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Q92TP3 (PDXA3_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxythreonine-4-phosphate dehydrogenase 3

EC=1.1.1.262
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase 3
Gene names
Name:pdxA3
Ordered Locus Names:RB1464
ORF Names:SMb20772
Encoded onPlasmid pSymB (megaplasmid 2)
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity. HAMAP-Rule MF_00536

Catalytic activity

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. HAMAP-Rule MF_00536

Cofactor

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5. HAMAP-Rule MF_00536

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00536

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00536.

Miscellaneous

The active site is located at the dimer interface By similarity.

Sequence similarities

Belongs to the PdxA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3483484-hydroxythreonine-4-phosphate dehydrogenase 3 HAMAP-Rule MF_00536
PRO_0000188823

Sites

Metal binding1801Divalent metal cation; shared with dimeric partner By similarity
Metal binding2241Divalent metal cation; shared with dimeric partner By similarity
Metal binding2791Divalent metal cation; shared with dimeric partner By similarity
Binding site2871Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92TP3 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 76F1B36A1AD334A2

FASTA34836,868
        10         20         30         40         50         60 
MTTSGADGTK ERRPVIALAM GDPAGISPEL TARLLALSDI RDAAHIIAIG DRRILDEGAR 

        70         80         90        100        110        120 
VAGVTLDLEA ASLDALDNAG TARHVFVDLA HLDPADVVRG EATLAGGTFA TRNFRTALEL 

       130        140        150        160        170        180 
AHAGKADAVC FTPFNKKAMR FAYPGYDDEI RFVADVLSFT GKVREFNVLE KVWNARVTSH 

       190        200        210        220        230        240 
IPLKDVASHL SVEAILAELK LTQACLKDAG YEEAKIAVAG LNPHAGDGGS FGMEEIDIIE 

       250        260        270        280        290        300 
PAVEKARALG FNVEGPFPAD TVFLRALKEG FNAVMTMYHD QGQIAMKIIG FDKGVTMMGG 

       310        320        330        340 
LPFPLCTPAH GTAYDIAGKG IADIGATREA ILLAARMAKK KRALSAAA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591985 Genomic DNA. Translation: CAC49864.1.
PIRH96024.
RefSeqNP_438004.1. NC_003078.1.

3D structure databases

ProteinModelPortalQ92TP3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SM_b20772.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC49864; CAC49864; SM_b20772.
GeneID1237796.
KEGGsme:SM_b20772.
PATRIC23639342. VBISinMel96828_6391.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1995.
KOK00097.
OMAWNARVTS.
OrthoDBEOG6GN6ZC.

Enzyme and pathway databases

BioCycSMEL266834:GJF6-4897-MONOMER.
UniPathwayUPA00244; UER00312.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
HAMAPMF_00536. PdxA.
InterProIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamPF04166. PdxA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDXA3_RHIME
AccessionPrimary (citable) accession number: Q92TP3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways