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Q93033 (IGSF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunoglobulin superfamily member 2

Short name=IgSF2
Alternative name(s):
Cell surface glycoprotein V7
Glu-Trp-Ile EWI motif-containing protein 101
Short name=EWI-101
CD_antigen=CD101
Gene names
Name:CD101
Synonyms:EWI101, IGSF2, V7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1021 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4+ CD56+ leukemic tumor cells. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.10

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4+ CD56+ blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients. Ref.1 Ref.3 Ref.5 Ref.8 Ref.10

Post-translational modification

N-glycosylated. Ref.3

Sequence similarities

Contains 7 Ig-like C2-type (immunoglobulin-like) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 10211001Immunoglobulin superfamily member 2
PRO_0000253539

Regions

Topological domain21 – 954934Extracellular Potential
Transmembrane955 – 97521Helical; Potential
Topological domain976 – 102146Cytoplasmic Potential
Domain22 – 139118Ig-like C2-type 1
Domain144 – 265122Ig-like C2-type 2
Domain279 – 389111Ig-like C2-type 3
Domain408 – 525118Ig-like C2-type 4
Domain541 – 651111Ig-like C2-type 5
Domain656 – 794139Ig-like C2-type 6
Domain808 – 925118Ig-like C2-type 7
Motif253 – 2553EWI motif

Amino acid modifications

Glycosylation441N-linked (GlcNAc...) Potential
Glycosylation3221N-linked (GlcNAc...) Potential
Disulfide bond43 ↔ 121 By similarity
Disulfide bond168 ↔ 249 By similarity
Disulfide bond304 ↔ 377 By similarity
Disulfide bond434 ↔ 511 By similarity
Disulfide bond562 ↔ 640 By similarity
Disulfide bond697 ↔ 778 By similarity
Disulfide bond834 ↔ 909 By similarity

Natural variations

Natural variant1571G → S.
Corresponds to variant rs34999087 [ dbSNP | Ensembl ].
VAR_054434
Natural variant2251N → S.
Corresponds to variant rs3754112 [ dbSNP | Ensembl ].
VAR_028371
Natural variant4151M → V. Ref.1
Corresponds to variant rs2249265 [ dbSNP | Ensembl ].
VAR_028372
Natural variant5181R → Q.
Corresponds to variant rs17235766 [ dbSNP | Ensembl ].
VAR_028373
Natural variant5251S → R.
Corresponds to variant rs17235773 [ dbSNP | Ensembl ].
VAR_028374
Natural variant6311T → S.
Corresponds to variant rs34510762 [ dbSNP | Ensembl ].
VAR_054435
Natural variant9331R → Q.
Corresponds to variant rs12093834 [ dbSNP | Ensembl ].
VAR_054436
Natural variant9551L → F.
Corresponds to variant rs34223095 [ dbSNP | Ensembl ].
VAR_054437
Natural variant9651V → I.
Corresponds to variant rs12097758 [ dbSNP | Ensembl ].
VAR_028375
Natural variant9881R → C.
Corresponds to variant rs12067543 [ dbSNP | Ensembl ].
VAR_028376
Natural variant9921R → W.
Corresponds to variant rs34248572 [ dbSNP | Ensembl ].
VAR_054438

Experimental info

Sequence conflict911S → G in CAA83923. Ref.1
Sequence conflict1291K → N in CAA83923. Ref.1
Sequence conflict1351S → R in CAA83923. Ref.1
Sequence conflict3521V → L in CAA83923. Ref.1
Sequence conflict6841V → G in CAA83923. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q93033 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: 12A07C648D21EB91

FASTA1,021115,109
        10         20         30         40         50         60 
MAGISYVASF FLLLTKLSIG QREVTVQKGP LFRAEGYPVS IGCNVTGHQG PSEQHFQWSV 

        70         80         90        100        110        120 
YLPTNPTQEV QIISTKDAAF SYAVYTQRVR SGDVYVERVQ GNSVLLHISK LQMKDAGEYE 

       130        140        150        160        170        180 
CHTPNTDEKY YGSYSAKTNL IVIPDTLSAT MSSQTLGKEE GEPLALTCEA SKATAQHTHL 

       190        200        210        220        230        240 
SVTWYLTQDG GGSQATEIIS LSKDFILVPG PLYTERFAAS DVQLNKLGPT TFRLSIERLQ 

       250        260        270        280        290        300 
SSDQGQLFCE ATEWIQDPDE TWMFITKKQT DQTTLRIQPA VKDFQVNITA DSLFAEGKPL 

       310        320        330        340        350        360 
ELVCLVVSSG RDPQLQGIWF FNGTEIAHID AGGVLGLKND YKERASQGEL QVSKLGPKAF 

       370        380        390        400        410        420 
SLKIFSLGPE DEGAYRCVVA EVMKTRTGSW QVLQRKQSPD SHVHLRKPAA RSVVMSTKNK 

       430        440        450        460        470        480 
QQVVWEGETL AFLCKAGGAE SPLSVSWWHI PRDQTQPEFV AGMGQDGIVQ LGASYGVPSY 

       490        500        510        520        530        540 
HGNTRLEKMD WATFQLEITF TAITDSGTYE CRVSEKSRNQ ARDLSWTQKI SVTVKSLESS 

       550        560        570        580        590        600 
LQVSLMSRQP QVMLTNTFDL SCVVRAGYSD LKVPLTVTWQ FQPASSHIFH QLIRITHNGT 

