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Protein

7-cyano-7-deazaguanine synthase

Gene

queC

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0).UniRule annotation

Catalytic activityi

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: 7-cyano-7-deazaguanine biosynthesis

This protein is involved in the pathway 7-cyano-7-deazaguanine biosynthesis, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 7-cyano-7-deazaguanine biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi185ZincUniRule annotation1
Metal bindingi193ZincUniRule annotation1
Metal bindingi196ZincUniRule annotation1
Metal bindingi199ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 17ATPUniRule annotationAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processQueuosine biosynthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
7-cyano-7-deazaguanine synthaseUniRule annotation (EC:6.3.4.20UniRule annotation)
Alternative name(s):
7-cyano-7-carbaguanine synthaseUniRule annotation
PreQ(0) synthaseUniRule annotation
Queuosine biosynthesis protein QueCUniRule annotation
Gene namesi
Name:queCUniRule annotation
Ordered Locus Names:RB1063
ORF Names:SMb20940
Encoded oniPlasmid pSymB (megaplasmid 2)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Plasmid pSymB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002469021 – 2367-cyano-7-deazaguanine synthaseAdd BLAST236

Structurei

3D structure databases

ProteinModelPortaliQ92UN9.
SMRiQ92UN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueC family.UniRule annotation

Phylogenomic databases

KOiK06920.
OMAiQDPIKYV.

Family and domain databases

CDDicd01995. ExsB. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC. 1 hit.
InterProiView protein in InterPro
IPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR42914. PTHR42914. 1 hit.
PfamiView protein in Pfam
PF06508. QueC. 1 hit.
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92UN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTIVICSGG LDSVSLAHKV AAEQELSGLL SFDYGQRHRK ELDFAAACAR
60 70 80 90 100
RLGVPHQIID IREIGRRLTG SALTDEVDVP DGHYAEETMK ATVVPNRNAI
110 120 130 140 150
MLAIAFGVAA ARKADAVATA VHGGDHFIYP DCRPGFIDAF QAMQDHALDG
160 170 180 190 200
YADVALYAPF VNVSKADIVA DGARHDTPFA ETWSCYKGGA RHCGRCGTCV
210 220 230
ERREAFHLAG VPDPTEYDDP DFWVAATGSF VAEEVK
Length:236
Mass (Da):25,482
Last modified:December 1, 2001 - v1
Checksum:iF7B3454904B2574D
GO

Sequence cautioni

The sequence CAA12530 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence CAA90569 differs from that shown. Reason: Frameshift at several positions.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50189 Genomic DNA. Translation: CAA90569.1. Frameshift.
AJ225561 Genomic DNA. Translation: CAA12530.1. Frameshift.
AL591985 Genomic DNA. Translation: CAC49463.1.
PIRiG95974.
S60183.
RefSeqiNP_437603.1. NC_003078.1.
WP_010975901.1. NC_003078.1.

Genome annotation databases

EnsemblBacteriaiCAC49463; CAC49463; SM_b20940.
GeneIDi1237394.
KEGGisme:SM_b20940.
PATRICifig|266834.11.peg.5991.

Similar proteinsi

Entry informationi

Entry nameiQUEC_RHIME
AccessioniPrimary (citable) accession number: Q92UN9
Secondary accession number(s): Q52925
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families