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Protein

Catalase-peroxidase

Gene

katG

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei92 – 921Transition state stabilizerUniRule annotation
Active sitei96 – 961Proton acceptorUniRule annotation
Metal bindingi258 – 2581Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-6287-MONOMER.

Protein family/group databases

PeroxiBasei2675. SmeCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:RA1286
ORF Names:SMa2379
Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Plasmid pSymA

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Catalase-peroxidasePRO_0000354887Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki95 ↔ 217Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-243)UniRule annotation
Cross-linki217 ↔ 243Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ92XG8.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ92XG8.
SMRiQ92XG8. Positions 20-726.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92XG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQKSDSAGK CPVAHTAPRG RSNRDWWPDQ LDVQVLHRHS GLSDPLGNTF
60 70 80 90 100
NYAEEFKKLD LDALKRDLRA LMTDSQDWWP ADFGHYGGLF IRMAWHSAGT
110 120 130 140 150
YRITDGRGGA GQGQQRFAPL NSWPDNANLD KARRLLWPIK QKYGNRISWA
160 170 180 190 200
DLLILTGNVA LESMGFKTFG FAGGRVDVWE PEELFWGPEG TWLGDERYSG
210 220 230 240 250
ERQLSEPLAA VQMGLIYVNP EGPNGNPDPV AAARDIRETF ARMAMNDEET
260 270 280 290 300
VALIAGGHTF GKTHGAGDPS FIGADPEGGA IEDQGLGWKS TFGTGVGKDA
310 320 330 340 350
ITGGPEVTWS QTPTRWSNHF FENLFNHEWE LTKSPAGAYQ WKAKNAEATI
360 370 380 390 400
PDAYDPSRKH VPTRLTTDLS LRFDPAYEKI SRRFLENPDE FADAFARAWF
410 420 430 440 450
KLTHRDMGPK VRYLGPEVPA EDLIWQDVIP AVDHRLVDET DIAGLKAKII
460 470 480 490 500
ASGLSVQELV STAWASASTF RGSDKRGGAN GARIRLAPQK DWEVNRPAQL
510 520 530 540 550
ARVLSVLEGI QRDFNAAQTD GKKISLADLI VLAGGAAVEK AAKAGGHDIT
560 570 580 590 600
VPFTPGRMDA SEAQTDAASF AALEPRADGF RNYVSTTRQQ FMKPEEALVD
610 620 630 640 650
RAQLLTLTAP EMTVLVGGLR VLKAGEPKHG VFTSRPEALT NDFFVNLLDM
660 670 680 690 700
GTQWSPIEGE EGVYEGRDRR TGAARWTGTR VDLIFGSHSQ LRAFAEVYAQ
710 720
SDAREKFVKD FVAAWTKVMN ADRFDLV
Length:727
Mass (Da):80,292
Last modified:December 1, 2001 - v1
Checksum:i31086D8C7AA793DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006469 Genomic DNA. Translation: AAK65944.1.
PIRiF95422.
RefSeqiNP_436532.1. NC_003037.1.
WP_010968229.1. NC_003037.1.

Genome annotation databases

EnsemblBacteriaiAAK65944; AAK65944; SMa2379.
GeneIDi1236323.
KEGGisme:SMa2379.
PATRICi23629130. VBISinMel96828_1343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006469 Genomic DNA. Translation: AAK65944.1.
PIRiF95422.
RefSeqiNP_436532.1. NC_003037.1.
WP_010968229.1. NC_003037.1.

3D structure databases

ProteinModelPortaliQ92XG8.
SMRiQ92XG8. Positions 20-726.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei2675. SmeCP01.

Proteomic databases

PRIDEiQ92XG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK65944; AAK65944; SMa2379.
GeneIDi1236323.
KEGGisme:SMa2379.
PATRICi23629130. VBISinMel96828_1343.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-6287-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiKATG_RHIME
AccessioniPrimary (citable) accession number: Q92XG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: December 1, 2001
Last modified: November 11, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.