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Protein

5-hydroxyisourate hydrolase 2

Gene

RB1166

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).By similarity

Miscellaneous

HIU hydrolysis also occurs spontaneously, but more slowly.

Catalytic activityi

5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10SubstrateBy similarity1
Binding sitei48SubstrateBy similarity1
Binding sitei117SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxyisourate hydrolase 2 (EC:3.5.2.17)
Short name:
HIU hydrolase 2
Short name:
HIUHase 2
Gene namesi
Ordered Locus Names:RB1166
ORF Names:SMb20872
Encoded oniPlasmid pSymB (megaplasmid 2)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Plasmid pSymB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506171 – 1205-hydroxyisourate hydrolase 2Add BLAST120

Proteomic databases

PRIDEiQ92UG5

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ92UG5
SMRiQ92UG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK07127

Family and domain databases

Gene3Di2.60.40.180, 1 hit
InterProiView protein in InterPro
IPR014306 Hydroxyisourate_hydrolase
IPR023418 Thyroxine_BS
IPR023416 Transthyretin/HIU_hydrolase_d
IPR036817 Transthyretin/HIU_hydrolase_sf
IPR023419 Transthyretin_CS
PANTHERiPTHR10395 PTHR10395, 1 hit
PfamiView protein in Pfam
PF00576 Transthyretin, 1 hit
SUPFAMiSSF49472 SSF49472, 1 hit
TIGRFAMsiTIGR02962 hdxy_isourate, 1 hit
PROSITEiView protein in PROSITE
PS00768 TRANSTHYRETIN_1, 1 hit
PS00769 TRANSTHYRETIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q92UG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSGRLTTH VLDTALGRPA HGLKIDLYRL EGDARHLIRT VHTNSDGRVD
60 70 80 90 100
GPLMEGAGFA TGTYELVFHA GDYFRSAGVK LPDPAFLELV PLRFGIADAD
110 120
SHYHVPLLLS PYGYSTYRGS
Length:120
Mass (Da):13,114
Last modified:May 2, 2002 - v2
Checksum:i1A12DCC4F2E46232
GO

Sequence cautioni

The sequence CAC49566 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591985 Genomic DNA Translation: CAC49566.1 Different initiation.
PIRiF95987
RefSeqiNP_437706.1, NC_003078.1

Genome annotation databases

EnsemblBacteriaiCAC49566; CAC49566; SM_b20872
GeneIDi1237497
KEGGisme:SM_b20872
PATRICifig|266834.11.peg.6092

Similar proteinsi

Entry informationi

Entry nameiHIUH2_RHIME
AccessioniPrimary (citable) accession number: Q92UG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: May 23, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

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