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Q93015

- NAT6_HUMAN

UniProt

Q93015 - NAT6_HUMAN

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Protein
N-acetyltransferase 6
Gene
NAT6, FUS2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor.1 Publication

GO - Molecular functioni

  1. N-acetyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyltransferase 6 (EC:2.3.1.-)
Alternative name(s):
Protein fusion-2
Short name:
Protein fus-2
Gene namesi
Name:NAT6
Synonyms:FUS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30252. NAT6.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA134979782.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286N-acetyltransferase 6
PRO_0000074536Add
BLAST

Proteomic databases

MaxQBiQ93015.
PaxDbiQ93015.
PRIDEiQ93015.

PTM databases

PhosphoSiteiQ93015.

Expressioni

Tissue specificityi

Strongly expressed in heart and skeletal muscle, followed by brain and pancreas, with weak expression in kidney, liver, and lung and no expression in placenta.

Gene expression databases

ArrayExpressiQ93015.
BgeeiQ93015.
GenevestigatoriQ93015.

Organism-specific databases

HPAiHPA039576.

Interactioni

Protein-protein interaction databases

BioGridi117293. 1 interaction.
IntActiQ93015. 1 interaction.
STRINGi9606.ENSP00000346927.

Structurei

3D structure databases

ProteinModelPortaliQ93015.
SMRiQ93015. Positions 135-198.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 207148N-acetyltransferase
Add
BLAST

Sequence similaritiesi

Belongs to the acetyltransferase family.

Phylogenomic databases

eggNOGiNOG325811.
HOGENOMiHOG000113734.
HOVERGENiHBG031735.
InParanoidiQ93015.
OMAiGCPIFWM.
PhylomeDBiQ93015.
TreeFamiTF106312.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q93015-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MELILSTSPA ELTLDPACQP KLPLDSTCQP EMTFNPGPTE LTLDPEHQPE    50
ETPAPSLAEL TLEPVHRRPE LLDACADLIN DQWPRSRTSR LHSLGQSSDA 100
FPLCLMLLSP HPTLEAAPVV VGHARLSRVL NQPQSLLVET VVVARALRGR 150
GFGRRLMEGL EVFARARGFR KLHLTTHDQV HFYTHLGYQL GEPVQGLVFT 200
SRRLPATLLN AFPTAPSPRP PRKAPNLTAQ AAPRGPKGPP LPPPPPLPEC 250
LTISPPVPSG PPSKSLLETQ YQNVRGRPIF WMEKDI 286
Length:286
Mass (Da):31,445
Last modified:June 1, 1998 - v2
Checksum:iA755E2E3367625DB
GO
Isoform 2 (identifier: Q93015-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQELTLSPGPAKLTPTLDPTHRM

Show »
Length:308
Mass (Da):33,831
Checksum:i09A5F1F976681DB5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti145 – 1451R → S in non-small cell lung cancer cell lines. 1 Publication
VAR_014224
Natural varianti207 – 2071T → S in non-small cell lung cancer cell lines. 1 Publication
VAR_014225

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MQELTLSPGPAKLTPTLDPT HRM in isoform 2.
VSP_037187

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF040706 mRNA. Translation: AAC70913.1.
AF040705 mRNA. Translation: AAC70912.1.
U73167 Genomic DNA. Translation: AAC02732.1.
BC004483 mRNA. Translation: AAH04483.2.
CCDSiCCDS43095.1. [Q93015-2]
CCDS56258.1. [Q93015-1]
RefSeqiNP_001186945.1. NM_001200016.1. [Q93015-1]
NP_001186947.1. NM_001200018.1. [Q93015-1]
NP_036323.2. NM_012191.3. [Q93015-2]
UniGeneiHs.129910.
Hs.736942.

