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Q92QZ0

- PDXA1_RHIME

UniProt

Q92QZ0 - PDXA1_RHIME

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Protein
4-hydroxythreonine-4-phosphate dehydrogenase 1
Gene
pdxA1, R01150, SMc00580
Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei140 – 1401Substrate By similarity
Binding sitei141 – 1411Substrate By similarity
Metal bindingi175 – 1751Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi220 – 2201Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi275 – 2751Divalent metal cation; shared with dimeric partner By similarity
Binding sitei283 – 2831Substrate By similarity
Binding sitei292 – 2921Substrate By similarity
Binding sitei301 – 3011Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. cobalt ion binding Source: UniProtKB-HAMAP
  4. magnesium ion binding Source: UniProtKB-HAMAP
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-1175-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase 1 (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase 1
Gene namesi
Name:pdxA1
Ordered Locus Names:R01150
ORF Names:SMc00580
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3423424-hydroxythreonine-4-phosphate dehydrogenase 1UniRule annotation
PRO_0000188821Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi266834.SMc00580.

Structurei

3D structure databases

ProteinModelPortaliQ92QZ0.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221592.
KOiK00097.
OMAiDTLFQDK.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92QZ0-1 [UniParc]FASTAAdd to Basket

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MSETSIGPVA LTMGDPAGIG PDITLSVWAK RADRPTPPFL YVGDPALLAA    50
RAKLLGQTVP ICETDCPGAV AAFRQALPVW PVRSPAPVIP GNPDAANASA 100
VTDAIDTAVR LVLAGEASAL ATNPISKAVL YEAGFRFPGH TEYLADLAAR 150
ATGVAALPVM MLAGPKLRAV PVTIHIPLKD VPAALTPDLI YETCTITAAD 200
LRSRFGLPAP RLAIAGLNPH AGEGGALGRE DDAVIRPVID RLRAEGLDVV 250
GPLPADTMFH DRARETYDVA ICMYHDQALI PAKALGFDDS VNVTLGLPFI 300
RTSPDHGTAF SLAGKGIARE ESLLAALRLA AELARNAGGT KR 342
Length:342
Mass (Da):35,613
Last modified:December 1, 2001 - v1
Checksum:i45C5CC060A7BCCBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591688 Genomic DNA. Translation: CAC45729.1.
RefSeqiNP_385256.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC45729; CAC45729; SMc00580.
GeneIDi1232794.
KEGGisme:SMc00580.
PATRICi23631597. VBISinMel96828_2559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591688 Genomic DNA. Translation: CAC45729.1 .
RefSeqi NP_385256.1. NC_003047.1.

3D structure databases

ProteinModelPortali Q92QZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc00580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC45729 ; CAC45729 ; SMc00580 .
GeneIDi 1232794.
KEGGi sme:SMc00580.
PATRICi 23631597. VBISinMel96828_2559.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221592.
KOi K00097.
OMAi DTLFQDK.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci SMEL266834:GJF6-1175-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiPDXA1_RHIME
AccessioniPrimary (citable) accession number: Q92QZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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