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Q92RL0 (PUR2_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase

EC=6.3.4.13
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene names
Name:purD
Ordered Locus Names:R00858
ORF Names:SMc00993
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
PRO_0000151474

Regions

Domain107 – 312206ATP-grasp
Nucleotide binding133 – 19361ATP By similarity

Sites

Metal binding2821Magnesium or manganese By similarity
Metal binding2841Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92RL0 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 5E65E13B606D204B

FASTA42344,324
        10         20         30         40         50         60 
MKVLLIGSGG REHALAWKIA QSPRLTKLYA APGNPGIAEE AAIVDLHTEN HEDVVDFCRT 

        70         80         90        100        110        120 
HAIDFVVVGP EAPLVAGLGD VLRAADIPTF GPSAAAAQLE GSKGFTKDLC ARYGIPTGAY 

       130        140        150        160        170        180 
RRFTDAEPAK AYIREEGAPI VIKADGLAAG KGVTVAMSLD EAFAAVDECF AGAFGAAGAE 

       190        200        210        220        230        240 
VVVEAYLDGE EASFFCLCDG KSVLPLASAQ DHKRVGDGDT GPNTGGMGAY SPAPVMTAEM 

       250        260        270        280        290        300 
VERTMKEIIE PTVRGMAESG YPFTGVFFAG LMITEKGPEL IEYNVRFGDP ECQVLMMRLE 

       310        320        330        340        350        360 
SDLLPLLYAA ATGTLEGMKA EWRDEAALTV VMASRGYPGA YEKDTPIAAL PDASAATKVF 

       370        380        390        400        410        420 
HAGTAMKGGG LVAAGGRVLN VTATGKTVGE AKDAAYAAVR DVSWENGFYR NDIGWRAVAR 


ETA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591688 Genomic DNA. Translation: CAC45430.1.
RefSeqNP_384964.1. NC_003047.1.

3D structure databases

ProteinModelPortalQ92RL0.
SMRQ92RL0. Positions 1-420.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SMc00993.

Proteomic databases

ProMEXQ92RL0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC45430; CAC45430; SMc00993.
GeneID1232499.
KEGGsme:SMc00993.
PATRIC23630975. VBISinMel96828_2251.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033463.
KOK01945.
OMADPEAMNV.
OrthoDBEOG69SKD1.
ProtClustDBPRK00885.

Enzyme and pathway databases

BioCycSMEL266834:GJF6-877-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR2_RHIME
AccessionPrimary (citable) accession number: Q92RL0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways