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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase 2

Gene

betB2

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

K+UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. NAD/NADP-dependent betaine aldehyde dehydrogenase 1 (betB1), NAD/NADP-dependent betaine aldehyde dehydrogenase 2 (betB2)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29Potassium 1UniRule annotation1
Metal bindingi96Potassium 1UniRule annotation1
Active sitei164Charge relay systemUniRule annotation1
Metal bindingi182Potassium 1; via carbonyl oxygenUniRule annotation1
Binding sitei211NAD/NADP; via amide nitrogenUniRule annotation1
Metal bindingi246Potassium 2; via carbonyl oxygenUniRule annotation1
Active sitei252Proton acceptorUniRule annotation1
Binding sitei286NAD/NADPUniRule annotation1
Binding sitei383NAD/NADPUniRule annotation1
Metal bindingi453Potassium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi456Potassium 2; via carbonyl oxygenUniRule annotation1
Active sitei460Charge relay systemUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi152 – 155NAD/NADPUniRule annotation4
Nucleotide bindingi178 – 181NAD/NADPUniRule annotation4
Nucleotide bindingi230 – 235NAD/NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADH 2UniRule annotation
Gene namesi
Name:betB2UniRule annotation
Ordered Locus Names:RA0952
ORF Names:SMa1731
Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Plasmid pSymA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000565541 – 481NAD/NADP-dependent betaine aldehyde dehydrogenase 2Add BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei286Cysteine sulfenic acid (-SOH)UniRule annotation1

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ92YD2
SMRiQ92YD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000271505
KOiK00130

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
HAMAPiMF_00804 BADH, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR011264 BADH
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Q92YD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPLCQPAA SHFIDGTFIE DRTGPEILSV NPVDGEIIAK LHGATSCIIE
60 70 80 90 100
KAIASAKRAQ KEWARKEPAE RGRVLSRAAD IMRARNRELS VLETRDTGKP
110 120 130 140 150
ISETLVADAA SGADCLEYFG AIAATLSGDS IQFGEDWVYT RREPLGVCLG
160 170 180 190 200
IGAWNYPIQI AAWKAAPALA CGNAMIFKPS EVTPLSALKL AEILTEAGLP
210 220 230 240 250
PGVFNIVQGA GDVGAELATH PAIAKVSLTG SVKTGARVAS AAMAGIRPVT
260 270 280 290 300
MELGGKSALI VFDDADVEAA VSGAILGNFY SAGQICSNGT RVFLQRGIRE
310 320 330 340 350
AFLARLLARV AALKIGDPMD EETDIGPLVS AAHRNRVATY VARAEVEGAY
360 370 380 390 400
QMAPPRKLPP GDAWHEPVVF TNVTDWMTLA REEVFGPVMA VLDFDDEQDV
410 420 430 440 450
VARANATDFG LAAGIFTRDL VRAHRLAAEL EAGTVWINAY NLTPAGMAFG
460 470 480
GIKRSGIGRE NGRVAIDHYT QLKSVFVSMQ T
Length:481
Mass (Da):51,097
Last modified:February 1, 2005 - v2
Checksum:i8C21F9C596E54988
GO

Sequence cautioni

The sequence AAK65610 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006469 Genomic DNA Translation: AAK65610.1 Different initiation.
PIRiH95380
RefSeqiNP_436198.1, NC_003037.1

Genome annotation databases

EnsemblBacteriaiAAK65610; AAK65610; SMa1731
GeneIDi1235988
KEGGisme:SMa1731
PATRICifig|266834.11.peg.981

Similar proteinsi

Entry informationi

Entry nameiBETB2_RHIME
AccessioniPrimary (citable) accession number: Q92YD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: February 28, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

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