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Q92TA4

- MASZ_RHIME

UniProt

Q92TA4 - MASZ_RHIME

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Protein
Malate synthase G
Gene
glcB, R00062, SMc02581
Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei274 – 2741Acetyl-CoA By similarity
Binding sitei311 – 3111Acetyl-CoA By similarity
Active sitei338 – 3381Proton acceptor By similarity
Binding sitei338 – 3381Glyoxylate By similarity
Metal bindingi430 – 4301Magnesium By similarity
Binding sitei430 – 4301Glyoxylate By similarity
Metal bindingi458 – 4581Magnesium By similarity
Binding sitei539 – 5391Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei629 – 6291Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-62-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:R00062
ORF Names:SMc02581
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Malate synthase GUniRule annotation
PRO_0000166898Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei615 – 6151Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi266834.SMc02581.

Structurei

3D structure databases

ProteinModelPortaliQ92TA4.
SMRiQ92TA4. Positions 2-720.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1242Acetyl-CoA binding By similarity
Regioni455 – 4584Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92TA4-1 [UniParc]FASTAAdd to Basket

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MDRVEKYGLQ IDAGLHRFLV EEAMPGTGVD ADRFFSAFSD LVHDLGPKNR    50
ALLVKRDELQ ARLDGWYREH GAPVDMEAYE AFLREIGYLL PEGPDFYVST 100
ANVDSEIATI AGPQLVVPVM NARYALNAAN ARWGSLYDAL YGTDAIAETD 150
GAERGKGYNP KRGAKVIAWA REFLDASAPL AAGRWSDAKS FSVEGATLTV 200
TLADGTKSAP RNSVQFAGYA GDPAAPSEIV LRRNGLHIVI VLDATTPIGK 250
ADAAGISDVV LESAITTIMD CEDSIAAVDA EDKVLVYRNW LGLMKGDLEE 300
EVTKGGRAFT RRLNPDRAYT APDGATLTLP GRSLMLVRNV GHLMTNPAVL 350
DRDGEEVPEG LMDAMVTALI ALHDIGRNGR RANSRSGSMY VVKPKMHGPE 400
EVAFACEIFA RVEAALGLPA NAMKMGIMDE ERRTTVNLKE CIRAARERVV 450
FINTGFLDRT GDEIHTSMEA GPMIRKGDMK QAPWISAYEN WNVDVGLECG 500
LSGHAQIGKG MWAMPDLMAA MLEQKIVHPK AGANTAWVPS PTAATLHATH 550
YHRVNVAEVQ ASLKSRTRAK LADILSVPVA ARPNWTEEEI QRELDNNAQG 600
ILGYVVRWVD QGVGCSKVPD INNVGLMEDR ATLRISAQHM ANWLHHGIVS 650
EAQIVETMQR MAAIVDGQNA GDPNYQPMAG RFEESIAFQA ALDLVLKGRE 700
QPNGYTEPVL HRRRLELKAK QGA 723
Length:723
Mass (Da):78,854
Last modified:December 1, 2001 - v1
Checksum:iA0E95E8A5164BB58
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591688 Genomic DNA. Translation: CAC41449.1.
RefSeqiNP_384168.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC41449; CAC41449; SMc02581.
GeneIDi1231687.
KEGGisme:SMc02581.
PATRICi23629277. VBISinMel96828_1416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591688 Genomic DNA. Translation: CAC41449.1 .
RefSeqi NP_384168.1. NC_003047.1.

3D structure databases

ProteinModelPortali Q92TA4.
SMRi Q92TA4. Positions 2-720.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc02581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC41449 ; CAC41449 ; SMc02581 .
GeneIDi 1231687.
KEGGi sme:SMc02581.
PATRICi 23629277. VBISinMel96828_1416.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci SMEL266834:GJF6-62-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiMASZ_RHIME
AccessioniPrimary (citable) accession number: Q92TA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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