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Q92S26

- HISX1_RHIME

UniProt

Q92S26 - HISX1_RHIME

Protein

Histidinol dehydrogenase 1

Gene

hisD1

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei130 – 1301NADBy similarity
    Binding sitei191 – 1911NADBy similarity
    Binding sitei214 – 2141NADBy similarity
    Binding sitei237 – 2371SubstrateBy similarity
    Metal bindingi259 – 2591ZincBy similarity
    Binding sitei259 – 2591SubstrateBy similarity
    Metal bindingi262 – 2621ZincBy similarity
    Binding sitei262 – 2621SubstrateBy similarity
    Active sitei327 – 3271Proton acceptorBy similarity
    Active sitei328 – 3281Proton acceptorBy similarity
    Binding sitei328 – 3281SubstrateBy similarity
    Metal bindingi361 – 3611ZincBy similarity
    Binding sitei361 – 3611SubstrateBy similarity
    Binding sitei415 – 4151SubstrateBy similarity
    Metal bindingi420 – 4201ZincBy similarity
    Binding sitei420 – 4201SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciSMEL266834:GJF6-627-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase 1 (EC:1.1.1.23)
    Short name:
    HDH 1
    Gene namesi
    Name:hisD1
    Ordered Locus Names:R00611
    ORF Names:SMc02307
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Histidinol dehydrogenase 1PRO_0000135832Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SMc02307.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92S26.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92S26-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIRLNYLDT SFERDFAAFL TTKREVSEDV NAVVRAIIDD VRARGDAALA    50
    DYSARFDGID FTVTGMAVTS AEIDAAIHAV APEVLGALKV AATRIEAHHR 100
    RQLPKDDIYE DQMGVGLGSR WTPIDAVGLY VPGGTASYPS SVLMNALPAK 150
    VAGVPRIVMV VPASGGSINP AVLAAARLAG VEEIYRIGGA QAVAALAYGT 200
    ETIEPVAKIV GPGNAYVAAA KRQVFGTVGI DMIAGPSEVL VIADRDNDPD 250
    WIAADLLAQA EHDAGAQAIL ITDDAAFGDA VEKAVERQLK TLPRAETAAA 300
    SWRDFGAVIL VPDFDKAVPL ANRIAPEHLE LATADPDAMV PAIRNAGAIF 350
    IGRHTPEVIG DYVGGSNHVL PTARSARFSS GLGVLDYVKR TSILRLGPDQ 400
    LRILGPAAIA LARSEGLEAH ARSVAIRLNL GEEG 434
    Length:434
    Mass (Da):45,555
    Last modified:December 1, 2001 - v1
    Checksum:iBEC67BD413535616
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC45183.1.
    RefSeqiNP_384717.1. NC_003047.1.

    Genome annotation databases

    EnsemblBacteriaiCAC45183; CAC45183; SMc02307.
    GeneIDi1232249.
    KEGGisme:SMc02307.
    PATRICi23630435. VBISinMel96828_1984.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC45183.1 .
    RefSeqi NP_384717.1. NC_003047.1.

    3D structure databases

    ProteinModelPortali Q92S26.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMc02307.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC45183 ; CAC45183 ; SMc02307 .
    GeneIDi 1232249.
    KEGGi sme:SMc02307.
    PATRICi 23630435. VBISinMel96828_1984.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci SMEL266834:GJF6-627-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiHISX1_RHIME
    AccessioniPrimary (citable) accession number: Q92S26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3