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Q93033

- IGSF2_HUMAN

UniProt

Q93033 - IGSF2_HUMAN

Protein

Immunoglobulin superfamily member 2

Gene

CD101

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4+ CD56+ leukemic tumor cells.6 Publications

    GO - Molecular functioni

    1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Source: InterPro

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Immunoglobulin superfamily member 2
    Short name:
    IgSF2
    Alternative name(s):
    Cell surface glycoprotein V7
    Glu-Trp-Ile EWI motif-containing protein 101
    Short name:
    EWI-101
    CD_antigen: CD101
    Gene namesi
    Name:CD101
    Synonyms:EWI101, IGSF2, V7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:5949. CD101.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: ProtInc
    3. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29762.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 10211001Immunoglobulin superfamily member 2PRO_0000253539Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 121PROSITE-ProRule annotation
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi168 ↔ 249PROSITE-ProRule annotation
    Disulfide bondi304 ↔ 377PROSITE-ProRule annotation
    Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi434 ↔ 511PROSITE-ProRule annotation
    Disulfide bondi562 ↔ 640PROSITE-ProRule annotation
    Disulfide bondi697 ↔ 778PROSITE-ProRule annotation
    Disulfide bondi834 ↔ 909PROSITE-ProRule annotation

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ93033.
    PRIDEiQ93033.

    PTM databases

    PhosphoSiteiQ93033.

    Expressioni

    Tissue specificityi

    Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4+ CD56+ blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients.5 Publications

    Gene expression databases

    BgeeiQ93033.
    CleanExiHS_IGSF2.
    GenevestigatoriQ93033.

    Organism-specific databases

    HPAiHPA057763.

    Interactioni

    Protein-protein interaction databases

    BioGridi114795. 3 interactions.
    IntActiQ93033. 4 interactions.
    MINTiMINT-1391008.
    STRINGi9606.ENSP00000256652.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93033.
    SMRiQ93033. Positions 356-384.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 954934ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini976 – 102146CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei955 – 97521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 139118Ig-like C2-type 1Add
    BLAST
    Domaini144 – 265122Ig-like C2-type 2Add
    BLAST
    Domaini279 – 389111Ig-like C2-type 3Add
    BLAST
    Domaini408 – 525118Ig-like C2-type 4Add
    BLAST
    Domaini541 – 651111Ig-like C2-type 5Add
    BLAST
    Domaini656 – 794139Ig-like C2-type 6Add
    BLAST
    Domaini808 – 925118Ig-like C2-type 7Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi253 – 2553EWI motif

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG285870.
    HOGENOMiHOG000293322.
    HOVERGENiHBG107997.
    InParanoidiQ93033.
    KOiK06522.
    OMAiGQLFCEA.
    OrthoDBiEOG78D7JP.
    PhylomeDBiQ93033.
    TreeFamiTF332702.

