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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137L-tryptophanUniRule annotation1
Binding sitei208ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 15ATPUniRule annotation3
Nucleotide bindingi21 – 22ATPUniRule annotation2
Nucleotide bindingi149 – 151ATPUniRule annotation3
Nucleotide bindingi217 – 221ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:R00399
ORF Names:SMc01121
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366671 – 354Tryptophan--tRNA ligaseAdd BLAST354

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi266834.SMc01121

Structurei

3D structure databases

ProteinModelPortaliQ92SI9
SMRiQ92SI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 22"HIGH" regionUniRule annotation9
Motifi217 – 221"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059940
KOiK01867
OMAiQRMTQFK

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 3 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q92SI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEFKPLVFS GVQPTGNLHL GNYLGAIRKF VALQENNDCI YCVVDLHSIT
60 70 80 90 100
AQLVHEDLPG QIRSIAAAFI ASGIDPEKHI VFNQSAVPQH AELAWIFNCV
110 120 130 140 150
ARIGWMNRMT QFKDKAGKDR ENASLGLLAY PSLMAADILV YRATHVPVGD
160 170 180 190 200
DQKQHLELTR DIAQKFNIDF MEHIRRGGYG VDIVVGEEPI HAYFPPVEPL
210 220 230 240 250
IGGPAPRVMS LRDGTKKMSK SDPSDLSRIN LMDDADTILK KIRKAKTDPD
260 270 280 290 300
ALPSEADGLK DRPEAENLVG IYAALADRSK EEVLAEFGGQ QFSTFKPALA
310 320 330 340 350
DLAVSVLSPI TGEMRRLMGD TAHIDAILRK GGERARERAE TTMREVREII

GFLQ
Length:354
Mass (Da):39,168
Last modified:December 1, 2001 - v1
Checksum:iEEEA6F4BFC1AF959
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA Translation: CAC41836.1
RefSeqiNP_384505.1, NC_003047.1
WP_010968551.1, NC_003047.1

Genome annotation databases

EnsemblBacteriaiCAC41836; CAC41836; SMc01121
GeneIDi1232033
KEGGisme:SMc01121
PATRICifig|266834.11.peg.1772

Similar proteinsi

Entry informationi

Entry nameiSYW_RHIME
AccessioniPrimary (citable) accession number: Q92SI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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