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Q92UG5

- HIUH2_RHIME

UniProt

Q92UG5 - HIUH2_RHIME

Protein

5-hydroxyisourate hydrolase 2

Gene

RB1166

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).By similarity

    Catalytic activityi

    5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei10 – 101SubstrateBy similarity
    Binding sitei48 – 481SubstrateBy similarity
    Binding sitei117 – 1171SubstrateBy similarity

    GO - Molecular functioni

    1. hydroxyisourate hydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. purine nucleobase metabolic process Source: UniProtKB-KW
    2. transport Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Purine metabolism

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-3188-MONOMER.
    SMEL266834:GJF6-4599-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxyisourate hydrolase 2 (EC:3.5.2.17)
    Short name:
    HIU hydrolase 2
    Short name:
    HIUHase 2
    Gene namesi
    Ordered Locus Names:RB1166
    ORF Names:SMb20872
    Encoded oniPlasmid pSymB (megaplasmid 2)0 Publication
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Plasmid pSymB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1201205-hydroxyisourate hydrolase 2PRO_0000050617Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi266834.SM_b20872.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92UG5.
    SMRiQ92UG5. Positions 5-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2351.
    KOiK07127.
    OrthoDBiEOG6038XF.

    Family and domain databases

    Gene3Di2.60.40.180. 1 hit.
    InterProiIPR014306. Hydroxyisourate_hydrolase.
    IPR023418. Thyroxine_BS.
    IPR023416. Transthyretin/HIU_hydrolase_SF.
    IPR023419. Transthyretin_CS.
    [Graphical view]
    PfamiPF00576. Transthyretin. 1 hit.
    [Graphical view]
    SUPFAMiSSF49472. SSF49472. 1 hit.
    TIGRFAMsiTIGR02962. hdxy_isourate. 1 hit.
    PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
    PS00769. TRANSTHYRETIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92UG5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKSGRLTTH VLDTALGRPA HGLKIDLYRL EGDARHLIRT VHTNSDGRVD    50
    GPLMEGAGFA TGTYELVFHA GDYFRSAGVK LPDPAFLELV PLRFGIADAD 100
    SHYHVPLLLS PYGYSTYRGS 120
    Length:120
    Mass (Da):13,114
    Last modified:May 2, 2002 - v2
    Checksum:i1A12DCC4F2E46232
    GO

    Sequence cautioni

    The sequence CAC49566.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591985 Genomic DNA. Translation: CAC49566.1. Different initiation.
    PIRiF95987.
    RefSeqiNP_437706.1. NC_003078.1.

    Genome annotation databases

    EnsemblBacteriaiCAC49566; CAC49566; SM_b20872.
    GeneIDi1237497.
    KEGGisme:SM_b20872.
    PATRICi23638742. VBISinMel96828_6092.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591985 Genomic DNA. Translation: CAC49566.1 . Different initiation.
    PIRi F95987.
    RefSeqi NP_437706.1. NC_003078.1.

    3D structure databases

    ProteinModelPortali Q92UG5.
    SMRi Q92UG5. Positions 5-120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SM_b20872.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC49566 ; CAC49566 ; SM_b20872 .
    GeneIDi 1237497.
    KEGGi sme:SM_b20872.
    PATRICi 23638742. VBISinMel96828_6092.

    Phylogenomic databases

    eggNOGi COG2351.
    KOi K07127.
    OrthoDBi EOG6038XF.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-3188-MONOMER.
    SMEL266834:GJF6-4599-MONOMER.

    Family and domain databases

    Gene3Di 2.60.40.180. 1 hit.
    InterProi IPR014306. Hydroxyisourate_hydrolase.
    IPR023418. Thyroxine_BS.
    IPR023416. Transthyretin/HIU_hydrolase_SF.
    IPR023419. Transthyretin_CS.
    [Graphical view ]
    Pfami PF00576. Transthyretin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49472. SSF49472. 1 hit.
    TIGRFAMsi TIGR02962. hdxy_isourate. 1 hit.
    PROSITEi PS00768. TRANSTHYRETIN_1. 1 hit.
    PS00769. TRANSTHYRETIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete sequence of the 1,683-kb pSymB megaplasmid from the N2-fixing endosymbiont Sinorhizobium meliloti."
      Finan T.M., Weidner S., Wong K., Buhrmester J., Chain P., Vorhoelter F.J., Hernandez-Lucas I., Becker A., Cowie A., Gouzy J., Golding B., Puehler A.
      Proc. Natl. Acad. Sci. U.S.A. 98:9889-9894(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiHIUH2_RHIME
    AccessioniPrimary (citable) accession number: Q92UG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: May 2, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    HIU hydrolysis also occurs spontaneously, but more slowly.

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3