       610        620        630        640        650        660 
IEWGNFLSRF QKKTKVSQSL FRSQLLVHDA TEEETGVYQC EVEVYDRNSL YNNRPPRASA 

       670        680        690        700        710        720 
ISHPLRIAVT LPESKLKVNS RSQVQELSIN SNTDIECSIL SRSNGNLQLA IIWYFSPVST 

       730        740        750        760        770        780 
NASWLKILEM DQTNVIKTGD EFHTPQRKQK FHTEKVSQDL FQLHILNVED SDRGKYHCAV 

       790        800        810        820        830        840 
EEWLLSTNGT WHKLGEKKSG LTELKLKPTG SKVRVSKVYW TENVTEHREV AIRCSLESVG 

       850        860        870        880        890        900 
SSATLYSVMW YWNRENSGSK LLVHLQHDGL LEYGEEGLRR HLHCYRSSST DFVLKLHQVE 

       910        920        930        940        950        960 
MEDAGMYWCR VAEWQLHGHP SKWINQASDE SQRMVLTVLP SEPTLPSRIC SSAPLLYFLF 

       970        980        990       1000       1010       1020 
ICPFVLLLLL LISLLCLYWK ARKLSTLRSN TRKEKALWVD LKEAGGVTTN RREDEEEDEG 


N 

« Hide

References

« Hide 'large scale' references
[1]"V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene."
Ruegg C.L., Rivas A., Madani N.D., Zeitung J., Laus R., Engleman E.G.
J. Immunol. 154:4434-4443(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-415.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies."
Rivas A., Ruegg C.L., Zeitung J., Laus R., Warnke R., Benike C., Engleman E.G.
J. Immunol. 154:4423-4433(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, GLYCOSYLATION, TISSUE SPECIFICITY.
[4]"Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism."
Soares L.R.B., Rivas A., Tsavaler L., Engleman E.G.
J. Immunol. 159:1115-1124(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation."
Bagot M., Martinel I., Charue D., Weill F., Boulland M.-L., Wechsler J., Freeman G.J., Bensussan A., Boumsell L.
Tissue Antigens 50:439-448(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, FUNCTION.
[6]"V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation."
Soares L.R.B., Tsavaler L., Rivas A., Engleman E.G.
J. Immunol. 161:209-217(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL-10 production."
Bouloc A., Bagot M., Delaire S., Bensussan A., Boumsell L.
Eur. J. Immunol. 30:3132-3139(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"CD101 expression by Langerhans cell histiocytosis cells."
Bouloc A., Boulland M.-L., Geissmann F., Fraitag S., Andry P., Teillac D., Bensussan A., Revuz J., Boumsell L., Wechsler J., Bagot M.
Histopathology 36:229-232(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[9]"EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily."
Stipp C.S., Kolesnikova T.V., Hemler M.E.
J. Biol. Chem. 276:40545-40554(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: DOMAIN EWI MOTIF.
[10]"CD4+ CD56+ blastic tumor cells express CD101 molecules."
Meyer N., Petrella T., Poszepczynska-Guigne E., Boumsell L., Wechsler J., Bensussan A., Bagot M.
J. Invest. Dermatol. 124:668-669(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z33642 mRNA. Translation: CAA83923.1.
AL445231 Genomic DNA. Translation: CAH71959.1.
CCDSCCDS891.1.
PIRI39207.
RefSeqNP_001243035.1. NM_001256106.2.
NP_001243038.1. NM_001256109.2.
NP_004249.2. NM_004258.5.
UniGeneHs.654598.

3D structure databases

ProteinModelPortalQ93033.
SMRQ93033. Positions 356-384.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114795. 3 interactions.
IntActQ93033. 4 interactions.
MINTMINT-1391008.
STRING9606.ENSP00000256652.

PTM databases

PhosphoSiteQ93033.

Polymorphism databases

DMDM223590070.

Proteomic databases

PaxDbQ93033.
PRIDEQ93033.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000256652; ENSP00000256652; ENSG00000134256.
ENST00000369470; ENSP00000358482; ENSG00000134256.
GeneID9398.
KEGGhsa:9398.
UCSCuc009whd.4. human.

Organism-specific databases

CTD9398.
GeneCardsGC01P117545.
H-InvDBHIX0028852.
HGNCHGNC:5949. CD101.
HPAHPA057763.
MIM604516. gene.
neXtProtNX_Q93033.
PharmGKBPA29762.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG285870.
HOGENOMHOG000293322.
HOVERGENHBG107997.
InParanoidQ93033.
KOK06522.
OMAGQLFCEA.
OrthoDBEOG78D7JP.
PhylomeDBQ93033.
TreeFamTF332702.

Gene expression databases

BgeeQ93033.
CleanExHS_IGSF2.
GenevestigatorQ93033.

Family and domain databases

Gene3D2.60.40.10. 7 hits.
InterProIPR002195. Dihydroorotase_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07679. I-set. 1 hit.
PF07686. V-set. 4 hits.
[Graphical view]
SMARTSM00409. IG. 7 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiIGSF2.
GenomeRNAi9398.
NextBio35203.
PROQ93033.
SOURCESearch...

Entry information

Entry nameIGSF2_HUMAN
AccessionPrimary (citable) accession number: Q93033
Secondary accession number(s): Q15856
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: February 10, 2009
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries