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Q93015

- NAT6_HUMAN

UniProt

Q93015 - NAT6_HUMAN

Protein

N-acetyltransferase 6

Gene

NAT6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor.1 Publication

    GO - Molecular functioni

    1. N-acetyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyltransferase 6 (EC:2.3.1.-)
    Alternative name(s):
    Protein fusion-2
    Short name:
    Protein fus-2
    Gene namesi
    Name:NAT6
    Synonyms:FUS2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30252. NAT6.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA134979782.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286N-acetyltransferase 6PRO_0000074536Add
    BLAST

    Proteomic databases

    MaxQBiQ93015.
    PaxDbiQ93015.
    PRIDEiQ93015.

    PTM databases

    PhosphoSiteiQ93015.

    Expressioni

    Tissue specificityi

    Strongly expressed in heart and skeletal muscle, followed by brain and pancreas, with weak expression in kidney, liver, and lung and no expression in placenta.

    Gene expression databases

    ArrayExpressiQ93015.
    BgeeiQ93015.
    GenevestigatoriQ93015.

    Organism-specific databases

    HPAiHPA039576.

    Interactioni

    Protein-protein interaction databases

    BioGridi117293. 1 interaction.
    IntActiQ93015. 1 interaction.
    STRINGi9606.ENSP00000346927.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93015.
    SMRiQ93015. Positions 135-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini60 – 207148N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the acetyltransferase family.Curated
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG325811.
    HOGENOMiHOG000113734.
    HOVERGENiHBG031735.
    InParanoidiQ93015.
    OMAiGCPIFWM.
    PhylomeDBiQ93015.
    TreeFamiTF106312.

    Family and domain databases

    Gene3Di3.40.630.30. 2 hits.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q93015-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MELILSTSPA ELTLDPACQP KLPLDSTCQP EMTFNPGPTE LTLDPEHQPE    50
    ETPAPSLAEL TLEPVHRRPE LLDACADLIN DQWPRSRTSR LHSLGQSSDA 100
    FPLCLMLLSP HPTLEAAPVV VGHARLSRVL NQPQSLLVET VVVARALRGR 150
    GFGRRLMEGL EVFARARGFR KLHLTTHDQV HFYTHLGYQL GEPVQGLVFT 200
    SRRLPATLLN AFPTAPSPRP PRKAPNLTAQ AAPRGPKGPP LPPPPPLPEC 250
    LTISPPVPSG PPSKSLLETQ YQNVRGRPIF WMEKDI 286
    Length:286
    Mass (Da):31,445
    Last modified:June 1, 1998 - v2
    Checksum:iA755E2E3367625DB
    GO
    Isoform 2 (identifier: Q93015-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MQELTLSPGPAKLTPTLDPTHRM

    Show »
    Length:308
    Mass (Da):33,831
    Checksum:i09A5F1F976681DB5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti145 – 1451R → S in non-small cell lung cancer cell lines. 1 Publication
    VAR_014224
    Natural varianti207 – 2071T → S in non-small cell lung cancer cell lines. 1 Publication
    VAR_014225

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MQELTLSPGPAKLTPTLDPT HRM in isoform 2. 1 PublicationVSP_037187

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF040706 mRNA. Translation: AAC70913.1.
    AF040705 mRNA. Translation: AAC70912.1.
    U73167 Genomic DNA. Translation: AAC02732.1.
    BC004483 mRNA. Translation: AAH04483.2.
    CCDSiCCDS43095.1. [Q93015-2]
    CCDS56258.1. [Q93015-1]
    RefSeqiNP_001186945.1. NM_001200016.1. [Q93015-1]
    NP_001186947.1. NM_001200018.1. [Q93015-1]
    NP_036323.2. NM_012191.3. [Q93015-2]
    UniGeneiHs.129910.
    Hs.736942.

