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Q92TA4

- MASZ_RHIME

UniProt

Q92TA4 - MASZ_RHIME

Protein

Malate synthase G

Gene

glcB

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei116 – 1161Acetyl-CoA; via carbonyl oxygenUniRule annotation
    Binding sitei274 – 2741Acetyl-CoAUniRule annotation
    Binding sitei311 – 3111Acetyl-CoAUniRule annotation
    Active sitei338 – 3381Proton acceptorUniRule annotation
    Binding sitei338 – 3381GlyoxylateUniRule annotation
    Metal bindingi430 – 4301MagnesiumUniRule annotation
    Binding sitei430 – 4301GlyoxylateUniRule annotation
    Metal bindingi458 – 4581MagnesiumUniRule annotation
    Binding sitei539 – 5391Acetyl-CoA; via carbonyl oxygenUniRule annotation
    Active sitei629 – 6291Proton donorUniRule annotation

    GO - Molecular functioni

    1. malate synthase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-HAMAP
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciSMEL266834:GJF6-62-MONOMER.
    UniPathwayiUPA00703; UER00720.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
    Gene namesi
    Name:glcBUniRule annotation
    Ordered Locus Names:R00062
    ORF Names:SMc02581
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 723723Malate synthase GPRO_0000166898Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei615 – 6151Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi266834.SMc02581.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92TA4.
    SMRiQ92TA4. Positions 2-720.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni123 – 1242Acetyl-CoA bindingUniRule annotation
    Regioni455 – 4584Glyoxylate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2225.
    HOGENOMiHOG000220740.
    KOiK01638.
    OMAiSQFIENE.
    OrthoDBiEOG6HJ286.

    Family and domain databases

    Gene3Di2.170.170.11. 2 hits.
    HAMAPiMF_00641. Malate_synth_G.
    InterProiIPR011076. Malate_synth-like.
    IPR023310. Malate_synth_G_beta_sub_dom.
    IPR001465. Malate_synthase.
    IPR006253. Malate_synthG.
    [Graphical view]
    PfamiPF01274. Malate_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51645. SSF51645. 1 hit.
    TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92TA4-1 [UniParc]FASTAAdd to Basket

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    MDRVEKYGLQ IDAGLHRFLV EEAMPGTGVD ADRFFSAFSD LVHDLGPKNR    50
    ALLVKRDELQ ARLDGWYREH GAPVDMEAYE AFLREIGYLL PEGPDFYVST 100
    ANVDSEIATI AGPQLVVPVM NARYALNAAN ARWGSLYDAL YGTDAIAETD 150
    GAERGKGYNP KRGAKVIAWA REFLDASAPL AAGRWSDAKS FSVEGATLTV 200
    TLADGTKSAP RNSVQFAGYA GDPAAPSEIV LRRNGLHIVI VLDATTPIGK 250
    ADAAGISDVV LESAITTIMD CEDSIAAVDA EDKVLVYRNW LGLMKGDLEE 300
    EVTKGGRAFT RRLNPDRAYT APDGATLTLP GRSLMLVRNV GHLMTNPAVL 350
    DRDGEEVPEG LMDAMVTALI ALHDIGRNGR RANSRSGSMY VVKPKMHGPE 400
    EVAFACEIFA RVEAALGLPA NAMKMGIMDE ERRTTVNLKE CIRAARERVV 450
    FINTGFLDRT GDEIHTSMEA GPMIRKGDMK QAPWISAYEN WNVDVGLECG 500
    LSGHAQIGKG MWAMPDLMAA MLEQKIVHPK AGANTAWVPS PTAATLHATH 550
    YHRVNVAEVQ ASLKSRTRAK LADILSVPVA ARPNWTEEEI QRELDNNAQG 600
    ILGYVVRWVD QGVGCSKVPD INNVGLMEDR ATLRISAQHM ANWLHHGIVS 650
    EAQIVETMQR MAAIVDGQNA GDPNYQPMAG RFEESIAFQA ALDLVLKGRE 700
    QPNGYTEPVL HRRRLELKAK QGA 723
    Length:723
    Mass (Da):78,854
    Last modified:December 1, 2001 - v1
    Checksum:iA0E95E8A5164BB58
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC41449.1.
    RefSeqiNP_384168.1. NC_003047.1.

    Genome annotation databases

    EnsemblBacteriaiCAC41449; CAC41449; SMc02581.
    GeneIDi1231687.
    KEGGisme:SMc02581.
    PATRICi23629277. VBISinMel96828_1416.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC41449.1 .
    RefSeqi NP_384168.1. NC_003047.1.

    3D structure databases

    ProteinModelPortali Q92TA4.
    SMRi Q92TA4. Positions 2-720.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMc02581.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC41449 ; CAC41449 ; SMc02581 .
    GeneIDi 1231687.
    KEGGi sme:SMc02581.
    PATRICi 23629277. VBISinMel96828_1416.

    Phylogenomic databases

    eggNOGi COG2225.
    HOGENOMi HOG000220740.
    KOi K01638.
    OMAi SQFIENE.
    OrthoDBi EOG6HJ286.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00720 .
    BioCyci SMEL266834:GJF6-62-MONOMER.

    Family and domain databases

    Gene3Di 2.170.170.11. 2 hits.
    HAMAPi MF_00641. Malate_synth_G.
    InterProi IPR011076. Malate_synth-like.
    IPR023310. Malate_synth_G_beta_sub_dom.
    IPR001465. Malate_synthase.
    IPR006253. Malate_synthG.
    [Graphical view ]
    Pfami PF01274. Malate_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51645. SSF51645. 1 hit.
    TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiMASZ_RHIME
    AccessioniPrimary (citable) accession number: Q92TA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 30, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3