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Q92S49

- PNCB_RHIME

UniProt

Q92S49 - PNCB_RHIME

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciSMEL266834:GJF6-594-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:R00580
    ORF Names:SMc02276
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Nicotinate phosphoribosyltransferasePRO_0000205842Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SMc02276.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92S49.
    SMRiQ92S49. Positions 1-426.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284929.
    KOiK00763.
    OMAiQAVFHRY.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92S49-1 [UniParc]FASTAAdd to Basket

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    MPKTDIARRV YNHTWKLDPI VRSLLDTDFY KLLMLQMIWQ LYPDVDATFS    50
    LINRTKTVRL ADEIDEQELR DQLDHARGLR FTKKEMIWLA GNSFYGRTQI 100
    FSPEFLAWLA RFRLPEYELS RRDGQFELTF RGRWAETTMW EIPALAIINE 150
    LRSRAAMKGL GPFTLDVLYA RAKAKMWSKV EQLREHPNLR ISDFGTRRRH 200
    SFLWQRWCVE ALKEGIGSSF TGSSNVLLAM DNDLEAVGTN AHELPMVAAA 250
    LTRNDRELAA APYKVLQDWN QLYGGNLLIV LPDAFGTAAF LRDAPDWVAD 300
    WTGFRPDSAP PIEGGEKIIA WWKKMGRDPR EKLLIFSDGL DVDTIIRTYC 350
    HFEGRVRMSF GWGTNLTNDF AGCAPTEING LNPISIVCKV SEANGRPAVK 400
    LSDNPRKATG DPAEVERYLK FFGSEDFVEQ SVRV 434
    Length:434
    Mass (Da):49,735
    Last modified:December 1, 2001 - v1
    Checksum:i34241F979F793723
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC45152.1.
    RefSeqiNP_384686.1. NC_003047.1.

    Genome annotation databases

    EnsemblBacteriaiCAC45152; CAC45152; SMc02276.
    GeneIDi1232217.
    KEGGisme:SMc02276.
    PATRICi23630379. VBISinMel96828_1957.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC45152.1 .
    RefSeqi NP_384686.1. NC_003047.1.

    3D structure databases

    ProteinModelPortali Q92S49.
    SMRi Q92S49. Positions 1-426.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMc02276.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC45152 ; CAC45152 ; SMc02276 .
    GeneIDi 1232217.
    KEGGi sme:SMc02276.
    PATRICi 23630379. VBISinMel96828_1957.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284929.
    KOi K00763.
    OMAi QAVFHRY.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci SMEL266834:GJF6-594-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiPNCB_RHIME
    AccessioniPrimary (citable) accession number: Q92S49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3