Reviewed, UniProtKB/Swiss-Prot Q92Y45 (MSRA3_RHIME)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA 3
      Short name=Protein-methionine-S-oxide reductase 3
    EC=1.8.4.11
Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase 3
      Short name=Peptide Met(O) reductase 3

Gene names

Name:	msrA3
Ordered Locus Names:	RA1043
ORF Names:	SMa1896

Encoded on

Plasmid pSymA (megaplasmid 1)

Organism

Rhizobium meliloti (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

382 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin. L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin.
Sequence similarities	Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 168	168	Peptide methionine sulfoxide reductase msrA 3		PRO_0000138575
Sites
	Active site	11	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92Y45-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 0FACD9C4642CDC25	FASTA	168	19,344
	10 20 30 40 50 60 MTKRAVLAGG CFWGMQDLIR KLPGVIETRV GYTGGDVPNA TYRNHGTHAE GIEIIFDPER 70 80 90 100 110 120 ISYRRILELF FQIHDPTTKD RQGNDIGTSY RSAIYYVDDE QKRIAQETIA DVEASGLWPG 130 140 150 160 KVVTEVEPVR DFWEAEPEHQ NYLERYPNGY TCHFPRPNWV LPRRSAAE

References

[1]

"Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmid." Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F., Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L., Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H. , Palm C., Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A., Long S.R. Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001) [PubMed: 11481432] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006469 Genomic DNA. Translation: AAK65701.1.
PIR	C95392.
RefSeq	NP_436289.1.
3D structure databases
HSSP	HSSP built from PDB template 1NWA based on UniProtKB P96814.
SMR	Q92Y45. Positions 3-164.
ModBase	Search...
Genome annotation databases
GeneID	1236079.
GenomeReviews	Gene locus RA1043 in contig AE006469_GR.
KEGG	sme:SMa1896.
NMPDR	fig|266834.1.peg.1043.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q92Y45.
Enzyme and pathway databases
BioCyc	SMEL266834:SMA1896-MON.
Family and domain databases
HAMAP	MF_01401. [Tree]
InterPro	IPR002569. MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
ProDom	PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA3_RHIME

Accession

Primary (citable) accession number: Q92Y45

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	December 1, 2001
Last modified:	November 4, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)