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Q93015 (NAT6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-acetyltransferase 6

EC=2.3.1.-
Alternative name(s):
Protein fusion-2
Short name=Protein fus-2
Gene names
Name:NAT6
Synonyms:FUS2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor. Ref.4

Subcellular location

Cytoplasm Ref.4.

Tissue specificity

Strongly expressed in heart and skeletal muscle, followed by brain and pancreas, with weak expression in kidney, liver, and lung and no expression in placenta.

Sequence similarities

Belongs to the acetyltransferase family.

Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseTumor suppressor
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionN-acetyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q93015-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q93015-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQELTLSPGPAKLTPTLDPTHRM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286N-acetyltransferase 6
PRO_0000074536

Regions

Domain60 – 207148N-acetyltransferase

Natural variations

Alternative sequence11M → MQELTLSPGPAKLTPTLDPT HRM in isoform 2.
VSP_037187
Natural variant1451R → S in non-small cell lung cancer cell lines. Ref.5
VAR_014224
Natural variant2071T → S in non-small cell lung cancer cell lines. Ref.5
VAR_014225

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 1998. Version 2.
Checksum: A755E2E3367625DB

FASTA28631,445
        10         20         30         40         50         60 
MELILSTSPA ELTLDPACQP KLPLDSTCQP EMTFNPGPTE LTLDPEHQPE ETPAPSLAEL 

        70         80         90        100        110        120 
TLEPVHRRPE LLDACADLIN DQWPRSRTSR LHSLGQSSDA FPLCLMLLSP HPTLEAAPVV 

       130        140        150        160        170        180 
VGHARLSRVL NQPQSLLVET VVVARALRGR GFGRRLMEGL EVFARARGFR KLHLTTHDQV 

       190        200        210        220        230        240 
HFYTHLGYQL GEPVQGLVFT SRRLPATLLN AFPTAPSPRP PRKAPNLTAQ AAPRGPKGPP 

       250        260        270        280 
LPPPPPLPEC LTISPPVPSG PPSKSLLETQ YQNVRGRPIF WMEKDI 

« Hide

Isoform 2 [UniParc].

Checksum: 09A5F1F976681DB5
Show »

FASTA30833,831

References

« Hide 'large scale' references
[1]Fong K., Zabarovsky E., Kashuba V., Kuzmin I., Latif F., Mele G., Sekido Y., Bader S., Duh F.-M., Wei M.-H., Lerman M.I., Minna J.D.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Pancreas.
[4]"The putative tumour suppressor Fus-2 is an N-acetyltransferase."
Zegerman P., Bannister A.J., Kouzarides T.
Oncogene 19:161-163(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes."
The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium
Lerman M.I., Minna J.D.
Cancer Res. 60:6116-6133(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: DISCUSSION OF SEQUENCE, VARIANTS SER-145 AND SER-207.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF040706 mRNA. Translation: AAC70913.1.
AF040705 mRNA. Translation: AAC70912.1.
U73167 Genomic DNA. Translation: AAC02732.1.
BC004483 mRNA. Translation: AAH04483.2.
CCDSCCDS43095.1. [Q93015-2]
CCDS56258.1. [Q93015-1]
RefSeqNP_001186945.1. NM_001200016.1. [Q93015-1]
NP_001186947.1. NM_001200018.1. [Q93015-1]
NP_036323.2. NM_012191.3. [Q93015-2]
UniGeneHs.129910.
Hs.736942.

3D structure databases

ProteinModelPortalQ93015.
SMRQ93015. Positions 135-198.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117293. 1 interaction.
IntActQ93015. 1 interaction.
STRING9606.ENSP00000346927.

PTM databases

PhosphoSiteQ93015.

Polymorphism databases

DMDM25008833.

Proteomic databases

MaxQBQ93015.
PaxDbQ93015.
PRIDEQ93015.

Protocols and materials databases

DNASU24142.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354862; ENSP00000346927; ENSG00000243477. [Q93015-2]
ENST00000417393; ENSP00000391893; ENSG00000243477. [Q93015-1]
ENST00000443094; ENSP00000410610; ENSG00000243477. [Q93015-1]
ENST00000443842; ENSP00000400559; ENSG00000243477. [Q93015-1]
ENST00000570345; ENSP00000459273; ENSG00000261871. [Q93015-1]
ENST00000571097; ENSP00000458495; ENSG00000261871. [Q93015-2]
ENST00000573208; ENSP00000459800; ENSG00000261871. [Q93015-1]
ENST00000575928; ENSP00000458407; ENSG00000261871. [Q93015-1]
GeneID24142.
KEGGhsa:24142.
UCSCuc003czi.3. human. [Q93015-1]
uc003czj.3. human. [Q93015-2]

Organism-specific databases

CTD24142.
GeneCardsGC03M050333.
HGNCHGNC:30252. NAT6.
HPAHPA039576.
MIM607073. gene.
neXtProtNX_Q93015.
PharmGKBPA134979782.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG325811.
HOGENOMHOG000113734.
HOVERGENHBG031735.
InParanoidQ93015.
OMAGCPIFWM.
PhylomeDBQ93015.
TreeFamTF106312.

Gene expression databases

ArrayExpressQ93015.
BgeeQ93015.
GenevestigatorQ93015.

Family and domain databases

Gene3D3.40.630.30. 2 hits.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi24142.
NextBio46825.
PROQ93015.
SOURCESearch...

Entry information

Entry nameNAT6_HUMAN
AccessionPrimary (citable) accession number: Q93015
Secondary accession number(s): Q93014
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM