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Protein

N-acetyltransferase 6

Gene

NAT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyltransferase 6 (EC:2.3.1.-)
Alternative name(s):
Protein fusion-2
Short name:
Protein fus-2
Gene namesi
Name:NAT6
Synonyms:FUS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30252. NAT6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi24142.
OpenTargetsiENSG00000243477.
PharmGKBiPA134979782.

Polymorphism and mutation databases

BioMutaiNAT6.
DMDMi25008833.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000745361 – 286N-acetyltransferase 6Add BLAST286

Proteomic databases

EPDiQ93015.
MaxQBiQ93015.
PaxDbiQ93015.
PeptideAtlasiQ93015.
PRIDEiQ93015.

PTM databases

iPTMnetiQ93015.
PhosphoSitePlusiQ93015.

Expressioni

Tissue specificityi

Strongly expressed in heart and skeletal muscle, followed by brain and pancreas, with weak expression in kidney, liver, and lung and no expression in placenta.

Gene expression databases

BgeeiENSG00000243477.
ExpressionAtlasiQ93015. baseline and differential.
GenevisibleiQ93015. HS.

Organism-specific databases

HPAiHPA039576.

Interactioni

Protein-protein interaction databases

BioGridi117293. 2 interactors.
IntActiQ93015. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ93015.
SMRiQ93015.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 207N-acetyltransferasePROSITE-ProRule annotationAdd BLAST148

Sequence similaritiesi

Belongs to the acetyltransferase family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IS85. Eukaryota.
ENOG4111U9V. LUCA.
GeneTreeiENSGT00390000000980.
HOGENOMiHOG000113734.
HOVERGENiHBG031735.
InParanoidiQ93015.
OMAiGCPIFWM.
OrthoDBiEOG091G0SQB.
PhylomeDBiQ93015.
TreeFamiTF106312.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q93015-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELILSTSPA ELTLDPACQP KLPLDSTCQP EMTFNPGPTE LTLDPEHQPE
60 70 80 90 100
ETPAPSLAEL TLEPVHRRPE LLDACADLIN DQWPRSRTSR LHSLGQSSDA
110 120 130 140 150
FPLCLMLLSP HPTLEAAPVV VGHARLSRVL NQPQSLLVET VVVARALRGR
160 170 180 190 200
GFGRRLMEGL EVFARARGFR KLHLTTHDQV HFYTHLGYQL GEPVQGLVFT
210 220 230 240 250
SRRLPATLLN AFPTAPSPRP PRKAPNLTAQ AAPRGPKGPP LPPPPPLPEC
260 270 280
LTISPPVPSG PPSKSLLETQ YQNVRGRPIF WMEKDI
Length:286
Mass (Da):31,445
Last modified:June 1, 1998 - v2
Checksum:iA755E2E3367625DB
GO
Isoform 2 (identifier: Q93015-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQELTLSPGPAKLTPTLDPTHRM

Show »
Length:308
Mass (Da):33,831
Checksum:i09A5F1F976681DB5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014224145R → S in non-small cell lung cancer cell lines. 1 Publication1
Natural variantiVAR_014225207T → S in non-small cell lung cancer cell lines. 1 PublicationCorresponds to variant rs200439690dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0371871M → MQELTLSPGPAKLTPTLDPT HRM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040706 mRNA. Translation: AAC70913.1.
AF040705 mRNA. Translation: AAC70912.1.
U73167 Genomic DNA. Translation: AAC02732.1.
BC004483 mRNA. Translation: AAH04483.2.
CCDSiCCDS43095.1. [Q93015-2]
CCDS56258.1. [Q93015-1]
RefSeqiNP_001186945.1. NM_001200016.1. [Q93015-1]
NP_001186947.1. NM_001200018.1. [Q93015-1]
NP_036323.2. NM_012191.3. [Q93015-2]
UniGeneiHs.129910.
Hs.736942.

Genome annotation databases

EnsembliENST00000354862; ENSP00000346927; ENSG00000243477. [Q93015-2]
ENST00000417393; ENSP00000391893; ENSG00000243477. [Q93015-1]
ENST00000443094; ENSP00000410610; ENSG00000243477. [Q93015-1]
ENST00000443842; ENSP00000400559; ENSG00000243477. [Q93015-1]
GeneIDi24142.
KEGGihsa:24142.
UCSCiuc003czi.4. human. [Q93015-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040706 mRNA. Translation: AAC70913.1.
AF040705 mRNA. Translation: AAC70912.1.
U73167 Genomic DNA. Translation: AAC02732.1.
BC004483 mRNA. Translation: AAH04483.2.
CCDSiCCDS43095.1. [Q93015-2]
CCDS56258.1. [Q93015-1]
RefSeqiNP_001186945.1. NM_001200016.1. [Q93015-1]
NP_001186947.1. NM_001200018.1. [Q93015-1]
NP_036323.2. NM_012191.3. [Q93015-2]
UniGeneiHs.129910.
Hs.736942.

3D structure databases

ProteinModelPortaliQ93015.
SMRiQ93015.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117293. 2 interactors.
IntActiQ93015. 2 interactors.

PTM databases

iPTMnetiQ93015.
PhosphoSitePlusiQ93015.

Polymorphism and mutation databases

BioMutaiNAT6.
DMDMi25008833.

Proteomic databases

EPDiQ93015.
MaxQBiQ93015.
PaxDbiQ93015.
PeptideAtlasiQ93015.
PRIDEiQ93015.

Protocols and materials databases

DNASUi24142.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354862; ENSP00000346927; ENSG00000243477. [Q93015-2]
ENST00000417393; ENSP00000391893; ENSG00000243477. [Q93015-1]
ENST00000443094; ENSP00000410610; ENSG00000243477. [Q93015-1]
ENST00000443842; ENSP00000400559; ENSG00000243477. [Q93015-1]
GeneIDi24142.
KEGGihsa:24142.
UCSCiuc003czi.4. human. [Q93015-1]

Organism-specific databases

CTDi24142.
DisGeNETi24142.
GeneCardsiNAT6.
HGNCiHGNC:30252. NAT6.
HPAiHPA039576.
MIMi607073. gene.
neXtProtiNX_Q93015.
OpenTargetsiENSG00000243477.
PharmGKBiPA134979782.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS85. Eukaryota.
ENOG4111U9V. LUCA.
GeneTreeiENSGT00390000000980.
HOGENOMiHOG000113734.
HOVERGENiHBG031735.
InParanoidiQ93015.
OMAiGCPIFWM.
OrthoDBiEOG091G0SQB.
PhylomeDBiQ93015.
TreeFamiTF106312.

Miscellaneous databases

GenomeRNAii24142.
PROiQ93015.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000243477.
ExpressionAtlasiQ93015. baseline and differential.
GenevisibleiQ93015. HS.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAT6_HUMAN
AccessioniPrimary (citable) accession number: Q93015
Secondary accession number(s): Q93014
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.