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Q92Q11 (GCSP_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:R01547
ORF Names:SMc02049
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166932

Amino acid modifications

Modified residue7041N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92Q11 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 4E6FD4F3AD392C62

FASTA954104,106
        10         20         30         40         50         60 
MSMPKDFTFT DYKPYDFANR RHIGPSPAEM DEMLKVVGYP SLDALIDDTV PPSIRQRTPL 

        70         80         90        100        110        120 
AWGAPMTERE ALDKLRETAN RNRKLVSLIG QGYYGTITPP VIQRNILENP AWYTAYTPYQ 

       130        140        150        160        170        180 
PEISQGRLEA LLNYQTMVCD LTGLDVANAS LLDEATAAAE AMAIAERVAK SKAKAFFIDE 

       190        200        210        220        230        240 
NCHPQTIALL KTRAEPLGWQ IVLGDPFEDL DAAGVFGAIF QYPGTYGHVR DFSGLIAKLH 

       250        260        270        280        290        300 
GQGAIAAVAA DPLALALLKS PGEMGADIAI GSTQRFGVPV GYGGPHAAYM AVKDAYKRSM 

       310        320        330        340        350        360 
PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM YAVFHGPDGI 

       370        380        390        400        410        420 
KAIAQSVHQK TVRLAMGLEK LGYTVEPDVF FDTITVEVGK LQGIILKAAV AEEVNLRKIG 

       430        440        450        460        470        480 
TTRIGISLDE RSRPVTLEAV WRAFGGDFKV EEFEPDYRLP QELLRTSAYL THPIFHMNRA 

       490        500        510        520        530        540 
ESEMTRYMRR LADRDLALDR AMIPLGSCTM KLNATAEMLP ITWPEFSEIH PFVPADQALG 

       550        560        570        580        590        600 
YQHLIEDLSQ KLCAITGYDA ISMQPNSGAQ GEYAGLLAIR AYHIANGNEH RDVCLIPTSA 

       610        620        630        640        650        660 
HGTNPASAQM AGMKVVVVKV SDAGEIDMDD FRAKAEQYAD TLSCCMITYP STHGVFEENV 

       670        680        690        700        710        720 
REVCEVVHKH GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL NLHKTFCIPH GGGGPGMGPI 

       730        740        750        760        770        780 
GVKSHLAPFL PGHPQTDGHE GAVSAAPFGS ASILPISWSY CLMMGGEGLT QATKVAILNA 

       790        800        810        820        830        840 
NYVAARLKGA YDVLYKSAKG RVAHECIIDT RPLAESAGVT VDDVAKRLID CGFHAPTMSW 

       850        860        870        880        890        900 
PVAGTLMIEP TESETKAELD RFCDAMLAIR EEARAIEDGR MDKVNNPLKN APHTVEDLVG 

       910        920        930        940        950 
DWDRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLV CTCPPIESYA EAAE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591688 Genomic DNA. Translation: CAC46126.1.
RefSeqNP_385653.1. NC_003047.1.

3D structure databases

ProteinModelPortalQ92Q11.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SMc02049.

Proteomic databases

PRIDEQ92Q11.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC46126; CAC46126; SMc02049.
GeneID1233201.
KEGGsme:SMc02049.
PATRIC23632441. VBISinMel96828_2971.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycSMEL266834:GJF6-1583-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_RHIME
AccessionPrimary (citable) accession number: Q92Q11
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families