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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase (trpE(G))
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpBUniRule annotation
Ordered Locus Names:R00028
ORF Names:SMc02766
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000989901 – 406Tryptophan synthase beta chainAdd BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi266834.SMc02766

Structurei

3D structure databases

ProteinModelPortaliQ92TC9
SMRiQ92TC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CG0 Bacteria
COG0133 LUCA
HOGENOMiHOG000161710
KOiK01696
OMAiHGMKSYF

Family and domain databases

CDDicd06446 Trp-synth_B, 1 hit
HAMAPiMF_00133 Trp_synth_beta, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR006653 Trp_synth_b_CS
IPR006654 Trp_synth_beta
IPR023026 Trp_synth_beta/beta-like
IPR036052 Trypto_synt_PLP_dependent
PANTHERiPTHR42882 PTHR42882, 1 hit
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF001413 Trp_syn_beta, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00263 trpB, 1 hit
PROSITEiView protein in PROSITE
PS00168 TRP_SYNTHASE_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q92TC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQPPKPNSF RSGPDEEGRF GIFGGRFVAE TLMPLILDLQ DEWARAKNDP
60 70 80 90 100
AFKAELENLG THYIGRPSPL YFAERLTAEL GGAKIYFKRE ELNHTGSHKI
110 120 130 140 150
NNCIGQILLA KRMGKTRIIA ETGAGQHGVA SATVAARFGL PCVVYMGATD
160 170 180 190 200
VERQAPNVFR MKLLGAEVKP VTAGNGTLKD AMNEALRDWV TNVDSTYYLI
210 220 230 240 250
GTAAGPHPYP EMVRDFQAVI GEEAKQQILE AEGRLPDLVV AAVGGGSNAI
260 270 280 290 300
GIFHSFLDDE GVRIVGVEAG GKGLDGDEHC ASLTAGSPGV LHGNRTYLLQ
310 320 330 340 350
DGDGQIKEGH SISAGLDYPG IGPEHAWLND IGRVEYVPIM DHEALEAFQT
360 370 380 390 400
LTRLEGIIPA LEPSHALAEV IKRAPKMGKD EIILMNLSGR GDKDIFTVGK

ILGMGQ
Length:406
Mass (Da):43,716
Last modified:December 1, 2001 - v1
Checksum:iC3FD389E8197D7C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA Translation: CAC41415.1
RefSeqiNP_384134.1, NC_003047.1
WP_003536446.1, NC_003047.1

Genome annotation databases

EnsemblBacteriaiCAC41415; CAC41415; SMc02766
GeneIDi1231653
KEGGisme:SMc02766
PATRICifig|266834.11.peg.1381

Similar proteinsi

Entry informationi

Entry nameiTRPB_RHIME
AccessioniPrimary (citable) accession number: Q92TC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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