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Q92TP3

- PDXA3_RHIME

UniProt

Q92TP3 - PDXA3_RHIME

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Protein

4-hydroxythreonine-4-phosphate dehydrogenase 3

Gene

pdxA3

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

Cofactori

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi180 – 1801Divalent metal cation; shared with dimeric partnerUniRule annotation
Metal bindingi224 – 2241Divalent metal cation; shared with dimeric partnerUniRule annotation
Metal bindingi279 – 2791Divalent metal cation; shared with dimeric partnerUniRule annotation
Binding sitei287 – 2871SubstrateUniRule annotation

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. NAD binding Source: InterPro
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-4897-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase 3UniRule annotation (EC:1.1.1.262UniRule annotation)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase 3UniRule annotation
Gene namesi
Name:pdxA3UniRule annotation
Ordered Locus Names:RB1464
ORF Names:SMb20772
Encoded oniPlasmid pSymB (megaplasmid 2)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Plasmid pSymB

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3483484-hydroxythreonine-4-phosphate dehydrogenase 3PRO_0000188823Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi266834.SM_b20772.

Structurei

3D structure databases

ProteinModelPortaliQ92TP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1995.
KOiK00097.
OMAiWNARVTS.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92TP3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTSGADGTK ERRPVIALAM GDPAGISPEL TARLLALSDI RDAAHIIAIG
60 70 80 90 100
DRRILDEGAR VAGVTLDLEA ASLDALDNAG TARHVFVDLA HLDPADVVRG
110 120 130 140 150
EATLAGGTFA TRNFRTALEL AHAGKADAVC FTPFNKKAMR FAYPGYDDEI
160 170 180 190 200
RFVADVLSFT GKVREFNVLE KVWNARVTSH IPLKDVASHL SVEAILAELK
210 220 230 240 250
LTQACLKDAG YEEAKIAVAG LNPHAGDGGS FGMEEIDIIE PAVEKARALG
260 270 280 290 300
FNVEGPFPAD TVFLRALKEG FNAVMTMYHD QGQIAMKIIG FDKGVTMMGG
310 320 330 340
LPFPLCTPAH GTAYDIAGKG IADIGATREA ILLAARMAKK KRALSAAA
Length:348
Mass (Da):36,868
Last modified:December 1, 2001 - v1
Checksum:i76F1B36A1AD334A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591985 Genomic DNA. Translation: CAC49864.1.
PIRiH96024.
RefSeqiNP_438004.1. NC_003078.1.

Genome annotation databases

EnsemblBacteriaiCAC49864; CAC49864; SM_b20772.
GeneIDi1237796.
KEGGisme:SM_b20772.
PATRICi23639342. VBISinMel96828_6391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591985 Genomic DNA. Translation: CAC49864.1 .
PIRi H96024.
RefSeqi NP_438004.1. NC_003078.1.

3D structure databases

ProteinModelPortali Q92TP3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SM_b20772.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC49864 ; CAC49864 ; SM_b20772 .
GeneIDi 1237796.
KEGGi sme:SM_b20772.
PATRICi 23639342. VBISinMel96828_6391.

Phylogenomic databases

eggNOGi COG1995.
KOi K00097.
OMAi WNARVTS.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci SMEL266834:GJF6-4897-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete sequence of the 1,683-kb pSymB megaplasmid from the N2-fixing endosymbiont Sinorhizobium meliloti."
    Finan T.M., Weidner S., Wong K., Buhrmester J., Chain P., Vorhoelter F.J., Hernandez-Lucas I., Becker A., Cowie A., Gouzy J., Golding B., Puehler A.
    Proc. Natl. Acad. Sci. U.S.A. 98:9889-9894(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiPDXA3_RHIME
AccessioniPrimary (citable) accession number: Q92TP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface.UniRule annotation

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3