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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathway: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Putative glucose-6-phosphate isomerase 2 (pgiA2), Putative glucose-6-phosphate isomerase 1 (pgiA1), Glucose-6-phosphate isomerase (pgi)
  3. Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfp)
  4. Fructose-bisphosphate aldolase (fbaB), Fructose-bisphosphate aldolase (cbbA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei346 – 3461Proton donorUniRule annotation
Active sitei377 – 3771UniRule annotation
Active sitei506 – 5061UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-495-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:R00483
ORF Names:SMc02163
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Glucose-6-phosphate isomerasePRO_0000180719Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc02163.

Structurei

3D structure databases

ProteinModelPortaliQ92SC4.
SMRiQ92SC4. Positions 15-538.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92SC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALVENLKA TARETDATDI RAAFAADPNR FSRFSTAFDD LLFDYSKCAV
60 70 80 90 100
NDRIIDGLEA LAKAAKVEEK RDAMFRGDII NITEERAVLH TALRNRSNRP
110 120 130 140 150
VLVDGKDVMP DVNAVLEAMG KFADDIRSGA LKGATGKKIT DVVNIGIGGS
160 170 180 190 200
DLGPVMATLA LAPFHDGPRL HFVSNVDGAH IADTLTLLDP ETSLFIVASK
210 220 230 240 250
TFTTIETMTN AATARAFIAG KLGEAAVGHH FAAVSTALDK VGAFGIDAAR
260 270 280 290 300
VFGFWDWVGG RYSIWSAIGL PLMIAIGKEN FGRFLDGGHA IDEHFRSAPL
310 320 330 340 350
RQNIPMLLGL IGFYNRNVLG YPSRAILPYD QRLTRFPAYL QQLDMESNGK
360 370 380 390 400
GVTLDSQPVE FSTGPVVWGE PGTNGQHAFY QLIHQGTDVI PAEFMIAANG
410 420 430 440 450
HEKDLRHQHQ LLMANCLAQS EALMKGRTLA EAKAQLTSKG MDDAKADKIA
460 470 480 490 500
PHRVFTGNRP SLTIVYDQLD PFALGRLIAL YEHRVFVEGA LFNINSFDQW
510 520 530 540
GVELGKELAT GLLPVIEGKE SAEGHDSSTA GLVAALLKAA R
Length:541
Mass (Da):58,611
Last modified:December 1, 2001 - v1
Checksum:i79F112BE8F9F57A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC41920.1.
RefSeqiNP_384589.1. NC_003047.1.
WP_010968607.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC41920; CAC41920; SMc02163.
GeneIDi1232118.
KEGGisme:SMc02163.
PATRICi23630183. VBISinMel96828_1860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC41920.1.
RefSeqiNP_384589.1. NC_003047.1.
WP_010968607.1. NC_003047.1.

3D structure databases

ProteinModelPortaliQ92SC4.
SMRiQ92SC4. Positions 15-538.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266834.SMc02163.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC41920; CAC41920; SMc02163.
GeneIDi1232118.
KEGGisme:SMc02163.
PATRICi23630183. VBISinMel96828_1860.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciSMEL266834:GJF6-495-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiG6PI_RHIME
AccessioniPrimary (citable) accession number: Q92SC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: May 27, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.