Reviewed, UniProtKB/Swiss-Prot Q92RA4 (MSRB1_RHIME)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrB 1
    EC=1.8.4.12
Alternative name(s):
    Peptide-methionine (R)-S-oxide reductase 1

Gene names

Name:	msrB1
Ordered Locus Names:	R00991
ORF Names:	SMc00117

Organism

Rhizobium meliloti (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

382 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	135 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity.
Sequence similarities	Belongs to the msrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 135	135	Peptide methionine sulfoxide reductase msrB 1 HAMAP MF_01400		PRO_0000140290
Sites
	Active site	124	1	Nucleophile By similarity
	Metal binding	52	1	Zinc By similarity
	Metal binding	55	1	Zinc By similarity
	Metal binding	101	1	Zinc By similarity
	Metal binding	104	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92RA4-1 [UniParc]. Last modified June 16, 2003. Version 2. Checksum: F22222B102456B35	FASTA	135	15,364
	10 20 30 40 50 60 MSENRMPKIT KTNEEWRAAL TPEQYRVTRE HGTERPFTGP FLDNKRHGTY KCVCCGRALF 70 80 90 100 110 120 RSDTKFDSGC GWPSYFAPVD PDAIAEYVDR SHLMVRTEIR CADCDAHLGH VFPDGPPPTG 130 LRYCLNGTAM TFEED

References

[1]

"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021." Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F. Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed: 11481430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL591688 Genomic DNA. Translation: CAC45563.1. Different initiation.
RefSeq	NP_385097.2.
3D structure databases
HSSP	HSSP built from PDB template 1L1D based on UniProtKB P14930.
ModBase	Search...
Genome annotation databases
GeneID	1232634.
GenomeReviews	Gene locus R00991 in contig AL591688_GR.
KEGG	sme:SMc00117.
NMPDR	fig|266834.1.peg.2285.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q92RA4.
Enzyme and pathway databases
BioCyc	SMEL266834:SMC00117-MON.
BRENDA	1.8.4.12. 142.
Family and domain databases
HAMAP	MF_01400. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
ProDom	PD004057. DUF25. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00357. MsrB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB1_RHIME

Accession

Primary (citable) accession number: Q92RA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	June 16, 2003
Last modified:	March 3, 2009
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)