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Protein

5-hydroxyisourate hydrolase 2

Gene

RB1166

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).By similarity

Miscellaneous

HIU hydrolysis also occurs spontaneously, but more slowly.

Catalytic activityi

5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10SubstrateBy similarity1
Binding sitei48SubstrateBy similarity1
Binding sitei117SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxyisourate hydrolase 2 (EC:3.5.2.17)
Short name:
HIU hydrolase 2
Short name:
HIUHase 2
Gene namesi
Ordered Locus Names:RB1166
ORF Names:SMb20872
Encoded oniPlasmid pSymB (megaplasmid 2)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Plasmid pSymB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506171 – 1205-hydroxyisourate hydrolase 2Add BLAST120

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ92UG5.
SMRiQ92UG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK07127.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiView protein in InterPro
IPR014306. Hydroxyisourate_hydrolase.
IPR023418. Thyroxine_BS.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
PANTHERiPTHR10395. PTHR10395. 1 hit.
PfamiView protein in Pfam
PF00576. Transthyretin. 1 hit.
SUPFAMiSSF49472. SSF49472. 1 hit.
TIGRFAMsiTIGR02962. hdxy_isourate. 1 hit.
PROSITEiView protein in PROSITE
PS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92UG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSGRLTTH VLDTALGRPA HGLKIDLYRL EGDARHLIRT VHTNSDGRVD
60 70 80 90 100
GPLMEGAGFA TGTYELVFHA GDYFRSAGVK LPDPAFLELV PLRFGIADAD
110 120
SHYHVPLLLS PYGYSTYRGS
Length:120
Mass (Da):13,114
Last modified:May 2, 2002 - v2
Checksum:i1A12DCC4F2E46232
GO

Sequence cautioni

The sequence CAC49566 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591985 Genomic DNA. Translation: CAC49566.1. Different initiation.
PIRiF95987.
RefSeqiNP_437706.1. NC_003078.1.

Genome annotation databases

EnsemblBacteriaiCAC49566; CAC49566; SM_b20872.
GeneIDi1237497.
KEGGisme:SM_b20872.
PATRICifig|266834.11.peg.6092.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHIUH2_RHIME
AccessioniPrimary (citable) accession number: Q92UG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: July 5, 2017
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families