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Q92YD2

- BETB2_RHIME

UniProt

Q92YD2 - BETB2_RHIME

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase 2

Gene

betB2

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    Binds 2 potassium ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi29 – 291Potassium 1UniRule annotation
    Metal bindingi96 – 961Potassium 1UniRule annotation
    Active sitei164 – 1641Charge relay systemUniRule annotation
    Metal bindingi182 – 1821Potassium 1; via carbonyl oxygenUniRule annotation
    Binding sitei211 – 2111NAD/NADP; via amide nitrogenUniRule annotation
    Metal bindingi246 – 2461Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei252 – 2521Proton acceptorUniRule annotation
    Binding sitei286 – 2861NAD/NADPUniRule annotation
    Binding sitei383 – 3831NAD/NADPUniRule annotation
    Metal bindingi453 – 4531Potassium 2; via carbonyl oxygenUniRule annotation
    Metal bindingi456 – 4561Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei460 – 4601Charge relay systemUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi152 – 1554NAD/NADPUniRule annotation
    Nucleotide bindingi178 – 1814NAD/NADPUniRule annotation
    Nucleotide bindingi230 – 2356NAD/NADPUniRule annotation

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, NADP, Potassium

    Enzyme and pathway databases

    BioCyciSMEL266834:GJF6-5958-MONOMER.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD/NADP-dependent betaine aldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADH 2UniRule annotation
    Gene namesi
    Name:betB2UniRule annotation
    Ordered Locus Names:RA0952
    ORF Names:SMa1731
    Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Plasmid pSymA

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 481481NAD/NADP-dependent betaine aldehyde dehydrogenase 2PRO_0000056554Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei286 – 2861Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Dimer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi266834.SMa1731.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92YD2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00130.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_00804. BADH.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92YD2-1 [UniParc]FASTAAdd to Basket

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    MATPLCQPAA SHFIDGTFIE DRTGPEILSV NPVDGEIIAK LHGATSCIIE    50
    KAIASAKRAQ KEWARKEPAE RGRVLSRAAD IMRARNRELS VLETRDTGKP 100
    ISETLVADAA SGADCLEYFG AIAATLSGDS IQFGEDWVYT RREPLGVCLG 150
    IGAWNYPIQI AAWKAAPALA CGNAMIFKPS EVTPLSALKL AEILTEAGLP 200
    PGVFNIVQGA GDVGAELATH PAIAKVSLTG SVKTGARVAS AAMAGIRPVT 250
    MELGGKSALI VFDDADVEAA VSGAILGNFY SAGQICSNGT RVFLQRGIRE 300
    AFLARLLARV AALKIGDPMD EETDIGPLVS AAHRNRVATY VARAEVEGAY 350
    QMAPPRKLPP GDAWHEPVVF TNVTDWMTLA REEVFGPVMA VLDFDDEQDV 400
    VARANATDFG LAAGIFTRDL VRAHRLAAEL EAGTVWINAY NLTPAGMAFG 450
    GIKRSGIGRE NGRVAIDHYT QLKSVFVSMQ T 481
    Length:481
    Mass (Da):51,097
    Last modified:February 1, 2005 - v2
    Checksum:i8C21F9C596E54988
    GO

    Sequence cautioni

    The sequence AAK65610.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006469 Genomic DNA. Translation: AAK65610.1. Different initiation.
    PIRiH95380.
    RefSeqiNP_436198.1. NC_003037.1.

    Genome annotation databases

    EnsemblBacteriaiAAK65610; AAK65610; SMa1731.
    GeneIDi1235988.
    KEGGisme:SMa1731.
    PATRICi23628404. VBISinMel96828_0981.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006469 Genomic DNA. Translation: AAK65610.1 . Different initiation.
    PIRi H95380.
    RefSeqi NP_436198.1. NC_003037.1.

    3D structure databases

    ProteinModelPortali Q92YD2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMa1731.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK65610 ; AAK65610 ; SMa1731 .
    GeneIDi 1235988.
    KEGGi sme:SMa1731.
    PATRICi 23628404. VBISinMel96828_0981.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00130.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    BioCyci SMEL266834:GJF6-5958-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_00804. BADH.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiBETB2_RHIME
    AccessioniPrimary (citable) accession number: Q92YD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3