Genome annotation databases

EnsembliENST00000354862; ENSP00000346927; ENSG00000243477. [Q93015-2]
ENST00000417393; ENSP00000391893; ENSG00000243477. [Q93015-1]
ENST00000443094; ENSP00000410610; ENSG00000243477. [Q93015-1]
ENST00000443842; ENSP00000400559; ENSG00000243477. [Q93015-1]
ENST00000570345; ENSP00000459273; ENSG00000261871. [Q93015-1]
ENST00000571097; ENSP00000458495; ENSG00000261871. [Q93015-2]
ENST00000573208; ENSP00000459800; ENSG00000261871. [Q93015-1]
ENST00000575928; ENSP00000458407; ENSG00000261871. [Q93015-1]
GeneIDi24142.
KEGGihsa:24142.
UCSCiuc003czi.3. human. [Q93015-1]
uc003czj.3. human. [Q93015-2]

Polymorphism databases

DMDMi25008833.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF040706 mRNA. Translation: AAC70913.1 .
AF040705 mRNA. Translation: AAC70912.1 .
U73167 Genomic DNA. Translation: AAC02732.1 .
BC004483 mRNA. Translation: AAH04483.2 .
CCDSi CCDS43095.1. [Q93015-2 ]
CCDS56258.1. [Q93015-1 ]
RefSeqi NP_001186945.1. NM_001200016.1. [Q93015-1 ]
NP_001186947.1. NM_001200018.1. [Q93015-1 ]
NP_036323.2. NM_012191.3. [Q93015-2 ]
UniGenei Hs.129910.
Hs.736942.

3D structure databases

ProteinModelPortali Q93015.
SMRi Q93015. Positions 135-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117293. 1 interaction.
IntActi Q93015. 1 interaction.
STRINGi 9606.ENSP00000346927.

PTM databases

PhosphoSitei Q93015.

Polymorphism databases

DMDMi 25008833.

Proteomic databases

MaxQBi Q93015.
PaxDbi Q93015.
PRIDEi Q93015.

Protocols and materials databases

DNASUi 24142.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354862 ; ENSP00000346927 ; ENSG00000243477 . [Q93015-2 ]
ENST00000417393 ; ENSP00000391893 ; ENSG00000243477 . [Q93015-1 ]
ENST00000443094 ; ENSP00000410610 ; ENSG00000243477 . [Q93015-1 ]
ENST00000443842 ; ENSP00000400559 ; ENSG00000243477 . [Q93015-1 ]
ENST00000570345 ; ENSP00000459273 ; ENSG00000261871 . [Q93015-1 ]
ENST00000571097 ; ENSP00000458495 ; ENSG00000261871 . [Q93015-2 ]
ENST00000573208 ; ENSP00000459800 ; ENSG00000261871 . [Q93015-1 ]
ENST00000575928 ; ENSP00000458407 ; ENSG00000261871 . [Q93015-1 ]
GeneIDi 24142.
KEGGi hsa:24142.
UCSCi uc003czi.3. human. [Q93015-1 ]
uc003czj.3. human. [Q93015-2 ]

Organism-specific databases

CTDi 24142.
GeneCardsi GC03M050333.
HGNCi HGNC:30252. NAT6.
HPAi HPA039576.
MIMi 607073. gene.
neXtProti NX_Q93015.
PharmGKBi PA134979782.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG325811.
HOGENOMi HOG000113734.
HOVERGENi HBG031735.
InParanoidi Q93015.
OMAi GCPIFWM.
PhylomeDBi Q93015.
TreeFami TF106312.

Miscellaneous databases

GenomeRNAii 24142.
NextBioi 46825.
PROi Q93015.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q93015.
Bgeei Q93015.
Genevestigatori Q93015.

Family and domain databases

Gene3Di 3.40.630.30. 2 hits.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Fong K., Zabarovsky E., Kashuba V., Kuzmin I., Latif F., Mele G., Sekido Y., Bader S., Duh F.-M., Wei M.-H., Lerman M.I., Minna J.D.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Pancreas.
  4. "The putative tumour suppressor Fus-2 is an N-acetyltransferase."
    Zegerman P., Bannister A.J., Kouzarides T.
    Oncogene 19:161-163(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes."
    The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium
    Lerman M.I., Minna J.D.
    Cancer Res. 60:6116-6133(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE, VARIANTS SER-145 AND SER-207.

Entry informationi

Entry nameiNAT6_HUMAN
AccessioniPrimary (citable) accession number: Q93015
Secondary accession number(s): Q93014
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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