    Family and domain databases

    Gene3Di2.60.40.10. 7 hits.
    InterProiIPR002195. Dihydroorotase_CS.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07679. I-set. 1 hit.
    PF07686. V-set. 4 hits.
    [Graphical view]
    SMARTiSM00409. IG. 7 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q93033-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGISYVASF FLLLTKLSIG QREVTVQKGP LFRAEGYPVS IGCNVTGHQG     50
    PSEQHFQWSV YLPTNPTQEV QIISTKDAAF SYAVYTQRVR SGDVYVERVQ 100
    GNSVLLHISK LQMKDAGEYE CHTPNTDEKY YGSYSAKTNL IVIPDTLSAT 150
    MSSQTLGKEE GEPLALTCEA SKATAQHTHL SVTWYLTQDG GGSQATEIIS 200
    LSKDFILVPG PLYTERFAAS DVQLNKLGPT TFRLSIERLQ SSDQGQLFCE 250
    ATEWIQDPDE TWMFITKKQT DQTTLRIQPA VKDFQVNITA DSLFAEGKPL 300
    ELVCLVVSSG RDPQLQGIWF FNGTEIAHID AGGVLGLKND YKERASQGEL 350
    QVSKLGPKAF SLKIFSLGPE DEGAYRCVVA EVMKTRTGSW QVLQRKQSPD 400
    SHVHLRKPAA RSVVMSTKNK QQVVWEGETL AFLCKAGGAE SPLSVSWWHI 450
    PRDQTQPEFV AGMGQDGIVQ LGASYGVPSY HGNTRLEKMD WATFQLEITF 500
    TAITDSGTYE CRVSEKSRNQ ARDLSWTQKI SVTVKSLESS LQVSLMSRQP 550
    QVMLTNTFDL SCVVRAGYSD LKVPLTVTWQ FQPASSHIFH QLIRITHNGT 600
    IEWGNFLSRF QKKTKVSQSL FRSQLLVHDA TEEETGVYQC EVEVYDRNSL 650
    YNNRPPRASA ISHPLRIAVT LPESKLKVNS RSQVQELSIN SNTDIECSIL 700
    SRSNGNLQLA IIWYFSPVST NASWLKILEM DQTNVIKTGD EFHTPQRKQK 750
    FHTEKVSQDL FQLHILNVED SDRGKYHCAV EEWLLSTNGT WHKLGEKKSG 800
    LTELKLKPTG SKVRVSKVYW TENVTEHREV AIRCSLESVG SSATLYSVMW 850
    YWNRENSGSK LLVHLQHDGL LEYGEEGLRR HLHCYRSSST DFVLKLHQVE 900
    MEDAGMYWCR VAEWQLHGHP SKWINQASDE SQRMVLTVLP SEPTLPSRIC 950
    SSAPLLYFLF ICPFVLLLLL LISLLCLYWK ARKLSTLRSN TRKEKALWVD 1000
    LKEAGGVTTN RREDEEEDEG N 1021
    Length:1,021
    Mass (Da):115,109
    Last modified:February 10, 2009 - v2
    Checksum:i12A07C648D21EB91
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911S → G in CAA83923. (PubMed:7722300)Curated
    Sequence conflicti129 – 1291K → N in CAA83923. (PubMed:7722300)Curated
    Sequence conflicti135 – 1351S → R in CAA83923. (PubMed:7722300)Curated
    Sequence conflicti352 – 3521V → L in CAA83923. (PubMed:7722300)Curated
    Sequence conflicti684 – 6841V → G in CAA83923. (PubMed:7722300)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti157 – 1571G → S.
    Corresponds to variant rs34999087 [ dbSNP | Ensembl ].
    VAR_054434
    Natural varianti225 – 2251N → S.
    Corresponds to variant rs3754112 [ dbSNP | Ensembl ].
    VAR_028371
    Natural varianti415 – 4151M → V.1 Publication
    Corresponds to variant rs2249265 [ dbSNP | Ensembl ].
    VAR_028372
    Natural varianti518 – 5181R → Q.
    Corresponds to variant rs17235766 [ dbSNP | Ensembl ].
    VAR_028373
    Natural varianti525 – 5251S → R.
    Corresponds to variant rs17235773 [ dbSNP | Ensembl ].
    VAR_028374
    Natural varianti631 – 6311T → S.
    Corresponds to variant rs34510762 [ dbSNP | Ensembl ].
    VAR_054435
    Natural varianti933 – 9331R → Q.
    Corresponds to variant rs12093834 [ dbSNP | Ensembl ].
    VAR_054436
    Natural varianti955 – 9551L → F.
    Corresponds to variant rs34223095 [ dbSNP | Ensembl ].
    VAR_054437
    Natural varianti965 – 9651V → I.
    Corresponds to variant rs12097758 [ dbSNP | Ensembl ].
    VAR_028375
    Natural varianti988 – 9881R → C.
    Corresponds to variant rs12067543 [ dbSNP | Ensembl ].
    VAR_028376
    Natural varianti992 – 9921R → W.
    Corresponds to variant rs34248572 [ dbSNP | Ensembl ].
    VAR_054438

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z33642 mRNA. Translation: CAA83923.1.
    AL445231 Genomic DNA. Translation: CAH71959.1.
    CCDSiCCDS891.1.
    PIRiI39207.
    RefSeqiNP_001243035.1. NM_001256106.2.
    NP_001243038.1. NM_001256109.2.
    NP_004249.2. NM_004258.5.
    UniGeneiHs.654598.