    Genome annotation databases

    EnsembliENST00000354862; ENSP00000346927; ENSG00000243477. [Q93015-2]
    ENST00000417393; ENSP00000391893; ENSG00000243477. [Q93015-1]
    ENST00000443094; ENSP00000410610; ENSG00000243477. [Q93015-1]
    ENST00000443842; ENSP00000400559; ENSG00000243477. [Q93015-1]
    GeneIDi24142.
    KEGGihsa:24142.
    UCSCiuc003czi.3. human. [Q93015-1]
    uc003czj.3. human. [Q93015-2]

    Polymorphism databases

    DMDMi25008833.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF040706 mRNA. Translation: AAC70913.1 .
    AF040705 mRNA. Translation: AAC70912.1 .
    U73167 Genomic DNA. Translation: AAC02732.1 .
    BC004483 mRNA. Translation: AAH04483.2 .
    CCDSi CCDS43095.1. [Q93015-2 ]
    CCDS56258.1. [Q93015-1 ]
    RefSeqi NP_001186945.1. NM_001200016.1. [Q93015-1 ]
    NP_001186947.1. NM_001200018.1. [Q93015-1 ]
    NP_036323.2. NM_012191.3. [Q93015-2 ]
    UniGenei Hs.129910.
    Hs.736942.

    3D structure databases

    ProteinModelPortali Q93015.
    SMRi Q93015. Positions 135-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117293. 1 interaction.
    IntActi Q93015. 1 interaction.
    STRINGi 9606.ENSP00000346927.

    PTM databases

    PhosphoSitei Q93015.

    Polymorphism databases

    DMDMi 25008833.

    Proteomic databases

    MaxQBi Q93015.
    PaxDbi Q93015.
    PRIDEi Q93015.

    Protocols and materials databases

    DNASUi 24142.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354862 ; ENSP00000346927 ; ENSG00000243477 . [Q93015-2 ]
    ENST00000417393 ; ENSP00000391893 ; ENSG00000243477 . [Q93015-1 ]
    ENST00000443094 ; ENSP00000410610 ; ENSG00000243477 . [Q93015-1 ]
    ENST00000443842 ; ENSP00000400559 ; ENSG00000243477 . [Q93015-1 ]
    GeneIDi 24142.
    KEGGi hsa:24142.
    UCSCi uc003czi.3. human. [Q93015-1 ]
    uc003czj.3. human. [Q93015-2 ]

    Organism-specific databases

    CTDi 24142.
    GeneCardsi GC03M050333.
    HGNCi HGNC:30252. NAT6.
    HPAi HPA039576.
    MIMi 607073. gene.
    neXtProti NX_Q93015.
    PharmGKBi PA134979782.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG325811.
    HOGENOMi HOG000113734.
    HOVERGENi HBG031735.
    InParanoidi Q93015.
    OMAi GCPIFWM.
    PhylomeDBi Q93015.
    TreeFami TF106312.

    Miscellaneous databases

    GenomeRNAii 24142.
    NextBioi 46825.
    PROi Q93015.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q93015.
    Bgeei Q93015.
    Genevestigatori Q93015.

    Family and domain databases

    Gene3Di 3.40.630.30. 2 hits.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fong K., Zabarovsky E., Kashuba V., Kuzmin I., Latif F., Mele G., Sekido Y., Bader S., Duh F.-M., Wei M.-H., Lerman M.I., Minna J.D.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Pancreas.
    4. "The putative tumour suppressor Fus-2 is an N-acetyltransferase."
      Zegerman P., Bannister A.J., Kouzarides T.
      Oncogene 19:161-163(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    5. "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes."
      The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium
      Lerman M.I., Minna J.D.
      Cancer Res. 60:6116-6133(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISCUSSION OF SEQUENCE, VARIANTS SER-145 AND SER-207.

    Entry informationi

    Entry nameiNAT6_HUMAN
    AccessioniPrimary (citable) accession number: Q93015
    Secondary accession number(s): Q93014
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3