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Q92YD2

- BETB2_RHIME

UniProt

Q92YD2 - BETB2_RHIME

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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase 2

Gene
betB2, RA0952, SMa1731
Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi29 – 291Potassium 1 By similarity
Metal bindingi96 – 961Potassium 1 By similarity
Active sitei164 – 1641Charge relay system By similarity
Metal bindingi182 – 1821Potassium 1; via carbonyl oxygen By similarity
Binding sitei211 – 2111NAD/NADP; via amide nitrogen By similarity
Metal bindingi246 – 2461Potassium 2; via carbonyl oxygen By similarity
Active sitei252 – 2521Proton acceptor By similarity
Binding sitei286 – 2861NAD/NADP By similarity
Binding sitei383 – 3831NAD/NADP By similarity
Metal bindingi453 – 4531Potassium 2; via carbonyl oxygen By similarity
Metal bindingi456 – 4561Potassium 2; via carbonyl oxygen By similarity
Active sitei460 – 4601Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi152 – 1554NAD/NADP By similarity
Nucleotide bindingi178 – 1814NAD/NADP By similarity
Nucleotide bindingi230 – 2356NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-5958-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase 2 (EC:1.2.1.8)
Short name:
BADH 2
Gene namesi
Name:betB2
Ordered Locus Names:RA0952
ORF Names:SMa1731
Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Plasmid pSymA

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481NAD/NADP-dependent betaine aldehyde dehydrogenase 2UniRule annotationPRO_0000056554Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei286 – 2861Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi266834.SMa1731.

Structurei

3D structure databases

ProteinModelPortaliQ92YD2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92YD2-1 [UniParc]FASTAAdd to Basket

« Hide

MATPLCQPAA SHFIDGTFIE DRTGPEILSV NPVDGEIIAK LHGATSCIIE    50
KAIASAKRAQ KEWARKEPAE RGRVLSRAAD IMRARNRELS VLETRDTGKP 100
ISETLVADAA SGADCLEYFG AIAATLSGDS IQFGEDWVYT RREPLGVCLG 150
IGAWNYPIQI AAWKAAPALA CGNAMIFKPS EVTPLSALKL AEILTEAGLP 200
PGVFNIVQGA GDVGAELATH PAIAKVSLTG SVKTGARVAS AAMAGIRPVT 250
MELGGKSALI VFDDADVEAA VSGAILGNFY SAGQICSNGT RVFLQRGIRE 300
AFLARLLARV AALKIGDPMD EETDIGPLVS AAHRNRVATY VARAEVEGAY 350
QMAPPRKLPP GDAWHEPVVF TNVTDWMTLA REEVFGPVMA VLDFDDEQDV 400
VARANATDFG LAAGIFTRDL VRAHRLAAEL EAGTVWINAY NLTPAGMAFG 450
GIKRSGIGRE NGRVAIDHYT QLKSVFVSMQ T 481
Length:481
Mass (Da):51,097
Last modified:February 1, 2005 - v2
Checksum:i8C21F9C596E54988
GO

Sequence cautioni

The sequence AAK65610.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006469 Genomic DNA. Translation: AAK65610.1. Different initiation.
PIRiH95380.
RefSeqiNP_436198.1. NC_003037.1.

Genome annotation databases

EnsemblBacteriaiAAK65610; AAK65610; SMa1731.
GeneIDi1235988.
KEGGisme:SMa1731.
PATRICi23628404. VBISinMel96828_0981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006469 Genomic DNA. Translation: AAK65610.1 . Different initiation.
PIRi H95380.
RefSeqi NP_436198.1. NC_003037.1.

3D structure databases

ProteinModelPortali Q92YD2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMa1731.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK65610 ; AAK65610 ; SMa1731 .
GeneIDi 1235988.
KEGGi sme:SMa1731.
PATRICi 23628404. VBISinMel96828_0981.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci SMEL266834:GJF6-5958-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiBETB2_RHIME
AccessioniPrimary (citable) accession number: Q92YD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: June 11, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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