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Protein

6,7-dimethyl-8-ribityllumazine synthase 1

Gene

ribH1

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.UniRule annotation

Catalytic activityi

1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate.UniRule annotation

Pathwayi: riboflavin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 6,7-dimethyl-8-ribityllumazine synthase 1 (ribH1), 6,7-dimethyl-8-ribityllumazine synthase 2 (ribH2)
  2. no protein annotated in this organism
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei165-amino-6-(D-ribitylamino)uracilUniRule annotation1
Active sitei84Proton donorUniRule annotation1
Binding sitei1095-amino-6-(D-ribitylamino)uracil; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei1231-deoxy-L-glycero-tetrulose 4-phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processRiboflavin biosynthesis

Enzyme and pathway databases

BRENDAi2.5.1.78 5347
UniPathwayiUPA00275; UER00404

Names & Taxonomyi

Protein namesi
Recommended name:
6,7-dimethyl-8-ribityllumazine synthase 1UniRule annotation (EC:2.5.1.78UniRule annotation)
Short name:
DMRL synthase 1UniRule annotation
Short name:
LS 1UniRule annotation
Short name:
Lumazine synthase 1UniRule annotation
Gene namesi
Name:ribH1UniRule annotation
Ordered Locus Names:R01215
ORF Names:SMc01777
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001347941 – 1536,7-dimethyl-8-ribityllumazine synthase 1Add BLAST153

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc01777

Structurei

3D structure databases

ProteinModelPortaliQ92QU0
SMRiQ92QU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni47 – 495-amino-6-(D-ribitylamino)uracil bindingUniRule annotation3
Regioni76 – 785-amino-6-(D-ribitylamino)uracil bindingUniRule annotation3
Regioni81 – 821-deoxy-L-glycero-tetrulose 4-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the DMRL synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UTT Bacteria
COG0054 LUCA
HOGENOMiHOG000229250
KOiK00794
OMAiHGNKGTE

Family and domain databases

CDDicd09209 Lumazine_synthase-I, 1 hit
Gene3Di3.40.50.960, 1 hit
HAMAPiMF_00178 Lumazine_synth, 1 hit
InterProiView protein in InterPro
IPR034964 LS
IPR002180 LS/RS
IPR036467 LS/RS_sf
PANTHERiPTHR21058 PTHR21058, 1 hit
PfamiView protein in Pfam
PF00885 DMRL_synthase, 1 hit
SUPFAMiSSF52121 SSF52121, 1 hit
TIGRFAMsiTIGR00114 lumazine-synth, 1 hit

Sequencei

Sequence statusi: Complete.

Q92QU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIKPVHIL IVEARFYDDM ADAMLDGAKH ALDAAGATYD IVTVPGALEI
60 70 80 90 100
PAAIAMALDG ADEGGAEYDG FVALGMVIRG ETYHFDIVAN ESARALMDLA
110 120 130 140 150
VSESLALGNG ILTVENDEQA WARARRTEGD KGGFAARAAL TMIELKQRLG

AEK
Length:153
Mass (Da):16,193
Last modified:December 1, 2001 - v1
Checksum:i8F50CA43DC559856
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA Translation: CAC45794.1
RefSeqiNP_385321.1, NC_003047.1
WP_003529297.1, NC_003047.1

Genome annotation databases

EnsemblBacteriaiCAC45794; CAC45794; SMc01777
GeneIDi1232859
KEGGisme:SMc01777
PATRICifig|266834.11.peg.2627

Similar proteinsi

Entry informationi

Entry nameiRISB1_RHIME
AccessioniPrimary (citable) accession number: Q92QU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health