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Q92X16 (PDXA2_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxythreonine-4-phosphate dehydrogenase 2

EC=1.1.1.262
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase 2
Gene names
Name:pdxA2
Ordered Locus Names:RB0146
ORF Names:SMb20146
Encoded onPlasmid pSymB (megaplasmid 2)
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity. HAMAP-Rule MF_00536

Catalytic activity

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. HAMAP-Rule MF_00536

Cofactor

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5. HAMAP-Rule MF_00536

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00536

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00536.

Miscellaneous

The active site is located at the dimer interface By similarity.

Sequence similarities

Belongs to the PdxA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3213214-hydroxythreonine-4-phosphate dehydrogenase 2 HAMAP-Rule MF_00536
PRO_0000188822

Sites

Metal binding1531Divalent metal cation; shared with dimeric partner By similarity
Metal binding1971Divalent metal cation; shared with dimeric partner By similarity
Metal binding2521Divalent metal cation; shared with dimeric partner By similarity
Binding site1231Substrate By similarity
Binding site1241Substrate By similarity
Binding site2601Substrate By similarity
Binding site2691Substrate By similarity
Binding site2781Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92X16 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: F6C54F187F325110

FASTA32133,689
        10         20         30         40         50         60 
MSKIIGITMG DPCGVGPEIT VRSLAEMSAA DREATRIYGN LATLEAAREA LGLSVDLQPY 

        70         80         90        100        110        120 
VVDLTVEGAP LPWGSLSAVA GDAAFRFIER AVRDAEAGNI GCIVTAPINK EALNMAGHHY 

       130        140        150        160        170        180 
DGHTGMLRSL TGSSAAYMLL ASERLKVIHV STHVSLKEAI GRATTERVLA TIRAGNAHLK 

       190        200        210        220        230        240 
RIGYEHPRIA VAGINPHCGE NGLFGTEDDD QIGPAVAAAR EEGIDVQGPI SADTVFHRAY 

       250        260        270        280        290        300 
SGGFDLVVAQ YHDQGHIPIK LVAFDTAVNV SVDLPIDRTS VDHGTAFDIA GKGIANHGNL 

       310        320 
NSAIAYARKL VAGQASRKAA S 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591985 Genomic DNA. Translation: CAC48546.1.
PIRB95860.
RefSeqNP_436686.1. NC_003078.1.

3D structure databases

ProteinModelPortalQ92X16.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SM_b20146.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC48546; CAC48546; SM_b20146.
GeneID1236477.
KEGGsme:SM_b20146.
PATRIC23636679. VBISinMel96828_5061.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1995.
HOGENOMHOG000221593.
KOK00097.
OMAYERPRIA.
OrthoDBEOG6GN6ZC.

Enzyme and pathway databases

BioCycSMEL266834:GJF6-3579-MONOMER.
UniPathwayUPA00244; UER00312.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
HAMAPMF_00536. PdxA.
InterProIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00557. pdxA. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDXA2_RHIME
AccessionPrimary (citable) accession number: Q92X16
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways