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Q92Q11

- GCSP_RHIME

UniProt

Q92Q11 - GCSP_RHIME

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, R01547, SMc02049
Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-1583-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:R01547
ORF Names:SMc02049
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000166932Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ92Q11.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi266834.SMc02049.

Structurei

3D structure databases

ProteinModelPortaliQ92Q11.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92Q11-1 [UniParc]FASTAAdd to Basket

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MSMPKDFTFT DYKPYDFANR RHIGPSPAEM DEMLKVVGYP SLDALIDDTV    50
PPSIRQRTPL AWGAPMTERE ALDKLRETAN RNRKLVSLIG QGYYGTITPP 100
VIQRNILENP AWYTAYTPYQ PEISQGRLEA LLNYQTMVCD LTGLDVANAS 150
LLDEATAAAE AMAIAERVAK SKAKAFFIDE NCHPQTIALL KTRAEPLGWQ 200
IVLGDPFEDL DAAGVFGAIF QYPGTYGHVR DFSGLIAKLH GQGAIAAVAA 250
DPLALALLKS PGEMGADIAI GSTQRFGVPV GYGGPHAAYM AVKDAYKRSM 300
PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM 350
YAVFHGPDGI KAIAQSVHQK TVRLAMGLEK LGYTVEPDVF FDTITVEVGK 400
LQGIILKAAV AEEVNLRKIG TTRIGISLDE RSRPVTLEAV WRAFGGDFKV 450
EEFEPDYRLP QELLRTSAYL THPIFHMNRA ESEMTRYMRR LADRDLALDR 500
AMIPLGSCTM KLNATAEMLP ITWPEFSEIH PFVPADQALG YQHLIEDLSQ 550
KLCAITGYDA ISMQPNSGAQ GEYAGLLAIR AYHIANGNEH RDVCLIPTSA 600
HGTNPASAQM AGMKVVVVKV SDAGEIDMDD FRAKAEQYAD TLSCCMITYP 650
STHGVFEENV REVCEVVHKH GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL 700
NLHKTFCIPH GGGGPGMGPI GVKSHLAPFL PGHPQTDGHE GAVSAAPFGS 750
ASILPISWSY CLMMGGEGLT QATKVAILNA NYVAARLKGA YDVLYKSAKG 800
RVAHECIIDT RPLAESAGVT VDDVAKRLID CGFHAPTMSW PVAGTLMIEP 850
TESETKAELD RFCDAMLAIR EEARAIEDGR MDKVNNPLKN APHTVEDLVG 900
DWDRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLV CTCPPIESYA 950
EAAE 954
Length:954
Mass (Da):104,106
Last modified:December 1, 2001 - v1
Checksum:i4E6FD4F3AD392C62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591688 Genomic DNA. Translation: CAC46126.1.
RefSeqiNP_385653.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC46126; CAC46126; SMc02049.
GeneIDi1233201.
KEGGisme:SMc02049.
PATRICi23632441. VBISinMel96828_2971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591688 Genomic DNA. Translation: CAC46126.1 .
RefSeqi NP_385653.1. NC_003047.1.

3D structure databases

ProteinModelPortali Q92Q11.
ModBasei Search...

Protein-protein interaction databases

STRINGi 266834.SMc02049.

Proteomic databases

PRIDEi Q92Q11.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC46126 ; CAC46126 ; SMc02049 .
GeneIDi 1233201.
KEGGi sme:SMc02049.
PATRICi 23632441. VBISinMel96828_2971.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SMEL266834:GJF6-1583-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiGCSP_RHIME
AccessioniPrimary (citable) accession number: Q92Q11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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