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Q93033

- IGSF2_HUMAN

UniProt

Q93033 - IGSF2_HUMAN

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Protein

Immunoglobulin superfamily member 2

Gene
CD101, EWI101, IGSF2, V7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4+ CD56+ leukemic tumor cells.6 Publications

GO - Molecular functioni

  1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Source: InterPro

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 2
Short name:
IgSF2
Alternative name(s):
Cell surface glycoprotein V7
Glu-Trp-Ile EWI motif-containing protein 101
Short name:
EWI-101
CD_antigen: CD101
Gene namesi
Name:CD101
Synonyms:EWI101, IGSF2, V7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:5949. CD101.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 954934Extracellular Reviewed predictionAdd
BLAST
Transmembranei955 – 97521Helical; Reviewed predictionAdd
BLAST
Topological domaini976 – 102146Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: ProtInc
  3. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29762.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 10211001Immunoglobulin superfamily member 2PRO_0000253539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 121 By similarity
Glycosylationi44 – 441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi168 ↔ 249 By similarity
Disulfide bondi304 ↔ 377 By similarity
Glycosylationi322 – 3221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi434 ↔ 511 By similarity
Disulfide bondi562 ↔ 640 By similarity
Disulfide bondi697 ↔ 778 By similarity
Disulfide bondi834 ↔ 909 By similarity

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ93033.
PRIDEiQ93033.

PTM databases

PhosphoSiteiQ93033.

Expressioni

Tissue specificityi

Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4+ CD56+ blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients.5 Publications

Gene expression databases

BgeeiQ93033.
CleanExiHS_IGSF2.
GenevestigatoriQ93033.

Organism-specific databases

HPAiHPA057763.

Interactioni

Protein-protein interaction databases

BioGridi114795. 3 interactions.
IntActiQ93033. 4 interactions.
MINTiMINT-1391008.
STRINGi9606.ENSP00000256652.

Structurei

3D structure databases

ProteinModelPortaliQ93033.
SMRiQ93033. Positions 356-384.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 139118Ig-like C2-type 1Add
BLAST
Domaini144 – 265122Ig-like C2-type 2Add
BLAST
Domaini279 – 389111Ig-like C2-type 3Add
BLAST
Domaini408 – 525118Ig-like C2-type 4Add
BLAST
Domaini541 – 651111Ig-like C2-type 5Add
BLAST
Domaini656 – 794139Ig-like C2-type 6Add
BLAST
Domaini808 – 925118Ig-like C2-type 7Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi253 – 2553EWI motif

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285870.
HOGENOMiHOG000293322.
HOVERGENiHBG107997.
InParanoidiQ93033.
KOiK06522.
OMAiGQLFCEA.
OrthoDBiEOG78D7JP.
PhylomeDBiQ93033.
TreeFamiTF332702.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR002195. Dihydroorotase_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF07686. V-set. 4 hits.
[Graphical view]
SMARTiSM00409. IG. 7 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93033-1 [UniParc]FASTAAdd to Basket

