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Q92T50 (TYPH_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:R00130
ORF Names:SMc04122
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01628

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 440440Thymidine phosphorylase HAMAP-Rule MF_01628
PRO_0000059060

Sequences

Sequence LengthMass (Da)Tools
Q92T50 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 9F1801BCB3A9CC3E

FASTA44046,128
        10         20         30         40         50         60 
MAMLPQEIIR KKRDGDRLDP AEIAGFIAGV TDGSVSEGQA AAFAMAVWFS GMNRDECVAL 

        70         80         90        100        110        120 
TLAMRDSGET LDWSDLARPI VDKHSTGGVG DNVSLMLAPI VAACGAAVPM ISGRGLGHTG 

       130        140        150        160        170        180 
GTLDKLESIP GYDIQPSPEL FRRVADEVGC AIIGQTADLA PADKRLYAIR DVTATVDSVP 

       190        200        210        220        230        240 
LITASILSKK LAAGLRSLVL DVKLGNGSFM TDPAETEVLA RSLVEVANGA GVRTSALITD 

       250        260        270        280        290        300 
MNEPLADAAG NALEIENCLA YLRGEKAGTR LDQVVMALAA EMLVAAGIAA HEAEAEAMAR 

       310        320        330        340        350        360 
RVLGSGEAME RFGLMVHRLG GPADFVDRPG AYLAKAPAIL AVPAGRHGYL TSCKTRELGM 

       370        380        390        400        410        420 
AVIELGGGRI RPDDRIDHRV GLTGLRPLGT KVEKGEPIAF VHAADQSQAE AIAKRVVTLY 

       430        440 
AIADEEPARR PVIVSKLRAG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591688 Genomic DNA. Translation: CAC41517.1.
RefSeqNP_384236.1. NC_003047.1.

3D structure databases

ProteinModelPortalQ92T50.
SMRQ92T50. Positions 3-437.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SMc04122.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC41517; CAC41517; SMc04122.
GeneID1231761.
KEGGsme:SMc04122.
PATRIC23629433. VBISinMel96828_1489.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000047313.
KOK00758.
OMAHYRITED.
OrthoDBEOG61ZTGG.

Enzyme and pathway databases

BioCycSMEL266834:GJF6-136-MONOMER.
UniPathwayUPA00578; UER00638.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_01628. Thymid_phosp.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_RHIME
AccessionPrimary (citable) accession number: Q92T50
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways