Reviewed, UniProtKB/Swiss-Prot Q92VM6 (ARLY2_RHIME)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase 2
      Short name=ASAL 2
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase 2

Gene names

Name:	argH2
Ordered Locus Names:	RB0673
ORF Names:	SMb21094

Encoded on

Plasmid pSymB (megaplasmid 2)

Organism

Rhizobium meliloti (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

382 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	Argininosuccinate lyase 2 HAMAP MF_00006		PRO_0000137813

Sequences

	Sequence		Length	Mass (Da)
	Q92VM6-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 376898B050516832	FASTA	488	53,037
	10 20 30 40 50 60 MTEPTQLWGG RFKSGPSEAL ANLSRAPRSY FRLYKEDIAG SRAHASELKR AGVLDESEFS 70 80 90 100 110 120 AIRAALEGIE ADVGAGREEP IAADEDLHTF LERLLMARLG TLGGKLRAGR SRNDQTANNT 130 140 150 160 170 180 RLYLRRMARE LSQGVIAIEE ALTEQASRHT ETVMPGFTHL QPAQPVVLGH HLMAHAQSLL 190 200 210 220 230 240 RDLQRFADWD RRFDRSPLGA AALAGSGIAR RPDLSAIDLG YSAACENSID AVAARDHVAE 250 260 270 280 290 300 FLFICSLVAV DLSRLAEEIC LWSSKQFSWV RLHDSYSTGS SIMPQKKNPD VAELTRGMSG 310 320 330 340 350 360 TLIGNIAGFL ATMKAMPLAY NRDLAEDKRS LFETIDVLEL VLPAFAGMVG TLEFDVEKLR 370 380 390 400 410 420 EEAPKGFTLA TEVADWLVGR DVPFAEAHEI TGAVVRFCEE RGHDLAGLTA EDLPGIDPRL 430 440 450 460 470 480 HPEMLAALVL EKALASRNGY GATAPEKVRE QIARFETALA ECCAFAGGPI GGGAFAGAKD GAEEARRR

References

[1]

"The complete sequence of the 1,683-kb pSymB megaplasmid from the N2-fixing endosymbiont Sinorhizobium meliloti." Finan T.M., Weidner S., Wong K., Buhrmester J., Chain P., Vorhoelter F.J., Hernandez-Lucas I., Becker A., Cowie A., Gouzy J., Golding B., Puehler A. Proc. Natl. Acad. Sci. U.S.A. 98:9889-9894(2001) [PubMed: 11481431] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL591985 Genomic DNA. Translation: CAC49073.1.
PIR	A95926.
RefSeq	NP_437213.1.
3D structure databases
SMR	Q92VM6. Positions 4-414, 30-460.
ModBase	Search...
Genome annotation databases
GeneID	1237004.
GenomeReviews	Gene locus RB0673 in contig AL591985_GR.
KEGG	sme:SM_b21094.
NMPDR	fig|266834.1.peg.5308.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG539632.
OMA	GALWGGR.
Enzyme and pathway databases
BioCyc	SMEL266834:SMB21094-MONOMER.
BRENDA	4.3.2.1. 142.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY2_RHIME

Accession

Primary (citable) accession number: Q92VM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	December 1, 2001
Last modified:	February 9, 2010
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)