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Protein

N-acetyltransferase 6

Gene

NAT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor.1 Publication

GO - Molecular functioni

  • acetyl-CoA binding Source: UniProtKB
  • N-acetyltransferase activity Source: UniProtKB

GO - Biological processi

  • protein acetylation Source: UniProtKB

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyltransferase 6 (EC:2.3.1.-)
Alternative name(s):
Protein fusion-2
Short name:
Protein fus-2
Gene namesi
Name:NAT6
Synonyms:FUS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000243477.5
HGNCiHGNC:30252 NAT6
MIMi607073 gene
neXtProtiNX_Q93015

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi24142
OpenTargetsiENSG00000243477
PharmGKBiPA134979782

Polymorphism and mutation databases

BioMutaiNAT6
DMDMi25008833

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000745361 – 286N-acetyltransferase 6Add BLAST286

Proteomic databases

EPDiQ93015
MaxQBiQ93015
PaxDbiQ93015
PeptideAtlasiQ93015
PRIDEiQ93015
ProteomicsDBi75670
75671 [Q93015-2]

PTM databases

iPTMnetiQ93015
PhosphoSitePlusiQ93015

Expressioni

Tissue specificityi

Strongly expressed in heart and skeletal muscle, followed by brain and pancreas, with weak expression in kidney, liver, and lung and no expression in placenta.

Gene expression databases

BgeeiENSG00000243477
ExpressionAtlasiQ93015 baseline and differential
GenevisibleiQ93015 HS

Organism-specific databases

HPAiHPA039576

Interactioni

Protein-protein interaction databases

BioGridi117293, 2 interactors
IntActiQ93015, 4 interactors
STRINGi9606.ENSP00000346927

Structurei

3D structure databases

ProteinModelPortaliQ93015
SMRiQ93015
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 207N-acetyltransferasePROSITE-ProRule annotationAdd BLAST148

Sequence similaritiesi

Belongs to the acetyltransferase family.Curated

Phylogenomic databases

eggNOGiENOG410IS85 Eukaryota
ENOG4111U9V LUCA
GeneTreeiENSGT00390000000980
HOGENOMiHOG000113734
HOVERGENiHBG031735
InParanoidiQ93015
OMAiGCPIFWM
OrthoDBiEOG091G0SQB
PhylomeDBiQ93015
TreeFamiTF106312

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q93015-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELILSTSPA ELTLDPACQP KLPLDSTCQP EMTFNPGPTE LTLDPEHQPE
60 70 80 90 100
ETPAPSLAEL TLEPVHRRPE LLDACADLIN DQWPRSRTSR LHSLGQSSDA
110 120 130 140 150
FPLCLMLLSP HPTLEAAPVV VGHARLSRVL NQPQSLLVET VVVARALRGR
160 170 180 190 200
GFGRRLMEGL EVFARARGFR KLHLTTHDQV HFYTHLGYQL GEPVQGLVFT
210 220 230 240 250
SRRLPATLLN AFPTAPSPRP PRKAPNLTAQ AAPRGPKGPP LPPPPPLPEC
260 270 280
LTISPPVPSG PPSKSLLETQ YQNVRGRPIF WMEKDI
Length:286
Mass (Da):31,445
Last modified:June 1, 1998 - v2
Checksum:iA755E2E3367625DB
GO
Isoform 2 (identifier: Q93015-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQELTLSPGPAKLTPTLDPTHRM

Show »
Length:308
Mass (Da):33,831
Checksum:i09A5F1F976681DB5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014224145R → S in non-small cell lung cancer cell lines. 1 Publication1
Natural variantiVAR_014225207T → S in non-small cell lung cancer cell lines. 1 PublicationCorresponds to variant dbSNP:rs200439690Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0371871M → MQELTLSPGPAKLTPTLDPT HRM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040706 mRNA Translation: AAC70913.1
AF040705 mRNA Translation: AAC70912.1
U73167 Genomic DNA Translation: AAC02732.1
BC004483 mRNA Translation: AAH04483.2
CCDSiCCDS43095.1 [Q93015-2]
CCDS56258.1 [Q93015-1]
RefSeqiNP_001186945.1, NM_001200016.1 [Q93015-1]
NP_001186947.1, NM_001200018.1 [Q93015-1]
NP_036323.2, NM_012191.3 [Q93015-2]
UniGeneiHs.129910
Hs.736942

Genome annotation databases

EnsembliENST00000354862; ENSP00000346927; ENSG00000243477 [Q93015-2]
ENST00000417393; ENSP00000391893; ENSG00000243477 [Q93015-1]
ENST00000443094; ENSP00000410610; ENSG00000243477 [Q93015-1]
ENST00000443842; ENSP00000400559; ENSG00000243477 [Q93015-1]
GeneIDi24142
KEGGihsa:24142
UCSCiuc003czi.4 human [Q93015-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNAT6_HUMAN
AccessioniPrimary (citable) accession number: Q93015
Secondary accession number(s): Q93014
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 1998
Last modified: June 20, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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