    Genome annotation databases

    EnsembliENST00000256652; ENSP00000256652; ENSG00000134256.
    ENST00000369470; ENSP00000358482; ENSG00000134256.
    GeneIDi9398.
    KEGGihsa:9398.
    UCSCiuc009whd.4. human.

    Polymorphism databases

    DMDMi223590070.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z33642 mRNA. Translation: CAA83923.1 .
    AL445231 Genomic DNA. Translation: CAH71959.1 .
    CCDSi CCDS891.1.
    PIRi I39207.
    RefSeqi NP_001243035.1. NM_001256106.2.
    NP_001243038.1. NM_001256109.2.
    NP_004249.2. NM_004258.5.
    UniGenei Hs.654598.

    3D structure databases

    ProteinModelPortali Q93033.
    SMRi Q93033. Positions 356-384.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114795. 3 interactions.
    IntActi Q93033. 4 interactions.
    MINTi MINT-1391008.
    STRINGi 9606.ENSP00000256652.

    PTM databases

    PhosphoSitei Q93033.

    Polymorphism databases

    DMDMi 223590070.

    Proteomic databases

    PaxDbi Q93033.
    PRIDEi Q93033.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256652 ; ENSP00000256652 ; ENSG00000134256 .
    ENST00000369470 ; ENSP00000358482 ; ENSG00000134256 .
    GeneIDi 9398.
    KEGGi hsa:9398.
    UCSCi uc009whd.4. human.

    Organism-specific databases

    CTDi 9398.
    GeneCardsi GC01P117545.
    H-InvDB HIX0028852.
    HGNCi HGNC:5949. CD101.
    HPAi HPA057763.
    MIMi 604516. gene.
    neXtProti NX_Q93033.
    PharmGKBi PA29762.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285870.
    HOGENOMi HOG000293322.
    HOVERGENi HBG107997.
    InParanoidi Q93033.
    KOi K06522.
    OMAi GQLFCEA.
    OrthoDBi EOG78D7JP.
    PhylomeDBi Q93033.
    TreeFami TF332702.

    Miscellaneous databases

    GeneWikii IGSF2.
    GenomeRNAii 9398.
    NextBioi 35203.
    PROi Q93033.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q93033.
    CleanExi HS_IGSF2.
    Genevestigatori Q93033.

    Family and domain databases

    Gene3Di 2.60.40.10. 7 hits.
    InterProi IPR002195. Dihydroorotase_CS.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07679. I-set. 1 hit.
    PF07686. V-set. 4 hits.
    [Graphical view ]
    SMARTi SM00409. IG. 7 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene."
      Ruegg C.L., Rivas A., Madani N.D., Zeitung J., Laus R., Engleman E.G.
      J. Immunol. 154:4434-4443(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-415.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies."
      Rivas A., Ruegg C.L., Zeitung J., Laus R., Warnke R., Benike C., Engleman E.G.
      J. Immunol. 154:4423-4433(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, GLYCOSYLATION, TISSUE SPECIFICITY.
    4. "Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism."
      Soares L.R.B., Rivas A., Tsavaler L., Engleman E.G.
      J. Immunol. 159:1115-1124(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation."
      Bagot M., Martinel I., Charue D., Weill F., Boulland M.-L., Wechsler J., Freeman G.J., Bensussan A., Boumsell L.
      Tissue Antigens 50:439-448(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION.
    6. "V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation."
      Soares L.R.B., Tsavaler L., Rivas A., Engleman E.G.
      J. Immunol. 161:209-217(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL-10 production."
      Bouloc A., Bagot M., Delaire S., Bensussan A., Boumsell L.
      Eur. J. Immunol. 30:3132-3139(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. Cited for: TISSUE SPECIFICITY.
    9. "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily."
      Stipp C.S., Kolesnikova T.V., Hemler M.E.
      J. Biol. Chem. 276:40545-40554(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOMAIN EWI MOTIF.
    10. Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiIGSF2_HUMAN
    AccessioniPrimary (citable) accession number: Q93033
    Secondary accession number(s): Q15856
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3