 360 RWKEFVRTLG LREAEIEAVE VEIGRFRDQQ YEMLKRWRQQ QPAGLGAVYA ALERMGLDGC 370 VEDLRSRLQR GP
	Isoform 10 (LARD-9) [UniParc]. Checksum: ED19B586ADD947B7	FASTA	380	41,193
	10 20 30 40 50 60 MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAGHYLKAP 70 80 90 100 110 120 CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS QVALENCSAV ADTRCGCKPG 130 140 150 160 170 180 WFVECQVSQC VSSSPFYCQP CLDCGALHRH TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP 190 200 210 220 230 240 TSTLGSCPER CAAVCGWRQN EAGMEALTPP PATHLSPLDS AHTLLAPPDS SEKICTVQLV 250 260 270 280 290 300 GNSWTPGYPE TQEALCPQVT WSWDQLPSRA LGPAAAPTLS PESPAGSPAM MLQPGPQLYD 310 320 330 340 350 360 VMDAVPARRW KEFVRTLGLR EAEIEAVEVE IGRFRDQQYE MLKRWRQQQP AGLGAVYAAL 370 380 ERMGLDGCVE DLRSRLQRGP
	Isoform 11 (Beta) [UniParc]. Checksum: 292A9B2899F3AE1F	FASTA	426	45,928
	10 20 30 40 50 60 MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAGHYLKAP 70 80 90 100 110 120 CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS QVALENCSAV ADTRCGCKPG 130 140 150 160 170 180 WFVECQVSQC VSSSPFYCQP CLDCGALHRH TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP 190 200 210 220 230 240 TPPPSLAGAP WGAVQSAVPL SVAGGRVGVF WVQVLLAGLV VPLLLGATLT YTYRHCWPHK 250 260 270 280 290 300 PLVTADEAGM EALTPPPATH LSPLDSAHTL LAPPDSSEKI CTVQLVGNSW TPGYPETQEA 310 320 330 340 350 360 LCPQVTWSWD QLPSRALGPA AAPTLSPESP AGSPAMMLQP GPQLYDVMDA VPARRWKEFV 370 380 390 400 410 420 RTLGLREAEI EAVEVEIGRF RDQQYEMLKR WRQQQPAGLG AVYAALERMG LDGCVEDLRS RLQRGP
	Isoform 12 (Beta soluble) [UniParc]. Checksum: 3D19F3E847BFC093	FASTA	277	29,111
	10 20 30 40 50 60 MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAGHYLKAP 70 80 90 100 110 120 CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS QVALENCSAV ADTRCGCKPG 130 140 150 160 170 180 WFVECQVSQC VSSSPFYCQP CLDCGALHRH TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP 190 200 210 220 230 240 TPPPSLAGAP WGAVQSAVPL SVAGGRVGGV LGMRVGELGW TEGRRVRRGA TTQHPPAAFS 250 260 270 VLGPGAPGWP CGPPPAWGHP DLHIPPLLAS QAPGYCR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A death-domain-containing receptor that mediates apoptosis." Kitson J., Raven T., Jiang Y.-P., Goeddel D.V., Giles K.M., Pun K.-T., Grinham C.J., Brown R., Farrow S.N. Nature 384:372-375(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4), MUTAGENESIS. Tissue: Lymphoid tissue.
[2]	"Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95." Chinnaiyan A.M., O'Rourke K., Yu G.-L., Lyons R.H., Garg M., Duan D.R., Xing L., Gentz R., Ni J., Dixit V.M. Science 274:990-992(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Umbilical vein endothelial cell.
[3]	Degli-Esposti M.A., Din W.S., Cosman D., Smith C.A., Goodwin R.G. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa-B." Marsters S.A., Sheridan J.P., Donahue C.J., Pitti R.M., Gray C.L., Goddard A.D., Bauer K.D., Ashkenazi A. Curr. Biol. 6:1669-1676(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Heart.
[5]	"LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing." Screaton G.R., Xu X.-N., Olsen A.L., Cowper A.E., Tan R., McMichael A.J., Bell J.I. Proc. Natl. Acad. Sci. U.S.A. 94:4615-4619(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9 AND 10).
[6]	"A new death receptor 3 isoform: expression in human lymphoid cell lines and non-Hodgkin's lymphomas." Warzocha K., Ribeiro P., Charlot C., Renard N., Coiffier B., Salles G. Biochem. Biophys. Res. Commun. 242:376-379(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 11 AND 12).
[7]	Shiozawa S., Konishi Y., Murayama K., Mukae N., Yamamoto E., Hayashi S., Sato M., Shiozawa K., Tsukamoto Y. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT GLY-159.
[8]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[9]	NIEHS SNPs program Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-23; GLY-159 AND ARG-254.
[10]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10). Tissue: Brain.
[12]	"TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)." Bodmer J.-L., Burns K., Schneider P., Hofmann K., Steiner V., Thome M., Bornand T., Hahne M., Schroeter M., Wilson A., French L.E., Browning J.L., Macdonald H.R., Tschopp J. Immunity 6:79-88(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-417. Tissue: Brain and Fetal lung.
[13]	Chaudhary P.M., Hood L.E. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 7-417. Tissue: Brain.
