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Protein

30S ribosomal protein S12

Gene

rpsL

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

With S4 and S5 plays an important role in translational accuracy.UniRule annotation
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
30S ribosomal protein S12UniRule annotation
Gene namesi
Name:rpsLUniRule annotation
Ordered Locus Names:R01351
ORF Names:SMc01314
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001462951 – 12330S ribosomal protein S12Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei893-methylthioaspartic acidBy similarity1

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.UniRule annotation

Protein-protein interaction databases

STRINGi266834.SMc01314.

Structurei

3D structure databases

ProteinModelPortaliQ92QH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S12P family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0048. LUCA.
HOGENOMiHOG000040063.
KOiK02950.
OMAiKSKVPAM.

Family and domain databases

CDDicd03368. Ribosomal_S12. 1 hit.
HAMAPiMF_00403_B. Ribosomal_S12_B. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSiPR01034. RIBOSOMALS12.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92QH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTVNQLIRK PRQAQVKRNK VPALQENPQK RGVCTRVYTT TPRKPNSALR
60 70 80 90 100
KVAKIRLTNG FEVIGYIPGE GHNLQEHSVV MIRGGRVKDL PGVRYHIIRG
110 120
VLDTQGVKNR KQRRSKYGAK RPK
Length:123
Mass (Da):14,029
Last modified:December 1, 2001 - v1
Checksum:i653ECA98BCE0B3B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC45930.1.
RefSeqiNP_385457.1. NC_003047.1.
WP_010969193.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC45930; CAC45930; SMc01314.
GeneIDi1233003.
KEGGisme:SMc01314.
PATRICi23632027. VBISinMel96828_2766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC45930.1.
RefSeqiNP_385457.1. NC_003047.1.
WP_010969193.1. NC_003047.1.

3D structure databases

ProteinModelPortaliQ92QH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266834.SMc01314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC45930; CAC45930; SMc01314.
GeneIDi1233003.
KEGGisme:SMc01314.
PATRICi23632027. VBISinMel96828_2766.

Phylogenomic databases

eggNOGiCOG0048. LUCA.
HOGENOMiHOG000040063.
KOiK02950.
OMAiKSKVPAM.

Family and domain databases

CDDicd03368. Ribosomal_S12. 1 hit.
HAMAPiMF_00403_B. Ribosomal_S12_B. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSiPR01034. RIBOSOMALS12.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS12_RHIME
AccessioniPrimary (citable) accession number: Q92QH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.