ID   Q92TT3_RHIME            Unreviewed;       420 AA.
AC   Q92TT3;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 103.
DE   SubName: Full=Adenylate cyclase protein {ECO:0000313|EMBL:CAC49814.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:CAC49814.1};
GN   Name=cyaG2 {ECO:0000313|EMBL:CAC49814.1};
GN   ORFNames=SM_b20707 {ECO:0000313|EMBL:CAC49814.1};
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OG   Plasmid pSymB {ECO:0000313|EMBL:CAC49814.1,
OG   ECO:0000313|Proteomes:UP000001976}.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834 {ECO:0000313|EMBL:CAC49814.1, ECO:0000313|Proteomes:UP000001976};
RN   [1] {ECO:0000313|EMBL:CAC49814.1, ECO:0000313|Proteomes:UP000001976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021 {ECO:0000313|EMBL:CAC49814.1,
RC   ECO:0000313|Proteomes:UP000001976};
RC   PLASMID=Plasmid pSymB {ECO:0000313|Proteomes:UP000001976};
RX   PubMed=11481431; DOI=10.1073/pnas.161294698;
RA   Finan T.M., Weidner S., Wong K., Buhrmester J., Chain P., Vorholter F.J.,
RA   Hernandez-Lucas I., Becker A., Cowie A., Gouzy J., Golding B., Puhler A.;
RT   "The complete sequence of the 1,683-kb pSymB megaplasmid from the N2-fixing
RT   endosymbiont Sinorhizobium meliloti.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9889-9894(2001).
RN   [2] {ECO:0000313|Proteomes:UP000001976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021 {ECO:0000313|Proteomes:UP000001976};
RC   PLASMID=Plasmid pSymB {ECO:0000313|Proteomes:UP000001976};
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
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DR   EMBL; AL591985; CAC49814.1; -; Genomic_DNA.
DR   PIR; F96018; F96018.
DR   RefSeq; NP_437954.1; NC_003078.1.
DR   RefSeq; WP_010976227.1; NC_003078.1.
DR   AlphaFoldDB; Q92TT3; -.
DR   EnsemblBacteria; CAC49814; CAC49814; SM_b20707.
DR   KEGG; sme:SM_b20707; -.
DR   PATRIC; fig|266834.11.peg.6336; -.
DR   eggNOG; COG2114; Bacteria.
DR   HOGENOM; CLU_039833_0_0_5; -.
DR   OrthoDB; 4565346at2; -.
DR   Proteomes; UP000001976; Plasmid pSymB.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF11; BLR2264 PROTEIN; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:CAC49814.1}; Plasmid {ECO:0000313|EMBL:CAC49814.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001976}.
FT   DOMAIN          240..370
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   420 AA;  46291 MW;  013B50188C1524FE CRC64;
     MATTNPSEAN VAVQSPTQPQ PPLPGESEGT WPARRRIIDW LVIETRGERF IDNIFVEMCD
     KLVEAGVPVA RATLHFRIHH PQWIGARILW RKGLAEAELD TYAYGVEDTT QYLSSPLRDF
     NEGAEEVRRR LDDPTSAGPD YPLYDELRAE GLTEYIIWPL LHTLGKRHAV TFASDRPGGF
     SSDDLAFLKD ILPALALVSE IRLKNRFART LLETYVGPHA SEQILAGATT RGSGVTVGAA
     ILICDLRDFT KLSDLWPRDD VIELLNGYFD AMSEPIERHG GEILKFMGDG LLAIFPLSNP
     CACSQLLGAI GEAQAALAVL NEENLRKGHD PLGYGIGVHV GDVMYGNIGS RRRLDFTVIG
     PAVNIASRLE TLTKELKRPV LLSRAFVEKA GCAGQMENLG SYALRGLDEP VDVFAFSRKK
//