Q92S26HISX_RHIMEHistidinol dehydrogenaseHDH1.1.1.23hisDR00611SMc02307Rhizobium meliloti (strain 1021)Ensifer melilotiSinorhizobium melilotiBacteriaPseudomonadotaAlphaproteobacteriaHyphomicrobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobiumAnalysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The composite genome of the legume symbiont Sinorhizobium meliloti.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADHZn(2+)Binds 1 zinc ion per subunit.Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.Belongs to the histidinol dehydrogenase family.Amino-acid biosynthesisHistidine biosynthesisMetal-bindingNADOxidoreductaseReference proteomeZincNAD(+)NAD(+)NAD(+)substratesubstrateZn(2+)substrateZn(2+)substratesubstrateZn(2+)substratesubstrateZn(2+)MAIRLNYLDTSFERDFAAFLTTKREVSEDVNAVVRAIIDDVRARGDAALADYSARFDGIDFTVTGMAVTSAEIDAAIHAVAPEVLGALKVAATRIEAHHRRQLPKDDIYEDQMGVGLGSRWTPIDAVGLYVPGGTASYPSSVLMNALPAKVAGVPRIVMVVPASGGSINPAVLAAARLAGVEEIYRIGGAQAVAALAYGTETIEPVAKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEVLVIADRDNDPDWIAADLLAQAEHDAGAQAILITDDAAFGDAVEKAVERQLKTLPRAETAAASWRDFGAVILVPDFDKAVPLANRIAPEHLELATADPDAMVPAIRNAGAIFIGRHTPEVIGDYVGGSNHVLPTARSARFSSGLGVLDYVKRTSILRLGPDQLRILGPAAIALARSEGLEAHARSVAIRLNLGEEG
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