ID   Q92XQ0_RHIME            Unreviewed;       494 AA.
AC   Q92XQ0;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 112.
DE   SubName: Full=Aldehyde dehydrogenase, NAD(P)-dependent {ECO:0000313|EMBL:AAK65852.1};
GN   ORFNames=SMa2213 {ECO:0000313|EMBL:AAK65852.1};
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OG   Plasmid pSymA {ECO:0000313|EMBL:AAK65852.1,
OG   ECO:0000313|Proteomes:UP000001976}.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834 {ECO:0000313|EMBL:AAK65852.1, ECO:0000313|Proteomes:UP000001976};
RN   [1] {ECO:0000313|EMBL:AAK65852.1, ECO:0000313|Proteomes:UP000001976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021 {ECO:0000313|EMBL:AAK65852.1,
RC   ECO:0000313|Proteomes:UP000001976};
RC   PLASMID=Plasmid pSymA {ECO:0000313|Proteomes:UP000001976};
RX   PubMed=11481432; DOI=10.1073/pnas.161294798;
RA   Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F.,
RA   Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L.,
RA   Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H., Palm C.,
RA   Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A.,
RA   Long S.R.;
RT   "Nucleotide sequence and predicted functions of the entire Sinorhizobium
RT   meliloti pSymA megaplasmid.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001).
RN   [2] {ECO:0000313|Proteomes:UP000001976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021 {ECO:0000313|Proteomes:UP000001976};
RC   PLASMID=Plasmid pSymA {ECO:0000313|Proteomes:UP000001976};
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; AE006469; AAK65852.1; -; Genomic_DNA.
DR   PIR; B95411; B95411.
DR   RefSeq; NP_436440.1; NC_003037.1.
DR   RefSeq; WP_010968142.1; NC_003037.1.
DR   AlphaFoldDB; Q92XQ0; -.
DR   EnsemblBacteria; AAK65852; AAK65852; SMa2213.
DR   GeneID; 61599930; -.
DR   KEGG; sme:SMa2213; -.
DR   PATRIC; fig|266834.11.peg.1248; -.
DR   HOGENOM; CLU_005391_0_0_5; -.
DR   OrthoDB; 8175464at2; -.
DR   Proteomes; UP000001976; Plasmid pSymA.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd07114; ALDH_DhaS; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345}; Plasmid {ECO:0000313|EMBL:AAK65852.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001976}.
FT   DOMAIN          15..479
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        252
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   494 AA;  53697 MW;  8143208F58A6A718 CRC64;
     MQNLPKLSMY IDGQWVAPAS GEYIETVDPF TARPWALVPR GNAEDADRAV RAAHRAFSQG
     PWGKMHPTER GRIIQRFAAL IEEHADALAD IEVRDNGRLL AEMTHQIRYI PRWYHYYAGF
     ADKIEGTLHP CDKPALSFSR HEPLGVCVGI VPWNAPLLLF SLKAAPALAA GNTLVMKPAE
     FTSATALKLM ELVEKAGFPT GVINVVTGYG PEVGEPLVTH PLTRHVGFTG STKTGAHLYS
     LAAKDVKRVS LELGGKSPNI VFGDADLDNA VRGVVGGIFG AVGQTCIAGS RLLVHRSIHD
     EFLEKLAVFT KTARIGDPRK VETQIGPIAN SMQFEKVLGY IDIARREGAE LILGGGRPDL
     EECGTGYFIE PTIFAGVSND MRIAREEVFG PVLSAIVFDE PEEALAIAND SEFGLGAGVW
     TSDMRLALKM SERLEAGSVW VNTYRDISYT TPFGGYKKSG IGRENGVAGI YEYLQTKAVW
     LSTAEEIANP FVIG
//