Reviewed, UniProtKB/Swiss-Prot Q92PD8 (HEM6_RHIME)

Names and origin

Protein names

Recommended name:
    Coproporphyrinogen 3 oxidase, aerobic
    EC=1.3.3.3
Alternative name(s):
    Coproporphyrinogen III oxidase, aerobic
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase

Gene names

Name:	hemF
Ordered Locus Names:	R01827
ORF Names:	SMc00180

Organism

Rhizobium meliloti (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

382 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen III (O2 route): step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the aerobic coproporphyrinogen III oxidase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Coproporphyrinogen 3 oxidase, aerobic		PRO_0000109914

Sequences

	Sequence		Length	Mass (Da)
	Q92PD8-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 8F7715ECD82FAEFA	FASTA	303	34,322
	10 20 30 40 50 60 MERPQLPQGL PADIEDKKAA AKAWFESLRD TICAAFEAIE DELTGPLSDR PAGRFVAKDW 70 80 90 100 110 120 LREEGAGGGG RMSMMEGRVF EKVGVHTSTV FGEFSPEFRE QIPGASEDPR FWASGISLIA 130 140 150 160 170 180 HPVNPNVPAV HMNTRMVVTT SNWFGGGADL TPVLDRRRIM TDPDTVLFHR AMEIACNRHP 190 200 210 220 230 240 VADHAKFKQW CDEYFYLKHR NEPRGTGGIF YDWLRSAEEL GGWDADFAFT RDVGKAFALV 250 260 270 280 290 300 YPRIVRTNFN KPWTEQDRNE QLVRRGRYVE FNLLYDRGTI FGLKTGGNVE SILSSLPPLV RWP

References

[1]

"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021." Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F. Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed: 11481430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL591688 Genomic DNA. Translation: CAC46406.1.
RefSeq	NP_385933.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1233492.
GenomeReviews	Gene locus R01827 in contig AL591688_GR.
KEGG	sme:SMc00180.
NMPDR	fig|266834.1.peg.3121.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q92PD8.
Enzyme and pathway databases
BioCyc	SMEL266834:SMC00180-MON.
Family and domain databases
HAMAP	MF_00333. [Tree]
InterPro	IPR001260. Coprogen_oxidas. [Graphical view]
Gene3D	G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHER	PTHR10755. Coprogen_oxidas. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 1 hit. [Graphical view]
PIRSF	PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTS	PR00073. COPRGNOXDASE.
PROSITE	PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEM6_RHIME

Accession

Primary (citable) accession number: Q92PD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	December 1, 2001
Last modified:	November 4, 2008
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)