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Q92QW2

- PUR5_RHIME

UniProt

Q92QW2 - PUR5_RHIME

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-1210-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:R01184
ORF Names:SMc00615
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148239Add
BLAST

Proteomic databases

PRIDEiQ92QW2.

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc00615.

Structurei

3D structure databases

ProteinModelPortaliQ92QW2.
SMRiQ92QW2. Positions 8-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92QW2-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSQSGKNGLT YSDAGVDIDA GNLMVEKIKP HVRSTRRPGA DGEIGGFGGL
60 70 80 90 100
FDLKAAGFSD PVLVAANDGV GTKLKIAIDA DKHDTVGIDL VAMCVNDLVV
110 120 130 140 150
QGAEPLFFLD YFATGKLDPD QGAAIVAGIA AGCREAGCAL IGGETAEMPG
160 170 180 190 200
MYSGGDYDLA GFAVGAAERG QLLPAGDIAE GDVILGLASS GVHSNGYSLV
210 220 230 240 250
RKIVSLSGLA WDAPAPFGEG TLADLLMTPT RIYVKPLLKA IRETGAIKAL
260 270 280 290 300
AHITGGGFPE NIPRVLPKHL AAEIDLGAIK PPAVFSWLAK TGGVAANEML
310 320 330 340 350
RTFNCGVGMI AVVPASEAEK VAAVLAGEGE TVFTLGRMVA RAEGAPGTIY

KGNLAI
Length:356
Mass (Da):36,330
Last modified:December 1, 2001 - v1
Checksum:iF5AF8E0753340CD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC45763.1.
RefSeqiNP_385290.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC45763; CAC45763; SMc00615.
GeneIDi1232828.
KEGGisme:SMc00615.
PATRICi23631669. VBISinMel96828_2595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC45763.1 .
RefSeqi NP_385290.1. NC_003047.1.

3D structure databases

ProteinModelPortali Q92QW2.
SMRi Q92QW2. Positions 8-341.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc00615.

Proteomic databases

PRIDEi Q92QW2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC45763 ; CAC45763 ; SMc00615 .
GeneIDi 1232828.
KEGGi sme:SMc00615.
PATRICi 23631669. VBISinMel96828_2595.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci SMEL266834:GJF6-1210-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiPUR5_RHIME
AccessioniPrimary (citable) accession number: Q92QW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3