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Q92QB4 (GCH1_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:R01420
ORF Names:SMc01005
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 204204GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119436

Sites

Metal binding931Zinc By similarity
Metal binding961Zinc By similarity
Metal binding1641Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92QB4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 48C12BB6F2DF7A1D

FASTA20422,786
        10         20         30         40         50         60 
MDAIVKNFPV LDDTGRPTQK EAEEAVRVLL RWAGEDPARE GLKDTPSRVA KAYREIFGGY 

        70         80         90        100        110        120 
DLVAEDVLGR TFEEVSGYDD IVLEKDIPFY SHCEHHMVPI IGKAHIAYLP NGRVLGLSKI 

       130        140        150        160        170        180 
ARVVDIYARR LQTQEAMTAQ IAKAIDETLM PRGVAVMIEA EHLCMAMRGI KKQGATTLTT 

       190        200 
TFTGAFKSEP AEQVRFMTML RGFK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591688 Genomic DNA. Translation: CAC45999.1.
RefSeqNP_385526.1. NC_003047.1.

3D structure databases

ProteinModelPortalQ92QB4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SMc01005.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC45999; CAC45999; SMc01005.
GeneID1233073.
KEGGsme:SMc01005.
PATRIC23632177. VBISinMel96828_2840.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAQRIAEHM.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycSMEL266834:GJF6-1455-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_RHIME
AccessionPrimary (citable) accession number: Q92QB4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways