Reviewed, UniProtKB/Swiss-Prot Q92YD2 (BETB2_RHIME)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase 2
      Short name=BADH 2
    EC=1.2.1.8

Gene names

Name:	betB2
Ordered Locus Names:	RA0952
ORF Names:	SMa1731

Encoded on

Plasmid pSymA (megaplasmid 1)

Organism

Rhizobium meliloti (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

382 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 481	481	Betaine aldehyde dehydrogenase 2 HAMAP MF_00804		PRO_0000056554
Regions
	Nucleotide binding	230 – 235	6	NAD By similarity
Sites
	Active site	252	1	By similarity
	Active site	286	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92YD2-1 [UniParc]. Last modified February 1, 2005. Version 2. Checksum: 8C21F9C596E54988	FASTA	481	51,097
	10 20 30 40 50 60 MATPLCQPAA SHFIDGTFIE DRTGPEILSV NPVDGEIIAK LHGATSCIIE KAIASAKRAQ 70 80 90 100 110 120 KEWARKEPAE RGRVLSRAAD IMRARNRELS VLETRDTGKP ISETLVADAA SGADCLEYFG 130 140 150 160 170 180 AIAATLSGDS IQFGEDWVYT RREPLGVCLG IGAWNYPIQI AAWKAAPALA CGNAMIFKPS 190 200 210 220 230 240 EVTPLSALKL AEILTEAGLP PGVFNIVQGA GDVGAELATH PAIAKVSLTG SVKTGARVAS 250 260 270 280 290 300 AAMAGIRPVT MELGGKSALI VFDDADVEAA VSGAILGNFY SAGQICSNGT RVFLQRGIRE 310 320 330 340 350 360 AFLARLLARV AALKIGDPMD EETDIGPLVS AAHRNRVATY VARAEVEGAY QMAPPRKLPP 370 380 390 400 410 420 GDAWHEPVVF TNVTDWMTLA REEVFGPVMA VLDFDDEQDV VARANATDFG LAAGIFTRDL 430 440 450 460 470 480 VRAHRLAAEL EAGTVWINAY NLTPAGMAFG GIKRSGIGRE NGRVAIDHYT QLKSVFVSMQ T

References

[1]

"Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmid." Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F., Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L., Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H. , Palm C., Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A., Long S.R. Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001) [PubMed: 11481432] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006469 Genomic DNA. Translation: AAK65610.1. Different initiation.
PIR	H95380.
RefSeq	NP_436198.1.
3D structure databases
SMR	Q92YD2. Positions 11-479.
ModBase	Search...
Genome annotation databases
GeneID	1235988.
GenomeReviews	Gene locus RA0952 in contig AE006469_GR.
KEGG	sme:SMa1731.
NMPDR	fig|266834.1.peg.952.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG752218.
Enzyme and pathway databases
BioCyc	SMEL266834:SMA1731-MONOMER.
BRENDA	1.2.1.8. 142.
Family and domain databases
HAMAP	MF_00804. BADH. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB2_RHIME

Accession

Primary (citable) accession number: Q92YD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	February 1, 2005
Last modified:	January 19, 2010
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)