« Hide

MAGISYVASF FLLLTKLSIG QREVTVQKGP LFRAEGYPVS IGCNVTGHQG     50
PSEQHFQWSV YLPTNPTQEV QIISTKDAAF SYAVYTQRVR SGDVYVERVQ 100
GNSVLLHISK LQMKDAGEYE CHTPNTDEKY YGSYSAKTNL IVIPDTLSAT 150
MSSQTLGKEE GEPLALTCEA SKATAQHTHL SVTWYLTQDG GGSQATEIIS 200
LSKDFILVPG PLYTERFAAS DVQLNKLGPT TFRLSIERLQ SSDQGQLFCE 250
ATEWIQDPDE TWMFITKKQT DQTTLRIQPA VKDFQVNITA DSLFAEGKPL 300
ELVCLVVSSG RDPQLQGIWF FNGTEIAHID AGGVLGLKND YKERASQGEL 350
QVSKLGPKAF SLKIFSLGPE DEGAYRCVVA EVMKTRTGSW QVLQRKQSPD 400
SHVHLRKPAA RSVVMSTKNK QQVVWEGETL AFLCKAGGAE SPLSVSWWHI 450
PRDQTQPEFV AGMGQDGIVQ LGASYGVPSY HGNTRLEKMD WATFQLEITF 500
TAITDSGTYE CRVSEKSRNQ ARDLSWTQKI SVTVKSLESS LQVSLMSRQP 550
QVMLTNTFDL SCVVRAGYSD LKVPLTVTWQ FQPASSHIFH QLIRITHNGT 600
IEWGNFLSRF QKKTKVSQSL FRSQLLVHDA TEEETGVYQC EVEVYDRNSL 650
YNNRPPRASA ISHPLRIAVT LPESKLKVNS RSQVQELSIN SNTDIECSIL 700
SRSNGNLQLA IIWYFSPVST NASWLKILEM DQTNVIKTGD EFHTPQRKQK 750
FHTEKVSQDL FQLHILNVED SDRGKYHCAV EEWLLSTNGT WHKLGEKKSG 800
LTELKLKPTG SKVRVSKVYW TENVTEHREV AIRCSLESVG SSATLYSVMW 850
YWNRENSGSK LLVHLQHDGL LEYGEEGLRR HLHCYRSSST DFVLKLHQVE 900
MEDAGMYWCR VAEWQLHGHP SKWINQASDE SQRMVLTVLP SEPTLPSRIC 950
SSAPLLYFLF ICPFVLLLLL LISLLCLYWK ARKLSTLRSN TRKEKALWVD 1000
LKEAGGVTTN RREDEEEDEG N 1021
Length:1,021
Mass (Da):115,109
Last modified:February 10, 2009 - v2
Checksum:i12A07C648D21EB91
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti157 – 1571G → S.
Corresponds to variant rs34999087 [ dbSNP | Ensembl ].
VAR_054434
Natural varianti225 – 2251N → S.
Corresponds to variant rs3754112 [ dbSNP | Ensembl ].
VAR_028371
Natural varianti415 – 4151M → V.1 Publication
Corresponds to variant rs2249265 [ dbSNP | Ensembl ].
VAR_028372
Natural varianti518 – 5181R → Q.
Corresponds to variant rs17235766 [ dbSNP | Ensembl ].
VAR_028373
Natural varianti525 – 5251S → R.
Corresponds to variant rs17235773 [ dbSNP | Ensembl ].
VAR_028374
Natural varianti631 – 6311T → S.
Corresponds to variant rs34510762 [ dbSNP | Ensembl ].
VAR_054435
Natural varianti933 – 9331R → Q.
Corresponds to variant rs12093834 [ dbSNP | Ensembl ].
VAR_054436
Natural varianti955 – 9551L → F.
Corresponds to variant rs34223095 [ dbSNP | Ensembl ].
VAR_054437
Natural varianti965 – 9651V → I.
Corresponds to variant rs12097758 [ dbSNP | Ensembl ].
VAR_028375
Natural varianti988 – 9881R → C.
Corresponds to variant rs12067543 [ dbSNP | Ensembl ].
VAR_028376
Natural varianti992 – 9921R → W.
Corresponds to variant rs34248572 [ dbSNP | Ensembl ].
VAR_054438

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911S → G in CAA83923. 1 Publication
Sequence conflicti129 – 1291K → N in CAA83923. 1 Publication
Sequence conflicti135 – 1351S → R in CAA83923. 1 Publication
Sequence conflicti352 – 3521V → L in CAA83923. 1 Publication
Sequence conflicti684 – 6841V → G in CAA83923. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z33642 mRNA. Translation: CAA83923.1.
AL445231 Genomic DNA. Translation: CAH71959.1.
CCDSiCCDS891.1.
PIRiI39207.
RefSeqiNP_001243035.1. NM_001256106.2.
NP_001243038.1. NM_001256109.2.
NP_004249.2. NM_004258.5.
UniGeneiHs.654598.

