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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase 2

Gene

betB2

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

K(+)UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi29 – 291Potassium 1UniRule annotation
Metal bindingi96 – 961Potassium 1UniRule annotation
Active sitei164 – 1641Charge relay systemUniRule annotation
Metal bindingi182 – 1821Potassium 1; via carbonyl oxygenUniRule annotation
Binding sitei211 – 2111NAD/NADP; via amide nitrogenUniRule annotation
Metal bindingi246 – 2461Potassium 2; via carbonyl oxygenUniRule annotation
Active sitei252 – 2521Proton acceptorUniRule annotation
Binding sitei286 – 2861NAD/NADPUniRule annotation
Binding sitei383 – 3831NAD/NADPUniRule annotation
Metal bindingi453 – 4531Potassium 2; via carbonyl oxygenUniRule annotation
Metal bindingi456 – 4561Potassium 2; via carbonyl oxygenUniRule annotation
Active sitei460 – 4601Charge relay systemUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi152 – 1554NAD/NADPUniRule annotation
Nucleotide bindingi178 – 1814NAD/NADPUniRule annotation
Nucleotide bindingi230 – 2356NAD/NADPUniRule annotation

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-5958-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADH 2UniRule annotation
Gene namesi
Name:betB2UniRule annotation
Ordered Locus Names:RA0952
ORF Names:SMa1731
Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Plasmid pSymA

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481NAD/NADP-dependent betaine aldehyde dehydrogenase 2PRO_0000056554Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei286 – 2861Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi266834.SMa1731.

Structurei

3D structure databases

ProteinModelPortaliQ92YD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92YD2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATPLCQPAA SHFIDGTFIE DRTGPEILSV NPVDGEIIAK LHGATSCIIE
60 70 80 90 100
KAIASAKRAQ KEWARKEPAE RGRVLSRAAD IMRARNRELS VLETRDTGKP
110 120 130 140 150
ISETLVADAA SGADCLEYFG AIAATLSGDS IQFGEDWVYT RREPLGVCLG
160 170 180 190 200
IGAWNYPIQI AAWKAAPALA CGNAMIFKPS EVTPLSALKL AEILTEAGLP
210 220 230 240 250
PGVFNIVQGA GDVGAELATH PAIAKVSLTG SVKTGARVAS AAMAGIRPVT
260 270 280 290 300
MELGGKSALI VFDDADVEAA VSGAILGNFY SAGQICSNGT RVFLQRGIRE
310 320 330 340 350
AFLARLLARV AALKIGDPMD EETDIGPLVS AAHRNRVATY VARAEVEGAY
360 370 380 390 400
QMAPPRKLPP GDAWHEPVVF TNVTDWMTLA REEVFGPVMA VLDFDDEQDV
410 420 430 440 450
VARANATDFG LAAGIFTRDL VRAHRLAAEL EAGTVWINAY NLTPAGMAFG
460 470 480
GIKRSGIGRE NGRVAIDHYT QLKSVFVSMQ T
Length:481
Mass (Da):51,097
Last modified:February 1, 2005 - v2
Checksum:i8C21F9C596E54988
GO

Sequence cautioni

The sequence AAK65610.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006469 Genomic DNA. Translation: AAK65610.1. Different initiation.
PIRiH95380.
RefSeqiNP_436198.1. NC_003037.1.

Genome annotation databases

EnsemblBacteriaiAAK65610; AAK65610; SMa1731.
GeneIDi1235988.
KEGGisme:SMa1731.
PATRICi23628404. VBISinMel96828_0981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006469 Genomic DNA. Translation: AAK65610.1. Different initiation.
PIRiH95380.
RefSeqiNP_436198.1. NC_003037.1.

3D structure databases

ProteinModelPortaliQ92YD2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266834.SMa1731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK65610; AAK65610; SMa1731.
GeneIDi1235988.
KEGGisme:SMa1731.
PATRICi23628404. VBISinMel96828_0981.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.
BioCyciSMEL266834:GJF6-5958-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiBETB2_RHIME
AccessioniPrimary (citable) accession number: Q92YD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: January 7, 2015
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.