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Q92UG5 (HIUH2_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxyisourate hydrolase 2

Short name=HIU hydrolase 2
Short name=HIUHase 2
EC=3.5.2.17
Gene names
Ordered Locus Names:RB1166
ORF Names:SMb20872
Encoded onPlasmid pSymB (megaplasmid 2)
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length120 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) By similarity.

Catalytic activity

5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.

Subunit structure

Homotetramer By similarity.

Miscellaneous

HIU hydrolysis also occurs spontaneously, but more slowly.

Sequence similarities

Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.

Sequence caution

The sequence CAC49566.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processPurine metabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Plasmid
Gene Ontology (GO)
   Biological_processpurine nucleobase metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

transport

Inferred from electronic annotation. Source: InterPro

   Molecular_functionhydroxyisourate hydrolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1201205-hydroxyisourate hydrolase 2
PRO_0000050617

Sites

Binding site101Substrate By similarity
Binding site481Substrate By similarity
Binding site1171Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92UG5 [UniParc].

Last modified May 2, 2002. Version 2.
Checksum: 1A12DCC4F2E46232

FASTA12013,114
        10         20         30         40         50         60 
MSKSGRLTTH VLDTALGRPA HGLKIDLYRL EGDARHLIRT VHTNSDGRVD GPLMEGAGFA 

        70         80         90        100        110        120 
TGTYELVFHA GDYFRSAGVK LPDPAFLELV PLRFGIADAD SHYHVPLLLS PYGYSTYRGS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591985 Genomic DNA. Translation: CAC49566.1. Different initiation.
PIRF95987.
RefSeqNP_437706.1. NC_003078.1.

3D structure databases

ProteinModelPortalQ92UG5.
SMRQ92UG5. Positions 5-120.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SM_b20872.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC49566; CAC49566; SM_b20872.
GeneID1237497.
KEGGsme:SM_b20872.
PATRIC23638742. VBISinMel96828_6092.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2351.
KOK07127.
OrthoDBEOG6038XF.
ProtClustDBCLSK808246.

Enzyme and pathway databases

BioCycSMEL266834:GJF6-4599-MONOMER.

Family and domain databases

Gene3D2.60.40.180. 1 hit.
InterProIPR014306. Hydroxyisourate_hydrolase.
IPR023418. Thyroxine_BS.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PfamPF00576. Transthyretin. 1 hit.
[Graphical view]
SUPFAMSSF49472. SSF49472. 1 hit.
TIGRFAMsTIGR02962. hdxy_isourate. 1 hit.
PROSITEPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIUH2_RHIME
AccessionPrimary (citable) accession number: Q92UG5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: November 13, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families