Genome annotation databases

EnsembliENST00000256652; ENSP00000256652; ENSG00000134256.
ENST00000369470; ENSP00000358482; ENSG00000134256.
GeneIDi9398.
KEGGihsa:9398.
UCSCiuc009whd.4. human.

Polymorphism databases

DMDMi223590070.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z33642 mRNA. Translation: CAA83923.1 .
AL445231 Genomic DNA. Translation: CAH71959.1 .
CCDSi CCDS891.1.
PIRi I39207.
RefSeqi NP_001243035.1. NM_001256106.2.
NP_001243038.1. NM_001256109.2.
NP_004249.2. NM_004258.5.
UniGenei Hs.654598.

3D structure databases

ProteinModelPortali Q93033.
SMRi Q93033. Positions 356-384.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114795. 3 interactions.
IntActi Q93033. 4 interactions.
MINTi MINT-1391008.
STRINGi 9606.ENSP00000256652.

PTM databases

PhosphoSitei Q93033.

Polymorphism databases

DMDMi 223590070.

Proteomic databases

PaxDbi Q93033.
PRIDEi Q93033.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256652 ; ENSP00000256652 ; ENSG00000134256 .
ENST00000369470 ; ENSP00000358482 ; ENSG00000134256 .
GeneIDi 9398.
KEGGi hsa:9398.
UCSCi uc009whd.4. human.

Organism-specific databases

CTDi 9398.
GeneCardsi GC01P117545.
H-InvDB HIX0028852.
HGNCi HGNC:5949. CD101.
HPAi HPA057763.
MIMi 604516. gene.
neXtProti NX_Q93033.
PharmGKBi PA29762.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG285870.
HOGENOMi HOG000293322.
HOVERGENi HBG107997.
InParanoidi Q93033.
KOi K06522.
OMAi GQLFCEA.
OrthoDBi EOG78D7JP.
PhylomeDBi Q93033.
TreeFami TF332702.

Miscellaneous databases

GeneWikii IGSF2.
GenomeRNAii 9398.
NextBioi 35203.
PROi Q93033.
SOURCEi Search...

Gene expression databases

Bgeei Q93033.
CleanExi HS_IGSF2.
Genevestigatori Q93033.

Family and domain databases

Gene3Di 2.60.40.10. 7 hits.
InterProi IPR002195. Dihydroorotase_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07679. I-set. 1 hit.
PF07686. V-set. 4 hits.
[Graphical view ]
SMARTi SM00409. IG. 7 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene."
    Ruegg C.L., Rivas A., Madani N.D., Zeitung J., Laus R., Engleman E.G.
    J. Immunol. 154:4434-4443(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-415.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies."
    Rivas A., Ruegg C.L., Zeitung J., Laus R., Warnke R., Benike C., Engleman E.G.
    J. Immunol. 154:4423-4433(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GLYCOSYLATION, TISSUE SPECIFICITY.
  4. "Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism."
    Soares L.R.B., Rivas A., Tsavaler L., Engleman E.G.
    J. Immunol. 159:1115-1124(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation."
    Bagot M., Martinel I., Charue D., Weill F., Boulland M.-L., Wechsler J., Freeman G.J., Bensussan A., Boumsell L.
    Tissue Antigens 50:439-448(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.
  6. "V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation."
    Soares L.R.B., Tsavaler L., Rivas A., Engleman E.G.
    J. Immunol. 161:209-217(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL-10 production."
    Bouloc A., Bagot M., Delaire S., Bensussan A., Boumsell L.
    Eur. J. Immunol. 30:3132-3139(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. Cited for: TISSUE SPECIFICITY.
  9. "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily."
    Stipp C.S., Kolesnikova T.V., Hemler M.E.
    J. Biol. Chem. 276:40545-40554(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN EWI MOTIF.
  10. Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiIGSF2_HUMAN
AccessioniPrimary (citable) accession number: Q93033
Secondary accession number(s): Q15856
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: February 10, 2009
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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