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Reviewed, UniProtKB/Swiss-Prot Q92S26 (HISX1_RHIME)

Last modified November 25, 2008. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Histidinol dehydrogenase 1
      Short name=HDH 1
    EC=1.1.1.23
Gene names
Name: hisD1
Ordered Locus Names: R00611
ORF Names: SMc02307
OrganismRhizobium meliloti (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier382 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

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Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.

Catalytic activity

L-histidinol + 2 NAD(+) = L-histidine + 2 NADH.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Sequence similarities

Belongs to the histidinol dehydrogenase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Histidinol dehydrogenase 1
PRO_0000135832

Sites

Active site3271Proton acceptor By similarity
Active site3281Proton acceptor By similarity
Metal binding2591Zinc By similarity
Metal binding2621Zinc By similarity
Metal binding3611Zinc By similarity
Metal binding4201Zinc By similarity
Binding site1301NAD By similarity
Binding site1911NAD By similarity
Binding site2141NAD By similarity
Binding site2371Substrate By similarity
Binding site2591Substrate By similarity
Binding site2621Substrate By similarity
Binding site3281Substrate By similarity
Binding site3611Substrate By similarity
Binding site4151Substrate By similarity
Binding site4201Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q92S26-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: BEC67BD413535616

FASTA43445,555
        10         20         30         40         50         60 
MAIRLNYLDT SFERDFAAFL TTKREVSEDV NAVVRAIIDD VRARGDAALA DYSARFDGID 

        70         80         90        100        110        120 
FTVTGMAVTS AEIDAAIHAV APEVLGALKV AATRIEAHHR RQLPKDDIYE DQMGVGLGSR 

       130        140        150        160        170        180 
WTPIDAVGLY VPGGTASYPS SVLMNALPAK VAGVPRIVMV VPASGGSINP AVLAAARLAG 

       190        200        210        220        230        240 
VEEIYRIGGA QAVAALAYGT ETIEPVAKIV GPGNAYVAAA KRQVFGTVGI DMIAGPSEVL 

       250        260        270        280        290        300 
VIADRDNDPD WIAADLLAQA EHDAGAQAIL ITDDAAFGDA VEKAVERQLK TLPRAETAAA 

       310        320        330        340        350        360 
SWRDFGAVIL VPDFDKAVPL ANRIAPEHLE LATADPDAMV PAIRNAGAIF IGRHTPEVIG 

       370        380        390        400        410        420 
DYVGGSNHVL PTARSARFSS GLGVLDYVKR TSILRLGPDQ LRILGPAAIA LARSEGLEAH 

       430 
ARSVAIRLNL GEEG

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References

[1]"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021."
Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. expand/collapse author list , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.
Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed: 11481430] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1021.

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Cross-references

Sequence databases

AL591688 Genomic DNA. Translation: CAC45183.1.
RefSeqNP_384717.1.

3D structure databases

HSSPHSSP built from PDB template 1K75 based on UniProtKB P06988.
ModBaseSearch...

Genome annotation databases

GeneID1232249.
GenomeReviewsGene locus R00611 in contig AL591688_GR.
KEGGsme:SMc02307.
NMPDRfig|266834.1.peg.1905.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ92S26.

Enzyme and pathway databases

BioCycSMEL266834:SMC02307-MON.

Family and domain databases

HAMAPMF_01024.
[Tree]
InterProIPR001692. Histidinol_DHase.
IPR012131. Hstdl_DHase_prok.
[Graphical view]
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSPR00083. HOLDHDRGNASE.
ProDomPD002680. Histidinol_dh. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHISX1_RHIME
AccessionPrimary (citable) accession number: Q92S26
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: December 1, 2001
Last modified: November 25, 2008
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents