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Protein

Putative D-threonate 4-phosphate dehydrogenase

Gene

pdxA2

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).By similarity

Catalytic activityi

D-threonate 4-phosphate + NAD+ = dihydroxyacetone phosphate + CO2 + NADH.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123SubstrateBy similarity1
Binding sitei124SubstrateBy similarity1
Metal bindingi153Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi197Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi252Divalent metal cation; shared with dimeric partnerBy similarity1
Binding sitei260SubstrateBy similarity1
Binding sitei269SubstrateBy similarity1
Binding sitei278SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism
LigandMetal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative D-threonate 4-phosphate dehydrogenaseBy similarity (EC:1.1.1.-By similarity)
Gene namesi
Name:pdxA2Imported
Ordered Locus Names:RB0146
ORF Names:SMb20146
Encoded oniPlasmid pSymB (megaplasmid 2)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Plasmid pSymB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001888221 – 321Putative D-threonate 4-phosphate dehydrogenaseAdd BLAST321

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ92X16.
SMRiQ92X16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family. PdxA2 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000221593.
KOiK00097.
OMAiYERPRIA.

Family and domain databases

InterProiView protein in InterPro
IPR005255. PdxA.
PANTHERiPTHR30004. PTHR30004. 1 hit.
PfamiView protein in Pfam
PF04166. PdxA. 1 hit.
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92X16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIIGITMG DPCGVGPEIT VRSLAEMSAA DREATRIYGN LATLEAAREA
60 70 80 90 100
LGLSVDLQPY VVDLTVEGAP LPWGSLSAVA GDAAFRFIER AVRDAEAGNI
110 120 130 140 150
GCIVTAPINK EALNMAGHHY DGHTGMLRSL TGSSAAYMLL ASERLKVIHV
160 170 180 190 200
STHVSLKEAI GRATTERVLA TIRAGNAHLK RIGYEHPRIA VAGINPHCGE
210 220 230 240 250
NGLFGTEDDD QIGPAVAAAR EEGIDVQGPI SADTVFHRAY SGGFDLVVAQ
260 270 280 290 300
YHDQGHIPIK LVAFDTAVNV SVDLPIDRTS VDHGTAFDIA GKGIANHGNL
310 320
NSAIAYARKL VAGQASRKAA S
Length:321
Mass (Da):33,689
Last modified:December 1, 2001 - v1
Checksum:iF6C54F187F325110
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591985 Genomic DNA. Translation: CAC48546.1.
PIRiB95860.
RefSeqiNP_436686.1. NC_003078.1.
WP_003532057.1. NC_003078.1.

Genome annotation databases

EnsemblBacteriaiCAC48546; CAC48546; SM_b20146.
GeneIDi1236477.
25014138.
KEGGisme:SM_b20146.
PATRICifig|266834.11.peg.5061.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPDXA2_RHIME
AccessioniPrimary (citable) accession number: Q92X16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families