Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q92QZ0 (PDXA1_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxythreonine-4-phosphate dehydrogenase 1

EC=1.1.1.262
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase 1
Gene names
Name:pdxA1
Ordered Locus Names:R01150
ORF Names:SMc00580
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity. HAMAP-Rule MF_00536

Catalytic activity

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. HAMAP-Rule MF_00536

Cofactor

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5. HAMAP-Rule MF_00536

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00536

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00536.

Miscellaneous

The active site is located at the dimer interface By similarity.

Sequence similarities

Belongs to the PdxA family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3423424-hydroxythreonine-4-phosphate dehydrogenase 1 HAMAP-Rule MF_00536
PRO_0000188821

Sites

Metal binding1751Divalent metal cation; shared with dimeric partner By similarity
Metal binding2201Divalent metal cation; shared with dimeric partner By similarity
Metal binding2751Divalent metal cation; shared with dimeric partner By similarity
Binding site1401Substrate By similarity
Binding site1411Substrate By similarity
Binding site2831Substrate By similarity
Binding site2921Substrate By similarity
Binding site3011Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92QZ0 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 45C5CC060A7BCCBD

FASTA34235,613
        10         20         30         40         50         60 
MSETSIGPVA LTMGDPAGIG PDITLSVWAK RADRPTPPFL YVGDPALLAA RAKLLGQTVP 

        70         80         90        100        110        120 
ICETDCPGAV AAFRQALPVW PVRSPAPVIP GNPDAANASA VTDAIDTAVR LVLAGEASAL 

       130        140        150        160        170        180 
ATNPISKAVL YEAGFRFPGH TEYLADLAAR ATGVAALPVM MLAGPKLRAV PVTIHIPLKD 

       190        200        210        220        230        240 
VPAALTPDLI YETCTITAAD LRSRFGLPAP RLAIAGLNPH AGEGGALGRE DDAVIRPVID 

       250        260        270        280        290        300 
RLRAEGLDVV GPLPADTMFH DRARETYDVA ICMYHDQALI PAKALGFDDS VNVTLGLPFI 

       310        320        330        340 
RTSPDHGTAF SLAGKGIARE ESLLAALRLA AELARNAGGT KR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591688 Genomic DNA. Translation: CAC45729.1.
RefSeqNP_385256.1. NC_003047.1.

3D structure databases

ProteinModelPortalQ92QZ0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SMc00580.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC45729; CAC45729; SMc00580.
GeneID1232794.
KEGGsme:SMc00580.
PATRIC23631597. VBISinMel96828_2559.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1995.
HOGENOMHOG000221592.
KOK00097.
OMADTLFQDK.
OrthoDBEOG6GN6ZC.

Enzyme and pathway databases

BioCycSMEL266834:GJF6-1175-MONOMER.
UniPathwayUPA00244; UER00312.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
HAMAPMF_00536. PdxA.
InterProIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00557. pdxA. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDXA1_RHIME
AccessionPrimary (citable) accession number: Q92QZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways