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Q92UG5

- HIUH2_RHIME

UniProt

Q92UG5 - HIUH2_RHIME

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Protein

5-hydroxyisourate hydrolase 2

Gene
RB1166, SMb20872
Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) By similarity.

Catalytic activityi

5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Substrate By similarity
Binding sitei48 – 481Substrate By similarity
Binding sitei117 – 1171Substrate By similarity

GO - Molecular functioni

  1. hydroxyisourate hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. purine nucleobase metabolic process Source: UniProtKB-KW
  2. transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3188-MONOMER.
SMEL266834:GJF6-4599-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxyisourate hydrolase 2 (EC:3.5.2.17)
Short name:
HIU hydrolase 2
Short name:
HIUHase 2
Gene namesi
Ordered Locus Names:RB1166
ORF Names:SMb20872
Encoded oniPlasmid pSymB (megaplasmid 2)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Plasmid pSymB

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1201205-hydroxyisourate hydrolase 2PRO_0000050617Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi266834.SM_b20872.

Structurei

3D structure databases

ProteinModelPortaliQ92UG5.
SMRiQ92UG5. Positions 5-120.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2351.
KOiK07127.
OrthoDBiEOG6038XF.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR014306. Hydroxyisourate_hydrolase.
IPR023418. Thyroxine_BS.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
TIGRFAMsiTIGR02962. hdxy_isourate. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92UG5-1 [UniParc]FASTAAdd to Basket

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MSKSGRLTTH VLDTALGRPA HGLKIDLYRL EGDARHLIRT VHTNSDGRVD    50
GPLMEGAGFA TGTYELVFHA GDYFRSAGVK LPDPAFLELV PLRFGIADAD 100
SHYHVPLLLS PYGYSTYRGS 120
Length:120
Mass (Da):13,114
Last modified:May 2, 2002 - v2
Checksum:i1A12DCC4F2E46232
GO

Sequence cautioni

The sequence CAC49566.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591985 Genomic DNA. Translation: CAC49566.1. Different initiation.
PIRiF95987.
RefSeqiNP_437706.1. NC_003078.1.

Genome annotation databases

EnsemblBacteriaiCAC49566; CAC49566; SM_b20872.
GeneIDi1237497.
KEGGisme:SM_b20872.
PATRICi23638742. VBISinMel96828_6092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591985 Genomic DNA. Translation: CAC49566.1 . Different initiation.
PIRi F95987.
RefSeqi NP_437706.1. NC_003078.1.

3D structure databases

ProteinModelPortali Q92UG5.
SMRi Q92UG5. Positions 5-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SM_b20872.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC49566 ; CAC49566 ; SM_b20872 .
GeneIDi 1237497.
KEGGi sme:SM_b20872.
PATRICi 23638742. VBISinMel96828_6092.

Phylogenomic databases

eggNOGi COG2351.
KOi K07127.
OrthoDBi EOG6038XF.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-3188-MONOMER.
SMEL266834:GJF6-4599-MONOMER.

Family and domain databases

Gene3Di 2.60.40.180. 1 hit.
InterProi IPR014306. Hydroxyisourate_hydrolase.
IPR023418. Thyroxine_BS.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view ]
Pfami PF00576. Transthyretin. 1 hit.
[Graphical view ]
SUPFAMi SSF49472. SSF49472. 1 hit.
TIGRFAMsi TIGR02962. hdxy_isourate. 1 hit.
PROSITEi PS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete sequence of the 1,683-kb pSymB megaplasmid from the N2-fixing endosymbiont Sinorhizobium meliloti."
    Finan T.M., Weidner S., Wong K., Buhrmester J., Chain P., Vorhoelter F.J., Hernandez-Lucas I., Becker A., Cowie A., Gouzy J., Golding B., Puehler A.
    Proc. Natl. Acad. Sci. U.S.A. 98:9889-9894(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiHIUH2_RHIME
AccessioniPrimary (citable) accession number: Q92UG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: July 9, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

HIU hydrolysis also occurs spontaneously, but more slowly.

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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