[14]	"Prevention of constitutive TNF receptor 1 signaling by silencer of death domains." Jiang Y., Woronicz J.D., Liu W., Goeddel D.V. Science 283:543-546(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH BAG4.
[15]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y09392 mRNA. Translation: CAA70561.1. Y09392 mRNA. Translation: CAA70559.1. Y09392 mRNA. Translation: CAA70560.1. U72763 mRNA. Translation: AAC50819.1. U83599 Genomic DNA. Translation: AAB41434.1. U83600 Genomic DNA. Translation: AAB41435.1. U78029 mRNA. Translation: AAB40918.1. U74611 mRNA. Translation: AAB39714.1. U94501 mRNA. Translation: AAC51306.1. U94504 mRNA. Translation: AAC51309.1. U94502 mRNA. Translation: AAC51307.1. U94503 mRNA. Translation: AAC51308.1. U94505 mRNA. Translation: AAC51310.1. U94506 mRNA. Translation: AAC51311.1. U94507 mRNA. Translation: AAC51312.1. U94508 mRNA. Translation: AAC51313.1. U94509 mRNA. Translation: AAC51314.1. U94510 mRNA. Translation: AAC51315.1. U94512 mRNA. Translation: AAC51316.1. U83598 mRNA. Translation: AAB41433.1. AF026070 mRNA. Translation: AAC39556.1. AF026071 mRNA. Translation: AAB82288.1. AB051850 Genomic DNA. Translation: BAB40662.1. AB051851 Genomic DNA. Translation: BAB40663.1. AY358309 mRNA. Translation: AAQ88676.1. AY254324 Genomic DNA. Translation: AAO63495.1. U75380 mRNA. Translation: AAC51192.1. AL158217 Genomic DNA. Translation: CAI22153.1. AL158217 Genomic DNA. Translation: CAI22154.1. AL158217 Genomic DNA. Translation: CAI22155.1. BC117189 mRNA. Translation: AAI17190.1. BC143886 mRNA. Translation: AAI43887.1. U75381 mRNA. Translation: AAC51193.1. U83597 mRNA. Translation: AAB41432.1.
IPI	IPI00003999. IPI00219572. IPI00219573. IPI00219577. IPI00219578. IPI00219579. IPI00219580. IPI00220675. IPI00220676. IPI00220677. IPI00299520. IPI00514425.
RefSeq	NP_001034753.1. NM_001039664.1. NP_003781.1. NM_003790.2. NP_683866.1. NM_148965.1. NP_683867.1. NM_148966.1. NP_683868.1. NM_148967.1. NP_683871.1. NM_148970.1.
UniGene	Hs.462529.
3D structure databases
ProteinModelPortal	Q93038.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-59563N.
Polymorphism databases
DMDM	2501233.
Proteomic databases
PaxDb	Q93038.
PRIDE	Q93038.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000348333; ENSP00000314451; ENSG00000215788. ENST00000351748; ENSP00000326762; ENSG00000215788. ENST00000351959; ENSP00000337713; ENSG00000215788. ENST00000356876; ENSP00000349341; ENSG00000215788. ENST00000377782; ENSP00000367013; ENSG00000215788. ENST00000414040; ENSP00000404274; ENSG00000215788. ENST00000480393; ENSP00000434129; ENSG00000215788. ENST00000485036; ENSP00000431554; ENSG00000215788. ENST00000502588; ENSP00000423121; ENSG00000215788. ENST00000502730; ENSP00000421976; ENSG00000215788. ENST00000510563; ENSP00000424071; ENSG00000215788.
GeneID	8718.
KEGG	hsa:8718.
UCSC	uc001ana.3. human. uc001ane.3. human. uc001anf.3. human. uc001ang.3. human. uc001anh.3. human. uc001ani.1. human.
Organism-specific databases
CTD	8718.
GeneCards	GC01M006521.
HGNC	HGNC:11910. TNFRSF25.
MIM	603366. gene.
neXtProt	NX_Q93038.
PharmGKB	PA36603.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG25022.
HOVERGEN	HBG058493.
KO	K05160.
OMA	WDQLPSR.
OrthoDB	EOG4HMJ9R.
Gene expression databases
ArrayExpress	Q93038.
Bgee	Q93038.
Genevestigator	Q93038.
GermOnline	ENSG00000171680. Homo sapiens.
Family and domain databases
Gene3D	1.10.533.10. 1 hit.
InterPro	IPR011029. DEATH-like_dom. IPR000488. Death_domain. IPR001368. TNFR/NGFR_Cys_rich_reg. IPR022329. TNFR_25. [Graphical view]
Pfam	PF00531. Death. 1 hit. [Graphical view]
PRINTS	PR01972. TNFACTORR25.
SMART	SM00005. DEATH. 1 hit. SM00208. TNFR. 2 hits. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 1 hit.
PROSITE	PS50017. DEATH_DOMAIN. 1 hit. PS00652. TNFR_NGFR_1. 2 hits. PS50050. TNFR_NGFR_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8718.
NextBio	32691.
SOURCE	Search...

Entry information

Entry name

TNR25_HUMAN

Accession

Primary (citable) accession number: Q93038
Secondary accession number(s): B1ALX2 , B1ALX3, B7ZLL7, O00275, O00276, O00277, O00278, O00279, O00280, O14865, O14866, P78507, P78515, Q17RU4, Q92983, Q93036, Q93037, Q99722, Q99830, Q99831, Q9BY86, Q9UME0, Q9UME1, Q9UME5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 132 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.