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Q92S49

- PNCB_RHIME

UniProt

Q92S49 - PNCB_RHIME

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-594-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:R00580
ORF Names:SMc02276
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Nicotinate phosphoribosyltransferasePRO_0000205842Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc02276.

Structurei

3D structure databases

ProteinModelPortaliQ92S49.
SMRiQ92S49. Positions 1-426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284929.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92S49-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKTDIARRV YNHTWKLDPI VRSLLDTDFY KLLMLQMIWQ LYPDVDATFS
60 70 80 90 100
LINRTKTVRL ADEIDEQELR DQLDHARGLR FTKKEMIWLA GNSFYGRTQI
110 120 130 140 150
FSPEFLAWLA RFRLPEYELS RRDGQFELTF RGRWAETTMW EIPALAIINE
160 170 180 190 200
LRSRAAMKGL GPFTLDVLYA RAKAKMWSKV EQLREHPNLR ISDFGTRRRH
210 220 230 240 250
SFLWQRWCVE ALKEGIGSSF TGSSNVLLAM DNDLEAVGTN AHELPMVAAA
260 270 280 290 300
LTRNDRELAA APYKVLQDWN QLYGGNLLIV LPDAFGTAAF LRDAPDWVAD
310 320 330 340 350
WTGFRPDSAP PIEGGEKIIA WWKKMGRDPR EKLLIFSDGL DVDTIIRTYC
360 370 380 390 400
HFEGRVRMSF GWGTNLTNDF AGCAPTEING LNPISIVCKV SEANGRPAVK
410 420 430
LSDNPRKATG DPAEVERYLK FFGSEDFVEQ SVRV
Length:434
Mass (Da):49,735
Last modified:December 1, 2001 - v1
Checksum:i34241F979F793723
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC45152.1.
RefSeqiNP_384686.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC45152; CAC45152; SMc02276.
GeneIDi1232217.
KEGGisme:SMc02276.
PATRICi23630379. VBISinMel96828_1957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC45152.1 .
RefSeqi NP_384686.1. NC_003047.1.

3D structure databases

ProteinModelPortali Q92S49.
SMRi Q92S49. Positions 1-426.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc02276.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC45152 ; CAC45152 ; SMc02276 .
GeneIDi 1232217.
KEGGi sme:SMc02276.
PATRICi 23630379. VBISinMel96828_1957.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284929.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci SMEL266834:GJF6-594-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiPNCB_RHIME
AccessioniPrimary (citable) accession number: Q92S49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3