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Q92TA4

- MASZ_RHIME

UniProt

Q92TA4 - MASZ_RHIME

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Protein

Malate synthase G

Gene

glcB

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161Acetyl-CoA; via carbonyl oxygenUniRule annotation
Binding sitei274 – 2741Acetyl-CoAUniRule annotation
Binding sitei311 – 3111Acetyl-CoAUniRule annotation
Active sitei338 – 3381Proton acceptorUniRule annotation
Binding sitei338 – 3381GlyoxylateUniRule annotation
Metal bindingi430 – 4301MagnesiumUniRule annotation
Binding sitei430 – 4301GlyoxylateUniRule annotation
Metal bindingi458 – 4581MagnesiumUniRule annotation
Binding sitei539 – 5391Acetyl-CoA; via carbonyl oxygenUniRule annotation
Active sitei629 – 6291Proton donorUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-62-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:glcBUniRule annotation
Ordered Locus Names:R00062
ORF Names:SMc02581
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Malate synthase GPRO_0000166898Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei615 – 6151Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi266834.SMc02581.

Structurei

3D structure databases

ProteinModelPortaliQ92TA4.
SMRiQ92TA4. Positions 2-720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1242Acetyl-CoA bindingUniRule annotation
Regioni455 – 4584Glyoxylate bindingUniRule annotation

Sequence similaritiesi

Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92TA4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRVEKYGLQ IDAGLHRFLV EEAMPGTGVD ADRFFSAFSD LVHDLGPKNR
60 70 80 90 100
ALLVKRDELQ ARLDGWYREH GAPVDMEAYE AFLREIGYLL PEGPDFYVST
110 120 130 140 150
ANVDSEIATI AGPQLVVPVM NARYALNAAN ARWGSLYDAL YGTDAIAETD
160 170 180 190 200
GAERGKGYNP KRGAKVIAWA REFLDASAPL AAGRWSDAKS FSVEGATLTV
210 220 230 240 250
TLADGTKSAP RNSVQFAGYA GDPAAPSEIV LRRNGLHIVI VLDATTPIGK
260 270 280 290 300
ADAAGISDVV LESAITTIMD CEDSIAAVDA EDKVLVYRNW LGLMKGDLEE
310 320 330 340 350
EVTKGGRAFT RRLNPDRAYT APDGATLTLP GRSLMLVRNV GHLMTNPAVL
360 370 380 390 400
DRDGEEVPEG LMDAMVTALI ALHDIGRNGR RANSRSGSMY VVKPKMHGPE
410 420 430 440 450
EVAFACEIFA RVEAALGLPA NAMKMGIMDE ERRTTVNLKE CIRAARERVV
460 470 480 490 500
FINTGFLDRT GDEIHTSMEA GPMIRKGDMK QAPWISAYEN WNVDVGLECG
510 520 530 540 550
LSGHAQIGKG MWAMPDLMAA MLEQKIVHPK AGANTAWVPS PTAATLHATH
560 570 580 590 600
YHRVNVAEVQ ASLKSRTRAK LADILSVPVA ARPNWTEEEI QRELDNNAQG
610 620 630 640 650
ILGYVVRWVD QGVGCSKVPD INNVGLMEDR ATLRISAQHM ANWLHHGIVS
660 670 680 690 700
EAQIVETMQR MAAIVDGQNA GDPNYQPMAG RFEESIAFQA ALDLVLKGRE
710 720
QPNGYTEPVL HRRRLELKAK QGA
Length:723
Mass (Da):78,854
Last modified:December 1, 2001 - v1
Checksum:iA0E95E8A5164BB58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC41449.1.
RefSeqiNP_384168.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC41449; CAC41449; SMc02581.
GeneIDi1231687.
KEGGisme:SMc02581.
PATRICi23629277. VBISinMel96828_1416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC41449.1 .
RefSeqi NP_384168.1. NC_003047.1.

3D structure databases

ProteinModelPortali Q92TA4.
SMRi Q92TA4. Positions 2-720.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc02581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC41449 ; CAC41449 ; SMc02581 .
GeneIDi 1231687.
KEGGi sme:SMc02581.
PATRICi 23629277. VBISinMel96828_1416.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci SMEL266834:GJF6-62-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiMASZ_RHIME
AccessioniPrimary (citable) accession number: Q92TA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3